Jiayuh Lin, Ph.D. :: Nationwide Children's Hospital, Columbus, Ohio

Contact Information

The Research Institute at Nationwide Children's Hospital
700 Children's Drive
Columbus, Ohio 43205 [ map ]
PH: (614) 722-5086
FX: (614) 722-5895
E-mail Me

Biography

View CV »

Gender:

  • Male

Languages Spoken:

  • English

Research Interests

Research Center:

Areas of Interest:

  • My laboratory studies the cancer biology of Signal Transducer and Activator of Transcription 3 (STAT3) oncogenic pathway and STAT1 tumor suppressor in human cancers. Constitutive activation of STAT3 is frequently detected in most types of human cancers. We are studying the activation of STAT3 by upstream tyrosine kinases, HGF and SDF-1 and how they may function in STAT3-mediated cell survival, proliferation, tumor angiogenesis, and tumor cells/stroma fibroblasts interaction in cancer cells. The laboratory is also developing novel structure-based design of small molecule compounds that selectively target STAT3 oncogenic pathway in cancer cells as a new cancer therapeutic approach. Further, we are examining the interaction between STAT1 and p53 tumor suppressor and how they cooperate to mediate tumor suppression in cancer cells.

Education and Training

Post Doctoral

  • University of Delaware, Department of Biological Sciences
    Date Completed: 06/30/1991

Post Doctoral

  • Princeton University, Department of Molecular Biology
    Date Completed: 06/30/1996

Professional Experience

2005–present

  • Associate Professor with Tenure, Department of Pediatrics, College of Medicine and Public Health, Ohio State University.

2005–present

  • Investigator, Center for Childhood Cancer, The Research Institute at Nationwide Children's Hospital.

2005–present

  • Graduate Faculty, Integrated Biomedical Science, Molecular, Cellular & Developmental Biology, and Ohio State Biochemistry Graduate Programs, Ohio State University.

2001–2004

  • Graduate Faculty in Cellular and Molecular Biology Graduate Program and Cancer Biology Training Program at the University of Michigan Health System.

1998–2004

  • Assistant Professor (Tenure Track) at the Division of Gynecologic Oncology, University of Michigan Comprehensive Cancer Center.

1997–1998

  • Research Investigator/Instructor, Department of Dermatology, University of Michigan Medical Center.

