Irina Alexandra Buhimschi, MD :: Nationwide Children's Hospital, Columbus, Ohio

Irina Alexandra Buhimschi, MD

Irina Alexandra Buhimschi, MD

Contact Information

700 Children's Drive
Columbus, OH 43205 [ map ]
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Biography

Dr. Irina Buhimschi serves as director of the Center for Perinatal Research at Nationwide Children's Hospital. She is also a tenured professor in the Department of Pediatrics and Obstetrics/Gynecology at The Ohio State University College of Medicine.

Gender:

  • Female

Languages Spoken:

  • English
  • Romanian

Research Interests

Research Center:

Research Funding*:

  • ID#: March of Dimes Ohio Collaborative

    Role on Project: Theme 5 Leader

    Direct costs per year: $187,821

    Total direct costs for project period: $619,809 (first 3 years)

    Project period: 10/01/2014 – 2/29/2016 – 2/29/2018
  • ID#: OAA-12-000027/SOL-OAA-13

    Type: Saving Lives at Birth Transition Grant

    PI: Irina A. Buhimschi

    Direct costs per year: $414,297

    Total direct costs for project period: $1,657,191

    Project period: 01/01/2014 – 12/31/2017

  • ID#: R01 HD062007-01

    Type: R01 (Investigator Initiated)

    PI: Irina A. Buhimschi & Catalin S. Buhimschi (MPI)

    Direct costs per year: $250,000

    Total direct costs for project period: $1,000,000

    Project period: 09/01/2010 – 05/31/2015

Education and Training

Medical School

  • University of Medicine and Pharmacy "Carol Davila," Bucharest, Romania
    Date Completed: 06/30/1990

Post Doctoral

  • Postdoctoral Fellow, Department of Obstetrics, Gynecology & Reproductive Sciences, University of Texas Medical Branch, Galveston, Texas
    Date Completed: 06/30/1995

Master's

  • University of Texas Medical Branch, Galveston, Texas
    Date Completed: 06/30/1995

Post Doctoral

  • Postdoctoral Fellow, Department of Obstetrics & Gynecology, Division of Perinatal Research, University of Maryland School of Medicine, Baltimore, Maryland
    Date Completed: 06/30/1999

Section:

  • Center for Perinatal Research

Date of Appointment at Nationwide Children’s Hospital:

  • 04/01/2013

Professional Experience

2013–present

  • Director, Center for Perinatal Research, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio

2013–present

  • Professor (with tenure), Department of Pediatrics & Obstetrics/ Gynecology, The Ohio State University College of Medicine, Columbus, Ohio

2008–2013

  • Associate Professor, Department of Obstetrics, Gynecology & Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut

2005–2013

  • Research Personnel, Yale Biomedical Center of High Performance Computing

2005–2008

  • Assistant Professor, Department of Obstetrics, Gynecology & Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut

2003–2005

  • Associate Research Scientist, Department of Obstetrics, Gynecology & Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut

2001–2003

  • Assistant Professor, Department of Obstetrics & Gynecology, Division of Maternal Fetal Medicine, Wayne State University, Detroit, Michigan

1999–2001

  • Assistant Professor, Department of Obstetrics & Gynecology, Division of Perinatal Research, University of Maryland School of Medicine, Baltimore, Maryland

1997–1999

  • Postdoctoral Fellow, Department of Obstetrics & Gynecology, Division of Perinatal Research, University of Maryland School of Medicine, Baltimore, Maryland

1995–1997

  • Postdoctoral Fellow, Deptartment of Obstetrics, Gynecology & Reproductive Sciences, University of Texas Medical Branch, Galveston, Texas

1993–1995

  • Graduate Student, Graduate School of Biomedical Sciences, University of Texas Medical Branch, Galveston, Texas

1991–1993

  • Resident, Obstetrics & Gynecology, Filantropia Clinical Hospital, Bucharest, Romania

1990–1991

  • Intern, Obstetrics & Gynecology, Filantropia Clinical Hospital, Bucharest, Romania

