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December 2011 :: Dr. Denis Guttridge Discusses NF-kB Therapy for Duchenne Muscular Dystrophy 

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Guest:  Denis Guttridge, PhD, Associate Professor, Molecular Virology, Immunology and Medical Genetics, The Ohio State University

Access an abstract of this month’s featured research articles: Improvement of cardiac contractile function by peptide-based inhibition of NF-κB in the utrophin/dystrophin-deficient murine model of muscular dystrophy.  J Transl Med. 2011 May 17;9:68. doi: 10.1186/1479-5876-9-68.

Peptide-based inhibition of NF-κB rescues diaphragm muscle contractile dysfunction in a murine model of Duchenne muscular dystrophy.  Mol Med. 2011 May-Jun;17(5-6):508-15. doi: 10.2119/molmed.2010.00263. 

September 2011 :: Dr. Jill Rafael-Fortney Discusses the Effects of Lisinopril and Spironolactone on DMD mice

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Guest:  Jill Rafael-Fortney, PhD, Department of Molecular and Cellular Biochemistry, The Ohio State University

Access an abstract of this month’s featured research article:  Early Treatment with Lisinopril and Spironolactone Preserves Cardiac and Skeletal Muscle in Duchenne Muscular Dystrophy Mice. Circulation. 2011 Aug 2;124(5):582-8.

August 2011 :: Dr. Valérie Allamand Discusses the Function of Selenoprotein N in Muscle and Its Link to Neuromuscular Disorders

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Guest: Valérie Allamand, PhD, the Institute of Myology, Paris, France

Access an abstract of this month’s featured research article: Satellite cell loss and impaired muscle regeneration in selenoprotein N deficiency. Hum Mol Genet. 2011 Feb 15;20(4):694-704.
 

July 2011 :: Dr. Carsten Bonnemann Discusses Collagen VI Myopathies and a Novel Cause of Ullrich Congenital Muscular Dystrophy

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Guest: Dr. Carsten Bonnemann, MD, Senior Investigator, Neurogenetics Branch, and Chief of Neuromuscular and Neurogenetic Disorders of Childhood Section, National Institutes of Neurological Disorders and Stroke, National Institutes of Health

Access an abstract of this month's featured research article: Large genomic deletions: a novel cause of Ullrich congenital muscular dystrophy. Ann Neurol. 2011 Jan;69(1):206-11.
 

July 2011 :: Dr. Carsten Bonnemann Discusses Collagen VI Myopathies and a Novel Cause of Ullrich Congenital Muscular Dystrophy

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Guest: Dr. Carsten Bonnemann, MD, Senior Investigator, Neurogenetics Branch, and Chief of Neuromuscular and Neurogenetic Disorders of Childhood Section, National Institutes of Neurological Disorders and Stroke, National Institutes of Health

Access an abstract of this month's featured research article: Large genomic deletions: a novel cause of Ullrich congenital muscular dystrophy. Ann Neurol. 2011 Jan;69(1):206-11.
 

June 2011 :: Dr. Paul Martin Discusses How the CMAH Gene Deletion in the mdx Mouse Model of Duchenne Muscular Dystrophy Helps Better Mimic the More Severe Aspects of DMD

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Guest:  Paul Martin, PhD, principal investigator, Center for Gene Therapy, The Research Institute at Nationwide Children’s Hospital

Access an abstract of this month’s featured research article:  A human-specific deletion in mouse Cmah increases disease severity in the mdx model of Duchenne muscular dystrophy. Sci Transl Med. 2010 Jul 28;2(42):42ra54.
 

February 2011: Dr. Scott Harper Discusses DUX4 as a Potential Candidate Gene for Facioscapulohumeral Muscular Dystrophy

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Guest: Scott Harper, PhD, Nationwide Children's Hospital

Access an abstract of this Month's Featured Research Article: DUX4, a candidate gene for facioscapulohumeral muscular dystrophy, causes p53-dependent myopathy in vivo. Ann Neurol. 2010 Oct 28. [Epub ahead of print]
 

January 2011: Dr. Jerry Mendell Discusses Dystrophin Immunity in Duchenne Muscular Dystrophy

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Guest: Jerry Mendell, MD, Nationwide Children's Hospital

Access an abstract of this Month's Featured Research Article: Dystrophin immunity in Duchenne's muscular dystrophy. N Engl J Med. 2010 Oct 7;363(15):1429-37.