Hakan Cam, PhD :: Nationwide Children's Hospital, Columbus, Ohio

Contact Information

The Research Institute at Nationwide Children's Hospital
700 Children's Drive
Columbus, Ohio 43205 [ map ]
PH: (614) 355.1998
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Dr. Cam earned his bachelor's degree in Biology from Cukurova University in Adana, Turkey, followed by his Master of Science in Molecular Biology at the Max Delbrück Center for Molecular Medicine at Humboldt University in Berlin, Germany. He completed his PhD in Molecular Tumor Biology at the Rudolf Virchow Center for Experimental Biomedicine at the University of Würzburg in Germany, before finishing postdoctoral research fellowships in Molecular Pharmacology and Biochemistry at St. Jude Children's Research Hospital. In 2010, Dr. Cam joined The Research Institute at Nationwide Children's Hospital as a principal investigator in the Center for Childhood Cancer and Blood Diseases and The Ohio State University as a professor of Pediatrics in the College of Medicine.

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  • Male

Languages Spoken:

  • English

Research Interests

Research Center:

Areas of Interest:

  • Dr. Cam's work has focused largely on pediatric sarcomas. Specifically, his research involves understanding the oncogenic p53 family members in the genesis of pediatric sarcomas, and developing approaches to inhibit these signaling pathways.

    The p53 family of tumor suppressor genes provides an important defense against cancer. In response to DNA damage and to oncogenic signaling the three proteins of this family - p53, p63 and p73 get activated and cooperate to induce cell cycle arrest or apoptosis resulting in restriction of tumor formation by eliminating potentially malignant cells. Importantly, alteration of this coordination often causes cancer.

    In addition, the most frequent mutations in cancer patients are found in the p53 tumor suppressor gene which normally functions as a "guardian of the genome" to prevent the development of tumors. This integrative function is assisted by p63 and p73. Despite the striking similarities among the p53 family members, their roles in tumorigenesis appear to be quite different.

    Dr. Cam's research therefore focuses on a comparative analysis of the three genes using genetic approaches in both pediatric cell culture and animal models to understand:
    - How do p53 and its family members suppress tumorigenesis?
    - How do the oncogenic p53 family members, e.g. Δ133p53, ΔNp53, ΔNp63 and ΔNp73 enhance tumor formation?
    - How do the p53 family members regulate gene expression?
    - How do the p53 family members interact with other signaling networks?

Education and Training

Undergraduate School

  • Cukurova University
    Date Completed: 06/30/1996

Graduate School

  • Max Delbrück Center for Molecular Medicine Humboldt University
    Date Completed: 06/30/2002

Post Doctoral

  • Rudolf-Virchow-Center for Experimental Biomedicine, University of Wuerzburg
    Date Completed: 06/30/2006


  • St.Jude Children’s Research Hospital
    Date Completed: 06/30/2010

Professional Experience


  • Principal Investigator, Center for Childhood Cancer, The Research Institute at Nationwide Children's Hospital, Columbus, OH


  • Cam M, Bid HK, Xiao L, Zambetti GP, Houghton PJ, Cam H. 2014. p53/TAp63 and AKT Regulate mTORC1 Signaling through two Independent Parallel Pathways in the Presence of DNA Damage.  J Biol Chem. Vol. 289, no. 7. (February): 4083-94.
  • Bid HK, Roberts RD, Cam M, Audino A, Kurmasheva RT, Lin J, Houghton PJ, Cam H. 2014. ?Np63 promotes pediatric neuroblastoma and osteosarcoma by regulating tumor angiogenesis.  Cancer Res. Vol. 74, no. 1. (January): 320-9.
  • Shen C, Oswald D, Phelps D, Cam H, Pelloski CE, Pang Q, Houghton PJ. 2013. Regulation of FANCD2 by the mTOR pathway contributes to the resistance of cancer cells to DNA double-strand breaks.  Cancer Res. Vol. 73, no. 11. (June): 3393-401.
  • Cam,Hakan; Houghton,Peter,J. 2011. Regulation of mammalian target of rapamycin complex 1 (mTORC1) by hypoxia: causes and consequences.  TARGETED ONCOLOGY. Vol. 6, no. 2. (June): 95-102.
  • Cam,Hakan; Easton,John,B; High,Anthony; Houghton,Peter,J. 2010. mTORC1 Signaling under Hypoxic Conditions Is Controlled by ATM-Dependent Phosphorylation of HIF-1 alpha.  MOLECULAR CELL. Vol. 40, no. 4. (November): 509-520.
  • Cam H, Easton JB, High A, Houghton PJ. mTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1α. Mol Cell. 2010 Nov 24;40(4):509-20. PubMed ID: 21095582
  • Cam,H; Houghton,PJ. 2008. mTOR: A critical regulator of p53 during a variety of stresses.  CELLSCIENCE. Vol. 4, no. 3. (January): ISSN: 1742-8130.
  • Cam H, Houghton PJ. mTOR: a critical regulator of p53 during a variety of stresses.  Cellscience. 2008 Jan; Vol. 4 No 3 ISSN 1742-8130
  • Cam,Hakan; Griesmann,Heidi; Beitzinger,Michaela; Hofmann,Lars; Beinoraviciute-Kellner,Rasa; Sauer,Markus; Huettinger-Kirchhof,Nicole; Oswald,Claudia; Friedl,Peter; Gattenloehner,Stefan; Burek,Christof; Rosenwald,Andreas; Stiewe,Thorsten. 2006. p53 family members in myogenic differentiation and rhabdomyosarcoma development.  CANCER CELL. Vol. 10, no. 4. (October): 281-293.
  • Huttinger-Kirchhof,N; Cam,H; Griesmann,H; Hofmann,L; Beitzinger,M; Stiewe,T. 2006. The p53 family inhibitor Delta Np73 interferes with multiple developmental programs.  CELL DEATH AND DIFFERENTIATION. Vol. 13, no. 1. (January): 174-177.
  • Cam H, Griesmann H, Beitzinger M, Hofmann L, Beinoraviciute-Kellner R, Sauer M,Hüttinger-Kirchhof N, Oswald C, Friedl P, Gattenlöhner S, Burek C, Rosenwald A, Stiewe T. p53 family members in muscle differentiation and rhabdomyosarcoma development. Cancer Cell. 2006 Oct;10(4):281-93. PubMed ID: 17045206
  • Huttinger-Kirchhof N, Cam H, Griesmann H, Hofmann L, Beitzinger M, Stiewe T.The p53 family inhibitor δNp73 interferes with multiple developmental programs. Cell Death Differ. 2006 Jan;13(1):174-7. PubMed ID: 16341031
  • Engels,B; Cam,H; Schuler,T; Indraccolo,S; Gladow,M; Baum,C; Blankenstein,T; Uckert,W. 2003. Retroviral vectors for high-level transgene expression in T lymphocytes.  HUMAN GENE THERAPY. Vol. 14, no. 12. (August): 1155-1168.
  • Engels B, Cam H, Schuler T, Indraccolo S, Gladow M, Baum C, Blankenstein T, Uckert W.Retroviral vectors for high-level transgene expression in T lymphocytes. Human Gene Ther. 2003 Aug 10;14(12):1155-68. PubMed ID: 12908967
Nationwide Children's Hospital
700 Children's Drive Columbus, Ohio 43205 614.722.2000