Jennifer K. Trittmann, MD :: Nationwide Children's Hospital, Columbus, Ohio

Jennifer K. Trittmann, MD, MPH

Jennifer K. Trittmann, MD, MPH

Center for Perinatal Research
Principal Investigator

Neonatology
Physician Team

Neonatology Fellowship
Faculty

Contact Information

Neonatology
700 Children's Dr
Columbus, OH 43205 [ map ]
PH: (614) 722-4559
FX: (614) 722-4541

Biography

Jennifer Trittmann MD, MPH is Principal Investigator in the Center for Perinatal Research at The Research Institute at Nationwide Children’s Hospital and Neonatology Attending in the Department of Pediatrics. She is an Assistant Professor of Pediatrics at the Ohio State University College of Medicine. Dr. Trittmann’s research focuses on identifying risk factors that predict the evolution of pulmonary hypertension in bronchopulmonary dysplasia, which is the most common chronic lung disease of premature neonates.

Gender:

  • Female

Languages Spoken:

  • English

Research Interests

Research Center:

Areas of Interest:

  • Bronchopulmonary dysplasia (BPD) is the most common chronic lung disease of premature neonates. Pulmonary hypertension (PH) occurs in approximately 30% of BPD patients and is associated with a dramatic increase in morbidity and mortality. There are currently no tests for accurately predicting which BPD patients will develop this life-threatening complication. Nitric oxide (NO) metabolism has been found to be altered in patients with severe BPD. Nitric oxide, an endogenous pulmonary vasodilator, is produced by NO synthase from L-arginine in endothelial cells. In patients with PH from causes other than BPD, circulating levels of L-arginine are decreased, due to decreased endogenous L-arginine production resulting in decreased NO production in the lung. Therefore, the overall hypothesis of our research is that there are single nucleotide polymorphisms (SNPs) and/or metabolites involving the L-arginine/NO pathway that predict the development of PH in BPD, such that effective therapies can be initiated prior to the onset of PH.

Education and Training

Medical School

  • Ohio State University College of Medicine
    Date Completed: 06/30/2005

Residency

  • Nationwide Children's Hospital
    Date Completed: 06/30/2008

Fellowship

  • Nationwide Children's Hospital
    Date Completed: 09/28/2011

Department:

  • Pediatrics

Section:

  • Neonatology

Specialty:

  • Neonatal-Perinatal Medicine
  • Pediatrics

Date of Appointment at Nationwide Children’s Hospital:

  • 09/30/2011

Publications

  • Trittmann,J,K; Nelin,L,D; Klebanoff,M,A. 2013. Bronchopulmonary dysplasia and neurodevelopmental outcome in extremely preterm neonates.  EUROPEAN JOURNAL OF PEDIATRICS. Vol. 172, no. 9. (September): 1173-1180. PubMed ID: 23644648
  • Moorehead PA, Backes CH, Reber KM, Trittmann JK, Huang H, Bauer JA, Mahan JD. 2011. Fellows as teachers: enhancing pediatric resident education. In Pediatric Academic Societies
  • Backes,Carl,H; Reber,Kris,M; Trittmann,Jennifer,KB; Huang,Hong; Tomblin,Jordanna; Moorehead,Pamela,A; Bauer,John,A; Smith,Charles,V; Mahan,John,D. 2011. Fellows as teachers: a model to enhance pediatric resident education.  Medical education online. Vol. 16, no. January: 1-9. PubMed ID: 21912479
  • Trittmann JK, Hitchner J, Martin EM, Welty SE, Nelin LD. 2010. Bronchopulmonary dysplasia in the extremely preterm infant from an all referral NICU. In Pediatric Academic Societies
  • Trittmann JK, Cui H, Nelin LD. 2009. Inflammatory cytokines induce cationic amino acid transporter-2 expression via a src tyrosine kinase dependent mechanism in human pulmonary microvascular endothelial cells. In Pediatric Academic Societies
  • Trittmann JK, Peterson EE, Vaynshtok P, Gastier-Foster JM, Zmuda EJ, Rogers LK, Klebanoff MA, Nelin LD. Predicting risk factors for the evolution of pulmonary hypertension in bronchopulmonary dysplasia. In The Jackson Laboratory 53rd Annual Short Course on Medical and Experimental Mammalian Genetics.
  • Trittmann JK, Zmuda EJ, Vaynshtok PM, Nelin LD, Gastier-Foster JM, Vieland VJ, Klebanoff MA. Arginase I gene single nucleotide polymorphism associated with decreased risk of pulmonary hypertension in bronchopulmonary dysplasia.  Acta Paediatrica.
  • Trittmann JK, Nelin LD, Vaynshtok PM, Zmuda EJ, Gastier-Foster JM, Vieland VJ, Klebanoff MA. Genetic risk factors for pulmonary hypertension in premature neonates with bronchopulmonary dysplasia. In Pediatric Academic Societies
  • Trittmann JK, Rogers LK, Peterson E, Klebanoff MA, Nelin LD. Asymmetric dimethylarginine levels are elevated in preterm neonates with pulmonary hypertension and bronchopulmonary dysplasia. In Pediatric Academic Societies
Nationwide Children's Hospital
700 Children's Drive Columbus, Ohio 43205 614.722.2000