Nahla Saad Zaghloul, MD :: Nationwide Children's Hospital, Columbus, Ohio

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Nahla Saad Zaghloul, MD

Nahla Saad Zaghloul, MD

Center for Perinatal Research
Principal Investigator

Neonatology
Physician Team

Neonatology Fellowship
Faculty

Contact Information

Neonatology
700 Children's Dr
Columbus, OH 43205 [ map ]
PH: (614) 722-4530
FX: (614) 722-4541

Biography

Gender:

  • Female

Languages Spoken:

  • English

Research Interests

Research Center:

Areas of Interest:

  • Periventricular leukomalacia (PVL) is a major neuropathologic brain injury in premature infants and the leading cause of cerebral palsy. It underlies most of the neurologic morbidity (motor, cognitive, attention, behavioral and visual deficits) encountered in survivors of premature birth. A major pathogenic factor is maturation-dependent vulnerability of the oligodendroglial precursor cell (OPC) that are vulnerable to attack by free radicals generated by hypoxic ischemic injury. Microglia and astroglia are involved in PVL pathogenesis. NF-kB has many important physiological beneficial functions but has harmful inflammatory functions as well. I am currently studying the inhibition of microglial NF-kB and astroglial NF-kB as a novel therapeutic approach for PVL, in a hypoxic-ischemic mouse model of PVL. My studies focused on developing a new prophylactic/ therapeutic approach for PVL which can significantly reduce brain injury after hypoxic-ischemic insults manifested as improvement in long term motor and cognitive functions of the growing neonate.

Education and Training

Graduate School

  • Cairo University Faculty of Medicine
    Date Completed: 11/30/2003

Residency

  • Suez Canal University
    Date Completed: 10/30/2006

Fellowship

  • Stony Brook University Hospital
    Date Completed: 06/30/2007

Residency

  • Stony Brook University Hospital
    Date Completed: 06/30/2009

Fellowship

  • Cohen's CHildrens Medical Center of NY
    Date Completed: 06/30/2012

Department:

  • Pediatrics

Section:

  • Neonatology

Specialty:

  • Neonatal-Perinatal Medicine
  • Pediatrics

Date of Appointment at Nationwide Children’s Hospital:

  • 07/31/2012

Publications

  • Zaghloul,Nahla; Nasim,Mansoor; Patel,Hardik; Codipilly,Champa; Marambaud,Philippe; Dewey,Stephen; Schiffer,Wynne,K; Ahmed,Mohamed. 2012. Overexpression of extracellular superoxide dismutase has a protective role against hyperoxia-induced brain injury in neonatal mice.  FEBS JOURNAL. Vol. 279, no. 5. (March): 871-881.
  • Ahmed,Mohamed; Zhang,Yinzhong; Zaghloul, Nahla; Wolin, Michael; Miller, Edmund. 2012. Extracellular Superoxide Dismutase Overexpression Can Reverse the Course of Hypoxia-Induced Pulmonary Hypertension.  MOLECULAR MEDICINE. Vol. 18, no. 1. (February): 38-46.
Nationwide Children's Hospital
700 Children's Drive Columbus, Ohio 43205 614.722.2000