John A. Barnard, MD :: Nationwide Children’s Hospital, Columbus, Ohio

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Gastroenterology & Hepatology & Nutrition
700 Children's Dr
Columbus, OH 43205 [ map ]
PH: (614) 722-3450
FX: (614) 722-3454
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Biography

John A. Barnard, MD, is president of The Research Institute at Nationwide Children’s Hospital and holds the Ann I. Wolfe Endowed Chair in Pediatric Research Leadership. He is a professor of Pediatrics and vice chair for Research at The Ohio State University College of Medicine. He also is a practicing gastroenterologist in the Division of Gastroenterology, Hepatology and Nutrition at Nationwide Children's Hospital.

An accomplished physician-scientist, he has received more than $5 million in research funding during his career and has authored more than 80 scholarly works. He is principal investigator for a National Institutes of Health T32 training grants for pediatricians and is a co-principal investigator for the Clinical and Translational Science Award at The Ohio State University.

As president of The Research Institute, Dr. Barnard is responsible for strategic direction, overall administration, recruiting, allocation of resources and design of infrastructure in support of all research activities at Nationwide Children's Hospital. The Research Institute is one of the fastest growing pediatric research institutions in the United States and is currently ranked 6th nationally among the top ten free-standing children’s hospitals based on National Institutes of Health funding. In 2013, The Research Institute received more than $80 million in external funding.

Dr. Barnard received his medical degree from the University of Mississippi and was an intern and resident at the Vanderbilt University School of Medicine, where he also completed a fellowship in pediatric gastroenterology and nutrition. He was director of the Division of Gastroenterology, Hepatology and Nutrition Division at Vanderbilt prior to relocating to Columbus in 2000.

He has been named among the Best Doctors in America for the past decade and has served as president of the North American Society of Pediatric Gastroenterology, Hepatology and Nutrition and is currently the NASPGHAN Foundation president. In 2007 he was named the Executive of the Year by TechColumbus, a public-private partnership whose mission is to accelerate the advancement of Central Ohio’s innovation economy.

View CV »

Gender:

  • Male

Languages Spoken:

  • English

Research Interests

Education and Training

Undergraduate School

  • University of South Alabama
    Date Completed: 06/30/1976

Medical School

  • University of Mississippi
    Date Completed: 03/31/1980

Internship

  • Vanderbilt University Medical Center
    Date Completed: 06/30/1981

Residency

  • Vanderbilt University Medical Center
    Date Completed: 06/30/1983

Fellowship

  • Vanderbilt University Medical Center
    Date Completed: 06/30/1986

Department:

  • Pediatrics

Section:

  • Gastroenterology & Hepatology & Nutrition

Specialty:

  • Pediatric Gastroenterology
  • Pediatrics

Date of Appointment at Nationwide Children’s Hospital:

  • 11/21/2000

Professional Experience

2005–present

  • President, The Research Institute at Nationwide Children's Hospital and Vice Chair for Research, The Ohio State University

2000–present

  • Member, Division of Gastroenterology, Hepatology and Nutrition, Nationwide Children's Hospital

2000–present

  • Professor, Department of Pediatrics, Division of Gastroenterology, The Ohio State University

2006–2008

  • President, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition

2005–2008

  • Member, Gastrointestinal Cell and Molecular Biology NIH Study Section

1992–2000

  • Associate Professor of Pediatrics, Division of Gastroenterology and Nutrition Vanderbilt University School of Medicine

1987–1992

  • Assistant Professor of Pediatrics, Division of Gastroenterology and Nutrition Vanderbilt University School of Medicine, Nashville, TN

1986–1987

  • Assistant Professor of Pediatrics, Division of Gastroenterology and Nutrition University of South Alabama College of Medicine, Mobile, AL

1983–1986

  • Fellow in Pediatric Gastroenterology and Nutrition, Vanderbilt Children's Hospital, Nashville, TN

