Kristina M. Reber, MD

Kristina M. Reber, MD is the Interim Associate Division Chief of the Neonatology Section at Nationwide Children’s Hospital and an Assistant Professor of Pediatrics at The Ohio State University College of Medicine. The focus of Dr. Reber’s research has been on the developmental regulation of endothelial nitric oxide synthase (eNOS) in the newborn intestinal circulation. ENOS is an isoform of nitric oxide synthase that through the conversion of Larginine to L-citrulline forms nitric oxide. Differences in the regulation of the intestinal circulation found in Dr. Reber’s laboratory may partly account for the susceptibility of newborn infants to develop necrotizing enterocolitis, a disease that is associated with a high morbidity and mortality rate, particularly among infants born prematurely. Dr. Reber’s research has demonstrated a much lower vascular resistance in the newborn intestinal circulation when compared to the adult intestinal circulation, which is primarily due to the role of eNOS. Currently, Dr. Reber’s laboratory is looking at the role of shear stress in the regulation of eNOS in the newborn swine intestinal circulation and has demonstrated an association between oxidant production, shear stress and subsequent nitric oxide production in the endothelial cell from newborn swine intestinal circulation. Her current studies with endothelial cell culture will specifically examine the role of Rac, a small GTPase, in this proposed pathway using Rac transfection.

Gender:

• Female

Languages Spoken:

• English

Residency

• The Ohio State University

Medical School

• The Ohio State University

Fellowship

• The Ohio State University

Medical School

• Ohio State University College of Medicine
  Date Completed: 06/15/1991

Internship

• Nationwide Children's Hospital
  Date Completed: 06/30/1992

Residency

• Nationwide Children's Hospital
  Date Completed: 06/30/1994

Fellowship

• Nationwide Children's Hospital
  Date Completed: 06/30/1997

Department:

• Pediatrics

Section:

• Neonatology

Speciality:

• Neonatal-Perinatal Medicine
  
• Pediatrics
  

Date of Appointment at Nationwide Children’s Hospital:

