(From the August 2013 Issue of MedStat)
Researchers at Nationwide Children’s will use a $6.3 million grant to further their study of pediatric sarcomas, a rare form of the disease that affects bone or soft tissue and accounts for 11 percent of all childhood cancers. The project, funded by the National Institutes of Health and the National Cancer Institute, will be led by Peter Houghton, PhD, director of the Center for Childhood Cancer and Blood Diseases in The Research Institute at Nationwide Children’s. While more than 70 percent of children with sarcoma are cured, the outcome is still poor for those with advanced or metastatic disease. Specifically, the five-year, event-free survival rates are 30 percent or less in children with advanced or metastatic Ewing sarcoma, osteosarcoma or rhabdomyosarcoma. Intensive chemo-radiotherapy has not significantly altered this outcome, making the search for effective new therapies a critical pursuit. Experts in sarcoma biology, cellular signaling pathways and drug development will collaborate on the grant, bringing together researchers from Nationwide Children’s and The Ohio State University.
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