Greenberg Lab

Greenberg Lab

 
David Greenberg

David Greenberg, Ph.D.

David is a PhD and Principal Investigator in the Center with his interests focusing on the genetics of common disease in general and on the development of methodology for studying common disease genetics in particular. He also has the oldest and one of the largest studies in the genetics of idiopathic generalized epilepsy, with collaborations at more than 15 hospitals across the country. This research has been successful, with the identification of at least five areas of the genome that harbor genes for idiopathic generalized epilepsy, and the identification of two of the loci. His experience in real-world genetics as well as theory emphasizes the importance of understanding the clinical picture of disease in order to define the phenotype that will lead to a successful genetic analysis.

Dr. Greenberg has also developed analysis approaches and has been a leading advocate for the use of computer simulation in the study of genetic analysis. He has published extensively in computer simulation and developed the computer simulator used at the 11th and 14th Genetic Analysis Workshops. He has used his experience in genetic simulation to develop a suite of programs used to teach linkage analysis and association analysis to postdocs and students. This approach has been gratifyingly successful, with trainees developing a clear sense of the strengths and weakness of linkage methods and association methods. He has also supervised the development of a genetic data base analysis system with a web-based interface that allows researchers to conduct analysis experiments and vary phenotype definitions.

James Miller

James Miller

Dr. Miller received his PhD in Toxicology from The University of Michigan where he studied the effects of environmental toxins on mitochondrial function and cell death pathways in the CNS. Then he completed a postdoctoral fellowship at Colorado State University where his research focused on the roles of neuro-inflammation and early stress pathway activation in neuro-dengeneration and seizure.  James is in the Greenberg Lab focusing on understanding the molecular mechanisms responsible for the development of idiopathic generalized epilepsies, specifically juvenile myoclonic epilepsy (JME). Using transgenic mouse models, he is currently investigating whether defects in the development of the GABAergic inhibitory system may underlie susceptibility to JME.

Sandra Solove

Sandra Solove

Sandra has a BA from the University of Cincinnati, also a MA from University of Chicago and is a Licensed Independent Social Worker. She works in the Center as the Clinical Research Coordinator.  Sandra recruits and screens patients for a long-term multi-institution Family Study on the Genetics of Epilepsy. She maintains research documentation and communications for the study participants, IRB and regulatory bodies.

Emily Morris

Emily Morris

Emily received her Bachelor of Science at The Ohio State University in 2011. She currently is working toward her Master of Science in Evolution, Ecology, and Organismal Biology. She works as a Research Assistant in Dr. Greenberg’s lab. The main focus of her work is related to maintaining mouse colonies and utilizing the mouse model for related studies. As an assistant she has also received the skills and training for many other facets of the lab, including tissue culture and the sectioning and staining of tissue.

Darel Finley

Darel Finley

Darel is a Systems Programmer for the Greenberg Lab. He has served as a software developer for 25 years in the medical, manufacturing, and financial fields, including work for MD Anderson Cancer Center in Houston, TX, and Eli Lilly in Indianapolis, IN, as well as Chase, Nationwide Insurance, and AEP in Columbus, OH. He develops software for storage, analysis and graphical mapping of genetic data.

 

 

 

 

Nationwide Children's Hospital
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