(From the January 2014 issue of Research Now)
Dr. Santiago Partida-Sánchez’ lab studies the mechanisms that regulate immune cell migration during inflammation or infection. They have focused on macrophage responses induced by bacterial infections at the urinary tract (UTI). The lab’s central interest is to understand the functional role of two subtypes of macrophages: M1 and M2, with pro- and anti- inflammatory properties, respectively. Partida-Sánchez’ team found that classical inflammatory macrophages are associated to increased inflammation in both, genitourinary organs as well as systemic, following urinary tract infection. In collaboration with Dr. Sheryl Justice’s lab, the team reported that such changes in immunological status induced by urinary tract infected mothers, significantly correlated to lowest offspring weight and additional adverse perinatal outcomes. In contrast, non-classical anti-inflammatory macrophages appear to be required to prevent spreading of bacteria from the bladder to the kidney, protecting this vital organ from pyelonephritis and its serious complications.
The lab is interested in extending the functional characterization of M2 subtype of anti-inflammatory macrophages, and studying their potential therapeutic utility to attenuate a range of cardiovascular inflammatory diseases.
Sumoza-Toledo A, Lang I, Cortado H, Bhagat H,Mori Y, Fleig A, Penner R, Partida-Sánchez S. Dendritic Cell Maturation and Chemotaxis is Regulated by TRPM2-mediated Lysosomal Calcium Release. FASEB Journal. 2011 Oct, 25(10):3529-42.
Bolton M, Horvath Jr. DJ, Li B, Cortado H, Newsom D, White P, Partida-Sánchez S* and Justice SS*. Intrauterine growth restriction is a direct consequence of localized maternal uropathogenic Escherichia coli cystitis. PLoS One. 2012;7(3):e33897. Epub 2012 Mar 21.
*Shared senior and corresponding author.
Hans PC, Koenig SN, Huang N, Cheng J, Beceiro S, Guggilam A, Kuivaniemi HS, Partida-Sánchez S, Garg V. Inhibition of Notch1 Signaling Reduces Abdominal Aortic Aneurysm in Mice by Attenuating Macrophage-Mediated Inflammation. Arteriosclerosis, Thrombosis, and Vascular Biology. 2012 Dec, 32(12):3012-23.
McNally B, Willette M, Partida-Sánchez S, Flaño E. Intranasal administration of dsRNA induces interferon-α receptor-dependent accumulation of antigen experienced T cells in the airways. PLoS One. 2012, 7(12).