Nehal A. Parikh, DO, MS

Nehal Parikh, DO, MS joined the Section of Neonatology as an Associate Professor of Pediatrics and Principal Investigator in the Center for Perinatal Research at Nationwide Children’s Hospital in January 2011. Dr. Parikh completed his pediatrics residency at Winthrop University Hospital of State University of New York at Stony Brook. He completed a fellowship in neonatal-perinatal medicine at Thomas Jefferson University Hospital in Philadelphia and received an M.S. in Clinical Research from the University of Texas Health Science Center at Houston.
Dr. Parikh’s lab focuses on developing accurate and reliable brain segmentation methods for volumetric and diffusion tensor MRI and employing epidemiologic principles to elucidate the etiology, pathogenesis, and diagnosis of perinatal-neonatal brain injury in high-risk preterm and term infants.

Gender:

• Male

Languages Spoken:

• English
• Gujarati

Research Center:

• Center for Perinatal Research
• Center for Clinical and Translational Research

Areas of Interest:

• Perinatal-neonatal brain injury is a leading contributor of neurodevelopmental impairments. Our group’s goal is to improve the long-term quality of life of high-risk preterm and term newborns cared for in the neonatal ICU. Our work has been facilitated through generous support from the NIH (NINDS, NICHD, NCRR) and RINCH and enriched by collaborators in radiology, neurology, neuropathology, and developmental pediatrics. Studies designed to elucidate the etiology, pathogenesis, and diagnosis of perinatal-neonatal brain injury and aberrant brain development are facilitating targeted efforts at prevention and treatment of early insults. We have developed robust manual and automated brain MRI segmentation methods to objectively measure regional brain macro and microstructure in vivo using volumetric and diffusion tensor MRI. Using epidemiologic approaches, quantitative regional cerebral abnormalities are being correlated with antenatal, intrapartum, and neonatal clinical factors and functional neurodevelopmental assessments at and beyond 2 years of age.

Medical School

• New York College of Osteopathic Medicine of New Yo
  Date Completed: 05/31/1996

Residency

• SUNY Stony Brook School of Medicine
  Date Completed: 06/30/1999

Fellowship

• Jefferson Medical College Hospital
  Date Completed: 06/30/2002

Graduate School

• University of Texas Medical School at Houston
  Date Completed: 12/15/2007

Department:

• Pediatrics

Section:

• Neonatology

Speciality:

• Neonatal-Perinatal Medicine
  

Date of Appointment at Nationwide Children’s Hospital:

