K John McLaughlin :: Nationwide Children's Hospital, Columbus, Ohio

K. John McLaughlin, Ph.D.

K. John McLaughlin, Ph.D.

Contact Information

The Research Institute at Nationwide Children's Hospital
700 Children's Drive
Columbus, Ohio 43205 [ map ]
PH: (614) 355-3483
E-mail Me

Biography

K. John McLaughlin PhD is a principal investigator at The Research Institute at Nationwide Children’s Hospital since 2009, an Associate Professor in the Department of Pediatrics at the Ohio State College of Medicine and Director of the Transgenic and Embryonic Stem Cell Core Shared Resource. Dr. McLaughlin’s research interests include understanding the functional relevance of parent of origin specific expression (genomic imprinting). Current research is focused on using uni-parental, cells such as those derived from unfertilized eggs, as a source to generate stem cells that may be used for therapeutic transplantation.

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Gender:

  • Male

Languages Spoken:

  • English

Research Interests

Research Center:

Areas of Interest:

  • Genomic imprinting refers to the phenomenon that, in somatic cells, certain genes are preferentially expressed from one parental allele, such that maternally and paternally inherited genetic information is expressed unequally. We are interested in the consequences when imprinted gene expression patterns are disrupted, as this will lead to understanding as to why this unique gene control mechanism exists. We are using mouse models in which expression of imprinted genes is disturbed. One model is uniparental development including parthenogenesis and the paternal genome derived equivalent, androgenesis. We are currently integrating our study of uniparental cells within the concept of generating autologous embryonic stem cells. Parthenogenetic embryos have been discussed as a source of patient matching embryonic stem cells. To validate this concept we are investigating the capacity of parthenogenetic stem cell derived cells (fetal and grown under certain conditions in vitro/in tissue culture), to replace adult bone marrow/hematopoiesis. Additionally we are also testing androgenetic embryonic stem cells, to increase the potential patient pool for a therapeutic approach based on uniparental cells. Biologically, this model can be used as a system to study the relevance of genomic imprinting in adult tissues. An experimental strategy to investigate the ability of uniparental cells to engraft and differentiate in adults. Uniparental ES cells are injected into normal mouse blastocysts to generate composite fetuses (chimeras). Fetal liver cells from chimeras are then transplanted into lethally irradiated adults to reconstitute hematopoiesis. Investigating both androgenetic and gynogenetic/parthenogenetic cells, we are differentiating (in vivo and in vitro) and transplanting uniparental cells to various tissues to determine the broader utility for tissue replacement therapy.

Education and Training

Undergraduate School

  • University of Adelaide
    Date Completed: 06/30/1986

Undergraduate School

  • University of Adelaide
    Date Completed: 06/30/1987

Post Doctoral

  • University of Adelaide
    Date Completed: 06/30/1992

Professional Experience

2009–present

  • Associate Professor, Department of Pediatrics,
    The Ohio State University College of Medicine,
    Columbus, Ohio

2009–present

  • Director, Transgenic and Embryonic Stem Cell Core, Center for Molecular and Human Genetics, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio

1999–2008

  • Director, Myrin Rodent Barrier Facility, Center for Animal Transgenesis and Germ Cell Research, School of Veterinary Medicine, University of Pennsylvania

1999–2008

  • Assistant Professor, University of Pennsylvania, Department of Animal Biology, School of Veterinary Medicine

1998–1999

  • Lecturer C, University of Pennsylvania, Department of Animal Biology, School of Veterinary Medicine

1998–1998

  • Visiting Scientist, University of Western Ontario, Canada

1994–1998

  • Scientist, Max Planck Institute for Immunobiology, Freiburg,
    Germany

1992–1994

  • Postdoctoral Scientist, Beckman Research Institute, City of Hope Duarte, Los Angeles, USA

1991–1992

  • Visiting Postgraduate Research Scientist University of California, San Francisco, USA

