John A. Bauer, Ph.D.

John A. Bauer, MD is a principal investigator in the Center for Perinatal Research at The Research Institute at Nationwide Children's Hospital. Dr. Bauer’s central research interest is to conduct basic science with an opportunity to impact therapy. His current investigations are involved in addressing the following questions: How do reactive oxygen and reactive nitrogen species (so-called “oxidants”) participate in chronic disease? What are the mechanisms by which cellular oxidant injury occur? What are the consequences? How can we rationally develop better therapeutic strategies to affect these processes? Dr. Bauer is an Associate Professor of Pediatrics, Division of Pharmacy, Department of Pediatrics, The Ohio State University College of Medicine.

Languages Spoken:

• English

Research Center:

• Center for Perinatal Research

Undergraduate School

• State University of New York at Buffalo
  Date Completed: 06/30/1986

Post Doctoral

• State University of New York at Buffalo
  Date Completed: 06/30/1991

Post Doctoral

• State University of New York at Buffalo
  Date Completed: 06/30/1993

2000–present

• Associate Professor, Division of Pharmacolgy, College of Pharmacy, Member, Heart and Lung Research Institute, Department of Pediatrics, The Ohio State University

2003–2008

• Director, Center for Cardiovascular Medicine, Columbus Children's Research Institute

2002–2002

• Investigator, Center of Pharmacology and Toxicology, Columbus Children's Research Institute

1996–2000

• Assistant Professor, Division of Pharmacology, College of Pharmacy, The Ohio State University

1994–1996

• Research Assistant Professor, Department of Pharmaceutics, School of Pharmacy, State University of New York at Buffalo

1993–1996

• Co-Principal Investigator

1992–1993

• Instructor

1991–1993

• Postdoctoral Fellow/Research Associate

1987–1991

• Graduate Research Fellow, Eastman -Kodak, Department of Pharmaceutics, State University of New York at Buffalo

1985–1985

• Summer - Research Associate. Dupont Biomedical Products Division, Drug Delivery Group

