Kristina M. Reber, MD :: Nationwide Children’s Hospital, Columbus, Ohio

Kristina M. Reber, MD

Kristina M. Reber, MD Best Doctors 2011-2012

Clinical Researchers
Principal Investigator

Neonatology
Associate Division Chief

Neonatology Fellowship
Program Director

Contact Information

Neonatology
700 Children's Dr
Columbus, OH 43205 [ map ]
PH: (614) 722-4530
FX: (614) 722-4541
E-mail Me
The Research Institute
at Nationwide Children's Hospital
Columbus, OH 43205 [ map ]
PH: (614) 722-2700

Biography

Kristina M. Reber, MD is the Associate Division Chief of the Neonatology Section at Nationwide Children’s Hospital and an Assistant Professor of Pediatrics at The Ohio State University College of Medicine. The focus of Dr. Reber’s research has been on the developmental regulation of endothelial nitric oxide synthase (eNOS) in the newborn intestinal circulation. ENOS is an isoform of nitric oxide synthase that through the conversion of Larginine to L-citrulline forms nitric oxide. Differences in the regulation of the intestinal circulation found in Dr. Reber’s laboratory may partly account for the susceptibility of newborn infants to develop necrotizing enterocolitis, a disease that is associated with a high morbidity and mortality rate, particularly among infants born prematurely. Dr. Reber’s research has demonstrated a much lower vascular resistance in the newborn intestinal circulation when compared to the adult intestinal circulation, which is primarily due to the role of eNOS. Currently, Dr. Reber’s laboratory is looking at the role of shear stress in the regulation of eNOS in the newborn swine intestinal circulation and has demonstrated an association between oxidant production, shear stress and subsequent nitric oxide production in the endothelial cell from newborn swine intestinal circulation. Her current studies with endothelial cell culture will specifically examine the role of Rac, a small GTPase, in this proposed pathway using Rac transfection.

Gender:

  • Female

Languages Spoken:

  • English

Education and Training

Residency

  • The Ohio State University

Medical School

  • The Ohio State University

Fellowship

  • The Ohio State University

Medical School

  • Ohio State University College of Medicine
    Date Completed: 06/15/1991

Internship

  • Nationwide Children's Hospital
    Date Completed: 06/30/1992

Residency

  • Nationwide Children's Hospital
    Date Completed: 06/30/1994

Fellowship

  • Nationwide Children's Hospital
    Date Completed: 06/30/1997

Department:

  • Pediatrics

Section:

  • Neonatology

Specialty:

  • Neonatal-Perinatal Medicine
  • Pediatrics

Date of Appointment at Nationwide Children’s Hospital:

