(From the March 2014 issue of Research Now)
United States Patent no. 8,652,773, issued on February 18, was assigned to Nationwide Children's Hospital. The invention--Genes of an otitis media isolate of nontypeable Haemophilus influenza--was invented by Lauren Bakaletz, PhD, vice president of The Research Institute and director of the Center for Microbial Pathogenesis; Robert Munson, PhD, principal investigator in the Center for Microbial Pathogenesis; and David W. Dyer, PhD, professor of microbiology and immunology at Oklahoma University.
The invention relates to the polynucleotide sequence of a nontypeable stain of Haemophilus influenzae (NTHi) and polypeptides encoded by the polynucleotides and uses thereof. The invention also relates to NTHi genes which are upregulated during or in response to NTHi infection of the middle ear and/or the nasopharynx.
The patent was filed on September 12, 2012, under Application No. 13/612,176.