Publications

  • Li H, Xiao H, Lin L, Jou D, Kumari V, Lin J, Li C. 2014. Drug Design Targeting Protein-Protein Interactions (PPIs) Using Multiple Ligand Simultaneous Docking (MLSD) and Drug Repositioning: Discovery of Raloxifene and Bazedoxifene as Novel Inhibitors of IL-6/GP130 Interface.  J Med Chem. Vol. 57, no. 3. (February): 632-41.
  • Bid HK, Roberts RD, Cam M, Audino A, Kurmasheva RT, Lin J, Houghton PJ, Cam H. 2014. ?Np63 promotes pediatric neuroblastoma and osteosarcoma by regulating tumor angiogenesis.  Cancer Res. Vol. 74, no. 1. (January): 320-9.
  • Bid H., Kibbler A., Phelps D., Manap S., Xiao L., Lin J., Capper D., Oswald D., Geier B., DeWire M., Smith P., Kurmasheva R., Mo X., Fernandes S., Houghton P. 2013. Development, characterization, and reversal of acquired resistance to the MEK1 inhibitor selumetinib (AZD6244) in an in vivo model of childhood astrocytoma.  Clin Cancer Res. Vol. 19, no. 24. (December): 6716-29.
  • Lin L., Hutzen B, Lee, H-F, Peng Z., Lin H., Sun, D., Li P-K., Li C., Korkaya, H., Wicha M., and Lin J. 2013. Evaluation of STAT3 Signaling in ALDH+ and ALDH+/CD44+/CD24- Subpopulations of Breast Cancer Cells.  PLoS One. Vol. 8, no. 12. (December): ee82821.
  • Li L, Tang W, Wu X, Karnak D, Meng X, Thompson R, Hao X, Li Y, Qiao XT, Lin J, Fuchs J, Simeone DM, Chen ZN, Lawrence TS, Xu L. 2013. HAb18G/CD147 promotes pSTAT3-mediated pancreatic cancer development via CD44s.  Clin Cancer Res. Vol. 19, no. 24. (December): 6703-15.
  • Yu W, Xiao H, Lin J, Li C. 2013. Discovery of novel STAT3 small molecule inhibitors via in silico site-directed fragment-based drug design.  J Med Chem. Vol. 56, no. 11. (June): 4402-12.
  • Liu,Aiguo; Liu,Yan; Jin,Zhigang; Hu,Qun; Lin,Li; Jou,David; Yang,Jing; Xu,Zhenghu; Wang,Hong; Li,Chenglong; Lin,Jiayuh. 2012. XZH-5 Inhibits STAT3 Phosphorylation and Enhances the Cytotoxicity of Chemotherapeutic Drugs in Human Breast and Pancreatic Cancer Cells.  PLOS ONE. Vol. 7, no. 10. (October): ee46624.
  • Bill,Matthew,A; Nicholas,Courtney; Mace,Thomas,A; Etter,Jonathan,P; Li,Chenglong; Schwartz,Eric,B; Fuchs,James,R; Young,Gregory,S; Lin,Li; Lin,Jiayuh; He,Lei; Phelps,Mitch; Li,Pui-Kai; Lesinski,Gregory,B. 2012. Structurally Modified Curcumin Analogs Inhibit STAT3 Phosphorylation and Promote Apoptosis of Human Renal Cell Carcinoma and Melanoma Cell Lines.  PLOS ONE. Vol. 7, no. 8. (August): ee40724.
  • Lin,Li; Benson,Don,M; Deangelis,Stephanie; Bakan,Courtney,E; Li,Pui-Kai; Li,Chenglong; Lin,Jiayuh. 2012. A small molecule, LLL12 inhibits constitutive STAT3 and IL-6-induced STAT3 signaling and exhibits potent growth suppressive activity in human multiple myeloma cells.  INTERNATIONAL JOURNAL OF CANCER. Vol. 130, no. 6. (March): 1459-1469.
  • Couto,Jason,I; Bear,Misty,D; Lin,Jiayuh; Pennel,Michael; Kulp,Samuel,K; Kisseberth,William,C; London,Cheryl,A. 2012. Biologic activity of the novel small molecule STAT3 inhibitor LLL12 against canine osteosarcoma cell lines.  BMC veterinary research. Vol. 8, no. January: 244-?.
  • Lin,Li; Liu,Aiguo; Peng,Zhengang; Lin,Huey-Jen; Li,Pui-Kai; Li,Chenglong; Lin,Jiayuh. 2011. STAT3 Is Necessary for Proliferation and Survival in Colon Cancer-Initiating Cells.  CANCER RESEARCH. Vol. 71, no. 23. (December): 7226-7237.
  • Lin,Li; Fuchs,James; Li,Chenglong; Olson,Veronica; Bekaii-Saab,Tanios; Lin,Jiayuh. 2011. STAT3 signaling pathway is necessary for cell survival and tumorsphere forming capacity in ALDH(+)/CD133(+) stem cell-like human colon cancer cells.  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. Vol. 416, no. 3-4. (December): 246-251.
