Risa Kitagawa, PhD, and her co-workers in the Center for Childhood Cancer and Blood Diseases are investigating the role of a proto-oncoprotein, securin, in maintenance of genome stability and tumorigenesis. They use C. elegans as a model to analyze the physiologic functions of securin in organisms at well-defined developmental stages.
Fluorescence microscope-based time lapse analysis of single cells during animal development in combination with a genetic approach using RNAi-mediated gene silencing revealed a new molecular mechanism mediated by a HECT-E3 ligase which regulates the securin dynamics for proper meiotic progression. These studies will shed light on processes that can be exploited for cancer therapy.
Our research article entitled "HECT-E3 ligase ETC-1 regulates the abundance of cytoplasmic securin and cyclin B1 to promote timely anaphase during meiosis in C. elegant" describing our recent progress in this research has just been accepted this month by the journal, Development.
Contact: Risa Kitagawa, PhD