Medical Professional Publications

Innovation and Discovery

(From the August 2016 Issue of MedStat)

Researchers Develop Effective Strategy for Disrupting Bacterial Biofilms, Cause of Many Chronic and Recurrent Diseases

Biofilms are communities of bacteria that adhere to a surface and are nearly impossible to eradicate when they are pathogenic. The laboratories of Lauren Bakaletz, PhD, director of the Center for Microbial Pathogenesis at The Research Institute at Nationwide Children’s Hospital, and Steven Goodman, PhD, principal investigator in the Center for Microbial Pathogenesis, are co-developers of an innovative therapeutic that targets an integral component of extracellular DNA, which is universally found in biofilm matrixes in the majority of chronic and recurrent diseases, including urinary tract infections, middle ear infections, sinusitis and chronic wound infections. The novel approach was reported in a recent study published in the journal EBioMedicine.

Read the News Room article.

Psychosocial Standards of Care for Children with Cancer and Their Families

After a three-year-long process and consultations with dozens of professionals in the fields of oncology, psychiatry, psychology, social work and nursing, 15 “Psychosocial Standards of Care in Pediatric Oncology” were developed, with substantial contributions from Nationwide Children’s Hospital staff members. The recent publication identifies evidence-based standards for psychosocial care that experts consider essential for youth cancer patients and their families. Authors from Nationwide Children’s include Tammi Young-Saleme, PhD, director of Psychosocial Services and Program Development in the Division of Hematology/Oncology/BMT at Nationwide Children’s; Cynthia Gerhardt, PhD, director of the Center for Biobehavioral Health and co-director for the Patient-Centered Pediatric Research Fellowship (PC-PReP) in The Research Institute at Nationwide Children’s; and Stacy Flowers, PsyD, psychologist in Neuro-Oncology, Pediatric Psychology and Psychosocial Services.

Read the Pediatrics Online article.

Often-Unreported MRI Finding May Indicate Neurodevelopmental Impairment in Premature Infants

Magnetic resonance imaging of the brain is increasingly used to predict neurodevelopmental outcomes in premature infants, but the existing systems of scoring those MRIs rely heavily on expert opinion. Laurel Slaughter, MD, neurologist at Nationwide Children’s Hospital, is lead author of a study in the journal Neonatology that explored a more objective system for scoring MRIs. Moderate-to-severe gyral maturation delay, an abnormality of the brain’s gray matter, was found to be a significant predictor of overall neurodevelopmental impairment in premature infants with extremely low birth weights.

Read the Pediatrics Nationwide article.

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