  • Liu,Yan; Liu,Aiguo; Li,Huameng; Li,Chenglong; Lin,Jiayuh. 2011. Celecoxib Inhibits Interleukin-6/Interleukin-6 Receptor-Induced JAK2/STAT3 Phosphorylation in Human Hepatocellular Carcinoma Cells.  CANCER PREVENTION RESEARCH. Vol. 4, no. 8. (August): 1296-1305.
  • Li,Huameng; Liu,Aiguo; Zhao,Zhenjiang; Xu,Yufang; Lin,Jiayuh; Jou,David; Li,Chenglong. 2011. Fragment-Based Drug Design and Drug Repositioning Using Multiple Ligand Simultaneous Docking (MLSD): Identifying Celecoxib and Template Compounds as Novel Inhibitors of Signal Transducer and Activator of Transcription 3 (STAT3).  JOURNAL OF MEDICINAL CHEMISTRY. Vol. 54, no. 15. (August): 5592-5596.
  • Liu,Aiguo; Liu,Yan; Xu,Zhenghu; Yu,Wenying; Wang,Hong; Li,Chenglong; Lin,Jiayuh. 2011. Novel small molecule, XZH-5, inhibits constitutive and interleukin-6-induced STAT3 phosphorylation in human rhabdomyosarcoma cells.  CANCER SCIENCE. Vol. 102, no. 7. (July): 1381-1387.
  • Lin,L; Liu,Y; Li,H; Li,P-K; Fuchs,J; Shibata,H; Iwabuchi,Y; Lin,J. 2011. Targeting colon cancer stem cells using a new curcumin analogue, GO-Y030.  BRITISH JOURNAL OF CANCER. Vol. 105, no. 2. (July): 212-220.
  • Liu,Aiguo; Liu,Yan; Li,Pui-Kai; Li,Chenglong; Lin,Jiayuh. 2011. LLL12 Inhibits Endogenous and Exogenous Interleukin-6-induced STAT3 Phosphorylation in Human Pancreatic Cancer Cells.  ANTICANCER RESEARCH. Vol. 31, no. 6. (June): 2029-2035.
  • Liu,Yan; Liu,Aiguo; Xu,Zhenghu; Yu,Wenying; Wang,Hong; Li,Chenglong; Lin,Jiayuh. 2011. XZH-5 inhibits STAT3 phosphorylation and causes apoptosis in human hepatocellular carcinoma cells.  APOPTOSIS. Vol. 16, no. 5. (May): 502-510.
  • Abuzeid,Waleed,M; Davis,Samantha; Tang,Alice,L; Saunders,Lindsay; Brenner,J,Chadwick; Lin,Jiayuh; Fuchs,James,R; Light,Emily; Bradford,Carol,R; Prince,Mark,EP; Carey,Thomas,E. 2011. Sensitization of Head and Neck Cancer to Cisplatin Through the Use of a Novel Curcumin Analog.  ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY. Vol. 137, no. 5. (May): 499-507.
  • Ball,Sarah; Li,Chenglong; Li,Pui-Kai; Lin,Jiayuh. 2011. The Small Molecule, LLL12, Inhibits STAT3 Phosphorylation and Induces Apoptosis in Medulloblastoma and Glioblastoma Cells.  PLOS ONE. Vol. 6, no. 4. (April): ee18820.
  • Reed,Suzanne; Li,Huameng; Li,Chenglong; Lin,Jiayuh. 2011. Celecoxib inhibits STAT3 phosphorylation and suppresses cell migration and colony forming ability in rhabdomyosarcoma cells.  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. Vol. 407, no. 3. (April): 450-455.
  • Fossey,Stacey,L; Bear,Misty,D; Lin,Jiayuh; Li,Chenglong; Schwartz,Eric,B; Li,Pui-Kai; Fuchs,James,R; Fenger,Joelle; Kisseberth,William,C; London,Cheryl,A. 2011. The novel curcumin analog FLLL32 decreases STAT3 DNA binding activity and expression, and induces apoptosis in osteosarcoma cell lines.  BMC CANCER. Vol. 11, no. March: e112.
  • Liu,Yan; Lin,Jiayuh. 2011. Blocking the IL-6-STAT3 signaling pathway: potential liver cancer therapy.  FUTURE ONCOLOGY. Vol. 7, no. 2. (February): 161-164.
  • Onimoe,Grace-Ifeyinwa; Liu,Aiguo; Lin,Li; Wei,Chang-Ching; Schwartz,Eric,B; Bhasin,Deepak; Li,Chenglong; Fuchs,James,R; Li,Pui-Kai; Houghton,Peter; Termuhlen,Amanda; Gross,Thomas; Lin,Jiayuh. 2011. Small molecules, LLL12 and FLLL32, inhibit STAT3 and exhibit potent growth suppressive activity in osteosarcoma cells and tumor growth in mice.  INVEST NEW DRUGS. Vol. Epub ahead of print, no. February: eEpub ahead of print.
