Maria M. Talavera, DO :: Nationwide Children's Hospital, Columbus, Ohio
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Maria M. Talavera, DO

Maria M. Talavera, DO

Center for Perinatal Research
Principal Investigator

Neonatology
Physician Team

Neonatology Fellowship
Faculty

Contact Information

Neonatology
700 Children's Dr
Columbus, OH 43205 [ map ]
PH: (614) 722-4559
FX: (614) 722-4541

Location Information for Patients

Main Campus

Biography

Maria M. Talavera, DO, is a member of the Section of Neonatology at Nationwide Children’s Hospital and an Assistant Professor of Pediatrics at The Ohio State University College of Medicine. She is a principal investigator in the Center for Perinatal Research at the Research Institute at Nationwide Children’s Hospital. Dr. Talavera’s research focuses on necrotizing enterocolitis, a devastating gastrointestinal disease primarily affecting premature neonates. Dr. Talavera’s research goals aim at discovering novel therapeutic targets for necrotizing entercolitis.

Gender:

  • Female

Languages Spoken:

  • English

Research Interests

Research Center:

Areas of Interest:

  • Necrotizing enterocolitis (NEC) affects thousands of premature newborns in the USA every year, with an incidence ranging from 7-11% and mortality rates (15-30%) are essentially unchanged in the past 30 years. The pathogenesis of NEC remains unclear, although prematurity, formula feeding, bacterial colonization of the bowel, and mucosal injury secondary to intestinal hypoxia and ischemia have been implicated. The gap in knowledge regarding the precise pathophysiology of NEC has prevented the development of effective therapies and preventative strategies. The individual differences in patient susceptibility to NEC and its variable severity may be due to abnormalities in the balance of pro-inflammatory and anti-inflammatory mechanisms that contribute to immune homeostasis. In mammals, MAPKs are primarily deactivated by a family of dual specificity protein phosphatases (DUSP) via dephosphorylation of specific tyrosine and threonine residues. These phosphatases (MKP-1) are key regulators of the innate immune response during bacterial infection and play a significant role in the prevention and resolution of sepsis. The role of MKP-1 as an important inflammatory “watchdog” has never been investigated in the context of NEC. The overall goal of this research is to determine the mechanism by which the innate immune response leading to NEC is regulated by MKP-1.

Education and Training

Medical School

  • Ohio University College of Osteopathic Medicine
    Date Completed: 06/04/2005

Residency

  • Doctors Hospital
    Date Completed: 06/30/2006

Residency

  • Nationwide Children's Hospital
    Date Completed: 06/30/2008

Fellowship

  • New York Presbyterian Morgan Stanley Children's Ho
    Date Completed: 06/30/2011

Department:

  • Pediatrics

Section:

  • Neonatology

Specialty:

  • Neonatal-Perinatal Medicine
  • Pediatrics

Date of Appointment at Nationwide Children’s Hospital:

  • 08/01/2011

Publications

  • Talavera, Maria. Mitogen-Activated Protein Kinase Phosphatase-1 (MKP-1) Prevents Apoptosis due to LPS in Immature Rat Intestinal Epithelial Cells. In Pediatric Academic Societies’ Annual Meeting 2014
  • Talavera, Maria. The Role of Serotonin and SERT in Necrotizing Enterocolitis. In Greater New York Regional Perinatal Conference
  • Talavera, Maria. The Proinflammatory Role of Serotonin in a Murine model of NEC. In Pediatric Academic Societies’ Annual Meeting 2011
  • Talavera, Maria. The Role of MKP-1 in a Murine Model of Necrotizing Enterocolitis. In Pediatric Academic Societies’ Annual Meeting 2013
Nationwide Children's Hospital
700 Children's Drive Columbus, Ohio 43205 614.722.2000