Medical Professional Publications

Innovation and Discovery

(From the July 2016 Issue of MedStat)

Researchers Demonstrate Novel, Promising Strategy for Diagnosing UTIs in Children
Urinary tract infections (UTIs) are one of the most common infections in children and account for millions of unplanned pediatrician and urgent care visits each year in the United States. Andrew Schwaderer, MD, research director in the Section of Nephrology and principal investigator in the Center for Clinical and Translational Research in The Research Institute, and Joshua Watson, MD, attending physician in Infectious Diseases at Nationwide Children’s Hospital, are co-authors of a multi-institutional Pediatric Research study that evaluated antimicrobial peptides, formerly analyzed only in adults, as effective biomarkers for diagnosing urinary tract infections in children.

Read the Pediatrics Nationwide article.

Despite Safety Concerns, Nearly 1 in 4 Babies in the NICU Receive Acid Suppressing Medications
Since 2006, several studies have associated the use of some acid suppressive medications in neonatal intensive care units with infections, necrotizing enterocolitis and increased risk of death. Those medications – histamine-2 receptor antagonists such as ranitidine, and proton pump inhibitors such as esomeprazole – have not been FDA approved for use in newborns.  Jonathan Slaughter, MD, MPH, neonatologist at Nationwide Children’s and principal investigator in the Center for Perinatal Research in The Research Institute, is lead author of a study in The Journal of Pediatrics that shows just how frequently the drugs, originally formulated for older children and adults, have been prescribed for babies in the NICU at 43 children’s hospitals across the country.

Read the Pediatrics Online article.

Changes in Molecular Signaling Pathway May Flag CAVD, Most Prevalent Valvular Disorder in the United States
Long thought to be acquired during adulthood, increasing evidence has shown that calcific aortic valve disease (CAVD) has its origins during embryonic development. CAVD sends 55,000 patients to the hospital and causes 15,000 deaths annually, but the only effective therapy currently available is surgical repair and replacement, which is costly and risky. Joy Lincoln, PhD, principal investigator in the Center for Cardiovascular Research at The Research Institute at Nationwide Children’s Hospital, led a Arteriosclerosis, Thrombosis and Vascular Biology study showing that alterations in a signaling pathway contribute to CAVD, a finding that may provide a method for earlier diagnosis and a target for treatment therapies.

Read the Pediatrics Nationwide article.

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