1981–1983

  • Resident in Pediatrics, Vanderbilt Children's Hospital, Nashville, TN

1980–1981

  • Intern in Pediatrics, Vanderbilt Children's Hospital, Nashville, TN

Publications

  • Matta,Ranyia; Barnard,John,A; Wancket,Lyn,M; Yan,Jing; Xue,Jianjing; Grieves,Jessica; Frazier,W,Joshua; Nelin,Leif; Cato,Andrew,CB; Liu,Yusen. 2012. Knockout of Mkp-1 exacerbates colitis in Il-10-deficient mice.  AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY. Vol. 302, no. 11. (June): G1322-G1335.
  • Potter C; Hogan MJ; Henry-Kendjorsky K; Balint J; Barnard JA. 2011. Safety of pediatric percutaneous liver biopsy performed by interventional radiologists.  Journal Of Pediatric Gastroenterology And Nutrition. Vol. 53, no. 2. (August): e202.
  • Ferry GD; Balistreri WF; Barnard JA. 2010. Children's Digestive Health and Nutrition Foundation: building on the past, a foundation for the future.  Journal Of Pediatric Gastroenterology And Nutrition. Vol. 50, no. 2. (January): e230.
  • Yakovich A, HuangQ, Du J, Jiang B, Barnard J. 2010. Vectorial TGF beta signaling in polarized intestinal epithelial cells.  J Cell Phys.
  • Yang J, Chan CY, Jiang B, Yu X, Zhu G-Z, Chen Y, Barnard J, Mei W. 2009. hnRNP I inhibits notch signaling and regulates intestinal epithelial homeostasis in the zebrafish.  PloS Genetics. Vol. 2, no. 5. (January): ee1000363.
  • Allen CE, Du J, Jiang B, Huang Q, Yakovich AJ, Barnard JA. 2008. Transformation by oncogenic Ras expands the early genomic response to transforming growth factor beta in intestinal epithelial cells.  Neoplasia.. Vol. 10, no. 10. (October): 1073-1082.
  • Allen CE; Richards J; Muthusamy N; Auer H; Liu Y; Robinson ML; Barnard JA; Wu LC. 2007. Disruption of ZAS3 in mice alters NF-kappaB and AP-1 DNA binding and T-cell development.  Gene Expression. Vol. 14, no. 2. (January): e83.
  • Walker WA, Sherman P, Cohen M, Barnard J. 2007. State of pediatric gastroenterology, hepatology, and nutrition: 2006 and beyond.  Gastroenterology. Vol. 132, no. January: 434-436.
  • Allen CE, Richards J, Muthusamy N, Auer H, Liu Y, Robinson ML, Barnard JA, Wu L-C. 2007. Disruption of ZAS3 in mice alters NF-k and AP-1 DNA binding and T-cell development.  Gene Expression.
  • Consensus Development Panel. 2005. National Institutes of Health Consensus Development Conference Statement on Celiac Disease.  Gastroenterology. Vol. 4 Suppl 1, no. 128. (January): S1-9.
  • Barnard JA. 2005. Presentation of the 2004 Shwachman Award to Fayez K. Ghishan, MD.  J Pediatr Gastroenterol Nutr. Vol. 1, no. 40. (January): 20-21.
  • Crandall WV, Barnard JA, Cohen MB, Colletti RB, Harnsberger JK, Hart MH, Hayes JR, Sherman PM, Smith LJ, NASPGHAN Clinical Practice Committee. 2005. Pediatric Gastroenterology Workforce Survey, 2003-2004: A Report of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition.  J Pediatr Gastroenterol Nutr. Vol. 4, no. 40. (January): 397-405.
  • Murphy SJ; Doré JJ; Edens M; Coffey RJ; Barnard JA; Mitchell H; Wilkes M; Leof EB. 2004. Differential trafficking of transforming growth factor-beta receptors and ligand in polarized epithelial cells.  Molecular Biology Of The Cell. Vol. 15, no. 6. (June): e2853.
  • Barnard JA. 2004. Gastrointestinal polyps and polyp syndromes in adolescents.  Adolesc Med. Vol. 1, no. 15. (January): 119-129.
  • Du J, Jiang B, Coffey RJ, Barnard JA. 2004. Raf-1 and RhoA cooperate to transform intestinal epithelial cells and induce growth resistance to transforming growth factor beta.  Mol Cancer Res.
