Kirk M. McHugh, Ph.D.

Principal Investigator, Center for Molecular and Human Genetics. Director of Nephrology & Urology Research Affinity Group, Nationwide Children's Hospital. Director of Shared Resources, The Research Institute at Nationwide Children's Hospital. Faculty, Department of Pediatrics, The Ohio State University. Adjunct Faculty, Department of Physiology & Cell Biology, The Ohio State University. Adjunct Faculty, Division of Anatomy, The Ohio State University.

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Gender:

• Male

Languages Spoken:

• English

Research Center:

• Center for Molecular and Human Genetics

Areas of Interest:

• The current research efforts in my lab focus on the development and pathogenesis of the urogenital system. Urinary tract malformations, obstructive nephropathy, and renal hypoplasia/dysplasia comprise over 50% of the children with end-stage renal disease worldwide. These defects are extremely important in the terms of pediatric health care costs with end-stage renal disease estimated to cost 1.5 billion dollars annually in the United States alone. Studies in our lab focus on congenital defects in bladder smooth muscle development as well as the resulting pathologies associated with the development of obstructive nephropathy including chronic renal failure and kidney disease. We have identified a highly unique mouse model, designated mgb for megabladder, which permits the study of the development of obstructive nephropathy in utero, and our currently using a wide range of genetic and molecular approaches to identify the genes responsible for the developmental defects and subsequent pathologies observed in mgb mice. The identification and characterization of the factors responsible for the pathogenic changes in renal function following the development of congenital bilateral obstructive nephropathy in mgb mice will provide a platform for the evaluation of pharmacological, surgical, and gene therapy strategies designed to prevent and treat the pathogenic processes associated with the development of progressive renal failure in utero.

Undergraduate

• Mount Union College
  Date Completed: 06/30/1982

Post Doctoral

• University of Cincinnati College of Medicine
  Date Completed: 06/30/1986

2002–present

• Associate Professor, Department of Pediatrics, The Ohio State University

1994–2002

• Associate Professor, Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson Unversity, Philadelphia, PA

1989–1994

• Assistant Professor, Department of Anatomy and Developmental Biology, Thomas Jefferson University, Philadelphia

1986–1989

• Research Fellow, Basic Sciences Division, Children's Hospital Research Foundation, Cincinnati, OH

