Medical Professional Publications

Innovation and Discovery

(From the June 2017 Issue of MedStat)

Visit NationwideChildrens.org/Research-News for additional information regarding these articles. More news from The Research Institute can be found at NationwideChildrens.org/Research-Now.

The Maternal Microbiome: How Stress During Pregnancy Impacts Female Offspring in Adulthood

Previous research has demonstrated that stress during pregnancy changes the composition of the intestinal microbiota and is related to the emergence of behavioral disorders such as anxiety and depression. Michael Bailey, PhD, principal investigator in the Center for Microbial Pathogenesis in The Research Institute at Nationwide Children’s Hospital, is senior author of a recent study that suggests a critical window of pregnancy where stress is able to influence the microbiome and intrauterine environment, with lasting behavioral consequences. The new study shows that microbiome changes are manifested in the mother and also found in female offspring in adulthood, with a correlation between increased maternal stress and increased anxiety-like behavior as well as cognitive alterations in adult female offspring.

Read the Pediatrics Nationwide article.

Nationwide Children’s Hospital Research Team Awarded Innovative Development Grant from AHA

A multidisciplinary research team at Nationwide Children’s was recently awarded a grant from the American Heart Association (AHA) to harness the power of big data to improve outcomes in cardiovascular care. The team will use a cloud-based collaboration platform known as CardioGenomics eXchange commons (CGX), which allows for the analysis and exchange of genomic sequencing data among cardiovascular researchers. The project team, led by Katie Miller, PhD, postdoctoral scientist in Research Information Solutions and Innovation (RISI) at The Research Institute, was one of only two awardees out of 80 grant submissions. Simon Lin, MD, MBA, chief research information officer at The Research Institute, is the principal investigator for the project, and Vidu Garg, MD, director of the Center for Cardiovascular Research at The Research Institute and physician in The Heart Center at Nationwide Children’s, is co-principal investigator.

Read more in the Research Now article.

Does Celiac Disease Increase Risk for Functional Abdominal Pain?

Functional abdominal pain disorders (FAPDs), such as irritable bowel syndrome and functional dyspepsia, are highly prevalent around the world. In children, these disorders are associated with multiple comorbidities, poor quality of life, school absenteeism and enormous costs of care. A recent multinational study evaluated the prevalence of FAPDs in children with celiac disease (CD) and controls and found surprising results, suggesting that not all types of gastrointestinal inflammation lead to FAPDs in children. Miguel Saps, MD, an attending gastroenterologist in the Division of Gastroenterology, Hepatology and Nutrition at Nationwide Children’s Hospital, is leader of the study, which was published in the Journal of Pediatrics.

Read the Pediatrics Nationwide article.

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