  • Du,J,G; Bo,J; BARNARD,J,A. 2003. The p38 MAP kinase pathway interacts with Raf-1 serine threonine kinase to transform intestinal epithelial cells.  PEDIATRIC RESEARCH. Vol. 53, no. 4. (April): 175A-175A.
  • Du,J,G; Jiang,B; Barnard,J. 2003. Inhibition of TGF beta signaling transforms intestinal epithelial cells overexpressing the Raf-1 serine-threonine kinase.  GASTROENTEROLOGY. Vol. 124, no. 4. (April): A599-A599.
  • Barnard JA, Fine D. 2003. The HIPAA Privacy Rule and its impact on pediatric research.  J Pediatr Gastroenterol Nutr.
  • Jiang B, Zhang JS, Du J, Urrutia R, Barnard JA. 2003. Growth inhibitory signaling by TFG-beta is blocked in RAS-transformed intestinal epithelial cells at a post-receptor locus.  Cellular Signaling.
  • Erdman SH; Barnard JA. 2002. Gastrointestinal polyps and polyposis syndromes in children.  Current Opinion In Pediatrics. Vol. 14, no. 5. (October): e576.
  • Du,J,G; Jiang,B; Barnard,J. 2002. Activated Raf and RhoA cooperate to transform intestinal epithelial cells and induce resistance to growth inhibition by transforming growth factor beta.  GASTROENTEROLOGY. Vol. 122, no. 4. (April): A251-A251.
  • Hostetler MA; Barnard JA. 2002. Removal of esophageal foreign bodies in the pediatric ED: is ketamine an option?.  The American Journal Of Emergency Medicine. Vol. 20, no. 2. (March): e96.
  • Claar RL, Walker LS, Barnard JA. 2002. Children's knowledge, anticipatory anxiety, procedural distress, and recall of esophagogastroduodenoscopy.  J Pediatr Gastroenterology. Vol. 1, no. 34. (January): 68-72.
  • Barnard JA. 2002. Keys to writing a competitive grant.  J Pediatr Gastroenterology.
  • Erdman SH, Barnrd JA. 2002. Gastrointestinal polyps and polyposis syndromes in children.  Curr Opin Pediatr.
  • Washington K, Greenson J, Montgomery E, Shyr Y, Crissinger K, Polk DB, Banard JA, Lauwer G. 2002. Histopathology of ulcerative colitis in initial rectal biopsy in children.  Am J Surg Path. Vol. 11, no. 26. (January): 1441-1449.
  • Walker-Smith J, Barnrd J, Bhutta Z, Heubi J, Reeves Z, Schmitz J. 2002. Chronic diarrhea and malabsorption (including short gut syndrome): Working Froup Report of the First World Congress of Pediatric Gastroenterology, Hepatology and Nutrition.  J Pediatr Gastroenterol Nutr. Vol. Supp 2, no. 35. (January): S98-105.
  • Barnard JA. 2001. Epidermal growth factor receptor blockade: an emerging therapeutic modality in clinical gastroenterology.  Gastroenterology.
  • Corredor J, Wamback J, Barnard JA. 2001. Gastrointestinal polyps in children: advances in molecular genetics, diagnosis and management.  J Peds.
  • Bulus NM; Sheng HM; Sizemore N; Oldham SM; Barnett JV; Coffey RJ; Beauchamp DR; Barnard JA. 2000. Ras-mediated suppression of TGFbetaRII expression in intestinal epithelial cells involves Raf-independent signaling.  Neoplasia (New York, N.Y.). Vol. 2, no. 4. (July): e357.
  • Bulus N, Sheng H-M, Sizemore N, Oldham SM, Barnett JV, Coffey RJ, Beauchamp RD, Barnard JA. 2000. Ras-mediated suppression of TGF-betaRII expression in intestinal epithelial cells involves a Ras-independent signaling.  Neoplasia. Vol. 4, no. 2. (January): 357-364.
  • Hostetler MA and Barnard JA. 2000. Removal of esophageal foreign bodies in the pediatric emergency department: Is ketamine an option?.  Am J Emergency Med.