Publications

  • Oliver, EA, Reagan, PB, Slaughter, JL, Buhimschi, CS, Buhimschi, IA. 2016. Patterns of empiric antibiotic administration for presumed early-onset neonatal sepsis in neonatal intensive care units in the United States.  Am J Perinatol. Vol. Epub, no. December: ee.
  • Shook, LL, Buhimschi, CS, Dulay, AT, McCarthy, ME, Hardy, JT, Duzyj Buniak, CM, Zhao, G, Buhimschi, IA. 2016. Calciprotein particles as potential etiologic agents of idiopathic preterm birth.  Sci Transl Med. Vol. 8, no. November: e364.
  • Archabald, KL, Buhimschi, IA, Bahtiyar, MO, Dulay, AT, Abdel-Razeq, SS, Pettker, CM, Lipkind, HS, Hardy, JT, McCarthy, ME, Zhao, G, Bhandari, V, Buhimschi, CS. 2016. Limiting the exposure of select fetuses to intrauterine infection/inflammation improves short-term neonatal outcomes in preterm premature rupture of membranes.  Fetal Diagn Ther. Vol. Epub, no. October: ee.
  • Rood, KM, Buhimschi, IA, Rodewald Millen, K, Bahtiyar, MO, Thung, S, Summerfield, T Zhao, G, Ackerman, WE, 4th, Shellhaas, C, Samuels, P, Buhimschi, CS. 2016. Evidence for participation of neutrophil gelatinase-associated lipocalin/matrix metalloproteinase-9 (NGAL.MMP-9) complex in the inflammatory response to infection in pregnancies complicated by preterm birth.  AM J Reprod Immunol. Vol. 76, no. 2. (August): 108-17.
  • Ackerman, WE, 4th, Buhimschi, IA, Eidem HR, Rinker, DC, Rokas, A, Rood, K, Zhao, G, Summerfield, TL, Landon, MB, Buhimschi, CS. 2016. Comprehensive RNA profiling of villous trophoblast and decidua basalis in pregnancies complicated by preterm birth following intra-amniotic infection.  Placenta. Vol. 44, no. August: 23-33.
  • Hardy, JT, Buhimschi, IA, McCarthy, ME, Zhao, G, Laky, CA, Shook, LL, Buhimschi, CS. 2016. Imbalance of amniotic fluid activin-A and follistatin in intraamniotic infection, inflammation, and preterm birth.  J Clin Endocrinol Metab. Vol. 7, no. July: 2785-93.
  • Buhimschi, IA, Nayeri, UA, Zhao, G, Shook, LL, Pensalfini, A, Funai, EF, Bernstein, IM, Glabe, CG, Buhimschi, CS. 2016. Protein misfolding, congophilia, oligomerization and defective amyloid processing in preeclampsia.  Sci Transl Med. Vol. 6, no. 245. (July): e245ra92.
  • Zuckerwise, L, Li, J, Lu, L, Men, Y, Geng, T, Buhimschi, CS, Buhimschi, IA, Bukowski, R, Guller, S, Paidas, M, Huang, Y. 2016. H19 long noncoding RNA alters trophoblast cell migration and invasion by regulating TBR3 in placentae with fetal growth restriction.  Oncotarget. Vol. 7, no. 25. (June): 38398-38407.
  • Eidem, HR, Rinker, DC, Ackerman, WE, 4th, Buhimschi, IA, Buhimschi, CS, Dunn-Fletcher, C, Kallapur, SG, Pavlicev, M, Muglia, LJ, Abbot, P, Rokas, A. 2016. Compairing human and macaque placental transcriptomes to disentangle preterm birth pathology from gestational age effects.  Placenta. Vol. 41, no. May: 74-82.
  • Baumbusch, MA, Buhimschi, CS, Oliver, EA, Zhao, G, Thung, S, Rood, K, Buhimschi, IA. 2016. High Mobility Group-Box 1 (HMGB1) levels are increased in amniotic fluid of women with intra-amniotic inflammation-determined preterm birth, and the source may be the damaged fetal membranes.  Cytokine. Vol. 81, no. May: 82-7.