  • Wei,Chang-Ching; Ball,Sarah; Lin,Li; Liu,Aiguo; Fuchs,James,R; Li,Pui-Kai; Li,Chenglong; Lin,Jiayuh. 2011. Two small molecule compounds, LLL12 and FLLL32, exhibit potent inhibitory activity on STAT3 in human rhabdomyosarcoma cells.  INTERNATIONAL JOURNAL OF ONCOLOGY. Vol. 38, no. 1. (January): 279-285.
  • Liu,Yan; Fuchs,James; Li,Chenglong; Lin,Jiayuh. 2010. IL-6, a risk factor for hepatocellular carcinoma FLLL32 inhibits IL-6-induced STAT3 phosphorylation in human hepatocellular cancer cells.  CELL CYCLE. Vol. 9, no. 17. (September): 3423-3427.
  • Liu,Yan; Li,Chenglong; Lin,Jiayuh. 2010. STAT3 as a Therapeutic Target for Glioblastoma.  ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY. Vol. 10, no. 7. (September): 512-519.
  • Lin,Li; Deangelis,Stephanie; Foust,Elizabeth; Fuchs,James; Li,Chenglong; Li,Pui-Kai; Schwartz,Eric,B; Lesinski,Gregory,B; Benson,Don; Lue,Jiagao; Hoyt,Dale; Lin,Jiayuh. 2010. A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells.  MOLECULAR CANCER. Vol. 9, no. August: e217.
  • Liu,Yan; Li,Pui-Kai; Li,Chenglong; Lin,Jiayuh. 2010. Inhibition of STAT3 Signaling Blocks the Anti-apoptotic Activity of IL-6 in Human Liver Cancer Cells.  JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 285, no. 35. (August): 27429-27439.
  • Bill,Matthew,A; Fuchs,James,R; Li,Chenglong; Yui,Jennifer; Bakan,Courtney; Benson,Don,M; Schwartz,Eric,B; Abdelhamid,Dalia; Lin,Jiayuh; Hoyt,Dale,G; Fossey,Stacey,L; Young,Gregory,S; Carson,William,E; Li,Pui-Kai; Lesinski,Gregory,B. 2010. The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity.  MOLECULAR CANCER. Vol. 9, no. June: e165.
  • Lin,Li; Hutzen,Brian; Zuo,Mingxin; Ball,Sarah; Deangelis,Stephanie; Foust,Elizabeth; Pandit,Bulbul; Ihnat,Michael,A; Shenoy,Satyendra,S; Kulp,Samuel; Li,Pui-Kai; Li,Chenglong; Fuchs,James; Lin,Jiayuh. 2010. Novel STAT3 Phosphorylation Inhibitors Exhibit Potent Growth-Suppressive Activity in Pancreatic and Breast Cancer Cells.  CANCER RESEARCH. Vol. 70, no. 6. (March): 2445-2454.
  • Lin,Li; Hutzen,Brian; Li,Pui-Kai; Ball,Sarah; Zuo,Mingxin; Deangelis,Stephanie; Foust,Elizabeth; Sobo,Matthew; Friedman,Lauren; Bhasin,Deepak; Cen,Ling; Li,Chenglong; Lin,Jiayuh. 2010. A Novel Small Molecule, LLL12, Inhibits STAT3 Phosphorylation and Activities and Exhibits Potent Growth-Suppressive Activity in Human Cancer Cells.  NEOPLASIA. Vol. 12, no. 1. (January): 39-U58.
  • Hutzen,Brian; Friedman,Lauren; Sobo,Matthew; Lin,Li; Cen,Ling; De Angelis,Stephanie; Yamakoshi,Hiroyuki; Shibata,Hiroyuki; Iwabuchi,Yoshiharu; Lin,Jiayuh. 2009. Curcumin analogue GO-Y030 inhibits STAT3 activity and cell growth in breast and pancreatic carcinomas.  INTERNATIONAL JOURNAL OF ONCOLOGY. Vol. 35, no. 4. (October): 867-872.
  • Lin,Li; Hutzen,Brian; Ball,Sarah; Foust,Elizabeth; Sobo,Matthew; Deangelis,Stephanie; Pandit,Bulbul; Friedman,Lauren; Li,Chenglong; Li,Pui-Kai; Fuchs,James; Lin,Jiayuh. 2009. New curcumin analogues exhibit enhanced growth-suppressive activity and inhibit AKT and signal transducer and activator of transcription 3 phosphorylation in breast and prostate cancer cells.  CANCER SCIENCE. Vol. 100, no. 9. (September): 1719-1727.
  • Canner,J,A; SOBO,M; Ball,S; Hutzen,B; DEANGELIS,S; Willis,W; Studebaker,A,W; Ding,K; Wang,S; Yang,D; Lin,J. 2009. MI-63: A novel small-molecule inhibitor targets MDM2 and induces apoptosis in embryonal and alveolar rhabdomyosarcoma cells with wild-type p53.  BRITISH JOURNAL OF CANCER. Vol. 101, no. 5. (August): 774-781.
