Infectious Diseases Annual Report :: Nationwide Children's Hospital

Infectious Diseases 2014-2015 Annual Report

View the Nationwide Children's Hospital 2014-2015 Annual Report.

The specialists in the Division of Infectious Diseases at Nationwide Children’s Hospital provide expertise in diagnosis and management for children with all types of acute and chronic infections or immunodeficiency disorders. Research is conducted through the Division and in collaboration with the Center for Microbial Pathogenesis and the Center for Vaccines and Immunity, as well as other centers in The Research Institute.

Physicians provide direct care for patients admitted to Nationwide Children’s specialized Infectious Diseases Unit. In addition, our physicians care for patients with complicated infectious diseases or immunodeficiency disorders throughout the rest of the hospital, in close partnership with the primary care teams.

We have developed close collaborations with physicians in Hematology/Oncology/BMT, Pediatric Critical Care, Cardiology, Lung and Heart Transplant, Neonatology and the different surgical departments to optimize the infectious diseases-related care of those patients. Patients are evaluated as outpatients following referral to the Infectious Diseases Clinic, the Pediatric Tuberculosis Clinic, and the Immune Deficiency Clinic, all of which are located at Nationwide Children’s main campus.


The Division of Infectious Diseases continues to expand the breath of our clinical activities to help manage complex infections across all hospital units, both in the specialized Infectious Diseases Inpatient Unit and with a major growth of the Infectious Diseases Consult Service. In parallel, we have made significant progress with implementation of several Quality Initiative projects. Among them it is worthwhile underscoring the successful initiation of the Antimicrobial Stewardship Program, led by Preeti Jaggi, MD, and William Barson, MD.

This hospital-wide initiative is designed to optimize the use of antimicrobial agents across all clinical services by selecting the most appropriate antimicrobial agent for each type of infection and simultaneously trying to reduce the emergence of antibiotic-resistant bacteria that are so difficult to treat. Another innovative program led by Monica Ardura, DO, MSCS, in collaboration with Jane Balint, MD, from the Division of Gastroenterology at Nationwide Children’s, was the implementation of a new bundle protocol that has markedly reduced the central catheter-associated blood stream infections in patients with intestinal failure.

Finally, Dennis Cunningham Jr., MD, played a major role in a statewide initiative to reduce surgical-site infections. We have continued to strengthen our research collaborations with colleagues in the Center for Microbial Pathogenesis and the Center for Vaccines and Immunity, and we developed novel clinical research programs in a variety of pediatric infections including adenovirus (Dr. Jaggi, Amy Leber, PhD, and current fellow Eunkyung Song, MD); cytomegalovirus (Pablo Sanchez, MD, Asuncion Mejias, MD, PhD, MSCS, and current fellow Christopher Ouellette, MD); pneumococcus (Dr. Barson and Guliz Erdem, MD); tuberculosis (W. Garrett Hunt, MD); hepatitis (Jonathan Honegger, MD, and Chris Walker, PhD); rhinovirus (Dr. Mejias, current fellow Katherine Moyer, DO, and Santtu Heinonen) as well as pediatric pneumonia (Rebecca Wallihan, MD, and Octavio Ramilo, MD).

2014-2015 Grants Awarded

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Infectious Diseases

Barson, William
The United States Pediatric Multi-Center Pneumococcal Surveillance Study Group 
Baylor College of Medicine
Industry Sponsor
$55,200
 
Malvestutto, Carlos
Ryan White HIV Care:  Outpatient Ambulatory Services
Columbus Public Health
HRSA
$179,348
 
HIV Counseling, Testing, Linkage and Retention In Care for Youth at risk for or with HIV Infection
HRSA
$100,000
 
Ryan White HIV Care: Medical Case Management
Columbus Public Health
HRSA
$91,814
 
Provision of Behavioral Health Services:  Ryan White HIV Care Mental Health
Columbus Public Health
HRSA
$87,324
 
Minority Health Diabetes Education Project
Ohio Commission on Minority Health
$75,000
 
Ramilo, Octavio 
RNA Biosignatures in the Emergency Evaluation of Young Febrile Infants 
Wayne State University
National Institutes of Health
$911,178
 
Systems Analysis of Vaccine Responses in Healthy and Hyporesponsive Humans
Baylor Research Institute
National Institutes of Health 
$475,000
 
Effects of Prenatal Maternal Stress on Transcriptional Immune Profiled in Women and Infants: Implications from Antibody Responses to Vaccines
The Ohio State University Medical Center
$25,000
 
FinnBrain Birth Cohort Study: Transcriptional Profile Analysis in Infants Exposed to Parental Prenatal Stress 
University of Turku
$15,000

Center for Vaccines and Immunity

Feng, Zongdi
Mechanism of Immune Control of Hepatitis E Virus
American Association for the Study of Liver Diseases
$300,000
 