  • Higgins, RD, Saade, G, Polin, RA, Grobman, WA, Buhimschi, IA, Watterberg, K, Silver, RM, Raju, TN. 2016. Evaluation and management of women and newborns with a maternal diagnosis of chorioamnionitis: summary of a workshop.  obstet Gynecol. Vol. 127, no. 3. (March): 426-36.
  • Klebanoff, MA, Yossef-Salameh, L, Latimer, C, Oza-Frank, R, Kachoria, R, Reagan, PB, Oliver, EA, Buhimschi, CS, Buhimschi, IA. 2016. Development and validation of an algorithm to determine spontaneous versus provider-initiated preterm birth in US vital records.  Paediatr Perinat Epidemiol. Vol. 30, no. 2. (March): 134-40.
  • Jonas, SM, Deserno, TM, Buhimschi, CS, Makin, J, Choma, MA, Buhimschi, IA. 2016. Smartphone-based diagnostic for preeclampsia: an mHealth solution for administering the Congo Red Dot (CRD) test in settings with limited resources.  J Am Med Inform Assoc. Vol. 23, no. 1. (January): 166-73.
  • Guzeloglu-Kayisli, UA, Semerci, N, Basar, M, Buchwalder, LF, Buhimschi, CS, Buhimschi, IA, Arcuri, F, Larsen, K, Huang, JS, Schatz, F, Lockwood, CJ. 2015. Mechanisms of chorioamnionitis-associated preterm birth: interleukin-1B inhibits progesterone receptor expression in decidual cells.  J Pathol. Vol. 237, no. 4. (December): 412-34.
  • Dulay, AT, Buhimschi, IA, Zhao, G, Bahtiyar, MO, Thung, SF, Cackovic, M, Buhimschi, CS. 2015. Compartmentalizaion of acute phase reactants Interleukin-6, C-Reactive Protein and Procalcitronin as biomarkers of intra-amniotic infection and chorioamnionitis.  Cytokine. Vol. 76, no. 2. (December): 236-43.
  • Papanna, R, Mann, LK, Moise, KJ, Jr, Kyriakides, T, Johnson, A, Garcia, E, Buhimschi, CS, Buhimschi, IA. 2015. Histologic changes of the fetal membranes after fetoscopic laser surgery for twin-twin transfusion syndrome.  Pediatr Res. Vol. 78, no. 3. (September): 247-55.
  • Dulay, AT, Buhimschi, CS, Zhao, G, Oliver, EA, Abdel-Razeq, SS, Shook, LL, Bahtiyar, MO, Buhimschi, IA. 2015. Amniotic fluid soluble myeloid differentiation-2 (sMD-2) as regulator of intra-amniotic inflammation in infection-induced preterm birth.  Am J Reprod Immunol. Vol. 73, no. 6. (June): 507-21.
  • Allen, TK, Feng, L, Nazzal, M, Grotegut, CA, Buhimschi, IA, Murtha, AP. 2015. The effect of progestins on tumor necrosis factor a-induced matrix metalloproteinase-9 activity and gene expression in human primary amnion and chorion cells in vitro.  Anesth Analg. Vol. 120, no. 5. (May): 1085-94.
  • Nayeri, UA, Buhimschi, IA, Laky, CA, Cross, SN, Duzyj, CM, Ramma, W, Sibai, BM, Funai, EF, Ahmed, A, Buhimschi, CS. 2014. Antenatal corticosteroids impact the inflammatory rather than the antiangiogenic profile of women with preclampsia.  Hypertension. Vol. 63, no. 6. (June): 1285-92.
  • Papanna R, Block-Abraham D, Mann LK, Buhimschi IA, Bebbington M, Garcia E, Kahlek N, Harman C, Johnson A, Baschat A, Moise KJ Jr. Risk factors associated with preterm delivery after fetoscopic laser ablation for twin-twin transfusion syndrome (TTTS). Ultrasound Obstet Gynecol. Epub Sept 6, 2013