• 03/31/2011

• Parikh, N.A., Katsetos, C.D., Fritz, K.I., Legido, A., and Mishra, O.P. Neuronal Nitric Oxide Synthase Expression Following Hypoxia in the Cerebral Cortex of Newborn Piglets. Pediatr Res. 51(4):461A, 2002.
• Gupta, R.K., Hasan, K.M., Trivedi, R., Kanabar, B., Pradhan, M., Das, V., Parikh, N.A., and Narayana, P.A. Diffusion Tensor Imaging of the Developing Human Cerebrum. J Neurosci Res. 2005;81(2):172-178. PubMed ID: 15931676
• Tyson, J.E., Parikh, N.A., Langer, J., Green, C., Higgins, R., for the NICHD Neonatal Research Network. Intensive Care for Extreme Prematurity – Moving Beyond Gestational Age. N Engl J Med. 2008;358(16):1672-81. PubMed ID: 18420500
• Mietzsch, U., Parikh, N.A., Williams, A.L., Shankaran, S., and Lasky, R.E. Effects of Hypoxic-Ischemic Encephalopathy and Whole-Body Hypothermia on Neonatal Auditory Function: A Pilot Study. Am J of Perinatol. 2008;25(7):435-41. PubMed ID: 18720323
• Parikh, N.A., Fritz K.I., Zhu, A., Mishra, O.P., and Delivoria-Papadopoulos, M. Effect of Neuronal Nitric Oxide Synthase (nNOS) Inhibition on DNA Fragmentation in Neuronal Nuclei During Hypoxia in Newborn Piglets. Pediatr Res. 49(4):45A, 2001.
• Parikh, N.A., Lasky, R.E., Tyson, J.E., Kennedy, K.A., Zhang, Y., and Yu, X. Does Low Dose Hydrocortisone Improve Volumetric MRI Measures of Cerebral Growth in Extremely Low Birth Weight (ELBW) Infants at High Risk for Bronchopulmonary Dysplasia (BPD)?: A Randomized Trial. E-PAS 2009:Late-Breaker Platform.
• McGowan, J.E., Zubrow, A.B., Parikh, N.A., and Zhu, A. Mechanism of Cerebral Oxidant Injury During Hypoglycemia and Hypoxia. Pediatr Res. 49(4):351A, 2001.
• Parikh, N.A., Lasky, R.E., Tyson, J.E., Moya F.R., and Kennedy, K.A. Effects of Postnatal Dexamethasone on Cerebral Tissue Volumes in Extremely Low Birth Weight Infants. PAS 2005:57:1505A.
• Ambalavanan, N. and GDB Subcommittee for the NICHD Neonatal Research Network. Outcome Trajectories in Extremely Low Birth Weight (ELBW) Infants. E-PAS 2009:4765.3.
• Legido, A., Taylor, M.L., Geddes, J.F., Kaleyias, J.M., Parikh, N.A., Zanelli, S.A., de Chadarevian, J.P., and Katsetos, C.D. Decreased Immunoreactivity of Calbindin-D28K in Cerebellar Purkinje Cells of Children with Hypoxic/ Ischemic Encephalopathy. Annals of Neurology. 50(3S):S129, 2001.
• Katsetos, C.D., Parikh, N.A., Fritz, K.I., Legido, A., Delivoria-Papadopoulos, M., and Mishra, O.P. Effect of 7-Nitroindazole Sodium on the Cellular Distribution of Neuronal Nitric Oxide Synthase in the Cerebral Cortex of Hypoxic Newborn Piglets. Neurochem Res. 2006;31(7):899-906. PubMed ID: 16804757
• Zhang, Y., Yu, X., Lasky, R.E., Datta, S., Parikh, N.A., and Narayana, P.A. Comprehensive Brain MRI Segmentation in High Risk Preterm Newborns. PLoS One. 2010;5(11): e13874. PubMed ID: 21079730
• Parikh, N.A., Ashraf, Q.M., Legido, A., Chadarevian, J.P., and Katsetos, C.D. Expression of Neuronal Nitric Oxide Synthase during Hypoxia in the Cerebellum of Newborn Piglets." Pediatr Res. 49(4):442A, 2001.
• Lasky, R.E., Luck, M.L., Parikh, N.A., and Laughlin, N.K. The Effects of Early Lead Exposure on the Brains of Adult Rhesus Monkeys: A Volumetric MRI Study. Toxicol Sci. 2005;85(2):963-975. PubMed ID: 15788724
• Parikh, N., Tyson, J., Kennedy, K., Yu, X., Zhang, Y., Shukla, R., Narayana, P., and Lasky, R. Perinatal Predictors of MRI Brain Volume Abnormalities at Term in Extremely Low Birth Weight (ELBW) Infants. E-PAS 2010:3746.501.
• Fritz, K.I., Parikh, N.A., Zhu, A., Mishra, O.P., and Delivoria-Papadopoulos, M. Effect of Moderate Hypocapnic Ventilation on Neuronal Nuclear Ca++-Influx in the Cerebral Cortex of Newborn Piglets. Pediatr Res. 49(4):372A, 2001.