Publications

  • Zhou J, Leu NA, Eckardt S, McLauglin KJ, Wang PJ. 2014. STK31/TDRD8, a Germ Cell-Specific Factor is Dispensable for Reproduction in Mice.  PLoS One. Vol. 9, no. 2. (February): ee89471.
  • Wolber, W, Ahmad, R, Choi SW, Eckardt S, McLaughlin, KJ, Schmitt, J, Geis, C, Heckmann, M, Siren, AL, Muller, AM. 2013. Phenotype and stability of neural differentiation of androgentic murine ES cell-derived neural progenitor cells.  Cell Medicine. Vol. 5, no. June: 29-42.
  • Ahmad,Ruhel; Wolber,Wanja; Eckardt,Sigrid; Koch,Philipp; Schmitt,Jessica; Semechkin,Ruslan; Geis,Christian; Heckmann,Manfred; Bruestle,Oliver; McLaughlin,John,K; Siren,Anna-Leena; Mueller,Albrecht,M. 2012. Functional Neuronal Cells Generated by Human Parthenogenetic Stem Cells.  PLOS ONE. Vol. 7, no. 8. (August): ee42800.
  • Eckardt S; McLaughlin KJ; Willenbring H. 2011. Mouse chimeras as a system to investigate development, cell and tissue function, disease mechanisms and organ regeneration.  Cell Cycle (Georgetown, Tex.). Vol. 10, no. 13. (July): e2091.
  • Zhou J; Pan J; Eckardt S; Leu NA; McLaughlin KJ; Wang PJ. 2011. Nxf3 is expressed in Sertoli cells, but is dispensable for spermatogenesis.  Molecular Reproduction And Development. Vol. 78, no. 4. (April): e241.
  • Maclean JA; Bettegowda A; Kim BJ; Lou CH; Yang SM; Bhardwaj A; Shanker S; Hu Z; Fan Y; Eckardt S; McLaughlin KJ; Skoultchi AI; Wilkinson MF. 2011. The rhox homeobox gene cluster is imprinted and selectively targeted for regulation by histone h1 and DNA methylation.  Molecular And Cellular Biology. Vol. 31, no. 6. (March): e1275.
  • Eckardt S; Leu NA; Yanchik A; Hatada S; Kyba M; McLaughlin KJ. 2011. Gene therapy by allele selection in a mouse model of beta-thalassemia.  The Journal Of Clinical Investigation. Vol. 121, no. 2. (February): e623.
  • Popkie,Anthony,P; Zeidner,Leigh,C; Albrecht,Ashley,M; D'Ippolito,Anthony; Eckardt,Sigrid; Newsom,David,E; Groden,Joanna; Doble,Bradley,W; Aronow,Bruce; McLaughlin,K,John; White,Peter; Phiel,Christopher,J. 2010. Phosphatidylinositol 3-Kinase (PI3K) Signaling via Glycogen Synthase Kinase-3 (Gsk-3) Regulates DNA Methylation of Imprinted Loci.  JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 285, no. 53. (December): 41337-41347.
  • Yang,Fang; Cheng,Yong; An,Jee,Young; Kwon,Yong,Tae; Eckardt,Sigrid; Leu,N,Adrian; McLaughlin,K,John; Wang,Peijing,Jeremy. 2010. The Ubiquitin Ligase Ubr2, a Recognition E3 Component of the N-End Rule Pathway, Stabilizes Tex19.1 during Spermatogenesis.  PLOS ONE. Vol. 5, no. 11. (November): ee14017.
  • Espejel,Silvia; Roll,Garrett,R; Eckardt,Sigrid; McLaughlin,K,John; Willenbring,Holger. 2010. Pluripotent stem cells as a source of immunocompatible renal progenitor cells for therapy of nephropathic cystinosis.  PEDIATRIC NEPHROLOGY. Vol. 25, no. 10. (October): 2210-2211.
  • Espejel S; Roll GR; McLaughlin KJ; Lee AY; Zhang JY; Laird DJ; Okita K; Yamanaka S; Willenbring H. 2010. Induced pluripotent stem cell-derived hepatocytes have the functional and proliferative capabilities needed for liver regeneration in mice.  The Journal Of Clinical Investigation. Vol. 120, no. 9. (September): e3120.