Honegger, Jonathan
Phase 2 Open Label Study in Children with HCV
Industry Sponsor
$221,965
 
Peeples, Mark
Respiratory Syncytial Virus Targeting of the Human Airway Epithelium
National Institute of Allergy and Infectious Diseases
$362,000
 
Mechanism of Respiratory Syncytial Virus Fusion
National Institute of Allergy and Infectious Diseases
 $362,000
 
Respiratory Syncytial Virus Targeting of the Human Airway Epithelium
National Institute of Allergy and Infectious Diseases 
$47,000
 
Peptide vaccination studies 
Cystic Fibrosis Foundation
$37,594
 
Center Initiative for Harvesting Respiratory Epithelium from Cystic Fibrosis Patients
Cystic Fibrosis Foundation
$37,594
 
Respiratory Syncytial Virus Targeting of the Human Airway Epithelium
National Institute of Allergy and Infectious Diseases
$36,200
 
re:Viral Project
re: Viral Limited
$9,900
 
In vitro virus neutralization using A549 Human Cells
Industry Sponsor
$4,883
 
In vitro neutralization using A549 cells: Second Study
Industry Sponsor
$5,884
 
Walker, Christopher
Persistent hepatitis C virus replication and T cell immunity in pregnancy
National Institute of Allergy and Infectious Diseases
$584,545
 
Peptide vaccination studies 
Industry Sponsor
$125,129
 
HCV-Specific T Cell Responses
National Institute of Allergy and Infectious Diseases
$66,217

Center for Microbial Pathogenesis

Bakaletz, Lauren
Novel immunotherapeutics for the management of otitis media due to H. influenzae
National Institute on Deafness & Other Communication Disorders
$477,402 
 
Novel immunotherapeutics for the management of otitis media due to H. influenza
National Institute on Deafness & Other Communication Disorders 
$455,547
 
Determinants of H. influenzae Virulence in Otitis Media
National Institute on Deafness & Other Communication Disorders
$402,574
 
Biofilms in Human Medicine 
OSU College of Medicine
$8,083
 
White, Peter
Churchill Development Plan: Online Software as a Service
GenomeNext
$370,310
 
Chronic infection of the gallbladder by Salmonella
The Ohio State University
National Institutes of Health (NIH)
$132,544
 
Partida-Sanchez, Santiago
Novel Calcium Release Mechanism regulates Dendritic Cell function
National Institute of Allergy and Infectious Diseases
$362,000 
 
Targeting MicroRNA to Moderate Inflammation and CFTR Function in Cystic Fibrosis
Ohio State University
$5,000
 
Mason, Kevin
Disease severity of otitis media: Biofilms, invasion, and host responses
National Institute on Deafness & Other Communication Disorders
$329,625 
 
Disease severity of otitis media: Biofilms, invasion, and host responses
National Institute on Deafness & Other Communication Disorders
$70,000
 
Disease severity of otitis media: Biofilms, invasion, and host responses
National Institute on Deafness & Other Communication Disorders
$32,962
 
Edwards, Jennifer
Industry Study
Ohio State University
Industry Sponsor
$7,236


Infectious Diseases Faculty

Octavio Ramilo, MD
Division Chief

William J. Barson, MD
Section Chief

View Our Faculty »

Selected Infectious Diseases Publications

Ardura MI, Lewis J, Tansmore JL, Harp PL, Dienhart MC, Balint JP. Central catheterassociated bloodstream infection reduction with ethanol lock prophylaxis in pediatric intestinal failure: broadening quality improvement initiatives from hospital to home. JAMA Pediatrics. 2015 Apr;169(4):324-31.


Dong S, Bout-Tabaku S, Texter K, Jaggi P. Diagnosis of systemic-onset juvenile idiopathic arthritis after treatment for presumed Kawasaki disease.The Journal of Pediatrics. 2015 May;166(5):1283-8.


Olarte L, Barson WJ, Barson RM, Lin PL, Romero JR, Tan TQ, Givner LB, Bradley JS, Hoffman JA, Hultén KG, Mason EO, Kaplan SL. Impact of the 13-valent pneumococcal conjugate vaccine on pneumococcal meningitis in US children. Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America. 2015 Sep;61(5):767-75.


Toltzis P, O’Riordan M, Cunningham DJ, Ryckman FC, Bracke TM, Olivea J, Lyren A. A state-wide collaborative to reduce pediatric surgical site infections. Pediatrics. 2014 Oct;134(4):e1174-80.


Wallihan R, Ramilo O. Community-acquired pneumonia in children: current challenges and future directions. The Journal of Infection. 2014 Nov; 69(suppl 1):S87-90.

View Team Publications »

The Center for Microbial Pathogenesis

Center for Vaccines and Immunity

Nationwide Children's Hospital
700 Children's Drive Columbus, Ohio 43205 614.722.2000