Medical Professional Publications

Research Information Solutions and Innovation (RISI): 2015 Genomics IT Accomplishments

(From the January 2016 issue of Research Now)

The role of the Research Information Solutions and Innovation (RISI) department in The Research Institute at Nationwide Children's Hospital is to provide superior technological products/applications, service and support that strengthen the ability of all their clients to advance bold and innovative research discoveries.

In line with their mission to accelerate research through innovative information technology (IT) solutions and achieve the best outcomes in health care for children, RISI co-authored seven genomic IT-related publications in 2015:

  1. Rajeswari Swaminathan, Yungui Huang, Soheil Moosavinasab, Ronald Buckley, Christopher W Bartlett, Simon M Lin. A review on Genomics APIs. Computational and Structural Biotechnology Journal. Published on October 31 2015
  2. Zhang W, Yu Y, Hertwig F, Thierry-Mieg J, …, Lin SM, ... & Rosswog C (2015). Comparison of RNA-seq and microarray-based models for clinical endpoint prediction. Genome Biology, 16(1), 1-12.
  3. Herr, T M, ..., Lin SM, … & Starren J (2015). Practical considerations in genomic decision support: The eMERGE experience. Journal of Pathology Informatics, 6(1), 50.
  4. Ye Z, Kadolph C, Strenn R, Wall D, McPherson E, Lin S. WHATIF: An open-source desktop application for extraction and management of the incidental findings from next-generation sequencing variant data. Comput Biol Med. 2015 Apr 8. pii: S0010-4825(15)00106-7. doi: 10.1016/j.compbiomed.2015.03.028. [Epub ahead of print] PubMed PMID: 25890833.
  5. He M, Person TN, Hebbring SJ, Heinzen E, Ye Z, Schrodi SJ, McPherson EW, Lin SM, Peissig PL, Brilliant MH, O'Rawe J, Robison RJ, Lyon GJ, Wang K. SeqHBase: a big data toolset for family based sequencing data analysis. J Med Genet. 2015 Apr;52(4):282-8. doi: 10.1136/jmedgenet-2014-102907. Epub 2015 Jan 13. PubMed PMID: 25587064; PubMed Central PMCID: PMC4382803.
  6. Hebbring SJ, Rastegar-Mojarad M, Ye Z, Mayer J, Jacobson C, Lin S. Application of clinical text data for phenome-wide association studies (PheWASs). Bioinformatics. 2015 Feb 4. pii: btv076. [Epub ahead of print] PubMed PMID: 25657332.
  7. Rastegar-Mojarad M, Ye Z, Kolesar JM, Hebbring SJ, Lin SM. Opportunities for drug repositioning from phenome-wide association studies. Nature Biotechnology. 2015 Apr 7;33(4):342-5. doi: 10.1038/nbt.3183. PubMed PMID: 25850054.

From bioinformatics and biotechnology, to genome biology and medical genetics, RISI is working with partners in the Computational Resources program and the Battelle Center for Mathematical Medicine to meet the extreme demands on investigators for computational technology and services. RISI is committed to The Research Institute's vision of supporting cutting-edge, scienfitic research at the highest ethical standards by providing outstanding service to investigators at Nationwide Children's.

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