Medical Professional Publications

Innovation and Discovery

(From the September 2014 Issue of MedStat)

More news from The Research Institute can be found at NationwideChildrens.org/Research-Now.

Continuous Antibiotics Not Necessary for Many Children with Common Prenatal Abnormality
Up to 5 percent of all prenatal ultrasounds uncover antenatal hydronephrosis, or enlarged kidneys, the most commonly detected prenatal abnormality in the United States. Many children with this abnormality are treated continually with preventive antibiotics for the first few years of life with the hopes of preventing the condition’s associated urinary tract infections. Until recently, however, little evidence existed as to the benefits of this treatment, which involves considerable cost and inconvenience for families. But a study published in the Journal of Pediatric Urology found that, in most cases, continuous antibiotics for these children are unnecessary, findings that are especially of interest amidst increasing concern regarding antibiotic overuse.

Read the Research Now article.

L-cysteine May Be Effective and Safe for Clearing Central Venous Catheter Occlusions in Children
Researchers studying critically ill pediatric patients have found that L-cysteine – a commercially available, sterile solution – may be a potentially effective agent to clear central venous catheter (CVC) occlusions in the absence of hydrochloric acid (HCl). The study was published in Nutrition in Clinical Practice in August and was led by Steven Plogsted, PharmD, who is a clinical pharmacist at Nationwide Children’s Hospital. Pediatric patients, especially those in the pediatric intensive care unit (PICU), receive multiple medications and have a higher risk of CVC occlusion. Due to increased complexity of sterile compounding, manufacturing, and storage of 0.1N HCl, which is commonly used as a clearing agent for CVC occlusions, researchers examined L-cysteine as an alternative. CVC occlusions were effectively cleared by a single instillation of L-cysteine in 10 of 16 episodes, without any complications. This is the first-time that use of L-cysteine as a CVC clearing agent has been documented in the literature.

New Study Finds High School Lacrosse Players at Risk for Concussions
Lacrosse is one of the fastest-growing high school sports in the U.S., with more than 170,000 students now playing the hard-hitting game. The growing participation numbers, however, mean that more young people than ever are at risk of injury in lacrosse practice and competition. In a study published by The American Journal of Sports Medicine researchers from the Center for Injury Research and Policy at Nationwide Children’s Hospital and the Colorado School of Public Health found that high school players experienced 1,406 injuries over the 4 academic years from 2008 through 2012. The overall injury rate was 20 per 10,000 lacrosse competitions and practices. More than 22 percent of those injuries were concussions, making that the second most common injury diagnosis behind sprains and strains (38 percent).

Read the Research Now article.

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