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The specialists in the Division of Infectious Diseases at Nationwide Children’s Hospital provide expertise in diagnosis and management for children with all types of acute and chronic infections or immunodeficiency disorders. Research is conducted through the Division and in collaboration with the Center for Microbial Pathogenesis and the Center for Vaccines and Immunity, as well as other centers in The Research Institute.
Physicians provide direct care for patients admitted to Nationwide Children’s specialized Infectious Diseases Unit. In addition, our physicians care for patients with complicated infectious diseases or immunodeficiency disorders throughout the rest of the hospital, in close partnership with the primary care teams.
We have developed close collaborations with physicians in Hematology/Oncology/BMT, Pediatric Critical Care, Cardiology, Lung and Heart Transplant, Neonatology and the different surgical departments to optimize the infectious diseases-related care of those patients. Patients are evaluated as outpatients following referral to the Infectious Diseases Clinic, the Pediatric Tuberculosis Clinic, and the Immune Deficiency Clinic, all of which are located at Nationwide Children’s main campus.
The Division of Infectious Diseases continues to expand the breath of our clinical activities to help manage complex infections across all hospital units, both in the specialized Infectious Diseases Inpatient Unit and with a major growth of the Infectious Diseases Consult Service. In parallel, we have made significant progress with implementation of several Quality Initiative projects. Among them it is worthwhile underscoring the successful initiation of the Antimicrobial Stewardship Program, led by Preeti Jaggi, MD, and William Barson, MD.
This hospital-wide initiative is designed to optimize the use of antimicrobial agents across all clinical services by selecting the most appropriate antimicrobial agent for each type of infection and simultaneously trying to reduce the emergence of antibiotic-resistant bacteria that are so difficult to treat. Another innovative program led by Monica Ardura, DO, MSCS, in collaboration with Jane Balint, MD, from the Division of Gastroenterology at Nationwide Children’s, was the implementation of a new bundle protocol that has markedly reduced the central catheter-associated blood stream infections in patients with intestinal failure.
Finally, Dennis Cunningham Jr., MD, played a major role in a statewide initiative to reduce surgical-site infections. We have continued to strengthen our research collaborations with colleagues in the Center for Microbial Pathogenesis and the Center for Vaccines and Immunity, and we developed novel clinical research programs in a variety of pediatric infections including adenovirus (Dr. Jaggi, Amy Leber, PhD, and current fellow Eunkyung Song, MD); cytomegalovirus (Pablo Sanchez, MD, Asuncion Mejias, MD, PhD, MSCS, and current fellow Christopher Ouellette, MD); pneumococcus (Dr. Barson and Guliz Erdem, MD); tuberculosis (W. Garrett Hunt, MD); hepatitis (Jonathan Honegger, MD, and Chris Walker, PhD); rhinovirus (Dr. Mejias, current fellow Katherine Moyer, DO, and Santtu Heinonen) as well as pediatric pneumonia (Rebecca Wallihan, MD, and Octavio Ramilo, MD).
Infectious Diseases Faculty
Octavio Ramilo, MD
William J. Barson, MD
Selected Infectious Diseases Publications
Ardura MI, Lewis J, Tansmore JL, Harp PL, Dienhart MC, Balint JP. Central catheterassociated bloodstream infection reduction with ethanol lock prophylaxis in pediatric intestinal failure: broadening quality improvement initiatives from hospital to home. JAMA Pediatrics. 2015 Apr;169(4):324-31.
Dong S, Bout-Tabaku S, Texter K, Jaggi P. Diagnosis of systemic-onset juvenile idiopathic arthritis after treatment for presumed Kawasaki disease.The Journal of Pediatrics. 2015 May;166(5):1283-8.
Olarte L, Barson WJ, Barson RM, Lin PL, Romero JR, Tan TQ, Givner LB, Bradley JS, Hoffman JA, Hultén KG, Mason EO, Kaplan SL. Impact of the 13-valent pneumococcal conjugate vaccine on pneumococcal meningitis in US children. Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America. 2015 Sep;61(5):767-75.
Toltzis P, O’Riordan M, Cunningham DJ, Ryckman FC, Bracke TM, Olivea J, Lyren A. A state-wide collaborative to reduce pediatric surgical site infections. Pediatrics. 2014 Oct;134(4):e1174-80.
Wallihan R, Ramilo O. Community-acquired pneumonia in children: current challenges and future directions. The Journal of Infection. 2014 Nov; 69(suppl 1):S87-90.
The Center for Microbial Pathogenesis
Center for Vaccines and Immunity