  • Hutzen,Brian; Willis,William; Jones,Sarah; Cen,Ling; Deangelis,Stephanie; Fuh,Beng; Lin,Jiayuh. 2009. Dietary agent, benzyl isothiocyanate inhibits signal transducer and activator of transcription 3 phosphorylation and collaborates with sulforaphane in the growth suppression of PANC-1 cancer cells.  CANCER CELL INTERNATIONAL. Vol. 9, no. August: e24.
  • Friedman,Lauren; Lin,Li; Ball,Sarah; Bekaii-Saab,Tanios; Fuchs,James; Li,Pui-Kai; Li,Chenglong; Lin,Jiayuh. 2009. Curcumin analogues exhibit enhanced growth suppressive activity in human pancreatic cancer cells.  ANTI-CANCER DRUGS. Vol. 20, no. 6. (July): 444-449.
  • Fuchs,James,R; Pandit,Bulbul; Bhasin,Deepak; Etter,Jonathan,P; Regan,Nicholas; Abdelhamid,Dalia; Li,Chenglong; Lin,Jiayuh; Li,Pui-KaI. 2009. Structure-activity relationship studies of curcumin analogues.  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. Vol. 19, no. 7. (April): 2065-2069.
  • Fossey,Stacey,L; Liao,Albert,T; McCleese,Jennifer,K; Bear,Misty,D; Lin,Jiayuh; Li,Pui-Kai; Kisseberth,William,C; London,Cheryl,A. 2009. Characterization of STAT3 activation and expression in canine and human osteosarcoma.  BMC CANCER. Vol. 9, no. March: e81.
  • Cen,Ling; Hutzen,Brian; Ball,Sarah; DeAngelis,Stephanie; Chen,Chun-Liang; Fuchs,James,R; Li,Chenglong; Li,Pui-KaI; Lin,Jiayuh. 2009. New structural analogues of curcumin exhibit potent growth suppressive activity in human colorectal carcinoma cells.  BMC CANCER. Vol. 9, no. March: e99.
  • Liu,Zhongfa; Xie,Zhiliang; Jones,William; Pavlovicz,Ryan,E; Liu,Shujun; Yu,Jianhua; Li,Pui-Kai; Lin,Jiayuh; Fuchs,Jame,R; Marcucci,Guido; Li,Chenglong; Chan,Kenneth,K. 2009. Curcumin is a potent DNA hypomethylation agent.  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. Vol. 19, no. 3. (February): 706-709.
  • Fuh,B; SOBO,M; Cen,L; Josiah,D; Hutzen,B; Cisek,K; Bhasin,D; Regan,N; Lin,L; Chan,C; Caldas,H; DEANGELIS,S; Li,C; Li,P-K; Lin,J. 2009. LLL-3 inhibits STAT3 activity, suppresses glioblastoma cell growth and prolongs survival in a mouse glioblastoma model.  BRITISH JOURNAL OF CANCER. Vol. 100, no. 1. (January): 106-112.
  • Lieblein,Jacqueline,C; Ball,Sarah; Hutzen,Brian; Sasser,A,Kate; Lin,Huey-Jen; Huang,Tim,HM; Hall,Brett,M; Lin,Jiayuh. 2008. STAT3 can be activated through paracrine signaling in breast epithelial cells.  BMC CANCER. Vol. 8, no. October: e302.
  • Chen,Chun-Liang; Cen,Ling; Kohout,Jennifer; Hutzen,Brian; Chan,Christina; Hsieh,Fu-Chuan; Loy,Abbey; Huang,Victor; Cheng,Gong; Lin,Jiayuh. 2008. Signal transducer and activator of transcription 3 activation is associated with bladder cancer cell growth and survival.  MOLECULAR CANCER. Vol. 7, no. October: e78.
  • Chan,Christina; Lin,Huey-Jen; Lin,Jiayuh. 2008. Stress-associated hormone, norepinephrine, increases proliferation and IL-6 levels of human pancreatic duct epithelial cells and can be inhibited by the dietary agent, sulforaphane.  INTERNATIONAL JOURNAL OF ONCOLOGY. Vol. 33, no. 2. (August): 415-419.
  • Bhasin,Deepak; Cisek,Katryna; Pandharkar,Trupti; Regan,Nicholas; Li,Chenglong; Pandit,Bulbul; Lin,Jiayuh; Li,Pui-KaI. 2008. Design, synthesis, and studies of small molecule STAT3 inhibitors.  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. Vol. 18, no. 1. (January): 391-395.
  • Cen,L; Hsieh,F-C; Lin,H-J; Chen,C-S; Qualman,S,J; Lin,J. 2007. PDK-1/AKT pathway as a novel therapeutic target in rhabdomyosarcoma cells using OSU-03012 compound.  BRITISH JOURNAL OF CANCER. Vol. 97, no. 6. (September): 785-791.
  • Cen,Ling; Arnoczky,Kristy,J; Hsieh,Fu-Chuan; Lin,Huey-Jen; Qualman,Stephen,J; Yu,Songlin; Xiang,Huiyun; Lin,Jiayuh. 2007. Phosphorylation profiles of protein kinases in alveolar and embryonal rhabdomyosarcoma.  MODERN PATHOLOGY. Vol. 20, no. 9. (September): 936-946.