• Spencer JD; Schwaderer A; McHugh K; Vanderbrink B; Becknell B; Hains DS. 2011. The demographics and costs of inpatient vesicoureteral reflux management in the USA.  Pediatric Nephrology (Berlin, Germany). Vol. 26, no. 11. (November 1): 1995.
• Ingraham SE; McHugh KM. 2011. Current perspectives on congenital obstructive nephropathy.  Pediatric Nephrology (Berlin, Germany). Vol. 26, no. 9. (September 1): 1453.
• Becknell B; Pais P; Onimoe G; Rangarajan H; Schwaderer AL; McHugh K; Ranalli MA; Hains DS. 2011. Hepatoblastoma and prune belly syndrome: a potential association.  Pediatric Nephrology (Berlin, Germany). Vol. 26, no. 8. (August 1): 1269.
• Spencer JD; Schwaderer AL; Dirosario JD; McHugh KM; McGillivary G; Justice SS; Carpenter AR; Baker PB; Harder J; Hains DS. 2011. Ribonuclease 7 is a potent antimicrobial peptide within the human urinary tract.  Kidney International. Vol. 80, no. 2. (July 1): 174.
• Carpenter A, Becknell B, Hirselj D, McHugh KM. 2011. Urinary diversion via cutaneous vesicostomy in the megabladder mouse. In Kidney Development: Methods in Microbiology. Edited by Humana Press. New York, NY: Humana Press. (Formally Accepted)
• Carpenter A, Becknell B, McHugh KM. 2011. Renal ultrasound in the mouse.  Kidney Development" Methods in Microbiology. (Formally Accepted)
• Carpenter A, Becknell B, McHugh KM. 2011. Renal ultrasound in the mouse. In Kidney Development: Methods in Microbiology. Edited by Humana Press. New York: Humana Press. (Formally Accepted)
• Becknell B, Hains D, Schwaderer A, Vanderbrink B, Spencer JD, McHugh KM. 2011. Impact of urinary tract infection on inpatient healthcare utilization for congenital obstructive nephropathy.  Journal of Urology. (IF: 3.9) (Formally Accepted)
• Becknell B, Pais P, Onimoe G, Rangarajan H, Schwaderer AL, McHugh KM, Ranalli MA, Hains DS. 2011. Hepatoblastoma and Prune belly syndrome: A Potential Association.  Pediatric Nephrology. (IF: 2.2) (Formally Accepted)
• Carpenter A, Becknell B, Hirselj D, McHugh KM. 2011. Urinary Diversion via cutaneous vesicostomy in the megabladder mouse.  Kidney Development: Methods in Microbiology. (Formally Accepted)
• Spencer JD, Schwaderer A, McHugh K, Vanderbrink B, Becknell B, Hains D. 2011. The demographics and costs of inpatient vesicoureteral reflux management in the USA.  Pediatric Nephrology. (IF: 2.2) (Formally Accepted)
• Ingraham S, McHugh KM. 2011. Current persepectives in congenital obstructive nephropathy. Review of Congenital Obstructive Nephropathy, by Ingraham S, McHugh KM. Current persepectives in congenital obstructive nephropathy. Pediatric Nephrology ed. Vol. 26: 1453-1461. [Peer Reviewed] (Published)
• Ingraham SE; Saha M; Carpenter AR; Robinson M; Ismail I; Singh S; Hains D; Robinson ML; Hirselj DA; Koff SA; Bates CM; McHugh KM. 2010. Pathogenesis of renal injury in the megabladder mouse: a genetic model of congenital obstructive nephropathy.  Pediatric Research. Vol. 68, no. 6. (December 1): 500.
• Hains DS; Sims-Lucas S; Carpenter A; Saha M; Murawski I; Kish K; Gupta I; McHugh K; Bates CM. 2010. High incidence of vesicoureteral reflux in mice with Fgfr2 deletion in kidney mesenchyma.  The Journal Of Urology. Vol. 183, no. 5. (May 1): 2077. (IF: 3.9)
• Ingraham, S.E., Saha, M., Carpenter, A., Robinson, M., Ismail, I., Singh, S., Hains, D., Robinson, M.L., Hirselj, D., Koff, S.A., Bates, C.M. and McHugh, K.M. 2010. Pathogenesis of Renal Injury in the Megabladder Mouse: A Genetic Model of Congenital Obstructive Nephropathy.  Pediatric Research. no. 60. : 500-507. (IF: 2.8)
• Ingraham S.E., Carpenter A.R., Hirselj D., and McHugh K.M. 2010. Megabladder Mouse: A Genetic Model of Congenital Obstructive Nephropathy [Abstract]. American Society of Pediatric Nephrology: American Society of Pediatric Nephrology [Peer Reviewed] (Published)
• Spencer, J.D., Schwaderer, A., McHugh, K.M., Hains, D. 2010. Rnase 7: A Novel Antimicrobial Peptide in the Human Kidney and Urinary Tract [Abstract]. American Society of Nephrology: American Society of Nephrology [Peer Reviewed] (Published)
• Ingraham S.E., Carpenter A.R., Hirselj D., Robinson M., DeSouza, K.R., McHugh K.M. 2010. Characterization of renal injury in Megabladder mouse, a unique mouse model of congenital obstructive nephropathy [Abstract]. American Society of Nephrology: American Society of Nephrology [Peer Reviewed] (Published)
• Ingraham, S.E., Carpenter, A.R., Hirselj D., Robinson M., DeSouza, K.R., McHugh, K.M. 2010. Patterns of Renal Injury in Megabladder Mouse, A Unique Model of Congenital Obstructive Nephropathy [Abstract]. 11th International Workshop on Developmental Nephrology: 11th International Workshop on Developmental Nephrology [Peer Reviewed] (Published)