  • Espejel,Silvia; Roll,Garrett,R; McLaughlin,K,John; Lee,Andrew,Y; Zhang,Jenny,Y; Laird,Diana,J; Okita,Keisuke; Yamanaka,Shinya; Willenbring,Holger. 2010. Induced pluripotent stem cell-derived hepatocytes have the functional and proliferative capabilities needed for liver regeneration in mice.  JOURNAL OF CLINICAL INVESTIGATION. Vol. 120, no. 9. (September): 3120-3126.
  • Balbach ST; Esteves TC; Brink T; Gentile L; McLaughlin KJ; Adjaye JA; Boiani M. 2010. Governing cell lineage formation in cloned mouse embryos.  Developmental Biology. Vol. 343, no. 1-2. (July): e71.
  • Zheng,Ke; Xiol,Jordi; Reuter,Michael; Eckardt,Sigrid; Leu,N,Adrian; McLaughlin,K,John; Stark,Alexander; Sachidanandam,Ravi; Pillai,Ramesh,S; Wang,Peijing,Jeremy. 2010. Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway.  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. Vol. 107, no. 26. (June): 11841-11846.
  • Shufaro,Yoel; Lacham-Kaplan,Orly; Tzuberi,Ben-Zion; McLaughlin,John; Trounson,Alan; Cedar,Howard; Reubinoff,Benjamin,E. 2010. Reprogramming of DNA Replication Timing.  STEM CELLS. Vol. 28, no. 3. (March): 443-449.
  • Shufaro Y; Lacham-Kaplan O; Tzuberi BZ; McLaughlin J; Trounson A; Cedar H; Reubinoff BE. 2010. Reprogramming of DNA replication timing.  Stem Cells (Dayton, Ohio). Vol. 28, no. 3. (March): e443.
  • Balbach, S., Esteves, T., Brink, T., Gentile, L., McLaughlin, K.J., Adjaye, J., and Boiani, M. (2010). Governing cell lineage formation in cloned mouse embryos. Dev Biol (in press).
  • Choi SW; Eckardt S; Ahmad R; Wolber W; McLaughlin KJ; Siren AL; Muller AM. 2010. Two paternal genomes are compatible with dopaminergic in vitro and in vivo differentiation.  The International Journal Of Developmental Biology. Vol. 54, no. 11-12. (January): e1755.
  • Liu J; Carvalho LP; Bhattacharya S; Carbone CJ; Kumar KG; Leu NA; Yau PM; Donald RG; Weiss MJ; Baker DP; McLaughlin KJ; Scott P; Fuchs SY. 2009. Mammalian casein kinase 1alpha and its leishmanial ortholog regulate stability of IFNAR1 and type I interferon signaling.  Molecular And Cellular Biology. Vol. 29, no. 24. (December): e6401.
  • Choi YH; Harding HD; Hartman DL; Obermiller AD; Kurosaka S; McLaughlin KJ; Hinrichs K. 2009. The uterine environment modulates trophectodermal POU5F1 levels in equine blastocysts.  Reproduction (Cambridge, England). Vol. 138, no. 3. (September): e589.
  • Pan J; Eckardt S; Leu NA; Buffone MG; Zhou J; Gerton GL; McLaughlin KJ; Wang PJ. 2009. Inactivation of Nxf2 causes defects in male meiosis and age-dependent depletion of spermatogonia.  Developmental Biology. Vol. 330, no. 1. (June): e167.
  • De Sousa,Paul,A; Gardner,John; Sneddon,Sharon; Pells,Steve; Tye,Britt,Jorgensen; Dand,Pawlina; Collins,Daniel,M; Stewart,Karen; Shaw,Lisa; Przyborski,Stefan; Cooke,Michael; McLaughlin,K,John; Kimber,Susan,J; Lieberman,Brian,A; Wilmut,Ian; Brison,Daniel,R. 2009. Clinically failed eggs as a source of normal human embryo stem cells.  STEM CELL RESEARCH. Vol. 2, no. 3. (May): 188-197.