• Lee, H.C., Green, C., Hintz, S.R., Tyson, J.E., Parikh, N.A., Langer, J., Gould, J.B. Prediction of Mortality for Extremely Premature Infants in a Population Based Cohort. Pediatrics. Sept. 2010;126(3):e644-50. PubMed ID: 20713479
• Ramirez, M.M., Bertles, A., Parikh, N., Blackwell, S., and Tyson, J.E. Parental wishes, resuscitation decisions, and prognostic estimates at 22-24 wks gestation. Am J Obstet Gynecol 2008 SMFM meeting supplement. Am J Obstet Gynecol. 199(6); Supplement A: 219, p S72; 2008.
• Parikh, N.A., Locke, R.L., Paul, D.A., Chidekel, A., Leef, K., Emberger, J., and Stefano, J.L. The Effect of Inhaled Corticosteroids on Markers of Pulmonary Inflammation and Lung Maturation in Preterm Infants with Evolving Chronic Lung Disease. J Am Osteopath Assoc. 2004;104(3):114-120. PubMed ID: 15083986
• Parikh, N.A., Lasky, R.E., Tyson, J.E., Moya F.R., and Kennedy, K.A. Effects of Postnatal Dexamethasone on Brain Component Volumes in Extremely Low Birth Weight Infants. J Investig Med. 53(1):S291, 2005.
• Hirsch, D., Parikh, N., and Davis, J.M. Hypernatremic Dehydration and Fever in Breastfed Newborns Prior to Newborn Discharge." Pediatr Res. 49(4):342A, 2001.
• Parikh, N.A., Katsetos, C.D., Legido, A., Fritz, K.I., and Mishra, O.P. Effect of Neuronal Nitric Oxide Synthase (nNOS) Inhibition on Caspase-3 Expression During Hypoxia in the Cerebral Cortex of Newborn Piglets. Pediatr Res. 53(4):63A, 2003.
• Parikh, N.A., Yu, X., Zhang, Y., Lasky, R.E., Datta, S., Tyson, J.E., and Narayana, P.A. Reliable and Accurate Brain Volume Segmentation in Extremely Low Birth Weight Infants. E-PAS 2009:3868.279.
• Lasky, R.E, Parikh, N.A., Williams, A.L., Padhye, N.S., and Shankaran, S. Changes in the PQRST Intervals and Heart Rate Variability Associated with Re-warming in Two Newborns Undergoing Hypothermia Therapy. Neonatology. 2009;96:93-95 PubMed ID: 19252411
• Parikh, N.A., Lasky, R.E., Kennedy, K.A., Moya, F.R., Hochhauser, L., Romo, S., and, Tyson, J.E. Postnatal Dexamethasone Therapy and Cerebral Tissue Volumes in Extremely Low Birth Weight Infants. Pediatrics. 2007;119(2):262-272. PubMed ID: 17272615
• Parikh, N.A., Katsetos, C.D., Ashraf, Q.M., Haider, S.H., Legido, A., Delivoria-Papadopoulos, M., and Mishra, O.P. Hypoxia-Induced Caspase-3 Activation and DNA Fragmentation in Cortical Neurons of Newborn Piglets: Role of Nitric Oxide. Neurochem Res. 2003;28(9):1351-1357. PubMed ID: 12938857
• Bertles, A., Parikh, N., Tyson, J.E., Blackwell, S., and Ramirez, M.M. Can ultrasound estimate of fetal weight substitute for birth weight in predicting survival at the threshold of viability? Am J Obstet Gynecol 2008 SMFM meeting supplement. Am J Obstet Gynecol. 199(6); Supplement A:734, p S209; 2008.
• Parikh, N.A., C. Arnold, Tyson, J.E. Evidence-Based Treatment Decisions for Extremely Preterm Newborns. Pediatrics. 2010;125:813-816. PubMed ID: 20351013
• Parikh, N.A., Tyson J.E., and the NICHD Neonatal Research Network. Viability, Treatment, and Outcome at 18-22 Months for Extremely Premature Infants. E-PAS 2006:59:5531.175.
• Wyckoff, M.H., Parikh, N., Balachanadran, N., Moya, F., Laptook, A.R. Improved Temperature Profile Using a ThermoTek (TT) Cooling System for Induction of Hypothermia Compared to the Cincinnati Sub-Zero (CSZ). E-PAS 2006:59:443.
• Parikh, N.A., Lasky, R.E., Bonfante-Mejia, E., Shankaran, S., and Tyson, J.E. Relationship of MRI Cerebral Tissue Volumes to Whole-Body Hypothermia Therapy for Hypoxic-Ischemic Encephalopathy and Neurosensory Outcomes. E-PAS 2008:5365.7
• Haider, S.H., Ashraf, Q.M., Parikh, N.A., Delivoria-Papadopoulos, M., and Mishra, O.P. The Expression of Protein Tyrosine Phosphatase (PTP-1B) Following Hypoxia on Neuronal Cell Membranes of Newborn Piglets. Pediatr Res. 51(4):443A, 2002.