• Hain DS, Sims-Lucas S, Carpenter A, Saha M, Murawsik I, Kish K, Gupta I, McHugh K, Bates CM. 2010. High Incidence of Vesico-ureteral Reflux in Mice with Deletion of Fibroblast Growth Factor Receptor 2 in Kidney Mesenchyme.  Journal of Urology. no. 183. : 2077-2084. (IF: 3.9)
• Ingraham SE, McHugh KM. 2010. Current Perspectives in Congenital Obstructive Nephropathy.  Pediatric Nephrology. (IF: 2.2) (Formally Accepted)
• Sims-Lucas S, Argyropoulos C, Kish K, McHugh K, Bertram JF, Quigley R, Bates CM. 2010. 3 dimensional technique reveals new ureteric and mesenchymal defects in Fgfr2 mutant kidneys.  Journal of the American Society of Nephrology. Vol. 20. : 2525-2533. (IF: 8.3)
• Spencer JD; Schwaderer A; McHugh K; Hains DS. 2010. Pediatric urinary tract infections: an analysis of hospitalizations, charges, and costs in the USA.  Pediatric Nephrology. Vol. 25, no. 12. : 2469. (IF: 2.2)
• Spencer JD, Schwaderer A, DiRosario J, McHugh KM, McGillivary G, Carpenter A, Baker P, Harder J, Hains D. 2010. Ribonuclease 7: A Potent Antimicrobial Peptide Within the Human Kidney and Urinary Tract.  Kidney International. (IF: 6.1) (Formally Accepted)
• Sims-Lucas S; Argyropoulos C; Kish K; McHugh K; Bertram JF; Quigley R; Bates CM. 2009. Three-dimensional imaging reveals ureteric and mesenchymal defects in Fgfr2-mutant kidneys.  Journal Of The American Society Of Nephrology: JASN. Vol. 20, no. 12. (December 1): 2525. (IF: 8.3)
• Saha M; Ingraham SE; Carpenter A; Robinson M; McHugh KE; Singh S; Robinson ML; McHugh KM. 2009. Identification of distinct myocardin splice variants in the bladder.  The Journal Of Urology. Vol. 182, no. 2. (August 1): 766. (IF: 3.9)
• Singh, S., Robinson, M., Ismail, I., Saha, M., Auer, H., Kornacher, K., Robinson, M.L., Bates, C.M., and McHugh, K.M. 2009. Transcriptional Profiling of the Megabladder Mouse - A Unique Model of Bladder Dysmorphogenesis [Abstract]. Barcelona Biomed Conferences: Barcelona Biomed Conferences [Peer Reviewed] (Published)
• Ingraham S.E., Saha M., Carpenter A.R., and McHugh K. 2009. Pathogenesis of Renal Injury in Megabladder (mgb) Mouse; A Genetic Model of Congenital Obstructive Nephropathy [Abstract]. American Society of Pediatric Nephrology: American Society of Pediatric Nephrology [Peer Reviewed] (Published)
• DeSouza, K., Carpenter, A., and McHugh, K.M. 2009. Characterizing the role of MYOCD in smooth muscle differentiation [Abstract]. American Society of Nephrology: American Society of Nephrology [Peer Reviewed] (Published)
• DeSouza, K., and McHugh, K.M. 2009. Characterizing the role of myocardin in smooth muscle differentiation [Abstract]. American Society of Pediatric Nephrology: American Society of Pediatric Nephrology [Peer Reviewed] (Published)
• Hirselj, D., Robinson, M., Singh S., Saha M., Koff, S., and McHugh, K.M. 2009. The Megabladder Mouse: A transgenic model for the study of obstructive uropathy [Abstract]. American Urological Association: American Urological Association [Peer Reviewed] (Published)
• Hains D, Sims-Lucas S, Kish K, Saha M, McHugh K, Bates CM. 2008. Role of fibroblast growth factor receptor 2 in kidney mesenchyme.  Pediatric Research. Vol. 64, no. 6. (December): 592-598. (IF: 2.8)
• Hains D; Sims-Lucas S; Kish K; Saha M; McHugh K; Bates CM. 2008. Role of fibroblast growth factor receptor 2 in kidney mesenchyme.  Pediatric Research. Vol. 64, no. 6. (December 1): 592.
• Singh S; Robinson M; Ismail I; Saha M; Auer H; Kornacker K; Robinson ML; Bates CM; McHugh KM. 2008. Transcriptional profiling of the megabladder mouse: a unique model of bladder dysmorphogenesis.  Developmental Dynamics: An Official Publication Of The American Association Of Anatomists. Vol. 237, no. 1 (January 1): 170.
• Hains D, Sims-Lucas S, Kish K, Saha M, McHugh KM, Bates CM. 2008. Role of Fibroblastic Growth Factor 2 in Kidney Mesenchyme.  Pediatric Research. Vol. 64: 592-598.
• Singh S; Robinson M; Ismail I; Saha M; Auer H; Kornacker K; Robinson ML; Bates CM; McHugh KM. 2008. Transcriptional profiling of the megabladder mouse: a unique model of bladder dysmorphogenesis.  Developmental Dynamics: An Official Publication Of The American Association Of Anatomists. Vol. 237, no. 1. (January 1): 170.
• Saha, M., Carpenter, A., Robinson, M., Bates, C.M., and McHugh, K.M. 2008. The Megabladder Mouse Represents a Prospective Model of In Utero Obstructive Nephropathy [Abstract]. Journal of the American Society Nephrology: Journal of the American Society Nephrology [Peer Reviewed] (Published)
• Singh S, Robinson M, Ismail I, Saha M, Auer H, Kornacker K, Robinson ML, Bates CM, McHugh KM. 2008. Transcriptional profiling of the megabladder mouse: a unique model of bladder dysmorphogenesis.  Dev Dyn.. Vol. 237, no. 1. (January): 170-186. (IF: 3.1)