  • Chen,Chun-Liang; Loy,Abbey; Cen,Ling; Chan,Christina; Hsieh,Fu-Chuan; Cheng,Gong; Wu,Bryant; Qualman,Stephen,J; Kunisada,Keita; Yamauchi-Takihara,Keiko; Lin,Jiayuh. 2007. Signal transducer and activator of transcription 3 is involved in cell growth and survival of human rhabdomyosarcoma and osteosarcoma cells.  BMC CANCER. Vol. 7, no. June: e111.
  • Chen,C-L; Hsieh,F-C; Lieblein,J,C; Brown,J; Chan,C; Wallace,J,A; Cheng,G; Hall,B,M; Lin,J. 2007. Stat3 activation in human endometrial and cervical cancers.  BRITISH JOURNAL OF CANCER. Vol. 96, no. 4. (February): 591-599.
  • Chen,Chun-Liang; Hsieh,Fu-Chuan; Lin,Jiayuh. 2006. Systemic evaluation of total Stat3 and Stat3 tyrosine phosphorylation in normal human tissues.  EXPERIMENTAL AND MOLECULAR PATHOLOGY. Vol. 80, no. 3. (June): 295-305.
  • Tang,H,J; Jin,X,H; Wang,S,M; Yang,D,J; Cao,Y,Y; Chen,J,Y; Gossett,D,R; Lin,J,Y. 2006. A small molecule compound inhibits AKT pathway in ovarian cancer cell lines.  GYNECOLOGIC ONCOLOGY. Vol. 100, no. 2. (February): 308-317.
  • Lin,H,J; Hsieh,F,C; Song,H; Lin,J. 2005. Elevated phosphorylation and activation of PDK-I/AKT pathway in human breast cancer.  BRITISH JOURNAL OF CANCER. Vol. 93, no. 12. (December): 1372-1381.
  • Hsieh,F,C; Cheng,G; Lin,J. 2005. Evaluation of potential Stat3-regulated genes in human breast cancer.  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. Vol. 335, no. 2. (September): 292-299.
  • Song,H; Wang,R,X; Wang,S,M; Lin,J. 2005. A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells.  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. Vol. 102, no. 13. (March): 4700-4705.
  • Mahidhara,R,S; de Oliveira,P,EQ; Kohout,J; Beer,D,G; Lin,J,Y; Watkins,S,C; Robbins,P,D; Hughes,S,J. 2005. Altered trafficking of Fas and subsequent resistance to Fas-mediated apoptosis occurs by a wild-type p53 independent mechanism in esophageal adenocarcinoma.  JOURNAL OF SURGICAL RESEARCH. Vol. 123, no. 2. (February): 302-311.
  • Gossett,D,R; Bradley,M,S; Jin,X,H; Lin,J,Y. 2005. 17-Allyamino-17-demethoxygeldanamycin and 17-NN-dimethyl ethylene diamine-geldanamycin have cytotoxic activity against multiple gynecologic cancer cell types.  GYNECOLOGIC ONCOLOGY. Vol. 96, no. 2. (February): 381-388.
  • Jin,X; Gossett,D,R; Wang,S; Yang,D; Cao,Y; Chen,J; Guo,R; Reynolds,R,K; Lin,J. 2004. Inhibition of AKT survival pathway by a small molecule inhibitor in human endometrial cancer cells.  BRITISH JOURNAL OF CANCER. Vol. 91, no. 10. (November): 1808-1812.
  • Song,H; Jin,X,H; Lin,J,Y. 2004. Stat3 upregulates MEK5 expression in human breast cancer cells.  ONCOGENE. Vol. 23, no. 50. (October): 8301-8309.
  • Reid,T; Jin,X,H; Song,H; Tang,H,J; Reynolds,R,K; Lin,J. 2004. Modulation of Janus kinase 2 by p53 in ovarian cancer cells.  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. Vol. 321, no. 2. (August): 441-447.
  • Song,H; Sondak,V,K; Barber,D,L; REID,T,J; Lin,J. 2004. Modulation of Janus kinase 2 by cisplatin in cancer cells.  INTERNATIONAL JOURNAL OF ONCOLOGY. Vol. 24, no. 4. (April): 1017-1026.
  • Tang,H,J; Qian,D; Sondak,V,K; Stachura,S; Lin,J. 2004. A modified p53 enhances apoptosis in sarcoma cell lines mediated by doxorubicin.  BRITISH JOURNAL OF CANCER. Vol. 90, no. 6. (March): 1285-1292.
  • Song,H; Ethier,S,P; Dziubinski,M,L; Lin,J,Y. 2004. Stat3 modulates heat shock 27 kDa protein expression in breast epithelial cells.  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. Vol. 314, no. 1. (January): 143-150.