  • De Sousa PA, Gardner J, Sneddon S, Pells S, Tye BJ, Dand P, Collins DM, Stewart K, Shaw L, Przborski S, Cooke M, McLaughlin KJ, Kimber SJ, Lieberman BA, Wilmut I, Brison DR. "Clinically failed eggs as a source of normal human embryo stem cells".  Stemm Cells Res. 2009 Feb 6 (epub) PubMed ID: 19393594
  • Eckardt, S; McLaughlin, KJ. 2009. Production of Uniparental Embryonic Stem Cell Lines. In Trends in Stem Cell Biology and Technology. Edited by H. Baharvand. New York: Humana Press.
  • Liu J, Carc=valho LP, Bhattachariya S, Carbone CJ, Kumar KG, Leu NA, Yau PM, Donald RG, Weiss MJ, Baker DP, McLaughlin KJ, Fuchs SY. "Mammalian casein kinase 1alpha and its leishmanial ortholog regulate stability of IFNAR1 and Type I interferon signaling". Mol Cell Biol. 2009 Oct 5 (Epub) PubMed ID: 19805514
  • Pan J, Eckardt S, Leu NA, Buffone MG, Zhou J, Gerton GL, McLaughlin KJ, Wang PJ. "Inactivation of Nxf2 causes defects in male meiosis and age-dependent depletion of spermatogonia".  Dev Biol. 2009 Jun 1;330(1):167-74 PubMed ID: 19345203
  • Choi YH, Harding HD, Hartman DL, Obermiller AD, Kurosaka S, McLaughlin KJ, Hinrichs K. "The uterine environment modulates trophectodermal POU5F1 levels in equine blastocysts". Reproduction. 2009 Sep;138 (3): 589-99 PubMed ID: 19525365
  • Rai R; Wong CC; Xu T; Leu NA; Dong DW; Guo C; McLaughlin KJ; Yates JR 3rd; Kashina A. 2008. Arginyltransferase regulates alpha cardiac actin function, myofibril formation and contractility during heart development.  Development (Cambridge, England). Vol. 135, no. 23. (December): e3881.
  • Dinger TC; Eckardt S; Choi SW; Camarero G; Kurosaka S; Hornich V; McLaughlin KJ; Müller AM. 2008. Androgenetic embryonic stem cells form neural progenitor cells in vivo and in vitro.  Stem Cells (Dayton, Ohio). Vol. 26, no. 6. (June): e1474.
  • Yang F; Gell K; van der Heijden GW; Eckardt S; Leu NA; Page DC; Benavente R; Her C; Höög C; McLaughlin KJ; Wang PJ. 2008. Meiotic failure in male mice lacking an X-linked factor.  Genes & Development. Vol. 22, no. 5. (March): e682.
  • Yang F; Eckardt S; Leu NA; McLaughlin KJ; Wang PJ. 2008. Mouse TEX15 is essential for DNA double-strand break repair and chromosomal synapsis during male meiosis.  The Journal Of Cell Biology. Vol. 180, no. 4. (February): e673.
  • Eckardt S, Dinger TC, Kurosaka S, Leu NA, Muller AM, McLaughlin KJ. "In vivo and vitro differentiation of uniparental embryonic stem cells into hematopoietic and neural cell types". Organogenesis. 2008 Jan;4(1):33-41 PubMed ID: 19279713
  • Yang F, Gell K, van der Heijden GW, Eckardt S, Leu NA, Page DC, Benavente R, Her C, Hoog C, McLaughlin KJ, Wang PJ. "Meiotic failure in male mice lacking an x-linked factor".  Genes Dev. 2008 Mar 1;22(5):682-91 PubMed ID: 18316482
  • Eckardt S, McLaughlin KJ. "Transplation of chimeric fetal liver to study hematopoiesis". Methods Mol Biol. 2008 430:195-211. PubMed ID: 18370301
  • Eckardt,Sigrid; McLaughlin,K,John. 2008. Transplantation of chimeric fetal liver to study hematopoiesis.  Methods in molecular biology (Clifton, N.J.). Vol. 430, no. January: 195-211.