• Singh S; Robinson M; Nahi F; Coley B; Robinson ML; Bates CM; Kornacker K; McHugh KM. 2007. Identification of a unique transgenic mouse line that develops megabladder, obstructive uropathy, and renal dysfunction.  Journal Of The American Society Of Nephrology: JASN. Vol. 18, no. 2 (February 1): 461.
• Singh S; Robinson M; Nahi F; Coley B; Robinson ML; Bates CM; Kornacker K; McHugh KM. 2007. Identification of a unique transgenic mouse line that develops megabladder, obstructive uropathy, and renal dysfunction.  Journal Of The American Society Of Nephrology: JASN. Vol. 18, no. 2. (February 1): 461.
• Auer H, Newsom DL, Nowak NJ, McHugh KM, Singh S, Yu CY, Yang Y, Wenger GD, Gastier-Foster JM, Kornacker K. 2007. Gene-resolution analysis of DNA copy number variation using oligonucleotide expression microarrays.  BMC Genomics. Vol. 30. (IF: 4.2)
• Schwaderer A, Bates CM, McHugh K, McBride KL. 2007. Renal anomalies in family members of infants with bilateral renal agenesis/adysplasia. Pediatric Nephrology. Vol. 22: 52-56.
• Schwaderer AL; Bates CM; McHugh KM; McBride KL. 2007. Renal anomalies in family members of infants with bilateral renal agenesis/adysplasia.  Pediatric Nephrology (Berlin, Germany). Vol. 22, no. 1 (January 1): 52.
• Singh S, Robinson M, Ismail I, Saha M, Auer H, Kornacker K, Robinson ML, Bates CM, McHugh KM. 2007. Transcriptional profiling of the megabladder mouse: A unique model of bladder dysmorphogenesis. Developmental Dynamics.
• Auer H; Newsom DL; Nowak NJ; McHugh KM; Singh S; Yu CY; Yang Y; Wenger GD; Gastier-Foster JM; Kornacker K. 2007. Gene-resolution analysis of DNA copy number variation using oligonucleotide expression microarrays.  BMC Genomics. Vol. 8 (January 1): 111.
• Schwaderer AL; Bates CM; McHugh KM; McBride KL. 2007. Renal anomalies in family members of infants with bilateral renal agenesis/adysplasia.  Pediatric Nephrology (Berlin, Germany). Vol. 22, no. 1. (January 1): 52.
• Saha, M., Robinson, M., Singh, S., Ismail, I., and McHugh, K.M. 2007. Biochemical Markers of Hydroureteronephrosis in a Mouse Model of In Utero Obstructive Nephropathy [Abstract]. Kidney Development and Repair Conference: Kidney Development and Repair Conference [Peer Reviewed] (Published)
• Singh S, Robinson M, Nahi F, Coley B, Robinson ML, Bates CM, Kornacker K, McHugh KM. 2007. Identification of a unique transgenic mouse line that develops megabladder, obstructive uropathy, and renal dysfunction.  Journal of the American Society of Nephrology. Vol. 18, no. 2. : 461-471. (IF: 8.3)
• Ismail, I., Singh, S., Robinson, M., Saha, M., Bates, C.M., and McHugh, K.M. 2007. Examination of Progressive Renal Fibrosis in a Genetic Model of In Utero Obstructive Nephropathy: The Megabladder Mouse [Abstract]. Kidney Development and Repair Conference: Kidney Development and Repair Conference [Peer Reviewed] (Published)
• Singh, S., Robinson, M., Saha, M., Ismail, I., Robinson, M.L., Bates, C.M., and McHugh, K.M. 2007. Identification of a Unique Transgenic Model of In Utero Obstructive Nephropathy: The Megabladder Mouse [Abstract]. Kidney Development and Repair Conference: Kidney Development and Repair Conference [Peer Reviewed] (Published)
• Schwaderer A, Bates C, McHugh K, McBride K. 2006. Renal Anomalies in Family Members of Infants with Bilateral Renal Agenesis/Adysplasia.  Pediatric Nephrology. Vol. 22. : 52-56. (IF: 2.2)
• Singh, S., Chilton, M., Bailes, A., Pitre, D., B. Coley, B., Auer, H., K. Kornacker, K., Bates, C., Robinson, M., and McHugh, K.M. 2006. Identification of Candidate Genes in a Transgenic Mouse Model of Urogenital Development, Obstruction, and Chronic Renal Failure [Abstract]. Pediatric Academic Societies: Pediatric Academic Societies [Peer Reviewed] (Published)
• Barnard JA and McHugh KM. 2006. Growth Factors of the GI Tract. In Physiology of the Gastrointestinal Tract, Fourth Edition. Edited by Johnson LR. New York, NY, USA: Elsevier.
• Barnard J, McHugh KM. 2006. Growth factors in the gastrointestinal tract.  Physiology of the Gastrointestinal Tract. : 183-246.
• McHugh, K.M., Singh, S., Bailes, A., Chilton, M., Bates, C.M., and Robinson, M.L. 2005. A Genetic Model of Urogenital Development and Obstruction In a Transgenic Mouse Line Designated Megabladder (mgb) [Abstract]. FASEB Journal: FASEB Journal [Peer Reviewed] (Published)
• Singh, S., Bailes, A., Chilton, M., Pitre, D., Bates, C., Robinson, M., and McHugh, K.M. 2005. A Genetic Model of Urogenital Development and Obstruction In a Transgenic Mouse Line Designated Megabladder (mgb) [Abstract]. American Society of Nephrology: American Society of Nephrology [Peer Reviewed] (Published)
• S. Singh, F. Nahi, C. Bates, M. Robinson, and K.M. McHugh. 2005. A Genetic Model of Urogenital Development and Obstruction In a Transgenic Mouse Line Designated Megabladder (mgb) [Abstract]. Pediatric Academic Societies: Pediatric Academic Societies [Peer Reviewed] (Published)
