Medical Professional Publications

Innovation and Discovery

(From the September 2017 Issue of  MedStat)                     

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Bakaletz Lab Biofilm Work Published in Proceedings of the National Academy of Sciences

The laboratory of Lauren Bakaletz, PhD, director, Center for Microbial Pathogenesis and vice president of basic sciences, The Research Institute at Nationwide Children’s, studied the biofilm construction capabilities of nontypeable Haemophilus influenzae (NTHI), a bacterium responsible for sinusitis, pneumonia, exacerbations of cystic fibrosis and COPD, bronchitis and ear infections. Biofilms are large 3D communities of bacteria that adhere to body surfaces and protect bacteria from environmental stressors such as antibiotics and antibodies. The lab found that when H. influenzae builds its biofilms, it does so via an active and regulated means while remaining intact, unlike other bacteria which self-sacrifice in order to contribute to the biofilm. Other types of bacteria either explode, sending their DNA into the biofilm, or shuttle their DNA out into the environment through a syringe-like appendage produced by the bacterium, all to benefit the potency of the biofilm.

“We’re very excited that our work with biofilms has been accepted for publication by the Proceedings of the National Academy of Sciences,” says Dr. Bakaletz. “Our lab hopes to use what we’ve learned about H. influenzae biofilms to identify vaccine targets as well as improve existing methods of therapeutic treatment for the diseases of the respiratory tract caused by this prevalent pathogen.”

Read the News Room article. 

Meaningful Improvement of Child Health Requires Core Quality and Outcomes Measures

The seemingly infinite indicators large pediatric systems use to measure children’s health often fall short in determining patient outcomes and quality of care. In an editorial published in JAMA Pediatrics, Kelly Kelleher, MD, director of the Center for Innovation in Pediatric Practice at Nationwide Children’s Hospital, and co-author William Gardner from the Children’s Hospital of Eastern Ontario, calls for a national effort to develop a core set of quality and outcome measures for children.

“The specific health needs of children can change rapidly as they pass through the developmental stages,” notes Dr. Kelleher. “To respond to that, an exclusively pediatric measure set must be used. But the measure set must also be sensitive to development without excessively expanding the number of measures and making use of the set not feasible.”

Read the Pediatrics Nationwide article.

Poison Control Centers Received 275,000 Calls for Dietary Supplement Exposures from 2000 through 2012

U.S. Poison Control Centers receive a call every 24 minutes, on average, regarding dietary supplement exposures, according to a new study from the Center for Injury Research and Policy and the Central Ohio Poison Center. The study, published online in the Journal of Medical Toxicology, found the rate of calls regarding dietary supplement exposures increased (46.1 percent) during 2000 to 2002, decreased (8.8 percent) during 2002 to 2005 and increased again (49.3 percent) from 2005 to 2012. Seventy percent of dietary supplement exposure calls occurred among children younger than six years old and the majority of these were unintentional. Most exposures (97.3 percent) occurred at home, and in more than 97 percent of the cases, the child swallowed the substance. Serious medical outcomes accounted for 4.5 percent of exposures and the most serious outcomes (95 percent) occurred among children six years and older.

Read the News Room article.

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