Jennifer K. Trittmann, MD :: Nationwide Children's Hospital, Columbus, Ohio

Jennifer K. Trittmann, MD, MPH

Jennifer K. Trittmann, MD, MPH

Center for Perinatal Research
Principal Investigator

Neonatology
Physician Team

Neonatology Fellowship
Faculty

Contact Information

Neonatology
700 Children's Dr
Columbus, OH 43205 [ map ]
PH: (614) 722-4559
FX: (614) 722-4541

Location Information for Patients

Main Campus

Biography

Jennifer K. Trittmann, MD, MPH, is Assistant Professor in the Division of Neonatology, Department of Pediatrics at The Ohio State University College of Medicine and Principal Investigator in the Center for Perinatal Research at The Research Institute at Nationwide Children’s Hospital. Dr. Trittmann’s research focuses on bronchopulmonary dysplasia (BPD)-associated pulmonary hypertension (PH), a life-threatening neonatal disease characterized by progressive pulmonary vascular endothelial dysfunction and smooth muscle cell proliferation. Currently, there are no available predictive biomarkers or curative therapies for BPD-PH. Our labs at The Research Institute have discovered three potential biomarkers for BPD-PH: arginase-1 (ARG1), asymmetric dimethylarginine (ADMA), NᴳNᴳ-dimethylaminohydrolase-1 (DDAH1), that are differentially expressed in neonatal patients with BPD-PH versus BPD alone. Therefore, Dr. Trittmann aims to further develop ARG1, ADMA, and DDAH1 as clinical biomarkers for BPD-PH and to discover their mechanism of action as it relates to BPD-PH pathogenesis, in order to precisely target treatment to improve outcomes for neonatal patients with BPD-PH.

Learn about Dr. Trittmann’s Neonatal Lung Injury & Pulmonary Hypertension Focus Group.

View CV »

Gender:

  • Female

Languages Spoken:

  • English

Research Interests

Research Center:

Areas of Interest:

  • Bronchopulmonary dysplasia (BPD) is the most common complication of preterm birth, and one of the leading causes of pediatric chronic lung disease. There are approximately 14,000 new cases of BPD diagnosed each year in the United States. Pulmonary hypertension (PH) complicates the clinical course in approximately 25-40% of BPD patients and is the greatest contributor to morbidity and mortality in BPD. PH is characterized by increased pulmonary vascular resistance caused by decreased vessel diameter as a result of vasoconstriction and/or vascular remodeling. Nitric oxide (NO) metabolism has been found to be altered in patients with severe BPD. NO, an endogenous pulmonary vasodilator, is produced by NO synthase (NOS) from L-arginine in pulmonary endothelial cells. L-arginine can also be metabolized by arginase to form ornithine and urea, and this is the first step in polyamine and proline synthesis that is necessary for the cell proliferation underlying vascular remodeling. Our group has shown that NO production can be influenced by the bioavailability of L-arginine to NOS either by alterations in cellular uptake of L-arginine or by metabolism by arginase. Furthermore, a product of protein methylation, ADMA, inhibits NOS production of NO and promotes vasoconstriction and proliferation. ADMA is degraded in the cell by dimethylarginine dimethylaminohydrolase (DDAH). These cell studies combined with patient sample data that demonstrate the differential expression of ARG1, ADMA, and DDAH1 in neonatal patients with BPD-PH versus BPD alone, provide a foundation of evidence to further develop arginase, ADMA, and DDAH as clinical biomarkers and therapeutic targets to improve outcomes for neonates with BPD-PH.

Research Funding*:

  • NIH, National Heart, Lung, and Blood Institute: Mentored Clinical Scientist Research Career Development Award (K08): Novel therapeutic targets for bronchopulmonary dysplasia-associated pulmonary hypertension.

Education and Training

Medical School

  • Ohio State University College of Medicine
    Date Completed: 06/30/2005

Residency

  • Nationwide Children's Hospital
    Date Completed: 06/30/2008

Graduate School

  • The Ohio State University College of Public Health
    Date Completed: 06/12/2011

Fellowship

  • Nationwide Children's Hospital
    Date Completed: 09/28/2011

Department:

  • Pediatrics

Section:

  • Neonatology

Specialty:

  • Neonatal-Perinatal Medicine
  • Pediatrics

Date of Appointment at Nationwide Children’s Hospital:

  • 09/30/2011

Professional Experience

2011–present

  • Principal Investigator, The Research Institute at Nationwide Children’s Hospital, Columbus, Ohio

2011–present

  • Pediatric Academic Association, Inc., Columbus

2011–present

  • Assistant Professor, The Ohio State University, Division of Neonatology, Department of Pediatrics, Nationwide Children’s Hospital, Columbus, Ohio