  • 09/16/1997

Professional Experience

1998–present

  • Assistant Professor of Pediatrics, The Ohio State University, Columbus, OH

1997–present

  • Attending in Neonatology, Nationwide Children's Hospital, Columbus, OH

1997–present

  • Attending in Neonatology, Mt. Carmel East Hospital, Columbus, OH

1994–1997

  • Fellow in Neonatology, Columbus Children's Hospital, Columbus, OH

1991–1994

  • Resident in Pediatrics, Columbus Children's Hospital, Columbus, OH

Publications

  • Pallotto, EK, Hunt PG, Reber KM, Evans JR, Padula MA. 2012. Standardizing Diagnoses in Neonatology: Bronchopulmonary Dysplasia and Beyond.  NeoReviews. Vol. 13, no. 10. (October): e577-e582.
  • Repnikova E, Astbury C, Reshmi S, Atkin J, Lamb Thrush D, Mitchell A, Pyatt R, Reber K, Ramsey S, Slavin T, Gastier-Foster J. 2012. Microarray Comparative Genomic Hybridization and Cytogenetic Characterization of Tissue-specific Mosaicism in Three Patients.  Am J Med Genet A. Vol. 158A, no. 8. (August): 1924-33.
  • Shepherd EG, Alexander LJ, Kuehne B, Reber KM, Nelin LD. 2011. The Fi02 is associated with the successful extubation of mechanically ventilated neonates.  Research and Reports in Neonatology. Vol. 1, no. December: 55-59.
  • Backes CH, Reber KM, Trittman JK, Huang H, Tomblin J, Moorehead PA, Smith CV, Mahan JD. 2011. Fellows as Teachers: a model to enhance pediatric resident education.  Med Educ Online. Vol. 16, no. September: 10-16.
  • Stenger MR, Reber KM, Giannone PJ, Nankervis CA. 2011. Probiotics and prebiotics for the prevention of necrotizing enterocolitis.  Curr Infect Dis Rep. Vol. 13, no. 1. (February): 13-29.
  • Manaloor N, Reber KM, Rogers L. 2009. Plasma ADMA levels are elevated at DOL 1-3 in preterm infants that subsequently develop necrotizing enterocolitis. In Annual Meeting of the Pediatric-Academic-Societies/Society-for-Pediatric-Research
  • Giannone PJ, Nankervis CA, Richter JM, Schanbacher BL, Reber KM. 2009. Prenatal lipopolysaccharide increases postnatal intestinal injury in a rat model of necrotizing enterocolitis.  J Pediatr Gastroenterol Nutr. Vol. 3, no. 48. (March): 276-282.
  • Ulbrich T, Plogsted S, Geraghty ME, Reber KM, Valentine CJ. 2009. Probiotics and Prebiotics: Why are they "bugging" us in the pharmacy.  J Pediatr Pharmacol Ther. Vol. 14, no. January: 17-24.
  • Backes,Carl,H; Reber,Kris,M; Trittmann,Jennifer,KB; Huang,Hong; Tomblin,Jordanna; Moorehead,Pamela,A; Bauer,John,A; Smith,Charles,V; Mahan,John,D. 2009. Probiotics and Prebiotics: Why Are They "Bugging" Us in the Pharmacy?.  J Pediatr Pharmacol Ther. Vol. 14, no. 14. (January): 17-24.
  • Nankervis CA, Giannone PJ, Reber KM. 2008. The neonatal intestinal vasculature: contributing factors to necrotizing enterocolitis. Review.  Semin Perinatol. Vol. 32, no. 2. (April): 83-91.
  • Caplan,Michael,S. 2008. Neonatal necrotizing enterocolitis - Introduction.  SEMINARS IN PERINATOLOGY. Vol. 32, no. 2. (April): 69-69.
  • Nowicki,Philip,T; Caniano,Donna,A; Hammond,Sue; Giannone,Peter,J; Besner,Gail,E; Reber,Kristina,M; Nankervis,Craig,A. 2007. Endothelial nitric oxide synthase in human intestine resected for necrotizing enterocolitis.  JOURNAL OF PEDIATRICS. Vol. 150, no. 1. (January): 40-45.
  • Giannone PJ, Bauer JA, Schanbacher BL, Reber KM. 2007. Effects of hyperoxia on postnatal intestinal development.  Biotechnic & Histochemistry. Vol. 82, no. 1. (January): 17-22.
  • Nowicki PT, Caniano DA, Hammond S, Giannone PJ, Besner GE, Reber KM, Nankervis CA. 2007. Endothelial nitric oxide synthase in human intestine resected for necrotizing enterocolitis.  Journal of Pediatrics. Vol. 150, no. 1. (January): 5-6.
  • Giannone,Peter,J; Schanbacher,Brandon,L; Bauer,John,A; Reber,Kristina,M. 2006. Effects of prenatal lipopolysaccharide exposure on epithelial development and function in newborn rat intestine.  JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION. Vol. 43, no. 3. (September): 284-290.
  • Luce W, Schanbacher BL, Bauer JA , Reber KM, Giannone PJ. 2006. Effect of Prenatal LPS treatment on apoptosis and proliferation in neonatal rat ileum. In Annual Meeting of the Pediatric-Academic-Societies/Society-for-Pediatric-Research
  • Reber KM, Schanbacher BL, Chen R, Giannone PJ. 2006. Maternal lipopolysaccharide exposure increases the incidence of severe necrotizing enterocolitis in the neonatal rat pup. In Annual Meeting of the Pediatric-Academic-Societies/Society-for-Pediatric-Research
  • Nowicki,P,T; Reber,K,M; Giannone,P,J; Nankervis,C,A; Hammond,S; Besner,G,E; Caniano,D,A. 2006. Intestinal O-2 consumption in necrotizing enterocolitis: Role of nitric oxide.  PEDIATRIC RESEARCH. Vol. 59, no. 4. (April): 500-505.