  • Bulus N; Barnard JA. 1999. Heparin binding epidermal growth factor-like growth factor is a transforming growth factor beta-regulated gene in intestinal epithelial cells.  Biochemical And Biophysical Research Communications. Vol. 264, no. 3. (November): e808.
  • Sizemore N; Cox AD; Barnard JA; Oldham SM; Reynolds ER; Der CJ; Coffey RJ. 1999. Pharmacological inhibition of Ras-transformed epithelial cell growth is linked to down-regulation of epidermal growth factor-related peptides.  Gastroenterology. Vol. 117, no. 3. (September): e567.
  • Wasback J, Barnard JA. 1999. SMAD4 germline mutations in juvenile polyposis coli.  J Pediat Gastroenterol Nutr.
  • Matern D, Starzl TE, Arnaout W, Barnrad JA, Bynon JS, Dhawan A, Emond J, Haagsma EB, Hug G, Lachaux A, Smit GP, Chen YT. 1999. Liver transplantation for glycogen storage disease types I, II, and IV.  Eur J Pediatr.
  • Sizemore N, cox AD, Barnard JA, Oldham SM, Reynolds ER, Der Cj, Coffey RJ. 1999. Pharmacological inhibition of ras-transformed epithelial cell growth is linked to down-regulation of epidermal growth factor-related peptides.  Gastroenterology.
  • Bulus N and Barnard JA. 1999. Heparin binding epidermal growth factor-like growth factor is a transforming growth factor beta-regulated gene in intestinal epithelial cells.  Biochem Biophys Res Comm.
  • Walker LS; Guite JW; Duke M; Barnard JA; Greene JW. 1998. Recurrent abdominal pain: a potential precursor of irritable bowel syndrome in adolescents and young adults.  The Journal Of Pediatrics. Vol. 132, no. 6. (June): e1010.
  • Acra SA; Bulus N; Bogatcheva G; Coffey RJ; Barnard JA. 1998. Increased intestinal epithelial proliferation in metallothioneine-transforming growth factor alpha transgenic mice.  Regulatory Peptides. Vol. 74, no. 2-3. (June): e105.
  • Walker LS, Guite J, Duke M, Barnard JA, Greene J. 1998. Recurrent abdominal pain: a precursor of irritable bowel syndrome in adolescents and young adults.  J Pediatrics. Vol. 6, no. 132. (January): 1010-1015.
  • Acra SA, Bulus N, Bogatcheva G, Coffey RJ, Barnard JA. 1998. Increased intestinal epithelial proliferation in metallothioneine-transforming growth factor alpha transgenic mice.  Regulatory Peptides.
  • Baranrd JA, Delzell JA, Bulus NM. 1997. Short chain fatty acid regulation of intestinal gene expression.  Advances in Experimental Medicine and Biology.
  • Barnard JA. 1997. Gastrointestinal disorders due to cow's milk consumption.  Pediatric Annals. Vol. 4, no. 26. (January): 244-250.
  • Pittman NS, Barnard JA. 1997. Gastrointestinal endoscopic procedures in children.  Pediatric Annals. Vol. 4, no. 26. (January): 218-224.
  • Winesett MP; Ramsey GW; Barnard JA. 1996. Type II TGF(beta) receptor expression in intestinal cell lines and in the intestinal tract.  Carcinogenesis. Vol. 17, no. 5. (May): e989.
  • Gangarosa LM; Dempsey PJ; Damstrup L; Barnard JA; Coffey RJ. 1996. Transforming growth factor-alpha.  Baillière's Clinical Gastroenterology. Vol. 10, no. 1. (March): e49.
  • Gangarosa LM, Dempsey PJ, Damstrup L, Barnard JA, Coffey RJ. 1996. Transforming growth factor-alpha.  Baillieres Clinical Gastroenterology. Vol. 1, no. 10. (January): 49-63.
  • Winesett MP, Pietsch JB, Barnard JA. 1996. Yersinia enterocolitica in a child with intussusception.  J Pediatr Gastro Nutr. Vol. 1, no. 23. (January): 77-80.
  • Winesett MP, Ramsey GW, Barnard JA. 1996. Type II TGF-beta receptor expression in intestinal cell lines and in the intestinal tract.  Carcinogenesis.
