Lynette K. Rogers, Ph.D.

Lynette K. Rogers, Ph.D. is a Principal Investigator in the Center for Perinatal Research at The Research Institute at Nationwide Children’s Hospital. She is an Associate Professor at The Ohio State University College of Medicine. Dr. Rogers NIH-funded research focuses on lung injury and growth deficits in preterm infants. Specifically, she is interested in natural product therapies that would lessen the long-term morbidities associated with prematurity.

Gender:

• Female

Languages Spoken:

• English

Research Center:

• Center for Perinatal Research

Areas of Interest:

• The ultimate goal of my lab is to identify the causes of premature birth, help design treatments that would prevent prematurity, and strive to help develop efficacious treatments that would decrease morbidities in prematurely born infants. The research efforts in my lab are two fold. First, we are working to identify biomarkers early in the life of a premature infant that would predict outcomes and development of diseases and better understand the mechanisms involved in these disease processes. We use a broad scope of analytical techniques to identify alterations in proteins and lipids in both animal models of premature birth as well as human studies. Secondly, our animal models focus on inflammation resolution. Inflammation is a large component of diseases associated with prematurity, specifically those that involve the lung. Impaired inflammatory resolution may, in part, be responsible for the progression and chronic state of lung diseases in the premature infant. We are working to develop interventions that would improve inflammatory resolution in a newborn mouse model.

Undergraduate School

• University of Southwestern Louisiana
  Date Completed: 06/30/1977

Post Doctoral

• The Ohio State University
  Date Completed: 06/30/2004

2012–present

• Associate Professor (with tenure), Department of Pediatrics, Ohio State University, Columbus, Ohio

2005–present

• Principal Investigator, Columbus Children’s Research Institute, Columbus, Ohio

2005–2012

• Assistant Professor, Department of Pediatrics, Ohio State University, Columbus, Ohio

2004–2005

• Senior Research Scientist, Columbus Children’s Research Institute, Columbus, Ohio

2000–2004

• Sr. Research Associate, Columbus Children’s Research Institute, Columbus, Ohio

1991–2000

• Research Assistant, Department of Pediatrics, Baylor College of Medicine, Houston Texas

1990–1991

• Research Technician, Shell Oil Co., Houston, Texas

1986–1990

• Research Technician, Department of Medicine, Baylor College of Medicine, Houston, Texas