• Singh, S., Chilton, M., Bailes, A., Pitre, D., B. Coley, B., Auer, H., K. Kornacker, K., Bates, C., Robinson, M., and McHugh, K.M. 2005. Identification of Candidate Genes in a Transgenic Mouse Model of Urogenital Development and Obstruction [Abstract]. American Society for Cell Biology: American Society for Cell Biology [Peer Reviewed] (Published)
• S. Singh, F. Nahi, C. Bates, M. Robinson, and K.M. McHugh. 2004. A Genetic Model of Urogenital Development and Obstruction In a Transgenic Mouse Line Designated Megabladder (mgb) [Abstract]. Molecular Biology Of the Cell: Molecular Biology Of the Cell [Peer Reviewed] (Published)
• Gabetta V; Trzyna W; Phiel C; McHugh KM. 2003. Vesicle-associated protein-A is differentially expressed during intestinal smooth muscle cell differentiation.  Developmental Dynamics: An Official Publication Of The American Association Of Anatomists. Vol. 228, no. 1. (September 1): 11. (IF: 3)
• Owens, N.H., Gabbeta, V., McHugh, K.M. 2002. Functional Analysis of Serum Response Factor in Cultured Smooth Muscle Cells [Abstract]. Molecular Biology Of the Cell: Molecular Biology Of the Cell [Peer Reviewed] (Published)
• Phiel CJ; Gabbeta V; Parsons LM; Rothblat D; Harvey RP; McHugh KM. 2001. Differential binding of an SRF/NK-2/MEF2 transcription factor complex in normal versus neoplastic smooth muscle tissues.  The Journal Of Biological Chemistry. Vol. 276, no. 37. (September 14): 34637. (IF: 5.3)
• Owens, N.H., Gabbeta, V., McHugh, K.M. 2001. Functional Analysis of Serum Response Factor in Cultured Smooth Muscle Cells [Abstract]. Molecular Biology of the Cell: Molecular Biology of the Cell [Peer Reviewed] (Published)
• Phiel, C.J., Gabbeta, V., Rothblat, D., Parsons, L.M., Harvey, R.P., and McHugh, K.M. 2001. Differential Binding of an SRF/NK-2/MEF2 Transcription Factor Complex in Normal Versus Neoplastic Smooth Muscle Tissues [Abstract]. Molecular Biology Of the Cell: Molecular Biology Of the Cell [Peer Reviewed] (Published)
• Van Bockstaele, E.J., Peoples, J., Drolet, G., McHugh, K., Telegan, P. 2000. Pre-Proenkephalin mRNA Levels are Decreased in Medullary Areas Following Chronic Morphine Treatment [Abstract]. Journal of Neuroscience: Journal of Neuroscience [Peer Reviewed] (Published)
• Van Bockstaele E, Peoples J, Menko, S, McHugh K. and Drolet G. 2000. Decreases in Endogenous Opiod Peptides in the Rat Medullo-Coerulear Pathway Following Chronic Morphine Treatment.  Journal of Neuroscience. Vol. 20. : 8659-8666. (IF: 8.2)
• Blennerhassett MG; Bovell FM; Lourenssen S; McHugh KM. 1999. Characteristics of inflammation-induced hypertrophy of rat intestinal smooth muscle cell.  Digestive Diseases And Sciences. Vol. 44, no. 7. (July 1): 1265. (IF: 2.1)
• Weston WM; LeClair EE; Trzyna W; McHugh KM; Nugent P; Lafferty CM; Ma L; Tuan RS; Greene RM. 1999. Differential display identification of plunc, a novel gene expressed in embryonic palate, nasal epithelium, and adult lung.  The Journal Of Biological Chemistry. Vol. 274, no. 19. (May 7): 13698. (IF: 5.3)
• McHugh, K, M., Gabbeta, V. 1999. Developmental Toxicity of Lead in Smooth Muscle [Abstract]. Toxicological Sciences: Toxicological Sciences [Peer Reviewed] (Published)
• Weston W, LeClair, E, Trzyna W, McHugh KM, Nugent, P, Lafferty C, Ma L, Tuan, R, Greene R. 1999. Differential Display Identification of a Novel Gene Expressed in Late Palate Development.  Biological Chemistry. Vol. 274: 13698-13703.
• Brittingham J; Phiel C; Trzyna WC; Gabbeta V; McHugh KM. 1998. Identification of distinct molecular phenotypes in cultured gastrointestinal smooth muscle cells.  Gastroenterology. Vol. 115, no. 3. (September 1): 605. (IF: 12)
• Wong JZ; Woodcock-Mitchell J; Mitchell J; Rippetoe P; White S; Absher M; Baldor L; Evans J; McHugh KM; Low RB. 1998. Smooth muscle actin and myosin expression in cultured airway smooth muscle cells.  The American Journal Of Physiology. Vol. 274, no. 5 Pt 1. (May 1): L786. (IF: 4.1)
• Phiel, C., McHugh, K.M. 1998. Identification of the Factors Controlling Gastrointestinal Smooth Muscle Myogenesis [Abstract]. Digestive Diseases and Sciences: Digestive Diseases and Sciences [Peer Reviewed] (Published)
• Phiel, C., Gabbeta, V., McHugh, K.M. 1998. Gastrointestinal Smooth Muscle Cells Recapitulate a Significant Portion of Their Myogenic Program In Vitro [Abstract]. Digestive Diseases and Sciences: Digestive Diseases and Sciences [Peer Reviewed] (Published)
• Huard, J., Yokoyama, T., Lavelle, J., Teahan, S., Wantanabe, T., Ozawa, H., Yoshimura, N., de Groat, W., Qu, Z., Chancellor, M. 1998. Differentiation of Primary Myoblast Injection Into the Lower Urinary Tract; Creation of Detrusor Cellular Myoplasty [Abstract]. Journal of Urology: Journal of Urology [Peer Reviewed] (Published)