  • Sacks AI; Warwick GJ; Barnard JA. 1995. Early proliferative events following intestinal resection in the rat.  Journal Of Pediatric Gastroenterology And Nutrition. Vol. 21, no. 2. (August): e158.
  • Threadgill DW, Dlugosz AA, Hansen L, Tennenbaum T, Lichti U, Yee D, LeMantia C, Mourton T, Herrup K, Harris RC, Barnard JA, Yuspa SH, Coffey Rj, Magnuson T. 1995. Targeted disruption of mouse EGF-receptor: Effect of genetic background on mutant phenotype.  Science. Vol. 5221, no. 269. (January): 230-234.
  • Barnard JA, Beauchamp RD, Russess WE, DuBois RN, Coffey RJ. 1995. Epidermal growth factor-related peptides and their relevance to gastrointestinal pathophysiology.  Gastroenterology.
  • Ghishan FK, Knobel S, Barnard JA, Breyer M. 1995. Expression of a novel sodium-hydrogen exchanger in the gastrointestinal tract and kidney.  J Memb Biol. Vol. 3, no. 144. (January): 267-271.
  • Winesett,M,P; RAMSEY,G,W; BARNARD,J,A. 1994. EXPRESSION OF THE TYPE-II TRANSFORMING GROWTH-FACTOR-BETA RECEPTOR IN THE INTESTINE.  GASTROENTEROLOGY. Vol. 106, no. 4. (April): A640-A640.
  • Heusinkveld DC and Barnard JA. 1994. Colitic cystica profunda in a pediatric patient.  J Pediar Gastro Nutr.
  • Barnard JA, Graves-Deal R, DuBois R, Cook P, Ramsey GW, Bishop PR, Damstrup L, Coffey RJ. 1994. Auto- and cross-induction within the mammalian epidermal growth factor-related peptide family.  J Biol Chem. Vol. 36, no. 269. (January): 22817-22822.
  • Barnard JA; Warwick GJ; Gold LI. 1993. Localization of transforming growth factor beta isoforms in the normal murine small intestine and colon.  Gastroenterology. Vol. 105, no. 1. (July): e67.
  • Sacks AI; Acra SA; Dykes W; Polk DB; Barnard JA; Pietsch J; Ghishan FK. 1993. Intestinal Na+/H+ exchanger activity is up-regulated by bowel resection in the weanling rat.  Pediatric Research. Vol. 33, no. 3. (March): e215.
  • Walker LS, Greene JW, Garber J, Horndasch RL, Barnard JA, Ghishan FK. 1993. Psychosocial factors in pediatric abdominal pain: Implications for assessment and treatment.  The Clinical Psychologist.
  • Barnard JA and Warwick GH. 1993. Butyrate rapidly induces growth inhibition and differentiation in HY-29 cells.  Cell Growth and Diff.
  • Barnard JA. 1993. Betacellulin. Newest addition to the epidermal growth factor family.  Gastroenterolo Nutr.
  • Polk WH, Dempsey PJ, Russell WE, Brown PI, Beauchamp RD, Barnard JA and Coffey RJ, Jr. 1992. Increased production of transforming growth factor ï?¡ following acute gastric mucosal injury.  Gastroenterology.
  • Barnard JA; Polk WH; Moses HL; Coffey RJ. 1991. Production of transforming growth factor-alpha by normal rat small intestine.  The American Journal Of Physiology. Vol. 261, no. 6 Pt 1. (December): eC994.
  • Coffey RJ; Barnard JA. 1991. Understanding autocrine growth regulation.  The Western Journal Of Medicine. Vol. 155, no. 2. (August): e189.
  • Barnard JA, Polk WH, Moses HL, and Coffey RJ. 1991. Transforming growth factor beta in the normal gastrointestinal tract.  Am J Physiol: Cell Physiol.
  • Barnard JA and Manci E. 1991. Idiopathic neonatal iron storage disease.  Gastroenterology.
  • Coffey RJ, Jr., Russell WE, BArnard JA. 1990. Pharmacokinetics of TGF-beta with emphasis on effects in liver and gut.  New York Acad Sci Ann.
  • Barnard JA, Lyons RM, Moses HL. 1990. The cell biology of transforming growth factor beta.  Biochimica Biophysica Acta.
  • Baliga BS; Borowitz SM; Barnard JA. 1990. Modulation of EGF-receptors by phorbol ester in small intestinal crypt cells.  Biochemistry International. Vol. 20, no. 1. (January): e161.