1985–1986

• Research Technician, Exxon Research and Development Co., Baytown, Texas

1977–1978

• Research Technician, University of Texas Health Science Center, Houston, Texas

• Valentine CJ, Morrow G, Pennell M, Morrow AL, Hodge A, Haben-Bartz A, Collins K, Rogers LK. 2013. Randomized Controlled Trial of Docosahexaenoic Acid Supplementation in Midwestern U.S. Human Milk Donors.  Breast Feeding Medicine. Vol. 8, no. 1. (February): 86-91.
• Rogers LK, Valentine CJ, Keim SA. 2012. DHA Supplementation: Current Implications in Pregnancy and Childhood.  Pharmacol Res. Vol. 70, no. 1. (December): 13-19.
• Yan,Jing; Meng,Xiaomei; Wancket,Lyn,M; Lintner,Katherine; Nelin,Leif,D; Chen,Bernadette; Francis,Kevin,P; Smith,Charles,V; Rogers,Lynette,K; Liu,Yusen. 2012. Glutathione reductase facilitates host defense by sustaining phagocytic oxidative burst and promoting the development of neutrophil extracellular traps.  Journal of immunology (Baltimore, Md. : 1950). Vol. 188, no. 5. (March): 2316-2327.
• Britt RD, Locy ML, Tipple TE, Nelin LD, Rogers LK. 2012. Lipopolysaccharide-induced Cyclooxygenase-2 Expression in Mouse Transformed Clara Cells.  Cell Physiol and Biochem. Vol. 29, no. 1-2. (March): 213-22.
• Tipple TE, Rogers LK. 2012. Methods for the Determination of Plasma or Tissue Glutathione Levels. In Methods in Molecular Biology. Edited by Craig Harris, Jason Hansen. Clifton, NJ: Humana Press.
• Kleinedler JJ, Orchard E, Foley JD, Rogers LK, Hebert VY, Dugas TR. 2011. A dietary approach to increase in-stent stenosis in a rat model of stenting angioplasty.  Atherosclerosis. Vol. 219, no. 2. (December): 484-91.
• Velten M, Hutchinson KR, Wold LE, Lucchesi PA, Rogers LK. 2011. Systemic Maternal Inflammation and Neonatal Hyperoxic Induce Remodeling and Impair Left Ventricular Function.  PLoS One. Vol. 6, no. 9. (September): ee24544.
• Rogers,Lynette,K; Velten,Markus. 2011. Maternal inflammation, growth retardation, and preterm birth: Insights into adult cardiovascular disease.  LIFE SCIENCES. Vol. 89, no. 13-14. (September): 417-421.
• Cua CL, Rogers LK, Chicoine LG, Augustine M, Jin Y, Nash PL and Nelin LD. 2011. Down syndrome patients with pulmonary hypertension have elevated plasma levels of asymmetric dimethylarginine.  European Journal of Pediatrics. Vol. 170, no. 7. (July): 859-863.
• Heyob KM, Rogers LK, Tipple TE, and Welty, SE. 2011. Riboflavin supplementation does not attenuate hyperoxic lung injury in transgenic spc-mthGR mice.  Experimental Lung Research. Vol. 3, no. 37. (April): 155-161.
• Rogers LK, Valentine CJ, Pennell M, Velten M, Britt RD, Dingess K, Zhao X, Welty SE, and Tipple TE. 2011. Maternal DHA Supplementation Decreases Lung Inflammation in Hyperoxia-Exposed Newborn Mice.  Journal of Nutrition. Vol. 2, no. 141. (February): 214-222.
• Valentine CJ, Morrow G, Fernandez S, Gulati P, Bartholomew D, Long D, Welty SE, Morrow AL, Rogers LK. 2010. Docosahexaenoic Acid and Amino Acid Contents in Pasteurized Donor Milk are Low for Preterm Infants.  Journal of Pediatrics. Vol. 6, no. 157. (December): 906-910.
• Farrell MR, Rogers LK, Liu Y, Welty SE, and Tipple TE. 2010. Thioredoxin-interacting protein inhibits hypoxia-inducible factor transcriptional activity.  Free Radical Biology and Medicine. Vol. 9, no. 49. (November): 1361-1367.
• Jiang B, Khandelwal A R, Rogers L K, Shi W, Orr A W, and Dugas T R. 2010. Antiretrovirals Induce Endothelial Dysfunction via Oxidant-Dependent Pathways and Promote Neointimal Hyperplasia in C57BL/6 mice.  Toxicological Sciences. Vol. 2, no. 117. (October): 524-536.
• Stenger MR, Rose MJ, Joshi MS, Rogers LK, Chicoine LG, Bauer JA, Nelin LD. 2010. Inhaled Nitric Oxide Prevents 3-Nitrotyrosine Formation in the Lungs of Neonatal Mice Exposed to >95% Oxygen.  Lung. Vol. 3, no. 188. (March): 214-227.
• Velten M, Heyob K M, Rogers L K, Welty S E. 2010. Deficits in Lung Alveolarization and Function After Systemic Maternal Inflammation and Neonatal Hyperoxia Exposure.  J Appl Physiol. Vol. 5, no. 108. (March): 1347-1356.
• Rogers LK; Tipple TE; Britt RD; Welty SE. 2010. Hyperoxia exposure alters hepatic eicosanoid metabolism in newborn mice.  Pediatric Research. Vol. 67, no. 2. (February): e144.