Publications

  • Trittmann, JK, Jin, Y, Chicoine, LG, Liu, Y, Chen, B, Nelin, LD. 2016. An arginase-1 SNP that protects against the development of pulmonary hypertension in bronchopulmonary dysplasia enhances NO-mediated apoptosis in lymphocytes.  Physiol Rep. Vol. 4, no. 22. (November): ee13041.
  • Nelin, LD, White, HA, Jin, Y, Trittmann, JK, Chen, B, Liu, Y. 2016. The Src family tyrosine kinases src and yes have differential effects on inflammation-induced apoptosis in human pulmonary microvascular endothelial cells.  Am J Physiol Long Cell Mol Physiol. Vol. 310, no. 9. (May): L880-8.
  • Trittmann, JK, Gastier-Foster, JM, Zmuda, EJ, Frick, J, Rogers, LK, Vieland, VJ, Chicoine, LG, Nelin, LD. 2016. A single nucleotide polymorphism in the dimethylarginine dimethylaminohydrolase gene is associated with lower risk of pulmonary hypertension in bronchopulmonary dysplasia.  Acta Paediatr. Vol. 105, no. 4. (April): e170-5.
  • Trittmann,Jennifer,K; Peterson,Eric; Rogers,Lynette,K; Chen,Bernadette; Backes,Carl,H; Klebanoff,Mark,A; Nelin,Leif,D. 2015. Plasma Asymmetric Dimethylarginine Levels Are Increased in Neonates with Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension.  JOURNAL OF PEDIATRICS. Vol. 166, no. 2. (February): 230-233.
  • Trittmann, JK; Peterson, E; Rogers, LK; Chen, B; Backes,CH; Klebanoff, MA; Nelin, LD. 2015. Plasma asymmetric dimethylarginine levels are increased in neonates with bronchopulmonary dysplasia-associated pulmonary hypertension.
  • Trittmann, JK; Zmuda, EJ; Gastier-Foster, JM; Vieland, VJ; Klebanoff, MA; Rogers, LK; Vaynshtok, PM; Peterson, EE; Nelin, LD. 2014. Biomarkers in the arginine metabolome predict pulmonary hypertension in patients with bronchopulmonary dysplasia. In International Conference of the Nitric-Oxide-Society
  • Trittmann JK, Zmuda EJ, Vaynshtok PM, Nelin LD, Gastier-Foster JM, Vieland VJ, Klebanoff MA. 2014. Arginase I gene single nucleotide polymorphism associated with decreased risk of pulmonary hypertension in bronchopulmonary dysplasia.  ACTA PAEDIATRICA. Vol. 10, no. 103. (October): 439-443.
  • Trittmann,J,K; Nelin,L,D; Klebanoff,M,A. 2013. Bronchopulmonary dysplasia and neurodevelopmental outcome in extremely preterm neonates.  EUROPEAN JOURNAL OF PEDIATRICS. Vol. 172, no. 9. (September): 1173-1180. PubMed ID: 23644648
  • Trittmann JK, Nelin LD, Vaynshtok PM, Zmuda EJ, Gastier-Foster JM, Vieland VJ, Klebanoff MA. 2013. Genetic risk factors for pulmonary hypertension in premature neonates with bronchopulmonary dysplasia. In Pediatric Academic Societies
  • Moorehead PA, Backes CH, Reber KM, Trittmann JK, Huang H, Bauer JA, Mahan JD. 2011. Fellows as teachers: enhancing pediatric resident education. In Pediatric Academic Societies
  • Backes,Carl,H; Reber,Kris,M; Trittmann,Jennifer,KB; Huang,Hong; Tomblin,Jordanna; Moorehead,Pamela,A; Bauer,John,A; Smith,Charles,V; Mahan,John,D. 2011. Fellows as teachers: a model to enhance pediatric resident education.
  • Backes,Carl,H; Reber,Kris,M; Trittmann,Jennifer,K; Huang,Hong; Tomblin,Jordanna; Moorehead,Pamela,A; Bauer,John,A; Smith,Charles,V; Mahan,John,D. 2011. Fellows as teachers: a model to enhance pediatric resident education.  MEDICAL EDUCATION ONLINE. Vol. 16, no. January: 1-9. PubMed ID: 21912479
  • Backes,Carl,H; Reber,Kris,M; Trittmann,Jennifer,KB; Huang,Hong; Tomblin,Jordanna; Moorehead,Pamela,A; Bauer,John,A; Smith,Charles,V; Mahan,John,D. 2011. Fellows as teachers: a model to enhance pediatric resident education.  MEDICAL EDUCATION ONLINE. Vol. 16, no. January: e7205.
  • Trittmann JK, Hitchner J, Martin EM, Welty SE, Nelin LD. 2010. Bronchopulmonary dysplasia in the extremely preterm infant from an all referral NICU. In Pediatric Academic Societies
  • Trittmann JK, Cui H, Nelin LD. 2009. Inflammatory cytokines induce cationic amino acid transporter-2 expression via a src tyrosine kinase dependent mechanism in human pulmonary microvascular endothelial cells. In Pediatric Academic Societies
  • Trittmann JK, Peterson EE, Vaynshtok P, Gastier-Foster JM, Zmuda EJ, Rogers LK, Klebanoff MA, Nelin LD. Predicting risk factors for the evolution of pulmonary hypertension in bronchopulmonary dysplasia. In The Jackson Laboratory 53rd Annual Short Course on Medical and Experimental Mammalian Genetics.
  • Trittmann JK, Rogers LK, Peterson E, Klebanoff MA, Nelin LD. Asymmetric dimethylarginine levels are elevated in preterm neonates with pulmonary hypertension and bronchopulmonary dysplasia. In Pediatric Academic Societies

Awards, Honors and Organizations

  • Member, American Academy of Pediatrics
  • Member, American Physiological Society, Respiratory Section
  • Member, March of Dimes
  • Member, Society for Pediatric Research
  • Member, American Thoracic Society
  • Member, American Academy of Pediatrics, Neonatal-Perinatal Section
  • Member, Nitric Oxide Society
  • Member, Ohio American Academy of Pediatrics
  • Member, NIH LRP Ambassador Program
Nationwide Children's Hospital
700 Children's Drive Columbus, Ohio 43205 614.722.2000