  • Wang, K, Ahmad, S, Cai, M, Tennie, J, Fujisawa, T, Crispi, F, Baily, J, Miller, MR, Cudmore, M, Hadoke, PW, Wang, R, Gratacos, E, Buhimschi, IA, Buhimschi, CS, Ahmed, A. 2013. Dysregulation of hydrogen sulfide producing enzyme cystahionine y-lyase contributes to maternal hypertension and placental abnormalities in preeclampsia.  Circulation. Vol. 127, no. 25. (June): 2514-22.
  • Wang K, Ahmad S, Cai M, Rennie J, Fujisawa T, Crispi F, Baily J, Miller MR, Cudmore MJ, Hadoke PWF, Wang R, Gratacós E, Buhimschi IA, Buhimschi CS, Ahmed AA. Dysregulation of the hydrogen sulfide (H2S) producing enzyme cystathionine ?-lyase (CSE) contributes to maternal hypertension and placental abnormalities in preeclampsia. Circulation. Epub 2013 May 23. PubMed ID: 23704251
  • Tang Z, Buhimschi IA, Buhimschi CS, Tadesse S, Norwitz E, Niven-Fairchild T, Huang ST, Guller S. Decreased levels of folate receptor-ß and reduced numbers of fetal macrophages (Hofbauer Cells) in placentas from pregnancies with severe pre-eclampsia. Am J Reprod Immunol. Epub 2013 Mar 11. PubMed ID: 23480364
  • Wang X, Buhimschi CS, Temoin S, Bhandari V, Han YW, Buhimschi IA. Comparative microbial analysis of paired amniotic fluid and cord blood from pregnancies complicated by preterm birth and early-onset neonatal sepsis. PLoS ONE. 8(2):e56131. Epub 2013 Feb 20. PubMed ID: 23437088
  • Tang, Z, Niven-Fairchild, T, Tadesse, S, Norwitz, ER, Buhimschi, CS< Buhimschi, IA, Guller, S. 2013. Glucocorticoids enhance CD163 expression in placental Hofbauer cells.  Endocrinolgy. Vol. 154, no. 1. (January): 471-82.
  • Buhimschi, IA, Nayeri, UA, Laky, CA, Razeq, SA, Dulay, AT, Buhimschi, CS. 2013. Advances in medical diagnosis of intra-amniotic infection.  Expert Opin Med Diagn. Vol. 7, no. 1. (January): 5-16.
  • Buhimschi,Irina,A. 2012. Using SELDI-TOF mass spectrometry on amniotic fluid and for clinical proteomics and theranostics in disorders of pregnancy.  Methods in molecular biology (Clifton, N.J.). Vol. 818, no. January: 171-197.
  • Buhimschi,Irina,A; Zhao,Guomao; Pettker,Christian,M; Bahtiyar,Mert,O; Magloire,Lissa,K; Thung,Stephen; Fairchild,Tracy; Buhimschi,Catalin,S. 2007. The receptor for advanced glycation end products (RAGE) system in women with intraamniotic infection and inflammation.  American journal of obstetrics and gynecology. Vol. 196, no. 2. (February): 181 e1-13.

Awards, Honors and Organizations

  • DevelopmentXChange Saving Lives at Birth Transition Grant Nominee, 2013
  • Society for Maternal Fetal Medicine, Research Excellence Award, 2000, 2005, 2008 (twice), 2009 (twice), 2010, 2011, 2012
  • Elected on Perinatal Research Society Council (Basic Science), 2011
  • NICHD “Vision” Workshop on Pregnancy & Pregnancy Outcomes, 2011
  • March of Dimes Award for Best Research in Prematurity, 2006
  • Perinatal Research Society [basic science section] membership (elected), 2005
  • Society for Obstetric Anesthesia and Perinatology, the Zuspan Award, 2004
  • Perinatal Research Society, Young Investigator Award, 2000
  • Lalor Burdik Foundation, Frontiers in Human Reproduction Fellowship Award, 1999
  • International Federation of Gynecology & Obstetrics, Prize Paper, 1994

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