| SELECTED PUBLICATIONS |
| Maitra, M., Schluterman, M.K., Nichols, H., Richardson, J.A., Lo, C., Srivastava, D. and Garg, V. “Interaction of Gata4 and Tbx5 is critical for normal cardiac development” Dev Biol, 326(2):368-77 (2009). PubMed ID: 19084512 |
| Pan, H., Richards, A.A., Xhu, X., Joglar, J.A., Yin, H.L., and Garg, V. “A novel mutation in LAMIN A/C is associated with isolated early-onset atrial fibrillation and progressive atrioventricular block followed by cardiomyopathy and sudden cardiac death” Heart Rhythm, 6(5):707-710 (2009). PubMed ID: 19328042 |
Giannone P.J., Luce W.A., Nankervis C.A., Hoffman T.M., Wold L.E. (2008) Necrotizing enterocolitis in neonates with congenital heart disease. Life Sciences. 82(7-8):341-7. PubMed ID: 18187159 |
| Eid AH, Chotani MA, Mitra S, Miller TJ, Flavahan S, Flavahan NA. 2008. Cyclic AMP acts through Rap1 and JNK signaling to increase expression of cutaneous smooth muscle α2C-adrenoceptors. Am J Physiol. Heart Circ Physiol. 295: H266-H272. PubMed ID: 18487435 |
| Giannone PJ, Luce WA, Nankervis CA, Hoffman TM, Wold LE. Necrotizing Enterocolitis in Neonates with Congenital Heart Disease. Life Sciences 2008 Feb 13; 82(7-8): 341-7. PubMed ID: 18187159 |
| Richards, A., Jaeckle, L., Nichols, H., Crider, B., Elder, F., Hauser, N., Zinn, A.R., and Garg, V. Cryptic chromosomal abnormalities identified in children with congenital heart disease and additional birth anomalies. Pediatr Res 64(4):358-363 (2008). PubMed ID: 18535492 |
| Shenouda SK, Lord KC, McIlwain E, Lucchesi PA, Varner KJ. Ecstasy produces left ventricular dysfunction and oxidative stress in rats. Cardiovasc Res. 2008 Jun 4. PubMed ID: 18495670 |
| Su J, Lucchesi PA, Gonzalez-Villalobos RA, Palen DI, Rezk BM, Suzuki Y, Boulares HA, Matrougui K. Role of Advanced Glycation End Products With Oxidative Stress in Resistance Artery Dysfunction in Type 2 Diabetic Mice. Arterioscler Thromb Vasc Biol. 2008 May 15. PubMed ID: 18483403 |
Saari J.T., Wold L.E., Duan J., Ren J., Carlson H.L., Bode A.M., Lentsch A.B., Zeng H., Schuschke D.A. (2007) Cardiac nitric oxide synthases are elevated in dietary copper deficiency. J Nutr Biochem. 18(7):443-448. PubMed ID: 16997540 |
Barcelo-Coblijn G., Wold L.E., Ren J., Murphy E.J. (2007) Prenatal ethanol exposure alters brain cholesterol content in adult rats. Lipids. Accepted. |
| Wold L.E., Dai W., Dow J.S., Kloner R.A. (2007) Stem cell therapy in the heart and vasculature. Methods Mol Med. 139:355-366. PubMed ID: 18287685 |
| Wold L.E., Ren J. Mechanical measurement of contractile function of isolated ventricular myocytes. (2007) Methods Mol Med. 139:263-270. PubMed ID: 18287678 |
| Bayoumi MM, Alkheraije KA, El-Sayed O, Wisel S, Sarker K, Chotani MA, Zweier JL, Nuovo G, Goldschmidt-Clermont PJ, Hassanain H. 2007. Vascular hypertrophy caused by transgenic overexpression of profilin 1. J Biol Chem. 282:37632-37639. PubMed ID: 17942408 |
| Eid A H, Maiti K, Mitra S, Chotani MA, Flavahan S, Bailey SR, Thompson-Torgerson CS, Flavahan NA. 2007. Estrogen increases smooth muscle expression of α2C-adrenoceptors and cold-induced constriction of cutaneous arteries. Am J Physiol. Heart Circ Physiol. 293: H1955-H1961. PubMed ID: 17644575 |
| Guggilam A, Haque M, Kerut EK, McIiwain E, Lucchesi PA, Sehgal I, Francis J. TNF? blockade decreases oxidative stress in the paraventricular nucleus and attenuates sympathoexcitation in heart failure rats. Am J Physiol Heart Circ Physiol. 293:H599-609, 2007. |
| Luce WA, Hoffman TM, Bauer JA. Developmental Influences on the Mechanisms, Treatment and Outcomes of Cardiovascular Dysfunction in Neonatal vs. Adult Sepsis. Critical Care. 2007;11(5):228. PubMed ID: 17903309 |
| Martin MM, Buckenberger JA, Jiang J, Malana GE, Nuovo GJ, Chotani M, Feldman DS, Schmittgen TD, Elton TS. 2007. The human angiotensin II type 1 receptor +1166 A/C polymorphism attenuates microRNA-155 binding. J Biol Chem. 282: 24262-24269. PubMed ID: 17588946 |
| Ryan TD, Rothstein EC, Aban I, Tallaj JA, Husain A, Lucchesi PA, Dell'Italia LJ. Left ventricular eccentric remodeling and matrix loss are mediated by bradykinin and precede cardiomyocyte elongation in rats with volume overload. J Am Coll Cardiol. 497:811-821, 2007. |
| Schluterman, M.K., Krysiak, A.E., Kathiriya, I.S., Abate, N., Chandalia, M., Srivastava, D., and Garg, V. “Screening and Biochemical Analysis of GATA4 Sequence Variations in Patients with Congenital Heart Disease”. Am J Med Genet A 143(8):817-823 (2007). PubMed ID: 17352393 |