  • Baliga BS; Borowitz SM; Barnard JA. 1989. Effects of EGF and PMA on the growth and proliferation of IEC-6 cells.  Biochemistry International. Vol. 19, no. 5. (November): e1045.
  • Barnard JA; Beauchamp RD; Coffey RJ; Moses HL. 1989. Regulation of intestinal epithelial cell growth by transforming growth factor type beta.  Proceedings Of The National Academy Of Sciences Of The United States Of America. Vol. 86, no. 5. (March): e1578.
  • Barnard JA, Beauchamp RD, Coffey RJ and Moses HL. 1989. Regulation of intestinal epithelial cell growth by transforming growth factor beta.  Proc Natl Acad Sci USA.
  • Baliga BS, Borowitz SM and Barnard JA. 1989. Effects of EGF and PMA on the growth and proliferation of IEC-6 cells.  Biochemistry International.
  • Beauchamp RD, Barnard JA, McCutchen CM, Cherner JA and Coffee RJ. 1989. Localization of TGFb and its receptor in gastric mucosal cells: Implications for a regulatory role in acid secretion and mucosal renewal.  J Clin Invest.
  • BARNARD,J,A; Beauchamp,R,D; Coffey,R,J; MOSES,H,L. 1988. DIFFERENTIAL EXPRESSION AND AUTOINDUCTION OF TRANSFORMING GROWTH FACTOR-BETA IN RAT INTESTINAL EPITHELIAL-CELLS.  GASTROENTEROLOGY. Vol. 94, no. 5. (May): A23-A23.
  • Barnard JA; Thaxter S; Kikuchi K; Ghishan FK. 1988. Taurine transport by rat intestine.  The American Journal Of Physiology. Vol. 254, no. 3 Pt 1. (March): eG334.
  • Barnard JA, Thaxter S, Kikuchi K and Ghishan FK. 1988. Taurine transport by rat jejunum.  Am J Physiol. Vol. (Gastrointest-Liver Physiol 17), no. 254. (January): G334-G338.
  • Barnard JA, BAscom CC, Lyons RM, Sipes NJ, Moses HL. 1988. Transforming growth factor-beta in the control of epidermal proliferation.  Am J Med Sci.
  • Barnard JA, Snyder P, Werner M, Greene HL and Edwards KM. 1988. Protein synthesis by HepG2 cells infected with influenza B virus.  Pediatr Res.
  • Barnard JA; Ghishan FK. 1987. Taurocholate transport by human ileal brush border membrane vesicles.  Gastroenterology. Vol. 93, no. 5. (November): e925.
  • Barnard JA, Marshall GS, Neblett W, Gray G and Ghishan FK. 1986. Noncirrhotic portal fibrosis after Wilm's tumor therapy.  Gastroenterology.
  • Barnard JA and Ghishan FK. 1986. Methylprednisolone accelerates the ontogeny of sodium taurocholate cotransport in rat ileal brush border membranes.  J Lab Clin Med.
  • Will M; Barnard JA; Said HM; Ghishan FK. 1985. Fetal hydantoin syndrome: inhibition of placental folic acid transport as a potential mechanism for fetal growth retardation in the rat.  Research Communications In Chemical Pathology And Pharmacology. Vol. 48, no. 1. (April): e91.
  • Barnard JA, Ghishan FK and Wilson FA. 1985. Ontogenesis of taurocholate transport by rat ileal brush border membrane vesicles.  J Clin Invest.
  • Barnard JA, Cotton R and Lutin W. 1985. Necrotizing enterocolitis: Variables associated with the severity of disease.  Am J Dis Child.
  • Ghishan FK, Greene HL, Halter S, Barnard JA and Moran JR. 1984. Noncirrhotic portal hypertension in congenital cytomegalovirus infection.  Hepatology.

Awards, Honors and Organizations

  • Listed, Best Doctors in America
  • Member, Gastrointestinal Cell and Developmental Biology Study Section, National Institutes of Health
  • President, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) Foundation
  • Former President of NASPGHAN
Nationwide Children's Hospital
700 Children's Drive Columbus, Ohio 43205 614.722.2000