Medical Professional Publications

Innovation and Discovery

(From the January 2016 Issue of MedStat)

Visit NationwideChildrens.org/Research-News for additional information regarding these articles. More news from The Research Institute can be found at NationwideChildrens.org/Research-Now.

CHIRP: Novel Project Collaboration to Benefit Children with Pneumonia

Worldwide, pneumonia is the leading cause of death in children under five years of age. Six pediatric hospitals in Ohio, with Nationwide Children’s Hospital as the project lead, are working to improve this in a collaborative clinical research project, known as the Children’s Hospitals’ Initiative for Research in Pneumonia (CHIRP). Rebecca Wallihan, MD, and Octavio Ramilo, MD, are leading the project at Nationwide Children's, along with teams from Clinical Research Services (Jessica Estep, RN, Michael Lawson, RN, and Kem Gentes, RN), the Emergency Department (Amy Nowakowsi) and Critical Care (Lisa Steele, RN).

Read the Research Now news item.

Antibiotics Alone Can Be a Safe, Effective Treatment for Children with Appendicitis

Katherine J. Deans, MD, and Peter C. Minneci, MD, principal investigators in the Center for Innovation in Pediatric Practice at The Research Institute and co-directors of the Center for Surgical Outcomes Research at Nationwide Children’s Hospital, published a recent study in JAMA Surgery showing that using antibiotics alone to treat children with uncomplicated acute appendicitis is a reasonable alternative to surgery when chosen by the family. Compared to urgent appendectomy, non-operative management was associated with less recovery time, lower health costs and no difference in the rate of complications at one year.

Read the News Room article.

Boosting Research with a Biobank for Down Syndrome

Certain conditions – such as congenital heart disease, childhood leukemia and epilepsy – are more common in patients with Down syndrome than in the general population, while others are less common, including solid mass tumors, high cholesterol and atherosclerosis. A new biobank at Nationwide Children’s, the first in the nation dedicated to Down syndrome, will enable clinical and translational researchers everywhere to shed light on these co-morbid conditions related to Down syndrome, including Alzheimer’s disease. The biobank will be housed in the Nationwide Children’s Biopathology Center (BPC), which also houses the biobank for the Children’s Oncology Group, the Cystic Fibrosis Therapeutics Development Network and the Nephrotic Syndrome Study Network, among others.

Read the Pediatrics Nationwide article.

Alternative Strategy for Gene Replacement Shows Promise in Duchenne Muscular Dystrophy

Duchenne muscular dystrophy(DMD) is the most common inherited neuromuscular disorder that affects 1/5,000 male births, and is caused by mutations in the DMD gene which lead to an absence of dystrophin, resulting in progressive or worsening muscle weakness. Louise Rodino-Klapac, PhD, principal investigator in the Center for Gene Therapy in The Research Institut at Nationwide Children’s Hospital, is senior author of a Human Gene Therapy study that supports the use of alpha 7 integrin as a potential therapy in a severe mouse model of DMD. Kristen Heller, PhD, post-doctoral scientists in the Rodino-Klapac lab is first author of the article and led the laboratory studies.

Read the Research Now article.

Moderate Amounts of Caffeine During Pregnancy Do Not Harm Baby’s IQ and Do Not Cause Behavioral Problems, Obesity

Women drinking and eating moderate amounts of caffeine during pregnancy should be reassured that they are not harming their child’s intelligence, according to a recent study from The Research Institute at Nationwide Children’s Hospital. The research, one of the first studies to focus on how in utero caffeine exposure affects a child’s future intelligence (IQ) and behavior later in childhood, found caffeine did not lead to a reduced IQ or increased behavioral problems. Mark A. Klebanoff, MD, principal investigator in the Center for Perinatal Research, and Sarah A. Keim, PhD, principal investigator in the Center for Biobehavioral Health at The Research Institute at Nationwide Children’s, were co-authors of the study, which was published in the American Journal of Epidemiology.

Read the News Room article.

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