Medical Professional Publications

Innovation and Discovery

(From the September 2015 Issue of MedStat)

More news from The Research Institute can be found at

DNABII Proteins Play Critical Role in Maintaining Biofilm Structure of Uropathogenic E. coli, a Major Cause of UTIs

Nearly half a million emergency room visits are the result of urinary tract infections (UTIs), according to the most recent national data on hospital discharges. UTIs can be caused by a number of different bacteria, but uropathogenic E. coli (UPEC) is a diverse group of E. coli strains known to cause more than 80% of UTIs. Steven D. Goodman, PhD, principal investigator in the Center for Microbial Pathogenesis at The Research Institute at Nationwide Children’s, is lead author of a Molecular Microbiology study that demonstrates the importance of DNABII proteins for the development of biofilms, microbial communities involved in most chronic and recurrent bacterial infections, including UTIs.

Read the Research Now article.

Virotherapy Shows Promise Against Highly Malignant Pediatric Tumors

Atypical teratoid/rhabdoid tumors (AT/RTs) are highly malignant, aggressive tumors that do not respond well to chemotherapy and primarily affect children under 3 years of age. The current survival rate for these children is 15 percent. Adam Studebaker, PhD, research scientist in the Center for Childhood Cancer and Blood Diseases at The Research Institute at Nationwide Children’s, is lead author of a recent Neuro-Oncology paper that shows virotherapy via a modified measles virus is an effective therapeutic agent against in vitro and in vivo models of AT/RTs.

Read the PediatricsOnline article

Biomarkers Identify Risk of Thrombosis, a Serious Complication of Nephrotic Syndrome

Thrombosis is a deadly and often underappreciated complication of nephrotic syndrome, and thrombosis incidence is increasing in both pediatric and adult populations. Bryce Kerlin, MD, principal investigator in the Center for Clinical and Translational Research at The Research Institute and a hematologist specializing in blood clotting disorders at Nationwide Children’s, is lead author on a Journal of the American Society of Nephrologists study that suggests protein in the urine and/or blood levels of albumin could be developed as clinically meaningful surrogate biomarkers of excessive blood clotting.

Read the Research Now article

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