Octavio Ramilo, MD

Octavio Ramilo, MD is the Henry G. Cramblett Chair in Infectious Diseases and Professor of Pediatrics at the Ohio State University College of Medicine and Chief of Infectious Diseases at Nationwide Children’s Hospital in Columbus, Ohio. He obtained his medical degree from the Universidad Complutense in Madrid, Spain. Professor Ramilo completed his pediatric residency at the Hospital “12 de Octubre” in Madrid and a subsequent Pediatric Infectious Disease Fellowship at UT Southwestern Medical Center in Dallas, Texas. He has been involved in translational and clinical research related to the role of the host immune response in pathogenesis of infectious diseases for over 20 years. His current research is focused on pathogenesis and treatment of respiratory infections, especially RSV, and the application of genomics technologies for improving diagnosis and understanding of host responses to infectious agents.

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Gender:

• Male

Languages Spoken:

• English
• Spanish

Research Center:

• Center for Vaccines and Immunity

Areas of Interest:

• Dr. Ramilo is studying the immunopathogenesis of viral infections, specifically respiratory syncytial virus (RSV). He is working to understand the infectious properties of the virus itself and to understand how the body’s immune response contributes to the lung damage and persistence of clinical symptoms related to RSV.

Medical School

• Universidad Complutense De Madrid
  Date Completed: 01/20/1982

Internship

• Universidad Complutense De Madrid
  Date Completed: 12/31/1986

Fellowship

• University of Texas Southwestern Medical Center
  Date Completed: 03/31/1990

Residency

• University of Texas Southwestern Medical Center
  Date Completed: 08/31/1992

Residency

• University of Texas Southwestern Medical Center
  Date Completed: 08/31/1993

Department:

• Pediatrics

Section:

• Infectious Diseases

Speciality:

• Pediatric Infectious Diseases
  

Date of Appointment at Nationwide Children’s Hospital:

• 12/31/2009

2009–present

• Principal Investigator, Center for Vaccines and Immunity,
  The Research Institute at Nationwide Children’s Hospital, Columbus, OH.

2009–present

• Professor of Pediatrics, The Ohio State University College of Medicine, Columbus, OH.

2004–2009

• Professor, Department of Pediatrics & Cancer Immunobiology Center University of Texas Southwestern Medical Center, Dallas, TX.

2003–2009

• Clinical Director, Ryan White Title IV Programs (DFAN & Youth Angle) University of Texas Southwestern Medical Center, Dallas, TX.

1999–2004

• Associate Professor, Pediatrics and Microbiology
  and Cancer Immunobiology Center University of Texas Southwestern Medical Center, Dallas, TX.

1993–2009

• Member, Molecular Microbiology and Immunology Graduate Programs, Division of Cell and Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX.

1993–1999

• Assistant Professor, Pediatrics and Microbiology; Member, Cancer Immunobiology Center, University of Texas Southwestern Medical Center, Dallas, TX.

1990–1993

• Assistant Instructor, Pediatrics and Microbiology, University of Texas Southwestern Medical Center, Dallas, TX.

