Medical Professional Publications

Innovation and Discovery

(From the May 2016 Issue of MedStat)

Transcriptional Profiling May Help Diagnose Rhinovirus Infection, Common Cause of Colds, Pneumonia and Other Respiratory Infections

Transcriptional profiling involves measuring the activity of thousands of genes at once to create a snapshot of cellular function. Researchers from Nationwide Children’s Hospital and The Ohio State University have found that transcriptional profiling may make quick work of discriminating between active rhinovirus and incidental virus detection – and improve clinical decisions as a result. M. Asuncion Mejias, MD, PhD, principal investigator in the Center for Vaccines and Immunity in The Research Institute at Nationwide Children’s, is senior author of the study, which was published in the American Journal of Respiratory and Critical Care Medicine.

Read the Research Now article.

Protocol Enables Babies with Neonatal Abstinence Syndrome to be Weaned off Treatment Drugs Faster

The number of babies born to mothers abusing prescription opioids and heroin in the state of Ohio has skyrocketed in the last decade. New research shows that the adoption of a strict protocol has enabled six regional perinatal centers across Ohio to wean babies exposed to opioids in utero off treatment drugs faster, resulting in improvements for newborns and families, as well as healthcare cost savings. The stringent rules and procedures were developed and tested by Akron Children’s Hospital, Cincinnati Children’s Hospital and Nationwide Children’s Hospital, using either methadone or morphine to wean newborns with neonatal abstinence syndrome (NAS). Mark Klebanoff, MD, principal investigator in the Center for Perinatal Research in The Research Institute at Nationwide Children’s, was one of the authors of the research study, which was published in the journal Pediatrics.

Read the Pediatrics Nationwide article.

Research Supports Conclusion that Functional Nausea in Children is a Real, Treatable Condition

Only within the last decade have many pediatric gastroenterologists begun to accept the diagnosis of “functional nausea,” or chronic nausea not associated with any underlying disease, but many physicians remain skeptical and may ignore or neglect the condition in children. A recent review article has collected the current knowledge on the mechanisms and treatment of functional nausea, demonstrating that the pediatric condition is real and interventions are possible. Carlo Di Lorenzo, MD, chief of the Division of Gastroenterology, Hepatology and Nutrition at Nationwide Children’s Hospital, is senior author of the article, which was published in the Journal of Pediatric Gastroenterology and Nutrition.

Read the Pediatrics Online article.

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