Medical Professional Publications

Innovation and Discovery

(From the October 2015 Issue of MedStat)

More news from The Research Institute can be found at NationwideChildrens.org/Research-Now.

Researchers Receive $6.75 Million Grant to Develop Vaccine for Respiratory Syncytial Virus

A major cause of infant mortality worldwide, respiratory syncytial virus (RSV) is the most common cause of bronchiolitis and pneumonia in children younger than 1 year of age in the United States, as well as the most frequent reason for hospitalization in that age group. Mark Peeples, PhD, and Octavio Ramilo, MD, both principal investigators in the Center for Vaccines and Immunity at The Research Institute at Nationwide Children’s, were recently awarded a $6.75 million grant from the National Institute of Allergy and Infectious Diseases to develop a vaccine for RSV. The research team also includes Asuncion Mejias, MD, PhD, principal investigator in the Center for Vaccines and Immunity; Jianrong Li, DVM, PhD, and Stefan Niewiesk, DVM, PhD, both from The Ohio State University School of Veterinary Medicine; and Michael Teng, PhD, from the University of South Florida.

Read the news release.

Type 2 Diabetes Correlated with Decreased Stiffness of Coronary Microvessels Implicated in Diabetic Heart Disease

In pediatric patients, the incidence of type 2 diabetes mellitus (T2DM) is increasing as childhood obesity rates climb, setting the stage for early cardiovascular complications in this population. Now, a multi-institutional team of researchers has found that microvessels, the tiny coronary blood vessels that regulate blood flow to the heart, are smaller and are less stiff in early T2DM as opposed to more stiff, which is the case for the larger arteries. Aaron J. Trask, PhD, FAHA, principal investigator in the Center for Cardiovascular and Pulmonary Research at The Research Institute at Nationwide Children’s, is senior author of the Annals of Biomedical Engineering study which underscores the potential importance of vascular stiffness in the progression of cardiovascular diseases in patients with T2DM.

Read the Research Now article

Quality Improvement Initiative Dramatically Reduces Central Line Infections in Neonates

Many infants in the NICU need central venous lines to survive, but the use of those lines carries a risk of central line-associated bloodstream infections (CLABSIs), which cause significant morbidity and mortality. A recent study from Nationwide Children’s Hospital, however, shows that even a network of neonatal nurseries spread across several hospitals can dramatically reduce CLABSIs and sustain the much lower rate for years. Edward Shepherd, MD, section chief of Neonatology at Nationwide Children’s Hospital, is lead author of the study published in The Journal of Pediatrics, which demonstrates that evidence-based quality improvement measures that were proven effective in reducing infections among adults and older children can also have success in neonates.

Read the PediatricsOnline article

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