• McCue P, McHugh M, McHugh KM. 1998. Diagnosing uterine smooth muscle tumors: A review.  LabMedica International. Vol. 15. : 12-16. (IF: 4.8)
• McCue P, McHugh M, McHugh KM. 1998. Diagnosing uterine smooth muscle tumors: a review. Review of Utereine Smooth Muscle Tumors, by McCue P, McHugh M, McHugh KM. Diagnosing uterine smooth muscle tumors: a review. LabMedica International ed. Vol. 15: 12-16. [Peer Reviewed] (Published)
• Brittingham J, Phiel C, Trzyna W, Gabbeta V, McHugh KM. 1998. Finally - A Clear DiagnosIdentification of Distinct Molecular Phenotypes in Cultured Gastrointestinal Smooth Muscle Cells.  Gastroenterology. Vol. 115. : 605-617. (IF: 12)
• Trzyna WC; Gabbeta V; McHugh KM. 1997. Isolation and characterization of a novel short chain alcohol dehydrogenase-like isozyme by differential display of distinct smooth muscle cell phenotypes.  The Journal Of Steroid Biochemistry And Molecular Biology. Vol. 63, no. 1-3. (September 1): 115. (IF: 3.1)
• Trzyna W; McHugh M; McCue P; McHugh KM. 1997. Molecular determination of the malignant potential of smooth muscle neoplasms.  Cancer. Vol. 80, no. 2. (July 15): 211. (IF: 5.1)
• Chakder S; McHugh KM; Rattan S. 1997. Inhibitory neurotransmission in lethal spotted mutant mice: a model for Hirschsprung's disease.  Gastroenterology. Vol. 112, no. 5. (May 1): 1575. (IF: 12)
• Brittingham J; Liaw D; Liddell R; McHugh M; McCue P; McHugh KM. 1997. Comparative analysis of smooth muscle isoactin gene expression in normal and neoplastic tissues.  Pathobiology: Journal Of Immunopathology, Molecular And Cellular Biology. Vol. 65, no. 3. (January 1): 113. (IF: 2.1)
• Rivas D, Chancellor M, Shupp-Byrne D, Shenot P, McHugh KM. 1997. A Molecular Marker for the Development of Interstitial Cystitis in a Rat Model: Isoactin Gene Expression.  J Urol. Vol. 157. : 1937-1940. (IF: 3.9)
• Graham, M., Willey, A., Zhu, Y., McHugh, K.M. 1997. TGF-b Induces Expression of Smooth Muscle Isoactins in Human Intestinal Smooth Muscle (HISM) Cells: The Role of Smooth Muscle Differentiation in Gut Repair [Abstract]. Gastroenterology: Gastroenterology [Peer Reviewed] (Published)
• Trzyna W, McHugh M, McCue P, McHugh KM. 1997. Finally - A clear diagnostic that shows if uterine smooth muscle tumors are benign or malignant [Abstract]. American Society for Cell Biology. 19 ed (Published)
• Blennerhassett, M., Lamb, D.P., Bovell, F.M. McHugh, K.M. 1997. Inflammation Causes Modulation of Smooth Muscle Actin Profiles in the Rat Small Intestine [Abstract]. Gastroenterology: Gastroenterology [Peer Reviewed] (Published)
• Phiel, C.J., McHugh, K.M. 1997. Identification of Factors Regulating Visceral Smooth Muscle Differentiation [Abstract]. Molecular Biology of the Cell: Molecular Biology of the Cell [Peer Reviewed] (Published)
• Trzyna, W.C., McHugh, M., McCue, P., McHugh, K.M. 1997. Molecular Determination of the Malignant Potential of Smooth Muscle Neoplasms [Abstract]. Molecular Biology of the Cell: Molecular Biology of the Cell [Peer Reviewed] (Published)
• Trzyna, W.C., Gabetta, V, McHugh, K.M. 1997. sHAND: A bHLH Transcription Factor Involved in Smooth Muscle Myogenesis [Abstract]. Molecular Biology of the Cell: Molecular Biology of the Cell [Peer Reviewed] (Published)
• McHugh KM. 1996. Molecular analysis of gastrointestinal smooth muscle development.  Journal Of Pediatric Gastroenterology And Nutrition. Vol. 23, no. 4. (November 1): 379. (IF: 2.2)
• McHugh KM. 1996. Molecular analysis of gastrointestinal smooth muscle development. Review of Smooth muscle development, by McHugh KM. Molecular analysis of gastrointestinal smooth muscle development. Journal of Pediatric Gastroenterology and Nutrition ed. Vol. 23: 379-394. [Peer Reviewed] (Published)
• Chakder, S., McHugh, K., Rattan, S. 1996. Animal Model for the Pathogenesis of Nitronergic Inhibitory Neurotransmission in Hirschsprung's Disease [Abstract]. American Gastroenterologic Association: American Gastroenterologic Association [Peer Reviewed] (Published)
• Rivas, D., McHugh, K., Shenot, P., Wantanabe, T., Shupp-Byrne, D., McCue, P., Salzman, S., and Chancellor, M. 1996. Bladder Smooth Muscle Isoactin Gene Expression in the Rat Model of Spinal Cord Injury [Abstract]. Journal of Urology: Journal of Urology [Peer Reviewed] (Published)
• Shenot, P., Rivas, D., McHugh, K., Hong, R., Wantanabe, T., Shupp-Byrne, D., McCue, P., Salzman, S., and Chancellor, M. 1996. Analysis of Bladder Smooth Muscle Isoactin Expression in Interstitial Cystitis Using Semi-Quantitative PCR Assay [Abstract]. Journal of Urology: Journal of Urology [Peer Reviewed] (Published)
• Rivas, D., McHugh, K., Shenot, P., Wantanabe, T., Shupp-Byrne, D., McCue, P., Salzman, S., and Chancellor, M. 1996. Bladder Smooth Muscle Isoactin Gene Expression in the Rat Model of Spinal Cord Injury [Abstract]. Journal Spinal Cord Medicine: Journal Spinal Cord Medicine [Peer Reviewed] (Published)