  • Nowicki PT, Nankervis CA, Reber KM, Giannone PJ. 2006. eNOS uncoupling is present in arterioles from human intestine resected for NEC. In Annual Meeting of the Pediatric-Academic-Societies/Society-for-Pediatric-Research
  • Stanley KP, Chicoine LG, Young TL, Reber KM, Lyons CR, Liu Y, Nelin L. 2006. Gene transfer with inducible nitric oxide synthase decreases production of urea by arginase in pulmonary arterial endothelial cells.  American Journal of Physiology Lung Cellular and Molecular Physiology. Vol. 290, no. February: L298-L306.
  • Nelin LD, Chicoine LG, Reber KM, English BK, Young TL, Liu Y. 2005. Cytokine-induced arginase expression depends on epidermal growth factor receptor.  American Journal of Physiology Lung Cellular and Molecular Physiology. Vol. 33, no. 4. (October): 394-401.
  • Giannone P, Schanbacher B , Smith C , Bauer J , Reber K. 2005. Effects of prenatal LPS exposure on epithelial development and function in newborn rat intestine. In 3rd International Congress of Developmental Origins of Health and Disease
  • Nowicki,P,T; Dunaway,D,J; Nankervis,C,A; Giannnone,P,J; Reber,K,M; Hammond,S,B; Besner,G,E; Caniano,D,A. 2005. Endothelin-1 in human intestine resected for necrotizing enterocolitis.  JOURNAL OF PEDIATRICS. Vol. 146, no. 6. (June): 805-810.
  • Reber K, B Schanbacher, P Shen, J Bauer, P Giannone. 2005. Effects of postnatal hyperoxia on the development of the intestinal microvasculature. In Annual Meeting of the Pediatric-Academic-Societies/Society-for-Pediatric-Research
  • Giannone P, Schanbacher B, Chen R, Bauer J, Reber K. 2005. Alterations in intestinal mucosa with postnatal hyperoxia exposure. In Annual Meeting of the Pediatric-Academic-Societies/Society-for-Pediatric-Research
  • Giannone P, Schanbacher B , Smith C , Bauer J , Reber K. 2005. Effects of prenatal lipopolysaccharide exposure on epithelial development and function in 2 week-old rat intestine. In Annual Meeting of the Pediatric-Academic-Societies/Society-for-Pediatric-Research
  • Su,B,GY; Reber,K,M; Nankervis,C,A. 2004. Developmental expression of endothelin receptors in postnatal swine mesenteric artery.  PEDIATRIC RESEARCH. Vol. 56, no. 3. (September): 359-365.
  • Reber K, Chen R, Shen P, Giannone P. 2004. Vascular endothelial growth factor expression decreases following feeding in the newborn intestine. In Annual Meeting of the Pediatric-Academic-Societies/Society-for-Pediatric-Research
  • Lamers L, Rowland D, Seguin J, Rosenburg E, Reber, KM. 2004. The effect of common origin of the carotid arteries in neurologic outcome after neonatal ecmo.  Journal of Pediatric Surgery. Vol. 39, no. 4. (April): 532-536.
  • Giannone P, Reber K. 2004. Developmental expression of toll-like receptors 2,4, and 9 in newborn and adult rat intestine. In Annual Meeting of the Pediatric-Academic-Societies/Society-for-Pediatric-Research
  • Giannone P, Young T, Chen R, Shen P, Reber K, Nelin L. 2004. The effect of lipopolysaccharide on VEGF and its receptors in the piglet lung. In Annual Meeting of the Pediatric-Academic-Societies/Society-for-Pediatric-Research
  • Reber,K,M; Nankervis,C,A. 2004. Necrotizing enterocolitis: preventative strategies.  CLINICS IN PERINATOLOGY. Vol. 31, no. 1. (March): 157-?.
  • Maheshwari A, Reber KM, Christensen R, Calhoun DA. 2004. Postnatal maturation of shear stress induced activation of NF-?B in endothelial cells. In 28th Annual Southeastern Conference on Perinatal Research
  • Nankervis,C,A; Reber,K,M. 2003. Role of endothelium-derived hyperpolarizing factor (EDHF) in regulation of newborn gut hemodynamics. In Annual Meeting of the Pediatric-Academic-Societies/Society-for-Pediatric-Research
  • Reber,K,M; Pohlman,D,L. 2003. An age-specific, oxidant-based, mechanism of shear-induced phosphorylation of endothelial nitric oxide synthase (eNOS) in newborn endothelial cells (ECs). In Annual Meeting of the Pediatric-Academic-Societies/Society-for-Pediatric-Research
  • Reber,K,M; Dunaway,D,J; Nankervis,C,A. 2003. The role of endothelium-derived hyperpolarizing factor (EDHF) in regulation of newborn (NB) intestinal microcirculation. In Annual Meeting of the Pediatric-Academic-Societies/Society-for-Pediatric-Research
  • Su,B,Y; Reber,K,M; Nankervis,C,A; Nowicki,P,T. 2003. Development of the myogenic response in postnatal intestine: role of PKC.  AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY. Vol. 284, no. 3. (March): G445-G452.
