Nephrology Annual Report :: Nationwide Children's Hospital

Nephrology 2014-2015 Annual Report

View the Nationwide Children's Hospital 2014-2015 Annual Report.

The Section of Nephrology at Nationwide Children’s Hospital provides specialized primary and consultative care for children with kidney and urinary tract problems through age 21. The section maintains an active inpatient service and outpatient clinical program. Disorders treated include acute kidney injury, chronic kidney disease, congenital anomalies of the kidneys and urinary tract, glomerular disorders, tubular disorders, urinary tract infection, kidney stones, fluid and electrolyte disorders, hypertension, and metabolic bone disease.

Amy Kogon, MD, joined our faculty this past year. She is primarily interested in mental health disorders and neurocognitive function in the chronic kidney disease population.

Clinical highlights include the opening of our first outreach clinic in Dublin; another clinic, combined with Urology to provide multidisciplinary care, entered its third year. Ongoing quality improvement activities include improving transition to adult care in kidney transplant patients, reducing catheter-associated infections, reducing hypotension associated with continuous renal replacement therapy initiation and improving care of pediatric chronic kidney disease.

The section maintains an active research program at The Research Institute at Nationwide Children’s. The section participates in clinical and translational studies involving urinary tract infection, obstructive uropathy, chronic kidney disease, dialysis, renal transplantation, nephrotic syndrome, hypertension, kidney stones and metabolic bone disorders. During the past year, four of the above faculty were supported by funding from the National Institutes of Health (NIH).

In addition, Brian Becknell, MD, PhD, was awarded a K08 grant to study the role of urothelium in the innate defense of the kidney. Nationwide Children’s is the Coordinating Center for one of only four national Participating Clinical Centers (Midwest Pediatric Nephrology Consortium) for the Cure Glomerulonephropathy Network, a five-year cohort study of 2,400 adults and children with glomerular disease funded by NIH/The National Institute of Diabetes and Digestive and Kidney Diseases that started this past year.

Research done by the faculty was presented at several national academic meetings. At the 2015 Pediatric Academic Societies Annual Meeting, three studies were selected for platform presentation, including one that was selected for the ASPN Trainee Research Award in Clinical Science. The faculty had 27 unique peer-reviewed publications, some of which are highlighted.

2014-2015 Grants Awarded


Ayoob, Rose
A Multicenter Single-arm Extension Study to Characterize the Long-term Safety of Study Drug in the Treatment of Secondary Hyperparathyroidism in Pediatric Subjects with Chronic Kidney Disease on Dialysis
Industry Sponsor
A Randomized, Open-Label, Controlled Study to Assess the Efficacy and Safety of Study Drug in Pediatric Subjects with Secondary Hyperparathyroidism and Chronic Kidney Disease Receiving Dialysis
Industry Sponsor
Becknell, Michael
Role of urothelium in epithelial integrity and innate defense of the kidney
National Institutes of Health
Ingraham, Susan
The Role of microRNA in Congenital Obstructive Nephropathy
National Institute of Diabetes & Digestive & Kidney Diseases
Mahan, John
Efficacy and safety in a dual endothelin receptor and angeotensin receptor blocker
Industry Sponsor
Patel, Hiren
International Pediatric Peritoneal Dialysis Network
The Children's Mercy Hospital
Schwaderer, Andrew
The interface between critical acid-base mediators and the renal bacterial defense
National Institutes of Health
Chronic Renal Insufficiency Cohort (CRIC) Study
University of Rochester
University of Pennsylvania
Smoyer, William
Integrative Proteomics & Metabolomics for Pediatric Glomerular Disease Biomarkers
National Institute of Diabetes & Digestive & Kidney Diseases
OSU Center for Clinical and Translational Science Award (UL1) – Administration
Ohio State University Research Foundation
National Institutes of Health
Nuclear Receptor and MAP Kinase Signaling in Podocyte Injury
National Institute of Diabetes & Digestive & Kidney Diseases
Expression Genetics in Drug Therapy
Ohio State University Research Foundation
National Institutes of Health
Spencer, John David
Ribonuclease 7: Antimicrobial Activity in the Human Kidney and Urinary Tract
National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)

Nephrology Faculty

Hiren P. Patel, MD

View Our Faculty »

Selected Nephrology Publications

Agrawal S, Guess AJ, Chanley MA, Smoyer WE. Albumin-induced podocyte injury and protection are associated with regulation of COX-2. Kidney International. 2014 Dec;86(6):1150-60.

Becknell B, Eichler TE, Beceiro S, Li B, Easterling RS, Carpenter AR, James CL, McHugh KM, Hains DS, Partida-Sanchez S, Spencer JD. Ribonucleases 6 and 7 have antimicrobial function in the human and murine urinary tract. Kidney International. 2015 Jan;87(1):151-61.

Hains DS, Chen X, Saxena V, Barr-Beare E, Flemming W, Easterling R, Becknell B, Schwartz GJ, Schwaderer AL. Carbonic anhydrase 2 deficiency leads to increased pyelonephritis susceptibility. American Journal of Physiology. Renal Physiology. 2014 Oct;307(7):F869-80.

Kusumi K, Becknell B, Schwaderer A. Trends in pediatric urolithiasis: patient characteristics, associated diagnoses, and financial burden. Pediatric Nephrology: Journal of the International Pediatric Nephrology Association. 2015 May;30(5):805-10.

Mahan JD, Stein DS. Teaching adults-best practices that leverage the emerging understanding of the neurobiology of learning. Current Problems in Pediatric and Adolescent Health Care. 2014 Jul;44(6):141-9.

View Team Publications »

Nationwide Children's Hospital
700 Children's Drive Columbus, Ohio 43205 614.722.2000