  • Eckardt S; Dinger TC; Kurosaka S; Leu NA; Müller AM; McLaughlin KJ. 2008. In vivo and in vitro differentiation of uniparental embryonic stem cells into hematopoietic and neural cell types.  Organogenesis. Vol. 4, no. 1. (January): e33.
  • Yang F, Eckardt S, Leu NA, McLaughlin KJ, Wang PJ. "Mouse TEX15 is essential for DNA double-strand break repair and chromosomal synapsis during male meiosis".  J Cell Biol. 2008 Feb 25;180(4):673-9. PubMed ID: 18283110
  • Rai R, Wong CC, Xu T, Leu NA, Dong DW, Guo C, McLaughlin KJ, Yaes JR 3rd, Kashina A. "Arginyltransferase regulates alpha cardia actin function, myofibril formation and contractility during heart development". Development.  2008 Dec;135(23):3881-9 PubMed ID: 18948421
  • Dinger TC, Eckardt S, Choi SW, Camarero G, Kurosaka S, Hornich V, McLaughlin KJ, Muller AM. "Androgenetic embryonic stem cells form neural progenitor cells in vivo and in vitro".  Stem Cells. 2008 Jun;26(6):1474-83 PubMed ID: 18369101
  • Kurosaka S; Eckardt S; Ealy AD; McLaughlin KJ. 2007. Regulation of blastocyst stage gene expression and outgrowth interferon tau activity of somatic cell clone aggregates.  Cloning And Stem Cells. Vol. 9, no. 4. (December): e630.
  • Wuensch A; Habermann FA; Kurosaka S; Klose R; Zakhartchenko V; Reichenbach HD; Sinowatz F; McLaughlin KJ; Wolf E. 2007. Quantitative monitoring of pluripotency gene activation after somatic cloning in cattle.  Biology Of Reproduction. Vol. 76, no. 6. (June): e983.
  • Changolkar LN; Costanzi C; Leu NA; Chen D; McLaughlin KJ; Pehrson JR. 2007. Developmental changes in histone macroH2A1-mediated gene regulation.  Molecular And Cellular Biology. Vol. 27, no. 7. (April): e2758.
  • Eckardt S; Leu NA; Bradley HL; Kato H; Bunting KD; McLaughlin KJ. 2007. Hematopoietic reconstitution with androgenetic and gynogenetic stem cells.  Genes & Development. Vol. 21, no. 4. (February): e409.
  • Kurosaka,Satoshi; Eckardt,Sigrid; Ealy,Alan,D; Mclaughlini,K,John. 2007. Regulation of blastocyst stage gene expression and outgrowth interferon tau activity of somatic cell clone aggregates.  CLONING AND STEM CELLS. Vol. 9, no. 4. (January): 630-641.
  • Yang F; De La Fuente R; Leu NA; Baumann C; McLaughlin KJ; Wang PJ. 2006. Mouse SYCP2 is required for synaptonemal complex assembly and chromosomal synapsis during male meiosis.  The Journal Of Cell Biology. Vol. 173, no. 4. (May): e497.
  • Eckardt S; Leu NA; Kurosaka S; McLaughlin KJ. 2005. Differential reprogramming of somatic cell nuclei after transfer into mouse cleavage stage blastomeres.  Reproduction (Cambridge, England). Vol. 129, no. 5. (May): e547.
  • Eckardt, S; Kurosaka S; McLaughlin, KJ. 2005. Epigentics and imprint resetting in cloned animals. In Genetics, Genomics, Proteomics and Bioinformatics. Edited by L.B. Borde, et al.. London: John Wiley & Sons Ltd..
  • Kurosaka S; Eckardt S; McLaughlin KJ. 2004. Pluripotent lineage definition in bovine embryos by Oct4 transcript localization.  Biology Of Reproduction. Vol. 71, no. 5. (November): e1578.
  • Kehler J; Tolkunova E; Koschorz B; Pesce M; Gentile L; Boiani M; Lomelí H; Nagy A; McLaughlin KJ; Schöler HR; Tomilin A. 2004. Oct4 is required for primordial germ cell survival.  EMBO Reports. Vol. 5, no. 11. (November): e1078.
