Kim L. McBride, MD, MS :: Nationwide Children’s Hospital, Columbus, Ohio

PediaCast Interview with Dr. Kim McBride

PediaCast with Dr. Mike features Kim McBride, MD, MS on the topic of Genetics of Congenital Heart Disease.

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Kim L. McBride, MD, MS

Kim L. McBride, MD, MS Best Doctors 2011-2012

Center for Molecular and Human Genetics
Principal Investigator

Genetics (CardioGenetics)
Member

Genetics (Molecular and Human)
Physician Team

Contact Information

Molecular/Human Genetics
700 Children's Dr
Columbus, OH 43205 [ map ]
PH: (614) 722-3537
FX: (614) 722-3546
E-mail Me
The Research Institute
at Nationwide Children's Hospital
Columbus, OH 43205 [ map ]
PH: (614) 722-2700

Office Practice Information:

  • Accepts patients 0-18.
  • Accepts patients 18 years or older.
  • Accepts Medicaid.
  • Provides prenatal visits for expecting parents.
  • This office is wheelchair accessible.
  • Practices at one of Nationwide Children's Close to Home Centers or Primary Care Centers.

Biography

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Kim L. McBride, MD, MS, is an Investigator in the Center for Molecular and Human Genetics at The Research Institute at Nationwide Children’s Hospital and an Assistant Professor in the Department of Pediatrics at The Ohio State University College of Medicine. He received his medical degree from the University of Saskatchewan, completed a residency in pediatrics at the Mayo Clinic and fellowships in clinical genetics and biochemical genetics at Baylor College of Medicine. He also received his Master’s degree at Baylor in the Clinical Scientist Training Program. Dr. McBride is board certified in pediatrics, clinical genetics and clinical biochemical genetics. He is a co-director of the Cardiovascular Genetics Clinic and also participates in the pediatric genetics and metabolic clinics. He cares for both pediatric and adult patients, with a special interest in genetic disorders involving the heart, inborn errors of metabolism, and lysosomal storage disease (particularly with enzyme replacement therapies). His research focuses on the genetics of congenital heart disease. National Institutes of Health (NIH)-funding was awarded to study the genetics of left ventricular outflow tract malformations (congenital aortic valve stenosis, coarctation of the aorta and hypoplastic left heart syndrome). This translational work is using linkage and association methods to dissect the genetic etiologies of these defects by high throughput genotyping methods. Several genes and cardiac developmental pathways have been identified for further exploration in the lab. He is the director of the Cell Line Core Shared Facility in The Research Institute.

Gender:

  • Male

Languages Spoken:

  • English

Research Interests

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Research Center:

Areas of Interest:

  • We are interested in the genetics of complex diseases. Our primary focus is to elucidate the causes of Cardiovascular Malformations. We also collaborate with other researchers investigating other diseases that impact children, such as Autism, Inflammatory Bowel Disease, Kidney Disease and Lupus.
  • Supporting Shared Resource: Our lab is the site for the Cell Line Core Shared Resource (Director, Kim L. McBride).
  • Collaborations with OSU: Cardiovascular Development – Dr. Susan Cole, Biological Sciences – Role of Notch in the development of cardiovascular malformations
  • Collaborations Internationally: Genetics of Cardiovascular Malformations– Dr Lars Larsen, Copenhagen Denmark – Linkage analysis of heart defects in the Denmark population
  • LVOTO Malformations Learn about our Genetics of Left Ventricular Outflow Tract Malformations Study http://www.nationwidechildrens.org/ventricular-outflow-tract-malformations
  • Collaborations with Nationwide Children’s Hospital: Autism – Dr. Gail Herman, Center for Molecular and Human Genetics – Genetics of autism Inflammatory Bowel Disease – Dr. Wallace Crandall, Gastroenterology and Dr. Laura Mackner, Center for Behavioral Health – Genetic variants involved in stress response in IBD Informed Consent Process – Dr Kelly Kelleher, Center for Innovation in Pediatric Practice – Study of health literacy and understanding of informed consent for genetic & biobanking studies Otitis Media – Dr. Lauren Bakaletz – Investigation of Copy Number Variants in the predisposition to OM in children
  • Cardiovascular malformations are common birth defects that occur in 5-8/1000 births. They contribute to a large proportion of infant deaths, and have heavy burdens on families and society from ongoing morbidity and high costs. We are interested in the etiology of a group of these malformations that involve obstruction of the left ventricular outflow tract, which includes Aortic Stenosis, Bicuspid Aortic Valve, Coarctation of the Aorta, and Hypoplastic Left Heart Syndrome. We have NIH funding to investigate the genetic etiology of these defects through Genome Wide Association Studies. Our lab is specialized in the collection and analysis of large amounts of clinical and genetic data. We have built an extensive database on our families that contains detailed phenotypic and clinical data on subjects and relatives. The lab has developed expertise in a variety of genotyping methods and platforms, RT-PCR, DNA sequencing, and cell culture methods. We have become proficient in the handling of this data in various database structures and analyzing the data using linkage, association and other statistical genetics techniques. We are also exploring the use of mouse models to understand the pathogenesis of human cardiovascular malformations.
  • Collaborations with Genetics of Cardiovascular Malformations – Dr. Peter Tishler, Harvard, Boston, MA – Linkage analysis of BAV families
  • Collaborations Nationally: Genetics of Cardiovascular Malformations – Dr. John Belmont, Baylor, Houston TX – Genome Wide Association Study of HLHS and related defects

Research Funding*:

  • Genetics of Congenital Left-Sided Heart Defects, National Heart, Lung and Blood Institute/National Cancer Institute
  • Child Health Research Career Development Award, National Institutes of Health

Education and Training

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Medical School

  • University of Saskatchewan
    Date Completed: 05/20/1987

Internship

  • Regina General Hospital - Chief Intern
    Date Completed: 06/30/1988

Internship

  • University of Saskatchewan College of Medicine
    Date Completed: 06/30/1988

Residency

  • Mayo Clinic (Rochester)
    Date Completed: 06/30/2000

Fellowship

  • Baylor Affiliated Hospitals (Houston)
    Date Completed: 03/30/2002

Fellowship

  • Baylor Affiliated Hospitals (Houston)
    Date Completed: 07/01/2003

Graduate School

  • Baylor College of Medicine - Masters Clinical Scientist Training Program
    Date Completed: 06/30/2004

Department:

  • Pediatrics

Section:

  • Molecular & Human Genetics

Speciality:

  • Clinical Biochemical Genetics, Certified
  • Clinical Genetics, Certified
  • Pediatrics, Certified

Date of Appointment at Children's Hospital:

  • 08/27/2004

Publications

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Nationwide Children's Hospital
700 Children's Drive Columbus, Ohio 43205 614.722.2000