• McHugh KM. 1995. Molecular analysis of smooth muscle development in the mouse.  Developmental Dynamics: An Official Publication Of The American Association Of Anatomists. Vol. 204, no. 3 (November 1): 278.
• Pavan WJ; Liddell RA; Wright A; Thibaudeau G; Matteson PG; McHugh KM; Siracusa LD. 1995. A high-resolution linkage map of the lethal spotting locus: a mouse model for Hirschsprung disease.  Mammalian Genome: Official Journal Of The International Mammalian Genome Society. Vol. 6, no. 1. (January 1): 1. (IF: 2.8)
• Rivas, D., M. Chancellor, and K. McHugh. 1995. Isoactin Gene Expression in the Rat Model of Spinal Cord Injury: A Potential Early Marker of Long-Term Bladder Function and Risk [Abstract]. Journal of Urology: Journal of Urology [Peer Reviewed] (Published)
• McHugh, K., D. Rivas, M. Chancellor. 1995. A Molecular Marker for the Development of Interstitial Cystitis in a Rat Model: Isoactin gene Expression [Abstract]. American Urologic Association: American Urologic Association [Peer Reviewed] (Published)
• Trzyna, W., Phiel, C., McHugh, K. 1995. Identification and Characterization of Differentially Expressed Gene Products During Gastrointestinal Smooth Muscle Development In Vitro [Abstract]. Molecular Biology Cell: Molecular Biology Cell [Peer Reviewed] (Published)
• McHugh, K.M., D. Rivas, S. Salzman, M. Chancellor. 1995. Bladder Smooth Muscle Isoactin Gene Expression in the Rat Model of Spinal Cord Injury [Abstract]. American Paraplegia Society: American Paraplegia Society [Peer Reviewed] (Published)
• Liddell RA; Chakder S; Rattan S; McHugh KM. 1994. Differential isoactin gene expression in the sphincteric and nonsphincteric gastrointestinal smooth muscles of the opossum.  Proceedings Of The Society For Experimental Biology And Medicine. Society For Experimental Biology And Medicine (New York, N.Y.). Vol. 205, no. 4. (April 1): 321. (IF: 3)
• Liddell RA, Thibaudeau G, Maddison P, Goldstein C, McHugh KM, Siracusa L, Pavin W. 1994. Molecular Genetic Mapping of the Lethal Spotting (ls) Mutation in the Mouse.  Mouse Genome. Vol. 92. : 688-690. (IF: 2.8)
• Brittingham, J. and McHugh, K.M. 1994. In Vitro Modulation of Intestinal Smooth Muscle Cell Phenotype by Fibronectin and Laminin [Abstract]. Molecular Biology Cell: Molecular Biology Cell [Peer Reviewed] (Published)
• McHugh, K.M. 1994. Molecular Analysis of Smooth Muscle Development in the Mouse [Abstract]. Molecular Biology Cell: Molecular Biology Cell [Peer Reviewed] (Published)
• Liddell RA; Mooers SU; Siegman MJ; McHugh KM. 1993. Altered isoactin gene expression in the affected bowel segments of the lethal spotted mouse.  Gastroenterology. Vol. 105, no. 2. (August 1): 441. (IF: 12)
• Liddell RA; Syms M; McHugh KM. 1993. Heterogeneous isoactin gene expression in the adult rat gastrointestinal tract.  Gastroenterology. Vol. 105, no. 2. (August 1): 347. (IF: 12)
• Brittingham, J. and McHugh, K. 1993. Characterization of Isoactin Gene Expression in Primary Cultures of Rat Gastrointestinal Smooth Muscle Cells [Abstract]. Molecular Biology Cell: Molecular Biology Cell [Peer Reviewed] (Published)
• Liaw, D., Liddell, R., Brittingham, J., McHugh, M., McCue, P., McHugh, K. 1993. Molecular Analysis of Smooth Muscle Isoactin Gene Expression in a Variety of Human Neoplasms [Abstract]. American Journal Clinical Pathology: American Journal Clinical Pathology [Peer Reviewed] (Published)
• Liddell, R., McHugh, K., Chakder, S. and Rattan, S. 1993. Differential Expression of Isoactin Genes in the Tonic Smooth Muscles of Gastrointestinal Sphincters. [Abstract]. Gastroenterology: Gastroenterology [Peer Reviewed] (Published)
• Liddell, R., Chakder, S., Rattan, S. and McHugh, K. 1992. Characterization of Isoactin Gene Expression in the Adult Gastrointestinal Tract of the Rat and Opossum [Abstract]. Philadelphia Gastrointestinal Research Forum: Philadelphia Gastrointestinal Research Forum [Peer Reviewed] (Published)
• McHugh KM; Crawford K; Lessard JL. 1991. A comprehensive analysis of the developmental and tissue-specific expression of the isoactin multigene family in the rat.  Developmental Biology. Vol. 148, no. 2. (December 1): 442. (IF: 4.4)
• Liddell, R.A., Brittingham, J., and McHugh, K.M. 1991. Heterogeneous Actin Gene Expression in the Adult Rat Gastrointestinal Tract. [Abstract]. Journal Cell Biology: Journal Cell Biology [Peer Reviewed] (Published)
• Mantle PG; McHugh KM; Adatia R; Heaton JM; Gray T; Turner DR. 1991. Penicillium aurantiogriseum-induced, persistent renal histopathological changes in rats; an experimental model for Balkan endemic nephropathy competitive with ochratoxin A.  IARC Scientific Publications. no. 115 (January 1): 119.