• Tipple TE; Welty SE; Nelin LD; Hansen JM; Rogers LK. 2009. Alterations of the thioredoxin system by hyperoxia: implications for alveolar development.  American Journal Of Respiratory Cell And Molecular Biology. Vol. 41, no. 5. (November): e612.
• Valentine CJ; Fernandez S; Rogers LK; Gulati P; Hayes J; Lore P; Puthoff T; Dumm M; Jones A; Collins K; Curtiss J; Hutson K; Clark K; Welty SE. 2009. Early amino-acid administration improves preterm infant weight.  Journal Of Perinatology: Official Journal Of The California Perinatal Association. Vol. 29, no. 6. (June): e428.
• Rogers LK; Tipple TE; Nelin LD; Welty SE. 2009. Differential responses in the lungs of newborn mouse pups exposed to 85% or >95% oxygen.  Pediatric Research. Vol. 65, no. 1. (January): e33.
• Heyob KM, Rogers LK, Welty SE. 2008. Glutathione Reductase Targeted to Type ll Cells Does Not Protect Mice from Hyperoxic Lung Injury.  Am J Resp Mol Cell Biol.. Vol. 39, no. 6. (January): 683-688.
• Park MS, Rieger-Fackeldey E, Schanbacher BL, Cook AC, Bauer JA, Rogers LK, Hansen TN, Welty SE, Smith CV. 2007. Altered Expressions of Fibroblast Growth Factor Receptors and Alveolarization in Neonatal Mice Exposed to 85% Oxygen.  Pediatric Research. Vol. 6, no. 62. (January): 652-657.
• Tipple TE, Welty SE, Rogers LK, Hansen TN, Choi YE, Kehrer JP, Smith CV. 2007. Thioredoxin-related mechanisms in hyperoxic lung injury in mice.  American Journal of Respiratory Cell and Molecular Biology. Vol. 37, no. 4. (January): 405-413.
• Rogers, Lynette, K; Leinweber, Barbara, L; Smith, Charles V. 2006. Detection of reversible protein thiol modifications in tissues.  Analytical biochemistry. Vol. 358, no. 2. (January): 171-84.
• Malleske, Daniel, T; Rogers, Lynette, K; Velluci, Sean, M; Young, Tamara, L; Park, Min, S; Long, Donald, W; Welty, Stephen, E; Smith, Charles, V; Nelin, Leif D. 2006. Hyperoxia increases hepatic arginase expression and ornithine production in mice.  Toxicology and applied pharmacology. Vol. 215, no. 1. (January): 109-17.
• Rogers LK; Bates CM; Welty SE; Smith CV. 2006. Diquat induces renal proximal tubule injury in glutathione reductase-deficient mice.  Toxicology and applied pharmacology. Vol. 217, no. 3. (January): 289-98.
• Rogers, Lynette, K; Tamura, Toshiya; Rogers, Bryan, J; Welty, Stephen, E; Hansen, Thomas, N; Smith, Charles V. 2004. Analyses of glutathione reductase hypomorphic mice indicate a genetic knockout.  Toxicological sciences. Vol. 82, no. 2. (January): 367-73.
• Jopperi-Davis, Katrina, S; Park, Min Soo; Rogers, Lynette, K; Backes, Carl H Jr; Lim, In Kyoung; Smith, Charles V. 2004. Compartmental inhibition of hepatic glutathione reductase activities by 1,3-bis(2-chloroethyl)-N-nitrosourea (BCNU) in Sprague-Dawley and Fischer-344 rats.  Toxicology letters. Vol. 147, no. 3. (January): 219-28.
• Rogers LK, Smith CV. 2003. Coenzyme A and coenzyme A-glutathione disulfide measurements by HPLC. In Current Protocols in Toxicology. Edited by Maines MD. New York City, NY: John Wiley and Sons.
• Jenniskens,F,A; Jopperi-Davis,K,S; Walters,L,C; Schorr,E,N; Rogers,L,K; Welty,S,E; Smith,C,V. 2002. Effects of fasting on coenzyme A and relate tissue contents of intermediates in rats.  PEDIATRIC RESEARCH. Vol. 52, no. 3. (September): 437-442.
• Jenniskens, Floor, A; Jopperi-Davis, Katrina, S; Walters, Lauren, C; Schorr, Erica, N; Rogers, Lynette, K; Welty, Stephen, E; Smith, Charles V. 2002. Effects of fasting on tissue contents of coenzyme A and related intermediates in rats.  Pediatric research. Vol. 52, no. 3. (January): 437-42.
• O'Donovan, Donough, J; Rogers, Lynette, K; Kelley, Donald, K; Welty, Stephen, E; Ramsay, Patricia, L; Smith, Charles V. 2002. CoASH and CoASSG levels in lungs of hyperoxic rats as potential biomarkers of intramitochondrial oxidant stresses.  Pediatric research. Vol. 51, no. 3. (January): 346-53.
• Fernandes, Caraciolo, J; Rong, Liang; Tamura, Toshiya; Stewart, Kerry, D; Rogers, Lynette, K; McMicken, Harilyn, W; Elliston, Jonathan, F; Hansen, Thomas, N; Smith, Charles V. 2002. Stable transfection of Chinese hamster ovary cells with glutamate-cysteine ligase catalytic subunit cDNA confers increased resistance to tert-butyl hydroperoxide toxicity.  Toxicology letters. Vol. 136, no. 2. (January): 107-20.