• Escosa-García,L; Ramilo,O; Mejías,A. 2013. [High-dose daptomycin use in methicillin-resistant Staphylococcus aureus disseminated infection].  Anales de pediatría (Barcelona, Spain : 2003). Vol. 78, no. 3. (March): 185-188.
• Bentebibel SE, Lopez S, Obermoser G, Schmitt N, Mueller C, Harrod C, Flano E, Mejias A, Albrecht RA, Blankenship D, Xu H, Pascual V, Banchereau J, Garcia-Sastre A, Palucka AK, Ramilo O, Ueno H. 2013. Induction of ICOS+CXCR3+CXCR5+ TH Cells Correlates with Antibody Responses to Influenza Vaccination.  Sci Transl Med.. Vol. 5, no. 176. (March): e176ra32.
• Mella,Cesar; Suarez-Arrabal,M,Carmen; Lopez,Santiago; Stephens,Julie; Fernandez,Soledad; Hall,Mark,W; Ramilo,Octavio; Mejias,Asuncion. 2013. Innate Immune Dysfunction is Associated with Enhanced Disease Severity In Infants with Severe Respiratory Syncytial Virus Bronchiolitis.  JOURNAL OF INFECTIOUS DISEASES. Vol. 207, no. 4. (February): 564-573.
• Hahn A, Wang W, Jaggi P, Dvorchik I, Ramilo O, Koranyi K, Mejias A. 2013. Human metapneumovirus infections are associated with severe morbidity in hospitalized children of all ages.  Epidemiol Infect.. Vol. 7, no. January: 1-11.
• Ramilo, O and Mejías, A. 2013. Diagnosis and Classification of Pathogens. In Genomic and Personalized Medicine. 2nd ed. Saunders: Elsevier.
• Jaggi,Preeti; Kajon,Adriana,E; Mejias,Asuncion; Ramilo,Octavio; Leber,Amy. 2013. Human Adenovirus Infection in Kawasaki Disease: A Confounding Bystander?.  CLINICAL INFECTIOUS DISEASES. Vol. 56, no. 1. (January): 58-64.
• Aquino,Victor,M; Cost,Carrye; Gomez,Ana; Bowers,Daniel,C; Ramilo,Octavio; Ahmad,Naveed; Winick,Naomi; Leavey,Patrick,J. 2012. Predictive Value of Interleukin-5 and Monocyte Chemotactic Protein-1 for Bacteremia in Children With Febrile Neutropenia.  JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY. Vol. 34, no. 6. (August): E241-E245.
• Ioannidis I, McNally B, Willette M, Peeples ME, Chaussabel D, Durbin JE, Ramilo O, Mejias A, Flaño E. 2012. Plasticity and virus specificity of the airway epithelial cell immune response during respiratory virus infection.  J Virol.. Vol. 86, no. 10. (May): 5422-36.
• Manzoni P, Paes B, Resch B, Carbonell-Estrany X, Bont L. 2012. High risk for RSV bronchiolitis in late preterms and selected infants affected by rare disorders: a dilemma of specific prevention.  Early Hum Dev.. Vol. 88, no. Suppl 2. (May): S34-41.
• Banchereau,Romain; Jordan-Villegas,Alejandro; Ardura,Monica; Mejias,Asuncion; Baldwin,Nicole; Xu,Hui; Saye,Elizabeth; Rossello-Urgell,Jose; Phuong Nguyen,P; Blankenship,Derek; Creech,Clarence,B; pascual,Virginia; Banchereau,Jacques; Chaussabel,Damien; Ramilo,Octavio. 2012. Host Immune Transcriptional Profiles Reflect the Variability in Clinical Disease Manifestations in Patients with Staphylococcus aureus Infections.  PLOS ONE. Vol. 7, no. 4. (April): ee34390.
• Nadorlik H, Marcon M, Koranyi K, Ramilo O, Mejias A. 2012. A 2-month-old with bacteremia and gastroenteritis.  Pediatr Infect Dis J.. Vol. 31, no. 2. (February): 210, 215-6.
• García C, Soriano-Fallas A, Lozano J, Leos N, Gomez AM, Ramilo O, Mejias A. 2012. Decreased innate immune cytokine responses correlate with disease severity in children with respiratory syncytial virus and human rhinovirus bronchiolitis.  Pediatr Infect Dis J.. Vol. 31, no. 1. (January): 86-9.
