Neonatology Research Advances :: Nationwide Children's Hospital

Neonatology Research and Innovation

Research efforts at Nationwide Children's Hospital’s Section of Neonatal Medicine are focused on making advances in the prevention, diagnosis and treatment of premature infants.

The research interests of the physician-scientists within the Section of Neonatal Medicine are vast, but the primary focus is on the prevention of complications of prematurity. By working directly with the Center for Perinatal Research – one of the eleven Centers of Emphasis at The Research Institute at Nationwide Children's Hospital, investigators are using basic science and translational research to develop cutting-edge interventions designed to prevent premature delivery.

Clinical Studies

Clinical researchers at Nationwide Children's are committed to identifying new approaches for the prevention, diagnosis and treatment of childhood diseases, taking research discoveries from the lab to the patient's bedside.

Browse current research studies being conducted at Nationwide Children’s related to Neonatology

Neonatology Research Areas of Focus

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Does Feed Fortification or Blood Transfusion Quickly Lead to NEC?
A first-of-its-kind neonatal intensive care study evaluates whether feeding advances or packed red blood cell transfusions have a short-term effect on the odds of developing necrotizing enterocolitis.

Which GERD Symptoms in NICU Babies Actually Need Treatment?
Researchers gain further insight into which gastroesophageal reflux disease symptoms merit the use of proton pump inhibitors and follow-up in NICU babies with dysphagia.

Indomethacin Prophylaxis Associated With Substantially Improved Survival in Extremely Preterm Babies
While influential studies conducted in the 1990s showed no mortality benefit, a more contemporary cohort demonstrates the relative risk of death was 48 percent less for babies who received prophylaxis.

DHA to Prevent Preterm Birth: The ADORE Trial
This Phase III trial will be the first study to evaluate high-dose docosahexaenoic acid with reduction of earliest preterm birth as a primary outcome.

Severe BPD Ventilator Strategies: A Quick Guide
A chart, adapted from the Bronchopulmonary Dysplasia Consortium, shows the differences in strategies between early acute care, when prevention is the goal, and later chronic care, when severe BPD is established.

Antibiotics for Presumed Early-onset Neonatal Sepsis Costly but Often Unnecessary
Overuse of the medication can lead to antibiotic resistance and necrotizing enterocolitis in this vulnerable population.

Infants Discharged From NICUs Have a Reduced Neurological Response to Touch
The degree of prematurity and the number of painful procedures experienced are independently associated with brain response attenuation; findings reinforce the importance of supportive touch and avoiding pain for babies in neonatal intensive care units.

How a QI Intervention Lowered Breast Milk Errors in a Busy NICU
Bedside barcode scanners and dedicated milk preparation technicians helped drive the decline.

Targeted Evaluation and Management of Difficult NICU Feeders Lead to Better Long-Term Outcomes
Individualized oral feeding strategies allow many neonates to be discharged without gastrostomy tubes, resulting in improved neurodevelopmental milestones at 2 years of age compared to gastrostomy-fed infants.

NSAIDs for Patent Ductus Arteriosus Do Not Improve Important Outcomes in Infants Born Preterm
A large comparative effectiveness study found no significant association between nonsteroidal anti-inflammatory treatment and odds of mortality or bronchopulmonary dysplasia, supporting a conservative treatment approach.

How to Reduce Necrotizing Enterocolitis in the NICU
A QI project with simple, inexpensive interventions significantly lowered the NEC infection rate in one of the country’s largest neonatal units.

How To Better Manage Pain in Newborns
A recent AAP policy statement focuses on nonpharmacologic interventions to limit neonate suffering.

Neonatology News

To learn more about the work being done at Nationwide Children's Section of Neonatal Medicine, read our News & Highlights.

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Ohio Perinatal Research Network

Nationwide Children’s is leading the effort with The Ohio State University Colleges of Medicine, Public Health and Nursing and The Ohio State University Medical Center to better understand preterm births and find prevention methods.

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