• Liddell, R.A., Siegman, M.J., and McHugh, K.M. 1991. Characterization of Isoactins Gene Expression in the Effected Colonic and Rectal Segments of the Lethal Spotted Mouse [Abstract]. Journal Cell Biology: Journal Cell Biology [Peer Reviewed] (Published)
• Brown CW; McHugh KM; Lessard JL. 1990. A cDNA sequence encoding cytoskeletal gamma-actin from rat.  Nucleic Acids Research. Vol. 18, no. 17. (September 11): 5312. (IF: 7.8)
• Liddell, R.A., Siegman, M.J., and McHugh, K.M. 1990. Characterization of Actin Gene Expression in the Lethal Spotted Mouse Model of Congenital Megacolon [Abstract]. Journal Cell Biology: Journal Cell Biology [Peer Reviewed] (Published)
• McHugh, K.M. 1990. The Developmental and Tissue-Specific Expression of the Actin Multigene Family in the Rat [Abstract]. Journal Cell Biology: Journal Cell Biology [Peer Reviewed] (Published)
• McHugh KM; Drake RL. 1989. Insulin-mediated regulation of epididymal fat pad malic enzyme.  Molecular And Cellular Endocrinology. Vol. 62, no. 2. (April 1): 227. (IF: 4.1)
• McHugh DM, Brown CW, Lessard JL. 1989. A Molecular Analysis of the Rat Stomach Alpha-Vascular, Gamma-Enteric and Gamma-Cytoplasmic Isoactins. In Cellular and Molecular Biology of Muscle Development. Edited by Stockdale F and Kedes L. New York, NY: Alan R. Liss, Inc.
• McHugh KM, Brown CW, Lessard JL. 1989. A molecular analysis of the rat stomach a-vascular, g-enteric, and g-cytoplasmic isoactins.  Cellular and Molecular Biology of Muscle Development. UCLA Symposium on Molecular and Cellular Biology. Vol. 93.
• McHugh KM; Lessard JL. 1988. The development expression of the rat alpha-vascular and gamma-enteric smooth muscle isoactins: isolation and characterization of a rat gamma-enteric actin cDNA.  Molecular And Cellular Biology. Vol. 8, no. 12. (December 1): 5224. (IF: 6.2)
• McHugh KM; Lessard JL. 1988. The nucleotide sequence of a rat vascular smooth muscle alpha-actin cDNA.  Nucleic Acids Research. Vol. 16, no. 9. (May 11): 4167. (IF: 7.8)
• Brown, C.W., McHugh, K.M., Lessard, J.L. 1988. Alternative 3'-Untranslated Regions in Two Rat Cytoplasmic g-Actin cDNA Clones [Abstract]. Journal Cellular Biochemist: Journal Cellular Biochemistry [Peer Reviewed] (Published)
• McHugh, K.M., Crawford, K. and Lessard, J.L. 1988. Isolation and Characterization of Smooth Muscle and g-Actin cDNAs in the Rat [Abstract]. Journal Cellular Biochemistry: Journal Cellular Biochemistry [Peer Reviewed] (Published)
• Brown, C.W., McHugh, K.M., and Lessard, J.L. 1988. Two mRNAs Differing in their 3' Untranslated Regions Encode Cytoplasmic g-Actin [Abstract]. Journal Cell Biology: Journal Cell Biology [Peer Reviewed] (Published)
• McHugh KM; Drake RL. 1988. Normal and diabetic malic enzyme: a biochemical comparison.  Molecular And Cellular Endocrinology. Vol. 55, no. 1. (January 1): 71. (IF: 4.1)
• Lessard, J.L., Crawford, K., Ayra, G., McHugh, K.M., Richardson, B. 1988. The Relationship Among the Actin Binding Sites for Monoclonal Antibodies, DNase 1 and Actin [Abstract]. Journal Cell Biology: Journal Cell Biology [Peer Reviewed] (Published)
• McHugh KM, Drake RL. 1987. Normal and diabeetic malic enzyme: a biochemical compairson.  Mol Cell Endocrinology. Vol. 55: 71-75.
• McHugh, K.M., Lessard, J.L. 1987. Isolation of a Unique Actin Specific cDNA Clone from Rat Stomach [Abstract]. Journal Cell Biology: Journal Cell Biology [Peer Reviewed] (Published)
• McHugh KM, Mucenski CG, Drake RL. 1986. An insulin-mediated differential induction of specific hepatic mRNAs.  ICSU Short Reports. Vol. 4. : 52-53.
• McHugh, K.M., Davis, B.B., Drake, R.L. 1986. Insulin Mediated Transcriptional and Post-Transcriptional Regulation of Epididymal Fat Pad Malic Enzyme [Abstract]. Journal Cell Biology: Journal Cell Biology [Peer Reviewed] (Published)
• Drake, R.L., Mucenski, C.G., McHugh, K.M. 1986. Insulin and Malic Enzyme: A Model to Study Hormonal Regulation of Liver Metabolism [Abstract]. Anatomic Record: Anatomic Record [Peer Reviewed] (Published)
• Drake RL; McHugh KM; Mucenski CG. 1984. Insulin and fructose regulate malic enzyme activity by different processes.  Biochemical And Biophysical Research Communications. Vol. 121, no. 2. (June 15): 730. (IF: 2.7)
• Drake, R.L. Mucenski, C.G., McHugh, K.M. 1984. Effects of Various Insulin Dosages on Hepatic Lipogenesis [Abstract]. Anatomic Record: Anatomic Record [Peer Reviewed] (Published)
• Drake, R.L., McHugh, K.M. Mucenski, C.G. 1984. Insulin and Malic Enzyme: Tissue Specific Regulation [Abstract]. Federation Proceedings: Federation Proceedings [Peer Reviewed] (Published)
• Kirk McHugh. issued 1998. Diagnostic Test to Determine the Malignant Potential of Smooth Muscle Tumors. patent no. 5710003.
• Kirk McHugh. issued 1998. Diagnostic Test to Determine the Malignant Potential of Smooth Muscle Tumors. patent no. International Patient PCU/US97/00976.