• Mejías, A and Ramilo O. 2012. Parainfluenza Viruses. In Principles and Practice of Pediatric Infectious Diseases.. 4 ed. Edited by Sarah Long. Saunders: Elsevier.
• Mejias,Asuncion; Ramilo,Octavio. 2011. Pneumococcal Pneumonia in Preschool Children Viral Coinfection Does Not Worsen Clinical Outcome Reply.  PEDIATRIC INFECTIOUS DISEASE JOURNAL. Vol. 30, no. 2. (February): 183-184.
• Garcia,Carla,G; Bhore,Rafia; Soriano-Fallas,Alejandra; Trost,Margaret; Chason,Rebecca; Ramilo,Octavio; Mejias,Asuncion. 2010. Risk Factors in Children Hospitalized With RSV Bronchiolitis Versus Non-RSV Bronchiolitis.  PEDIATRICS. Vol. 126, no. 6. (December): E1453-E1460.
• Kimberlin DW, Shalabi M, Abzug MJ, Lang D, Jacobs RF, Storch G, Bradley JS,Wade K, Ramilo O, Romero JR, Shelton M, Leach C, Guzman-Cottrill J, Robinson J,Abughali N, Englund J, Griffin J, Jester P, Cloud GA, Whitley RJ. 2010. Safety of Oseltamivir Compared With theAdamantanes in Children Less Than 12 Months of Age.  Pediatr. Infect. Dis. J.. Vol. 29, no. 3. (November): 195-198.
• Jordan-Villegas A, Chang ML, Ramilo O, Mejias A. 2010. Concomitant respiratory viral infections in Children with Kawasaki Disease.  Ped Infect Dis J. Vol. 29, no. 9. (January): 1-3.
• Mejias A and Ramilo O. 2010. RSV and Asthma, what is the evidence?.  Ed. Luzan. Vol. 1, no. January: 1-10.
• Techasaensiri B, Techasaensiri T, Mejias A, McCracken GH, Ramilo O. 2010. Viral Co-infections in Children with Invasive Pneumococcal Disease.  Ped Infect Dis J. Vol. 29, no. 6. (January): 1-6.
• Berry MPR, Graham CM, McNab FM, Xu Z, Bloch S, Oni T, Wilkinson K, Banchereau R, Skinner J, Wilkinson R, Quinn C, Blankenship D, Dhawan R, Cush J, Mejias A, Ramilo O, Kon O, Pascual V, Banchereau J, Chaussabel D, and O'Garra A. 2010. Transcriptional Profiling Reveals an Interferon-Inducible Neutrophil-Driven Signature in Human Tuberculosis.  Nature.
• Rodriguez R, Mejias A, and Ramilo O. 2010. Acute Bronchiolitis Infections in the Community.  n/a.
• Somers CC, Ahmad N, Mejias A, Buckingham SC, Carubelli C, Katz K, Leos N,Gomez AM, Devincenzo JP, Ramilo O, Jafri HS. 2009. Effect of dexamethasone onrespiratory syncytial virus-induced lung inflammation in children: results of arandomized, placebo controlled clinical trial.  Pediatr Allergy Immunol. Vol. 20, no. 5. (April): 477-485.
• Mejias A, Ramilo O. 2009. RSV persistence and recurrent wheezing.  Pediatr Infect Dis J. Vol. 28, no. 6. (March): 450-451.
• Ramilo O. 2009. Evolution of prophylaxis: MoAb, siRNA, vaccine, and small molecules.  Paediatr Respir Rev. Vol. 1, no. January: 23-25.
• Ardura MI, Banchereau R, Mejias A, Di Pucchio T, Glaser C, Allantaz F, Pascual V,Banchereau J, Chaussabel D, Ramilo O. 2009. Enhaced monocyte response anddecreased central memoryt T cells in Children with invasive Staphylococcus aureusinfections.  PLoS One. Vol. 4, no. 5. (January): ee5446.
• Ramilo O, Mejías A. 2009. Shifting the paradigm; host gene signatures for mdiagnois ofinfectious diseases.  Cell Host Microbe. Vol. 6, no. 3. (January): 199-200.
• Tripp R, Mejias A, Ramilo O. Host Gene Expression and RSV Infection. In Challenges and Opportunities for Respiratory Syncytial Virus Vaccines (CTMI).