Jeffrey R. O'Connell, Ph.D

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Gender:

• Male

Languages Spoken:

• English

Research Center:

• Battelle Center for Mathematical Medicine

Areas of Interest:

• My primary research focus is developing statistical and mathematical models for linkage and haplotype analysis. My current research projects include developing a new hidden Markov model for computing the likelihood of pedigree data, implementing new haplotyping algorithms based on sequential imputation that can incorporate linkage disequilibrium for fine mapping with SNP data. In addition, I am developing approximation methods for computing likelihoods of the large complex pedigrees that we have in our Amish family studies.

Undergraduate School

• University of Delaware
  Date Completed: 06/30/1979

Graduate School

• Drexel University
  Date Completed: 06/30/1984

Post Doctoral

• Drexel University
  Date Completed: 06/30/1990

Post Doctoral

• University of Oxford
  Date Completed: 06/30/2000

2002–present

• Assistant Professor, Division of Endocrinology, Diabetes and Nutrition, University of Maryland

2004–2005

• Adjunct Assistant Professor, Center for Statistical Genetics Research, University of Iowa

2000–2002

• Assistant Professor, Department of Human Genetics, University of Pittsburgh

1993–2000

• Programmer Analyst, University of Pittsburgh

1986–1993

• Mathematics Instructor, Math Department, Drexel University

1985–1986

• Mathematics Lecturer, University of Maryland, Pacific Division, Seoul, South Korea

1982–1984

• Teaching Assistant, Math Department, Drexel University

• Gillanders EM, Pearson JV, Sorant AJ, Trent JM, O'Connell JR, Bailey-Wilson JE.  The value of molecular haplotypes in a family-based linkage study.  Am J Hum Genet 79(3):458-468.  2006. PubMed ID: 16909384
• Zeggini E, Damcott CM, Hanson RL, Karim MA, Rayner NW, Groves CJ, Baier LJ, Hale TC, Hattersley AT, Hitman GA, Hunt SE, Knowler WC, Mitchell BD, Ng MC, O'Connell JR, Pollin TI, Vaxillaire M, Walker M, WAng X, Whittaker P, Xiang K, Jia W, Chan JC, Froguel P, Deloukas P, Shuldiner AR, Elbein SC, McCarthy MI, International Type 2 Diabetes 1q Consorium.  Variation within the gene encoding the upstream stimulatory factor 1 does not influence susceptibility to type 2 diabetes in samples from populations with replicated evidence of linkage to chromosome 1q.  Diabetes (11):3197.  2006. PubMed ID: 16936202
• Song Q, Cole JW, O'Connell JR, Stine OC, Gallagher M, Giles WH, Mitchell BD, Wozniak MA, Stern BJ, Sorkin JD, McArdie PF, Naj AC, Xu Q, Gibbons GH, Kittner SJ.  Phosphodiesterase 4D polymorphisms and the risk of cerebral infarction in a biracial poulation:  the Stroke Prevention in Young Women Study.  Hum Mol Genet 15(16)2468-2478.  2006 PubMed ID: 16835261
• Damcott CM, Ott SH, Pollin TI, Reinhart LJ, Wang J, O'Connell JR, Mitchell BD, Shuldiner AR.  Genetic variation in adiponectin receptor 1 and adiponectin receptor 2 is associated with type 2 diabetes in the Old Order Amish.  Diabetes 54(7):2245-2250.  2005 PubMed ID: 15983228
• Steinle NI, Pollin TI, O'Connell JR, Mitchell BD, Shuldiner AR.  Variants in the ghrelin gene are associated with metabolic syndrome in the Old Order Amish.  J Clin Endocrinol Metab 90(12):6672-6677.  2005. PubMed ID: 16204371
• Sabra MM, Damcott C, Fu M, Ott S, O'Connell JR, Mitchell BD, Shuldiner AR.  Vesicle-associated membrane protein 4, a positional candidate gene on 1q24-q25, is not associated with type 2 diabetes in the Old Order Amish.  Mol Genet Metab 85(2):133-139.  2005. PubMed ID: 15896658
• McArdle PF, Pollin TI, O'Connell JR, Sorkin JD, Agarwala R, Schaffer AA, Streeten EA, King TM, Shuldiner AR, Mitchell BD. Does having children extend life span? A genealogical study of parity and longevity in the Amish. J Gerontol A Biol Sci Med Sci, 61(2):190-196. 2006. PubMed ID: 16510865
• Song Q, Cole JW, O'Connell JR, Stine OC, Gallagher M, Giles WH, Mitchell BD, Wozniak MA, Stern BJ, Sorkin JD, McArdie PF, Naj AC, Xu Q, Gibbons GH, Kittner SJ. Phosphodiesterase 4D polymorphisms and the risk of cerebral infarction in a biracial poulation: the Stroke Prevention in Young Women Study. Hum Mol Genet 15(16)2468-2478. 2006 PubMed ID: 16835261