  • Lin J, Jin X, Gossett D, Wang S. 2003. Inhibition of AKT oncogenic pathway in endometrial cancer cells. In Cell and Molecular Biology of Endometrial Carcinoma. Tokyo: Springer-Verlag Tokyo.
  • Lin,J; Tang,H; Jin,X; Jia,G; Hsieh,J,T. 2002. p53 regulates Stat3 phosphorylation and DNA binding activity in human prostate cancer cells expressing constitutively active Stat3.  ONCOGENE. Vol. 21, no. 19. (May): 3082-3088.
  • Jin,X; Burke,W; Rothman,K; Lin,J. 2002. Resistance to p53-mediated growth suppression in human ovarian cancer cells retain endogenous wild-type p53.  ANTICANCER RESEARCH. Vol. 22, no. 2A. (March): 659-664.
  • Lu,W,G; Lin,J,Y; Chen,J,D. 2002. Expression of p14ARF overcomes tumor resistance to p53.  CANCER RESEARCH. Vol. 62, no. 5. (March): 1305-1310.
  • Lin,J,Y; Jin,X,H; Rothman,K; Lin,H,J; Tang,H,J; Burke,W. 2002. Modulation of signal transducer and activator of transcription 3 activities by p53 tumor suppressor in breast cancer cells.  CANCER RESEARCH. Vol. 62, no. 2. (January): 376-380.
  • Burke,W,M; Jin,X,H; Lin,H,J; Huang,M; Liu,R; Reynolds,R,K; Lin,J,Y. 2001. Inhibition of constitutively active Stat3 suppresses growth of human ovarian and breast cancer cells.  ONCOGENE. Vol. 20, no. 55. (November): 7925-7934.
  • Lo,P,K; Chen,J,Y; Tang,P,P; Lin,J,Y; Lin,C,H; Su,L,T; Wu,C,H; Chen,T,L; Yang,Y; Wang,F,F. 2001. Identification of a mouse thiamine transporter gene as a direct transcriptional target for p53.  JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 276, no. 40. (October): 37186-37193.
  • Lilja,J,F; Wu,D; Reynolds,R,K; Lin,J,Y. 2001. Growth suppression activity of the PTEN tumor suppressor gene in human endometrial cancer cells.  ANTICANCER RESEARCH. Vol. 21, no. 3B. (May): 1969-1974.
  • Lin,J,Y; Page,C; Jin,X,H; Sethi,A,O; Patel,R; Nunez,G. 2001. Suppression activity of pro-apoptotic gene products in cancer cells, a potential application for cancer gene therapy.  ANTICANCER RESEARCH. Vol. 21, no. 2A. (March): 831-839.
  • Pochampally,R; Li,C,G; Lu,W,G; Chen,L,H; Luftig,R; Lin,J; Chen,J,D. 2000. Temperature-sensitive mutants of p53 homologs.  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. Vol. 279, no. 3. (December): 1001-1010.
  • Huang,M; Page,C; Reynolds,R,K; Lin,J. 2000. Constitutive activation of Stat 3 oncogene product in human ovarian carcinoma cells.  GYNECOLOGIC ONCOLOGY. Vol. 79, no. 1. (October): 67-73.
  • Lin,J,Y; Jin,X,H; Page,C; Sondak,V,K; Jiang,G,H; Reynolds,R,K. 2000. A modified p53 overcomes mdm2-mediated oncogenic transformation: A potential cancer therapeutic agent.  CANCER RESEARCH. Vol. 60, no. 20. (October): 5895-5901.
  • Chung,J,H; Kang,S; Varani,J; Lin,J; Fisher,G,J; VOORHEES,J,J. 2000. Decreased extracellular-signal-regulated kinase and increased stress-activated MAP kinase activities in aged human skin in vivo.  JOURNAL OF INVESTIGATIVE DERMATOLOGY. Vol. 115, no. 2. (August): 177-182.
  • Page,C; Huang,M; Jin,X,H; Cho,K; Lilja,J; Reynolds,R,K; Lin,J,Y. 2000. Elevated phosphorylation of AKT and Stat3 in prostate, breast, and cervical cancer cells.  INTERNATIONAL JOURNAL OF ONCOLOGY. Vol. 17, no. 1. (July): 23-28.
  • Page,C; Lin,H,J; Jin,Y; Castle,V,P; Nunez,G; Huang,M; Lin,J,Y. 2000. Overexpression of Akt/AKT can modulate chemotherapy-induced apoptosis.  ANTICANCER RESEARCH. Vol. 20, no. 1A. (January): 407-416.
  • Fisher,G,J; Talwar,H,S; Lin,J,Y; VOORHEES,J,J. 1999. Molecular mechanisms of photoaging in human skin in vivo and their prevention by all-trans retinoic acid.  PHOTOCHEMISTRY AND PHOTOBIOLOGY. Vol. 69, no. 2. (February): 154-157.