  • Reber K, G Mager, C. Miller, P Nowicki. Relationship between flow rate and NO production in postnatal mesenteric arteries. Accepted with revisions to Am. J. Physiol, Feb. 1999.
  • Reber K, P Nowicki. Pressure and flow characteristics of terminal mesenteric arteries in postnatal intestine. Am. J. Physiol. 274. G290-G298, 1998.
  • Coley BD, J Seguin, L Cordero, M Hogan, E Rosenberg, K Reber. Neonatal total parenteral nutrition ascites from liver erosion by umbilical vein catheters. Pediatr Radiol. 28: 923-927, 1998.
  • Reber,K,M; Su,B,Y; Clark,K,R; Pohlman,D,L; Miller,C,E; Nowicki,P,T. 2002. Developmental expression of eNOS in postnatal swine mesenteric artery.  AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY. Vol. 283, no. 6. (December): G1328-G1335.
  • Reber K, Su B, Pohlman D, Miller C, Nowicki P. 2002. Endothelial nitric oxide synthase expression increases in mesenteric artery following the first feeding after birth. In Mead Johnson Nutritional Conference
  • Reber,K,M; Su,B,GY; Pohlman,D,L; Miller,C,E; Nowicki,P,T. 2002. Endothelial nitric oxide synthase (eNOS) expression increases in mesenteric artery following the first feeding after birth.
  • Reber,K,M; Nankervis,C,A; Nowicki,P,T. 2002. Newborn intestinal circulation - Physiology and pathophysiology.  CLINICS IN PERINATOLOGY. Vol. 29, no. 1. (March): 23-?.
  • Nankervis,C,A; Reber,K,M; Nowicki,P,T. 2001. Age-dependent changes in the postnatal intestinal microcirculation.  MICROCIRCULATION. Vol. 8, no. 6. (December): 377-387.
  • Reber K, Flavahan N, Nowicki P. 2001. Oxidant signaling may participate in the myogenic response in newborn terminal mesenteric arterioles. In Annual Meeting of the Pediatric-Academic-Societies/Society-for-Pediatric-Research
  • Reber,K,M; Mager,G,M; Miller,C,E; Nowicki,P,T. 2001. Relationship between flow rate and NO production in postnatal mesenteric arteries.  AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY. Vol. 280, no. 1. (January): G43-G50.
  • Reber,K,M; Nowicki,P,T. 2000. Phosphorylation of ecNOS mediates flow-induced dilation in the newborn, but not older intestinal circulation.
  • Reber,K,M; Flavahan,N,A; Su,B,S; Nowicki,P,T. 2000. Nitric oxide (NO) is produced in response to flow in newborn, but not adult endothelial cells (ECs), and its release is mediated by oxidant signaling.
  • Reber,K,M; Pohlman,D,L; Newbound,G,C; Nowicki,P,T. 2000. eeNOS (Endothelial nitric oxide synthase) expression is developmentally regulated in the perinatal swine intestinal vasculature.
  • Reber K, Magers G, Miller C, Nowicki P. 1999. Relationship between flow rate and nitric oxide production in postnatal mesenteric arteries. In Interdisciplinary Neonatal Nutrition Symposium
  • Reber,K,M; Nowicki,P,T. 1999. Nitric oxide (NO) production by the gut vascular endothelium is coupled to flow rate in 3-, but not 35-day old subjects.
  • Reber,K,M; Newbound,G,C; Nowicki,P,T. 1999. ecNOS expression is similar in mesenteric artery from 3- and 35-day old swine.
  • Coley B, Seguin J, Cordero L, Hogan M, Rosenburg E, Reber, K. 1998. Neonatal total parenteral nutrition ascites from liver erosion by umbilical vein catheters.  Pediatric Radiology. Vol. 28, no. 12. (December): 923-927.
  • Reber,K,M; Nowicki,P,T. 1998. Pressure and flow characteristics of terminal mesenteric arteries in postnatal intestine.  AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY. Vol. 274, no. 2. (February): G290-G298.
  • Reber,K,M; Nowicki,P,T. 1997. Flow-mediated dilation occurs in the perinatal mesenteric microvasculature and is age dependent.
  • Reber K, Rowland D, Caserta T, Seguin J. 1997. Does common origin of the carotid arteries affect neurologic outcome after neonatal ECMO?. In Annual Meeting of the Pediatric-Academic-Societies/Society-for-Pediatric-Research
  • Reber,K; Dunaway,D; Nowicki,P. 1996. The myogenic response within the postnatal gut microvasculature is age-dependent.
  • NOWICKJ,P; Reber,K. 1995. FLOW IS A STIMULUS FOR NITRIC-OXIDE (NO) RELEASE IN NEWBORN MESENTERIC-ARTERY (MA).
  • Giannone PJ, Schanbacher BL, Bauer JA, Reber KM. Effects of Hyperoxia on Postnatal Intestinal Development. Biotechnic and Histochemistry 82 (1): 17-22, January–February 2007.
  • Nowicki PT, Reber KM, Caniano D, Hammond S, Giannone PJ, Besner GE, Nankervis CA. Endothelial Nitric Oxide Synthase in Human Intestine Resected for Necrotizing Enterocolitis. Journal of Pediatrics 150(1): 40-45, January 2007.

Awards, Honors and Organizations

  • Listed, Best Doctors in America
Nationwide Children's Hospital
700 Children's Drive Columbus, Ohio 43205 614.722.2000