Medical Professional Publications

Innovation and Discovery

(From the April 2016 Issue of MedStat)

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New Approach to Gathering Protein Signatures, Implications for Research and Personalized Medicine

In the first comprehensive study of host protein and metabolite profiles in vivo in response to infection, researchers at Nationwide Children’s Hospital have shown that it is possible to obtain both host and bacteria protein signatures in a sample smaller than the average human biopsy. The technique described in the paper — unbiased two-dimensional liquid chromatography-tandem mass spectrometry — could change how researchers study infectious diseases and how they analyze samples for personalized medicine. Kevin Mason, PhD, and Sheryl Justice, PhD, principal investigators in the Center for Microbial Pathogenesis in The Research Institute at Nationwide Children’s, were co-authors of the study, which was published in the journal of Molecular and Cellular Proteomics in March 2016.

Read the Pediatrics Nationwide article.

Clinical Research Team Identifies Common Patterns in MRI and EEG Results, Supporting Diagnosis of Autoimmune Encephalitis in Children

Autoimmune encephalitis is a newly characterized condition with symptoms that may include alteration of mental status, behavioral changes, seizures and abnormal involuntary movements. Although criteria for diagnosing and testing exist for some neuroimmunological disorders, autoimmune encephalitis currently does not have widely accepted diagnostic criteria. Bethanie Morgan-Followell, MD, attending pediatric neurologist in the Section of Neurology, along with an interdisciplinary team at Nationwide Children’s Hospital, co-authored a recent Pediatrics Neurology study demonstrating the utility of two common tests for this rare but serious condition in which the immune system attacks the brain.

Read the Research Now article.

Loss of MHCI in Motor Neurons Leads to ALS Astrocyte Toxicity

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, is a devastating progressive neurodegenerative disease that results in the death of motor neurons, eventually resulting in the loss of the ability to walk, move, swallow and breathe. New research from scientists at Nationwide Children’s, however, is shining a light on the molecular mechanisms responsible for motor neuron death in ALS. The Nature Medicine study, published by a team led by Brian Kaspar, PhD, principal investigator in the Center for Gene Therapy in The Research Institute at Nationwide Children’s, demonstrates the explicit loss of major histocompatibility complex I (MHCI) expression in the outer membrane of motor neurons in ALS, leading to motor neuron vulnerability to ALS astrocyte toxicity.

Read the Pediatrics Nationwide article.

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