  • Eckardt S; McLaughlin KJ. 2004. Interpretation of reprogramming to predict the success of somatic cell cloning.  Animal Reproduction Science. Vol. 82-83, no. July: e97.
  • Boiani M; Eckardt S; Leu NA; Schöler HR; McLaughlin KJ. 2003. Pluripotency deficit in clones overcome by clone-clone aggregation: epigenetic complementation?.  The EMBO Journal. Vol. 22, no. 19. (October): e5304.
  • Boiani M; Eckardt S; Schöler HR; McLaughlin KJ. 2002. Oct4 distribution and level in mouse clones: consequences for pluripotency.  Genes & Development. Vol. 16, no. 10. (May): e1209.
  • Morali OG; Jouneau A; McLaughlin KJ; Thiery JP; Larue L. 2000. IGF-II promotes mesoderm formation.  Developmental Biology. Vol. 227, no. 1. (November): e133.
  • Finkenzeller,D; Fischer,B; MCLAUGHLIN,J; Schrewe,H; Ledermann,B; Zimmermann,W. 2000. Trophoblast cell-specific carcinoembryonic antigen cell adhesion molecule 9 is not required for placental development or a positive outcome of allotypic pregnancies.  MOLECULAR AND CELLULAR BIOLOGY. Vol. 20, no. 19. (October): 7140-7145.
  • Finkenzeller D; Fischer B; McLaughlin J; Schrewe H; Ledermann B; Zimmermann W. 2000. Trophoblast cell-specific carcinoembryonic antigen cell adhesion molecule 9 is not required for placental development or a positive outcome of allotypic pregnancies.  Molecular And Cellular Biology. Vol. 20, no. 19. (October): e7140.
  • Oh B; Hwang S; McLaughlin J; Solter D; Knowles BB. 2000. Timely translation during the mouse oocyte-to-embryo transition.  Development (Cambridge, England). Vol. 127, no. 17. (September): e3795.
  • Oh,B; Hwang,S,Y; MCLAUGHLIN,J; SOLTER,D; KNOWLES,B,B. 2000. Timely translation during the mouse oocyte-to-embryo transition.  DEVELOPMENT. Vol. 127, no. 17. (September): 3795-3803.
  • Herrmann BG; Koschorz B; Wertz K; McLaughlin KJ; Kispert A. 1999. A protein kinase encoded by the t complex responder gene causes non-mendelian inheritance.  Nature. Vol. 402, no. 6758. (November): e141.
  • SVENSSON,K; Mattsson,R; James,T,C; Wentzel,P; Pilartz,M; MacLaughlin,J; Miller,S,J; Olsson,T; Eriksson,U,J; OHLSSON,R. 1998. The paternal allele of the H19 gene is progressively silenced during early mouse development: the acetylation status of histones may be involved in the generation of variegated expression patterns.  DEVELOPMENT. Vol. 125, no. 1. (January): 61-69.
  • Svensson K; Mattsson R; James TC; Wentzel P; Pilartz M; McLaughlin J; Miller SJ; Olsson T; Eriksson UJ; Ohlsson R. 1998. The paternal allele of the H19 gene is progressively silenced during early mouse development: the acetylation status of histones may be involved in the generation of variegated expression patterns.  Development. Vol. 125, no. 1. (January): 61-69.
  • McLaughlin KJ; Kochanowski H; Solter D; Schwarzkopf G; Szabó PE; Mann JR. 1997. Roles of the imprinted gene Igf2 and paternal duplication of distal chromosome 7 in the perinatal abnormalities of androgenetic mouse chimeras.  Development (Cambridge, England). Vol. 124, no. 23. (December): e4897.
