Medical Professional Publications

Innovation and Discovery

(From the August 2017 Issue of MedStat)                             

Visit NationwideChildrens.org/Research-News for additional information regarding these articles. More news from The Research Institute can be found at NationwideChildrens.org/Research-Now.

Needle-free Immunization Prevents Experimental Otitis Media

The pathogen nontypeable Haemophilus influenza (NTHI) is responsible for the majority of cases of otitis media, or middle ear infections. Thanks to collaborative research between the Tulane University School of Medicine and the lab of Lauren Bakaletz, PhD, director of the Center for Microbial Pathogenesis at Nationwide Children’s Hospital and senior author of the study, an alternative way to deliver vaccines against ear infections has been developed. The new study published in Clinical and Vaccine Immunology uses a small bandage behind the ear to deliver the vaccine through the skin and prevent bacteria causing disease. This bandage approach had high overall vaccine efficacy and could reduce the burden of ear infections worldwide.

Read the Pediatrics Nationwide article.

Center for Healthy Weight and Nutrition Pursues Family Approach to Treating Childhood Obesity

Nationwide Children’s Hospital’s Center for Healthy Weight and Nutrition is joining three other universities on one of the largest family-based childhood obesity studies ever conducted.

Working with the University of Buffalo, Washington University in St. Louis, and the University of Rochester, the study will investigate the effectiveness of a treatment program that teaches both a child and their parents how to change their behaviors and attitudes regarding food, activity and stressful situations. Past studies have shown that this type of behavioral approach can carry a “halo effect,” with other family members often seeing benefit as well, which researchers will track.

Altogether, the study will treat more than 500 families of children between the ages of 6 and 12 and their parents as well as more than 200 siblings who are overweight or obese. The treatment program will be integrated into the primary care setting and families will meet regularly with a trained health coach. The intervention meets the recommendation from the recently published  U.S. Preventive Services Task Force guidelines for childhood obesity treatment says Dr Ihuoma Eneli, Director for the Center for Healthy Weight and Nutrition and a principal investigator in The Research Institute.

The study is funded for $8.8 million from the National Institutes of Health, of which Nationwide Children’s will receive $1.5 million. Dr. Eneli’s team will begin recruiting locally in July 2017 in at least 3 Nationwide Children’s primary care network practices.  

Read the article from Research Now

Sweat Chloride Should Be the First-Line CF Test, but Often Isn’t

The Cystic Fibrosis Foundation clearly states that sweat chloride needs to be the first test ordered after a positive newborn cystic fibrosis (CF) screening or clinical suspicion of CF. Shahid Sheikh, MD, is a member of the Section of Pulmonary Medicine and senior author of a study that indicates a different test is conducted first and is sometimes the only test. This variation from clinical guidelines was demonstrated to cost $500,000 in unnecessary testing and would have missed the diagnosis of 20 patients if they had not received the designated sweat test. This retrospective study was published in Worldwide Journal of Pediatrics and hopes to lessen variation for best practices and outcomes.

Read the Pediatrics Nationwide article.

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