• Parikh, N.A., Locke, R.G., Chidekel, A., Leef, K.H., Emberger, J., Paul, D.A., and Stefano, J.L. Effect of Inhaled Corticosteroids on Inflammatory Cytokines in Preterm Infants with Evolving Chronic Lung Disease. Pediatr Res. 51(4):356A, 2002.
• Parikh, N.A., Lasky, R.E., Garza, C., Bonfante-Mejia, E., Shankaran, S., and Tyson, J.E. Volumetric and Anatomic MRI for Hypoxic-Ischemic Encephalopathy: Relationship to Hypothermia Therapy and Neurosensory Impairments. J Perinatol. 2008. 29(2):143-149. PubMed ID: 19020525
• Legido, A., Parikh, N.A., Taylor, M.L., Kaleyias, J.M., de Chadarevian, J.P., and Katsetos, C.D. Decreased Immunoreactivity of Calbindin-D28K in Cerebellar Purkinje Cells of Children with Hypoxic/ Ischemic Encephalopathy. Pediatr Res. 51(4):447A, 2002.
• Zhou, Y., Parikh, N.A., Burson, K., Narayana, P.A. 3-Tesla Cerebral Proton Magnetic Resonance Spectroscopy in Healthy Term and Extremely Preterm Infants. 2011 ISMRM Annual Meeting. Abstract 5367.
• Parikh, N.A., Tyson J.E., and the NICHD Neonatal Research Network. Viability, Treatment, and Outcome at 18-22 Months for Extremely Premature Infants. E-PAS 2006:59:5531.175.
• Lasky RE, Church MW, Orlando MS, Morris BH, Parikh NA, Tyson JE, McDavid GE, Oh W, Stevenson DK, Van Meurs KP, Guillet R, Phelps DL. The Effects of Aggressive Versus Conservative Phototherapy on the Brainstem Auditory Evoked Responses of Extremely Low Birth Weight Infants. Pediatr Res. 2011 In press.
• Parikh, N.A., Locke, R.L., Paul, D.A., Chidekel, A., Leef, K., Emberger, J., and Stefano, J.L. The Effect of Inhaled Corticosteroids on Markers of Pulmonary Inflammation and Lung Maturation in Preterm Infants with Evolving Chronic Lung Disease. J Am Osteopath Assoc. 2004;104(3):114-120. PubMed ID: 15083986
• Bertles, A., Parikh, N., Tyson, J.E., Blackwell, S., and Ramirez, M.M. Can ultrasound estimate of fetal weight substitute for birth weight in predicting survival at the threshold of viability? Am J Obstet Gynecol 2008 SMFM meeting supplement. Am J Obstet Gynecol. 199(6); Supplement A:734, p S209; 2008.
• • Beauchamp MS, Beurlot MR, Fave E, Nath AR, Parikh NA, Saad ZS, Bortfeld H, Oghalai JS. The Developmental Trajectory of Brain-Scalp Distance from Birth through Childhood: Implications for Functional Neuroimaging. PLoS ONE. 2011;6(9): e2498.
• Shankaran S, Pappas A, McDonald SA, Laptook AR, Bara R, Ehrenkranz RA, Tyson JE, Goldberg R, Donovan EF, Fanaroff AA, Das A, Poole WK, Walsh M, Higgins RD, Welsh C, Salhab W, Carlo WA, Poindexter B, Stoll BJ, Guillet R, Finer NN, Stevenson DK, Bauer CR; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. [Parikh NA, UT-Houston site principal investigator]. Predictive value of an early amplitude integrated electroencephalogram and neurologic examination. Pediatrics. 2011;128(1):e112-20. PubMed ID: 21669899
• Parikh, N.A., Katsetos, C.D., Ashraf, Q.M., Haider, S.H., Legido, A., Delivoria-Papadopoulos, M., and Mishra, O.P. Hypoxia-Induced Caspase-3 Activation and DNA Fragmentation in Cortical Neurons of Newborn Piglets: Role of Nitric Oxide. Neurochem Res. 2003;28(9):1351-1357. PubMed ID: 12938857
• Ambalavanan, N. and GDB Subcommittee for the NICHD Neonatal Research Network. Outcome Trajectories in Extremely Low Birth Weight (ELBW) Infants. E-PAS 2009:4765.3.
• Wyckoff, M.H., Parikh, N., Balachanadran, N., Moya, F., Laptook, A.R. Improved Temperature Profile Using a ThermoTek (TT) Cooling System for Induction of Hypothermia Compared to the Cincinnati Sub-Zero (CSZ). E-PAS 2006:59:443.
• Lee, H.C., Green, C., Hintz, S.R., Tyson, J.E., Parikh, N.A., Langer, J., Gould, J.B. Prediction of Mortality for Extremely Premature Infants in a Population Based Cohort. Pediatrics. Sept. 2010;126(3):e644-50. PubMed ID: 20713479