  • McLaughlin KJ; Solter D; Mann J. 1997. Developmental consequences of two paternal copies of imprinted chromosome region distal 7 in mice.  Journal Of Cellular Physiology. Vol. 173, no. 2. (November): e242.
  • McLaughlin,K,J; SOLTER,D; Mann,J. 1997. Developmental consequences of two paternal copies of imprinted chromosome region distal 7 in mice.  JOURNAL OF CELLULAR PHYSIOLOGY. Vol. 173, no. 2. (November): 242-246.
  • Bierkamp C; Mclaughlin KJ; Schwarz H; Huber O; Kemler R. 1996. Embryonic heart and skin defects in mice lacking plakoglobin.  Developmental Biology. Vol. 180, no. 2. (December): e780.
  • Vetter DE; Mann JR; Wangemann P; Liu J; McLaughlin KJ; Lesage F; Marcus DC; Lazdunski M; Heinemann SF; Barhanin J. 1996. Inner ear defects induced by null mutation of the isk gene.  Neuron. Vol. 17, no. 6. (December): e1251.
  • Huber,O; Korn,R; MCLAUGHLIN,J; Ohsugi,M; Herrmann,B,G; KEMLER,R. 1996. Nuclear localization of beta-catenin by interaction with transcription factor LEF-1.  MECHANISMS OF DEVELOPMENT. Vol. 59, no. 1. (September): 3-10.
  • Huber O; Korn R; McLaughlin J; Ohsugi M; Herrmann BG; Kemler R. 1996. Nuclear localization of beta-catenin by interaction with transcription factor LEF-1.  Mechanisms Of Development. Vol. 59, no. 1. (September): e3.
  • McLaughlin KJ; Szabó P; Haegel H; Mann JR. 1996. Mouse embryos with paternal duplication of an imprinted chromosome 7 region die at midgestation and lack placental spongiotrophoblast.  Development (Cambridge, England). Vol. 122, no. 1. (January): e265.
  • McLaughlin,K,J. 1993. PRODUCTION OF TETRAPLOID EMBRYOS BY ELECTROFUSION.  GUIDE TO TECHNIQUES IN MOUSE DEVELOPMENT. Vol. 225, no. January: 919-930.
  • Payne D; McLaughlin KJ; Depypere HT; Kirby CA; Warnes GM; Matthews CD. 1991. Experience with zona drilling and zona cutting to improve fertilization rates of human oocytes in vitro.  Human Reproduction (Oxford, England). Vol. 6, no. 3. (March): e423.
  • Walker SK; Heard TM; Verma PJ; Rogers GE; Bawden CS; Sivaprasad AV; McLaughlin KJ; Seamark RF. 1990. In vitro assessment of the viability of sheep zygotes after pronuclear microinjection.  Reproduction, Fertility, And Development. Vol. 2, no. 6. (January): e633.
  • McLaughlin KJ; McLean DM; Stevens G; Ashman RA; Lewis PA; Bartsch BD; Seamark RF. 1990. Viability of one-cell bovine embryos cultured in synthetic oviduct fluid medium.  Theriogenoloy. Vol. 33, no. January: 1191-99.
  • McLaughlin KJ; Davies L; Seamark RF. 1990. In vitro embryo culture in the production of identical merino lambs by nuclear transplantation.  Reproduction, Fertility, And Development. Vol. 2, no. 6. (January): e619.
  • Vanderhyden BC; McLaughlin KJ; Rutledege JM; Armstrong DT. 1989. Zona drilling increases the penetrability of rat oocytes matured in vitro.  Biology Of Reproduction. Vol. 40, no. 5. (May): e953.
  • Depypere HT; McLaughlin KJ; Seamark RF; Warnes GM; Matthews CD. 1988. Comparison of zona cutting and zona drilling as techniques for assisted fertilization in the mouse.  Journal Of Reproduction And Fertility. Vol. 84, no. 1. (September): e205.
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