• O'Donovan DJ, Kelley DK, Rogers LK, Welty SE, Ramsay PL, Smith CV. 2002. Mitochondrial oxidant stress iin hyperoxia:CoASH and CoASSG.  Pediatr research. Vol. 51, no. January: 346-353.
• Rogers, Lynette, K; Gupta, Sanjiv; Welty, Stephen, E; Hansen, Thomas, N; Smith, Charles V. 2002. Nuclear and nucleolar glutathione reductase, peroxidase, and transferase activities in livers of male and female Fischer-344 rats.  Toxicological sciences : an official journal of the Society of Toxicology. Vol. 69, no. 1. (January): 279-85.
• Wong YL, Smith CV, McMicken HW, Rogers LK, Welty SE. 2001. Mitochondrial thiol status in the liver is altered by exposure to hyperoxia.  Toxicology letters. Vol. 123, no. 2-3. (January): 179-93.
• Rogers LK. Valentine CJ, Szczpyka M, Smith CV. 2000. Effects of hepatotoxic doses of acetaminophen and furosemide on tissue concentrations of CoASH and CoASSG in vivo.  Chemical research in toxicology. Vol. 13, no. 9. (January): 873-82.
• Yang CY, Gu ZW, Yang M, Lin SN, Garcia-Prats AJ, Rogers LK, Welty SE, Smith CV. 1999. Selective modification of apoB-100 in the oxidation of low density lipoproteins by myeloperoxidase in vitro.  Journal of lipid research. Vol. 40, no. 4. (January): 686-98.
• Rogers LK, Moorthy B, Smith CV. 1997. Acetaminophen binds to mouse hepatic and renal DNA at human therapeutic doses.  Chemical research in toxicology. Vol. 10, no. 4. (January): 470-6.
• Yang CY, Gu ZW, Yang H, Yang M, Wiseman WS, Rogers LK, Welty SE, Katta V, Rohde MF, Smith CV. 1997. Oxidation of bovine beta-casein by hypochlorite.  Free radical biology & medicine. Vol. 22, no. 7. (January): 1235-40.
• Gupta S, Rogers LK, Taylor SK, Smith CV. 1997. Inhibition of carbamyl phosphate synthetase-I and glutamine synthetase by hepatotoxic doses of acetaminophen in mice.  Toxicology and applied pharmacology. Vol. 146, no. 2. (January): 317-27.
• Gupta S, Kleiner HE, Rogers LK, Lau SS, Smith CV. 1997. Redox stress andhepatic DNA fragmentation induced by diquat in vivo are not accompanied by increased 8-hydroxydeoxyguanosine contents.  Redox Report. Vol. 3, no. January: 31-39.
• Benzick AE, Reddy SL, Gupta S, Rogers LK, Smith CV. 1994. Diquat- and acetaminophen-induced alterations of biliary efflux of iron in rats.  Biochemical pharmacology. Vol. 47, no. 11. (January): 2079-85.
• Gupta S, Rogers LK, Smith CV. 1994. Biliary excretion of lysosomal enzymes, iron, and oxidized protein in Fischer-344 and Sprague-Dawley rats and the effects of diquat and acetaminophen.  Toxicology and applied pharmacology. Vol. 125, no. 1. (January): 42-50.
• Gomez MR, Benzick A, Rogers LK, Heird WC, Smith CV. 1994. Attenuation of acetaminophen hepatotoxicity in mice as evidence for the bioavailability of the cysteine in D-glucose-L-cysteine in vivo.  Toxicology letters. Vol. 70, no. 1. (January): 101-8.
• Brown SA; Rogers LK; Dunn JK; Gotto AM Jr; Patsch W. 1990. Development of cholesterol homeostatic memory in the rat is influenced by maternal diets.  Metabolism: clinical and experimental. Vol. 39, no. 5. (January): 468-73.
• McDaniel LS, Rogers LK, Hill WE. 1978. Survival of recombination -deficient mutants of Escherichia coli during incubation with nalidixic acid.  Journal of Bacteriology. Vol. 134, no. January: 1195-1198.
• Wancket LM, Meng X, Rogers LK, Liu Y. 0. Mitogen-Activated Protein Kinase Phosphatase (MKP)-1 Protects Mice against Acetaminophen-induced Hepatic Injury.  Toxicologic Pathology.
• Jing Yan, Melissa M. Ralston, Xiaomei Meng, Kathleen D. Bongiovanni, Amanda L. Jones, Rainer Benndorf, Leif D. Nelin, Lynette K. Rogers, Charles V. Smith, Yusen Liu. Glutathione Reductase Is Essential for Host Defense against Bacterial Infection.  Free Radical Biology and Medicine.
• Rodney D. Britt Jr., Markus Velten, Trent E.Tipple, Leif D. Nelin, Lynette K. Rogers. Cyclooxygenase-2 in Newborn Hyperoxic Lung Injury.  Free Radical Biology and Medicine.
• Khandelwal, AR, Hebert, VY, Kleinedler, JJ, Rogers, LK, Ullevig, SL, Asmis, R, Dugas, TR. 0. Resveratrol and quercetin interact to inhibit neointimal hyperplasia.  Journal of Nutrition.
• Rogers LK, Young CM, Pennell ML, Tipple TE, Leonhart KL, Welty SE. 0. Plasma Lipid Metabolites are Associated with Gestational Age but Not Bronchopulmonary Dysplasia.  Acta Paediatrica.