1983–1986

• Research Assistant. Department of Pharmaceutics

• Stenger MR; Rose MJ; Joshi MS; Rogers LK; Chicoine LG; Bauer JA; Nelin LD. 2010. Inhaled nitric oxide prevents 3-nitrotyrosine formation in the lungs of neonatal mice exposed to >95% oxygen.  Lung. Vol. 188, no. 3. (June): e217.
• Rupp S; Zeiher AM; Dimmeler S; Tonn T; Bauer J; Jux C; Akintuerk H; Schranz D. 2010. A regenerative strategy for heart failure in hypoplastic left heart syndrome: intracoronary administration of autologous bone marrow-derived progenitor cells.  The Journal Of Heart And Lung Transplantation: The Official Publication Of The International Society For Heart Transplantation. Vol. 29, no. 5. (May): e574.
• Jin Y; Calvert TJ; Chen B; Chicoine LG; Joshi M; Bauer JA; Liu Y; Nelin LD. 2010. Mice deficient in Mkp-1 develop more severe pulmonary hypertension and greater lung protein levels of arginase in response to chronic hypoxia.  American Journal Of Physiology. Heart And Circulatory Physiology. Vol. 298, no. 5. (May): eH1518.
• Rose MJ; Stenger MR; Joshi MS; Welty SE; Bauer JA; Nelin LD. 2010. Inhaled nitric oxide decreases leukocyte trafficking in the neonatal mouse lung during exposure to >95% oxygen.  Pediatric Research. Vol. 67, no. 3. (March): e244.
• Han B; Baliga R; Huang H; Giannone PJ; Bauer JA. 2009. Decreased cardiac expression of vascular endothelial growth factor and redox imbalance in murine diabetic cardiomyopathy.  American Journal Of Physiology. Heart And Circulatory Physiology. Vol. 297, no. 2. (August): eH829.
• Chaves AA; Joshi MS; Coyle CM; Brady JE; Dech SJ; Schanbacher BL; Baliga R; Basuray A; Bauer JA. 2009. Vasoprotective endothelial effects of a standardized grape product in humans.  Vascular Pharmacology. Vol. 50, no. 1-2. (January): e20.
• Chaves AA, Joshi MS, Coyle CM, Brady JE, Dech SJ, Schanbacher BL, Baliga R, Basuray A, Bauer JA. 2009. Vasoprotective endothelial effects of a standardized grape product in humans.  Vascul Pharmacol..
• Monreal G; Nicholson LM; Han B; Joshi MS; Phillips AB; Wold LE; Bauer JA; Gerhardt MA. 2008. Cytoskeletal remodeling of desmin is a more accurate measure of cardiac dysfunction than fibrosis or myocyte hypertrophy.  Life Sciences. Vol. 83, no. 23-24. (December): e786.
• Monreal G, Nicholson LM, Han B, Joshi MS, Phillips AB, Wold LE, Bauer JA, Gerhardt MA. 2008. Cytoskeletal remodeling of desmin is a more accurate measure of cardiac dysfunction than fibrosis or myocyte hypertrophy.  Life Sci.. Vol. 83, no. 23-24. (December): 786-794.
• Bauer JA, Moffatt-Bruce SD, Elton TS, Feldman D. 2008. Purine metabolism in heart failure: oxidant biology and therapeutic indications.  Congest Heart Fail.. Vol. 14, no. 5. (September): 283-284.
• Bauer JA; Moffatt-Bruce SD; Elton TS; Feldman D. 2008. Purine metabolism in heart failure: oxidant biology and therapeutic indications.  Congestive Heart Failure (Greenwich, Conn.). Vol. 14, no. 5. (September): e283.
• Kumar B; Cordell KG; Lee JS; Worden FP; Prince ME; Tran HH; Wolf GT; Urba SG; Chepeha DB; Teknos TN; Eisbruch A; Tsien CI; Taylor JM; D'Silva NJ; Yang K; Kurnit DM; Bauer JA; Bradford CR; Carey TE. 2008. EGFR, p16, HPV Titer, Bcl-xL and p53, sex, and smoking as indicators of response to therapy and survival in oropharyngeal cancer.  Journal Of Clinical Oncology: Official Journal Of The American Society Of Clinical Oncology. Vol. 26, no. 19. (July): e3128.
• Joshi MS, Bauer JA, Werbovetz KA, Barszcz T, Patil PN. 2008. Pharmacological and biological screening of ascorbigen: protection against glucose-induced endothelial cell toxicity.  Phytother Res.. Vol. 22, no. 12. (January): 1581-1586.
• Joshi MS, Bauer JA. 2008. Preliminary computational modeling of nitric oxide synthase 3 interactions with caveolin-1: influence of exon 7 Glu298Asp polymorphism.  Acta Biochim Biophys Sin (Shanghai). Vol. 40, no. 1. (January): 47-54.
• Giannone PJ; Bauer JA; Schanbacher BL; Reber KM. 2007. Effects of hyperoxia on postnatal intestinal development.  Biotechnic & Histochemistry: Official Publication Of The Biological Stain Commission. Vol. 82, no. 1. (February): e17.
• Nishijima Y, Sridhar A, Viatchenko-Karpinksi S, Shaw C, Bonagura JD, Abraham WT, Joshi MS, Bauer JA, Hamlin RL, Gyorke S, Feldman DS, Carnes CA. 2007. Chronic cardiac resynchronization therapy and reverse ventricular remodeling in a model of nonischemic cardiomyopathy.  Life Sciences. Vol. 81, no. January: 1152-1159.
• Park MS, Rieger-Fackeldey E, Schanbacher BL, Cook AC, Bauer JA, Rogers LK, Hansen TN, Welty SE, Smith CV. 2007. Altered Expressions of Fibroblast Growth Factor Receptors and Alveolarization in Neonatal Mice Exposed to 85% Oxygen.  Pediatric Research. Vol. 62, no. 6. (January): 652-657.
• Carnes CA, Janssen PM, Ruehr ML, Nakayama H, Nakayama T, Haase H, Bauer JA, Chung MK, Fearon IM, Gillinov AM, Hamlin RL, Van Wagoner DR. 2007. Atrial glutathione content, calcium current, and contractility.  Journal of Biological Chemistry. Vol. 282, no. January: 28063-28073.
• Groner JA, Joshi MS, Bauer JA. 2007. Cardiovascular effects of passive smoking in adults and children. In Moss and Adams' Heart Disease in Infants, Children and Adolescents. Edited by Allen HD, Driscoll DJ, Saddy RE, Feltes TF. Philadelphia, PA: Lippincott, Williams and Wilkins.
• Joshi MS, Luce WA, Hoffman TM, Feltes TF, Bauer JA. 2007. Immune dysfunction and immunotherapy in heart disease. In Immune Dysfunction and Immunotherapy in Heart Disease. Edited by Watson RR, Larson D. Boston, MA: Blackwell Publishing.
• Luce WA, Hoffman TM, Bauer JA. 2007. Bench-to-Bedside review: Developmental influences on the mechanisms, treatment and outcomes of cardiovascular dysfunction in neonatal versus adult sepsis.  Critical Care. Vol. 11, no. 5. (January): e228.
• Luce WA, Joshi MS, Hoffman TM, Feltes TF, Bauer JA. 2007. Immune mechanisms in pediatric cardiovascular disease. In Immune Dysfunction and Immunotherapy in Heart Disease. Edited by Watson RR, Larson D. Boston, MA: Blackwell Publishing.
• Ma TC, Mihm MJ, Bauer JA, Hoyt KR. 2007. Bioenergetic and oxidative effects of free 3-nitrotryosine in culture: Selective vulnerability of dopaminergic neurons and increased sensitivity of non-dopaminergic neurons to dopamine oxidation.  Journal of Neurochemistry. Vol. 103, no. January: 131-144.
• Chicoine LG, Paffett ML, Girton MR, Metropoulus MJ, Joshi MS, Bauer JA, Nelin LD, Resta TC, Walker BR. 2007. Maturational changes in the regulation of pulmonary vascular tone by nitric oxide in neonatal rats.  American Journal of Physiology - Lung Cellular & Molecular Physiology. Vol. 293, no. 5. (January): L1261-L1270.
• Giannone PJ, Bauer JA, Schanbacher BL, Reber KM. 2007. Effects of hyperoxia on postnatal intestinal development.  Biotechnic & Histochemistry. Vol. 82, no. 1. (January): 17-22.
• Mihm M, Amann DM, Schanbacher BL, Altschuld RA, Bauer JA, Hoyt KR. 2007. Cardiac dysfunction in the R6/2 mouse model of Huntington’s Disease.  Neurobiology of Disease. Vol. 25, no. January: 297-308.
• Joshi M, Bauer JA. 2007. Preliminary computational modeling of NOS3 interactions with Caveolin-1: Influence of the Exon 7 Glu298Asp polymorphism.  Acta Biochimica et Biophysica Sinica. Vol. 39, no. January.
• Poladia DP; Schanbacher B; Wallace LJ; Bauer JA. 2005. Innervation and connexin isoform expression during diabetes-related bladder dysfunction: early structural vs. neuronal remodelling.  Acta Diabetologica. Vol. 42, no. 3. (October): e147.