• Parikh, N.A., C. Arnold, J Langer, Tyson, J.E. Evidence-Based Treatment Decisions for Extremely Preterm Newborns. Pediatrics. 2010;125:813-816. PubMed ID: 20351013
• Lasky, R.E., Luck, M.L., Parikh, N.A., and Laughlin, N.K. The Effects of Early Lead Exposure on the Brains of Adult Rhesus Monkeys: A Volumetric MRI Study. Toxicol Sci. 2005;85(2):963-975. PubMed ID: 15788724
• Sorrentino DF, Fritz KI, Haider SH, Parikh N, Papadopoulos MD, Mishra OP. Nitric oxide-mediated modification of the glycine binding site of the NMDA receptor during hypoxia in the cerebral cortex of the newborn piglet. Neurochem Res. 2004;29(2):455-9. PubMed ID: 15002744
• Tyson, J.E., Parikh, N.A., Langer, J., Green, C., Higgins, R., for the NICHD Neonatal Research Network. Intensive Care for Extreme Prematurity – Moving Beyond Gestational Age. N Engl J Med. 2008;358(16):1672-81. PubMed ID: 18420500
• Hirsch, D., Parikh, N., and Davis, J.M. Hypernatremic Dehydration and Fever in Breastfed Newborns Prior to Newborn Discharge." Pediatr Res. 49(4):342A, 2001.
• Parikh, N.A., Lasky, R.E., Tyson, J.E., Kennedy, K.A., Zhang, Y., and Yu, X. Does Low Dose Hydrocortisone Improve Volumetric MRI Measures of Cerebral Growth in Extremely Low Birth Weight (ELBW) Infants at High Risk for Bronchopulmonary Dysplasia (BPD)?: A Randomized Trial. E-PAS 2009:Late-Breaker Platform.
• Ramirez, M.M., Bertles, A., Parikh, N., Blackwell, S., and Tyson, J.E. Parental wishes, resuscitation decisions, and prognostic estimates at 22-24 wks gestation. Am J Obstet Gynecol 2008 SMFM meeting supplement. Am J Obstet Gynecol. 199(6); Supplement A: 219, p S72; 2008.
• Katsetos, C.D., Parikh, N.A., Fritz, K.I., Legido, A., Delivoria-Papadopoulos, M., and Mishra, O.P. Effect of 7-Nitroindazole Sodium on the Cellular Distribution of Neuronal Nitric Oxide Synthase in the Cerebral Cortex of Hypoxic Newborn Piglets. Neurochem Res. 2006;31(7):899-906. PubMed ID: 16804757
• Parikh, N.A., Lasky, R.E., Garza, C., Bonfante-Mejia, E., Shankaran, S., and Tyson, J.E. Volumetric and Anatomic MRI for Hypoxic-Ischemic Encephalopathy: Relationship to Hypothermia Therapy and Neurosensory Impairments. J Perinatol. 2008. 29(2):143-149. PubMed ID: 19020525
• Gupta, R.K., Hasan, K.M., Trivedi, R., Kanabar, B., Pradhan, M., Das, V., Parikh, N.A., and Narayana, P.A. Diffusion Tensor Imaging of the Developing Human Cerebrum. J Neurosci Res. 2005;81(2):172-178. PubMed ID: 15931676
• Mietzsch, U., Parikh, N.A., Williams, A.L., Shankaran, S., and Lasky, R.E. Effects of Hypoxic-Ischemic Encephalopathy and Whole-Body Hypothermia on Neonatal Auditory Function: A Pilot Study. Am J of Perinatol. 2008;25(7):435-41. PubMed ID: 18720323
• Parikh, N., Tyson, J., Kennedy, K., Yu, X., Zhang, Y., Shukla, R., Narayana, P., and Lasky, R. Perinatal Predictors of MRI Brain Volume Abnormalities at Term in Extremely Low Birth Weight (ELBW) Infants. E-PAS 2010:3746.501.
• Parikh, N.A., Lasky, R.E., Kennedy, K.A., Moya, F.R., Hochhauser, L., Romo, S., and, Tyson, J.E. Postnatal Dexamethasone Therapy and Cerebral Tissue Volumes in Extremely Low Birth Weight Infants. Pediatrics. 2007;119(2):262-272. PubMed ID: 17272615
• Lasky, R.E, Parikh, N.A., Williams, A.L., Padhye, N.S., and Shankaran, S. Changes in the PQRST Intervals and Heart Rate Variability Associated with Re-warming in Two Newborns Undergoing Hypothermia Therapy. Neonatology. 2009;96:93-95 PubMed ID: 19252411
• Zhang, Y., Yu, X., Lasky, R.E., Datta, S., Parikh, N.A.*, and Narayana, P.A. Comprehensive Brain MRI Segmentation in High Risk Preterm Newborns. PLoS One. 2010;5(11): e13874. PubMed ID: 21079730