  • Fisher,G,J; Talwar,H,S; Lin,J,Y; Lin,P,P; McPhillips,F; Wang,Z,Q; Li,X,Y; Wan,Y,S; Kang,S,W; VOORHEES,J,J. 1998. Retinoic acid inhibits induction of c-Jun protein by ultraviolet radiation that occurs subsequent to activation of mitogen-activated protein kinase pathways in human skin in vivo.  JOURNAL OF CLINICAL INVESTIGATION. Vol. 101, no. 6. (March): 1432-1440.
  • Chen,J,D; Wu,X,W; Lin,J,Y; Levine,A,J. 1996. mdm-2 inhibits the G(1) arrest and apoptosis functions of the p53 tumor suppressor protein.  MOLECULAR AND CELLULAR BIOLOGY. Vol. 16, no. 5. (May): 2445-2452.
  • Lin,J,Y; Reichner,C; Wu,X,W; Levine,A,J. 1996. Analysis of wild-type and mutant p21(WAF-1) gene activities.  MOLECULAR AND CELLULAR BIOLOGY. Vol. 16, no. 4. (April): 1786-1793.
  • Sabbatini,P; Lin,J,Y; Levine,A,J; White,E. 1995. ESSENTIAL ROLE FOR P53-MEDIATED TRANSCRIPTION IN E1A-INDUCED APOPTOSIS.  GENES & DEVELOPMENT. Vol. 9, no. 17. (September): 2184-2192.
  • Levine,A,J; Wu,M,C; Chang,A; Silver,A; Attiyeh,E,F; Lin,J; Epstein,C,B. 1995. The spectrum of mutations at the p53 locus. Evidence for tissue-specific mutagenesis, selection of mutant alleles, and a "gain of function" phenotype.  Annals of the New York Academy of Sciences. Vol. 768, no. September: 111-128.
  • Lin,J,Y; Teresky,A,K; Levine,A,J. 1995. 2 CRITICAL HYDROPHOBIC AMINO-ACIDS IN THE N-TERMINAL DOMAIN OF THE P53 PROTEIN ARE REQUIRED FOR THE GAIN OF FUNCTION PHENOTYPES OF HUMAN P53 MUTANTS.  ONCOGENE. Vol. 10, no. 12. (June): 2387-2390.
  • Chen,J; Lin,J; Levine,AJ. 1995. The ability of mdm2 to complex with p53 is required for the inhibition of transcription activation and suppression activities of p53.  MOLECULAR MEDICINE. Vol. 1, no. January: 142-152.
  • Lin,J,Y; Chen,J,D; Elenbaas,B; Levine,A,J. 1994. SEVERAL HYDROPHOBIC AMINO-ACIDS IN THE P53 AMINO-TERMINAL DOMAIN ARE REQUIRED FOR TRANSCRIPTIONAL ACTIVATION, BINDING TO MDM-2 AND THE ADENOVIRUS-5 E1B 55-KD PROTEIN.  GENES & DEVELOPMENT. Vol. 8, no. 10. (May): 1235-1246.
  • Lin,J; Wu,X; Chen,J; Chang,A; Levine,AJ. 1994. Functions of the p53 protein in growth regulation and tumor suppression.  COLD SPRING HARBOR SYMP QUANT BIOL. Vol. 59, no. January: 215-223.
  • Lin,J,Y; Simmons,D,T. 1991. THE ABILITY OF LARGE T-ANTIGEN TO COMPLEX WITH P53 IS NECESSARY FOR THE INCREASED LIFE-SPAN AND PARTIAL TRANSFORMATION OF HUMAN-CELLS BY SIMIAN VIRUS-40.  JOURNAL OF VIROLOGY. Vol. 65, no. 12. (December): 6447-6453.
  • Lin,J,Y; Simmons,D,T. 1991. STABLE T-P53 COMPLEXES ARE NOT REQUIRED FOR REPLICATION OF SIMIAN VIRUS-40 IN CULTURE OR FOR ENHANCED PHOSPHORYLATION OF T-ANTIGEN AND P53.  JOURNAL OF VIROLOGY. Vol. 65, no. 4. (April): 2066-2072.
  • Lin,J,Y; Simmons,D,T. 1990. TRANSFORMATION BY SIMIAN VIRUS-40 DOES NOT INVOLVE THE MUTATIONAL ACTIVATION OF P53 TO AN ONCOGENIC FORM.  VIROLOGY. Vol. 176, no. 1. (May): 302-305.
  • LEE,Y,HW; Lin,J,Y; Pao,C,C; LO,S,CJ. 1988. ENHANCED PRODUCTION OF HEPATITIS-B VIRUS SURFACE-ANTIGEN IN MOUSE C127 CELL ON A BOVINE PAPILLOMAVIRUS METALLOTHIONEIN VECTOR.  BIOCHEMISTRY INTERNATIONAL. Vol. 16, no. 1. (January): 101-109.
  • Lin, J and Simmons, DT. 0. The formation of stable T-p53 complexes is not required for replication of SV40 in culture. In Tumor virus meeting on SV40, polyoma, and adenoviruses
  • Bid,Hemant,K; Oswald,Duane; Li,Chenglong; London,Cheryl,A; Lin,Jiayuh; Houghton,Peter,J. Direct anti-angiogenic activity of a small molecular STAT3 inhibitor LLL12.  PLOS ONE.
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