• 09/16/1997

1998–present

• Assistant Professor of Pediatrics, The Ohio State University, Columbus, OH

1997–present

• Attending in Neonatology, Nationwide Children's Hospital, Columbus, OH

1997–present

• Attending in Neonatology, Mt. Carmel East Hospital, Columbus, OH

1994–1997

• Fellow in Neonatology, Columbus Children's Hospital, Columbus, OH

1991–1994

• Resident in Pediatrics, Columbus Children's Hospital, Columbus, OH

• Pallotto, EK, Hunt PG, Reber KM, Evans JR, Padula MA. 2012. Standardizing Diagnoses in Neonatology: Bronchopulmonary Dysplasia and Beyond.  NeoReviews. Vol. 13, no. 10. (October): e577-e582.
• Repnikova E, Astbury C, Reshmi S, Atkin J, Lamb Thrush D, Mitchell A, Pyatt R, Reber K, Ramsey S, Slavin T, Gastier-Foster J. 2012. Microarray Comparative Genomic Hybridization and Cytogenetic Characterization of Tissue-specific Mosaicism in Three Patients.  Am J Med Genet A. Vol. 158A, no. 8. (August): 1924-33.
• Shepherd EG, Alexander LJ, Kuehne B, Reber KM, Nelin LD. 2011. The Fi02 is associated with the successful extubation of mechanically ventilated neonates.  Research and Reports in Neonatology. Vol. 1, no. December: 55-59.
• Backes CH, Reber KM, Trittman JK, Huang H, Tomblin J, Moorehead PA, Smith CV, Mahan JD. 2011. Fellows as Teachers: a model to enhance pediatric resident education.  Med Educ Online. Vol. 16, no. September: 10-16.
• Stenger MR, Reber KM, Giannone PJ, Nankervis CA. 2011. Probiotics and prebiotics for the prevention of necrotizing enterocolitis.  Curr Infect Dis Rep. Vol. 13, no. 1. (February): 13-29.
• Giannone PJ, Nankervis CA, Richter JM, Schanbacher BL, Reber KM. 2009. Prenatal lipopolysaccharide increases postnatal intestinal injury in a rat model of necrotizing enterocolitis.  J Pediatr Gastroenterol Nutr. Vol. 3, no. 48. (March): 276-282.
• Ulbrich T, Plogsted S, Geraghty ME, Reber KM, Valentine CJ. 2009. Probiotics and Prebiotics: Why are they "bugging" us in the pharmacy.  J Pediatr Pharmacol Ther. Vol. 14, no. January: 17-24.
• Backes,Carl,H; Reber,Kris,M; Trittmann,Jennifer,KB; Huang,Hong; Tomblin,Jordanna; Moorehead,Pamela,A; Bauer,John,A; Smith,Charles,V; Mahan,John,D. 2009. Probiotics and Prebiotics: Why Are They "Bugging" Us in the Pharmacy?.  J Pediatr Pharmacol Ther. Vol. 14, no. 14. (January): 17-24.
• Nankervis CA, Giannone PJ, Reber KM. 2008. The neonatal intestinal vasculature: contributing factors to necrotizing enterocolitis. Review.  Semin Perinatol. Vol. 32, no. 2. (April): 83-91.
• Caplan,Michael,S. 2008. Neonatal necrotizing enterocolitis - Introduction.  SEMINARS IN PERINATOLOGY. Vol. 32, no. 2. (April): 69-69.
• Nowicki,Philip,T; Caniano,Donna,A; Hammond,Sue; Giannone,Peter,J; Besner,Gail,E; Reber,Kristina,M; Nankervis,Craig,A. 2007. Endothelial nitric oxide synthase in human intestine resected for necrotizing enterocolitis.  JOURNAL OF PEDIATRICS. Vol. 150, no. 1. (January): 40-45.
• Giannone PJ, Bauer JA, Schanbacher BL, Reber KM. 2007. Effects of hyperoxia on postnatal intestinal development.  Biotechnic & Histochemistry. Vol. 82, no. 1. (January): 17-22.
• Nowicki PT, Caniano DA, Hammond S, Giannone PJ, Besner GE, Reber KM, Nankervis CA. 2007. Endothelial nitric oxide synthase in human intestine resected for necrotizing enterocolitis.  Journal of Pediatrics. Vol. 150, no. 1. (January): 5-6.
• Giannone,Peter,J; Schanbacher,Brandon,L; Bauer,John,A; Reber,Kristina,M. 2006. Effects of prenatal lipopolysaccharide exposure on epithelial development and function in newborn rat intestine.  JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION. Vol. 43, no. 3. (September): 284-290.
• Nowicki,P,T; Reber,K,M; Giannone,P,J; Nankervis,C,A; Hammond,S; Besner,G,E; Caniano,D,A. 2006. Intestinal O-2 consumption in necrotizing enterocolitis: Role of nitric oxide.  PEDIATRIC RESEARCH. Vol. 59, no. 4. (April): 500-505.
• Nowicki,P,T; Dunaway,D,J; Nankervis,C,A; Giannnone,P,J; Reber,K,M; Hammond,S,B; Besner,G,E; Caniano,D,A. 2005. Endothelin-1 in human intestine resected for necrotizing enterocolitis.  JOURNAL OF PEDIATRICS. Vol. 146, no. 6. (June): 805-810.
• Su,B,GY; Reber,K,M; Nankervis,C,A. 2004. Developmental expression of endothelin receptors in postnatal swine mesenteric artery.  PEDIATRIC RESEARCH. Vol. 56, no. 3. (September): 359-365.
• Reber,K,M; Nankervis,C,A. 2004. Necrotizing enterocolitis: preventative strategies.  CLINICS IN PERINATOLOGY. Vol. 31, no. 1. (March): 157-?.
• Su,B,Y; Reber,K,M; Nankervis,C,A; Nowicki,P,T. 2003. Development of the myogenic response in postnatal intestine: role of PKC.  AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY. Vol. 284, no. 3. (March): G445-G452.
• Reber K, G Mager, C. Miller, P Nowicki. Relationship between flow rate and NO production in postnatal mesenteric arteries. Accepted with revisions to Am. J. Physiol, Feb. 1999.
• Reber K, P Nowicki. Pressure and flow characteristics of terminal mesenteric arteries in postnatal intestine. Am. J. Physiol. 274. G290-G298, 1998.
• Coley BD, J Seguin, L Cordero, M Hogan, E Rosenberg, K Reber. Neonatal total parenteral nutrition ascites from liver erosion by umbilical vein catheters. Pediatr Radiol. 28: 923-927, 1998.
• Reber,K,M; Su,B,Y; Clark,K,R; Pohlman,D,L; Miller,C,E; Nowicki,P,T. 2002. Developmental expression of eNOS in postnatal swine mesenteric artery.  AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY. Vol. 283, no. 6. (December): G1328-G1335.
• Reber,K,M; Nankervis,C,A; Nowicki,P,T. 2002. Newborn intestinal circulation - Physiology and pathophysiology.  CLINICS IN PERINATOLOGY. Vol. 29, no. 1. (March): 23-?.
• Nankervis,C,A; Reber,K,M; Nowicki,P,T. 2001. Age-dependent changes in the postnatal intestinal microcirculation.  MICROCIRCULATION. Vol. 8, no. 6. (December): 377-387.
• Reber,K,M; Mager,G,M; Miller,C,E; Nowicki,P,T. 2001. Relationship between flow rate and NO production in postnatal mesenteric arteries.  AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY. Vol. 280, no. 1. (January): G43-G50.
• Reber,K,M; Nowicki,P,T. 1998. Pressure and flow characteristics of terminal mesenteric arteries in postnatal intestine.  AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY. Vol. 274, no. 2. (February): G290-G298.
• Giannone PJ, Schanbacher BL, Bauer JA, Reber KM. Effects of Hyperoxia on Postnatal Intestinal Development. Biotechnic and Histochemistry 82 (1): 17-22, January–February 2007.
• Nowicki PT, Reber KM, Caniano D, Hammond S, Giannone PJ, Besner GE, Nankervis CA. Endothelial Nitric Oxide Synthase in Human Intestine Resected for Necrotizing Enterocolitis. Journal of Pediatrics 150(1): 40-45, January 2007.

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