| Zhang, X., Stewart, Jr., J.A., Kane, I.D., Massey, E.P., Cashatt, D.O., and Carver, W.E. Effects of elevated glucose on the interactions of cardiac fibroblasts with the extracellular matrix. In Vitro Cell Dev Biol , 2007. (Co-First Author). PubMed ID: 17849168 |
Wold L.E., Ceylan-Isik A.F., Fang C.X., Yang X., Li SY, Sreejayan N., Privratsky J.R. and J. Ren. (2006) Metallothionein alleviates cardiac dysfunction in streptozotocin-induced diabetes: Role of Ca(2+) cycling proteins, NADPH oxidase, Poly(ADP-Ribose) polymerase and myosin heavy chain isozyme. Free Radic Biol Med. 40(8):1419-1429. PubMed ID: 16631532 |
Wold L.E., Simkhovich B.Z., Kleinman M.T., Nordlie M.A., Dow J.S., Sioutas C., Kloner R.A. (2006) In vivo and in vitro models to test the hypothesis of particle-induced effects on cardiac function and arrhythmias. Cardiovasc Toxicol. 6(1):69-78. PubMed ID: 16845184 |
Nordlie, M.A., Wold L.E., Simkhovich B.Z., Sesti C. and R.A. Kloner. (2006) Molecular aspects of ischemic heart disease: Ischemia/reperfusion-induced genetic changes and potential applications of gene and RNAi therapy. J Cardiovasc Pharmacol Therapeut. 11(1):17-30. PubMed ID: 16703217 |
| Cismowski, M.J. (2006) Non-receptor activators of heterotrimeric G-protein signaling (AGS proteins). Sem. Cell Dev. Biol 17:334-44. PubMed ID: 16621626 |
| Garg, V. “Insights into the Genetic Basis of Congenital Heart Disease”. Cellular Molecular Life Sciences. 63(10):1141-1148 (2006). PubMed ID: 16568242 |
| Garg, V. “Molecular Genetics of Aortic Valve Disease”. Curr Opin in Cardiology 21(3): 180-184 (2006). PubMed ID: 16601454 |
| McNicholas-Bevensee. CM, DeAndrade, KB, Bradley, WE, Dell’Italia LJ, Lucchesi PA and Bevensee MO. Activation of gadolinium-sensitive ion channels in cardiomyocytes in early adaptive stages of volume-overload induced heart failure. Cardiovasc Res. 72:262-270, 2006 |
| Palen DI, Ouhtit A, Belmadani S, Lucchesi PA, Matrougui K. Hydrogen peroxide acts as relaxing factor in human vascular smooth muscle cells independent of MAP-kinase and nitric oxide. Front Biosci. 11:2526-34, 2006. |
| Rocic P, Rezk B, Lucchesi PA. PPAR-? agonists decrease hyperhomcysteinemia and cardiac dysfunction: new hope for ailing diabetic hearts? Am J Physiol Heart Circ Physiol. 291:H26-H28, 2006. |
| Sato M, Cismowski MJ, Toyota E, Smrcka AV, Lucchesi PA, Chilian WM, Lanier SM. Identification of a receptor-independent activator of G-Protein signaling (AGS8) in ischemic heart and its interaction with G??. Proc Natl Acad Sci USA. 103:797-802, 2006. |
| Sato, M., Cismowski, M.J., Toyota, E., Smrcka, A.V., Lucchesi, P.A., Chilian, W.M. and Lanier, S.M. (2006) Identification of a receptor-independent activator of G-protein signaling (AGS8) in ischemic heart and its interaction with Gbg. Proc. Natl. Acad. Sci. USA 103:797-802. PubMed ID: 16407149 |
| Su, J DI Palen, PA Lucchesi, K Matrougui. MMP-9 deletion regulates flow-induced dilation but not myogenic tone in mesenteric resistance arteries. Biochem Biophys Res Commun, 349:1177-1181, 2006. |
| Chotani MA, Mitra S, Eid AH, Han SA, Flavahan NA. 2005. Distinct cyclic AMP signaling pathways differentially regulate α2C-adrenoceptor expression: role in serum induction in human arteriolar smooth muscle cells. Am. J. Physiol. Heart Circ. Physiol, special “Translational Physiology” series article; 288: H69-H76. PubMed ID: 15345481 |
| Cismowski, M.J. and Lanier, S.M. (2005) Activation of heterotrimeric G-proteins independent of a G-protein coupled receptor and the implications for signal processing. Rev. Physiol. Biochem. Pharmacol. 155:57-80. PubMed ID: 16041530 |
| Garg, V., Muth, A.N., Ransom, J.F., Schluterman, M.K., Barnes, R., King, I.N., Grossfeld, P.D., and Srivastava, D. “Mutations in NOTCH1 Cause Aortic Valve Disease”. Nature 437(7056):270-274 (2005). PubMed ID: 16025100 |
| Blumer, J.B., Cismowski, M.J., Sato, M. and Lanier, S.M. (2005) AGS proteins diversify G-protein signaling. Trends Pharmacol. Sci. 26:470-476. PubMed ID: 16084602 |
| Borg T.K., Stewart, Jr., J.A., and Sutton, M.A. Imaging the cardiovascular system: Seeing is believing. Microsc Microanal. 11, 189-99, 2005. PubMed ID: 16060971 |
| Palen DI, S Belmadani, PA Lucchesi, K Matrougui. Role of SHP-1, Kv.1.2, and cGMP in nitric oxide-induced ERK1/2 MAP kinase dephosphorylation in rat vascular smooth muscle cells. Cardiovasc Res. 2005, Nov 1;68(2):268-77. |
| Rocic P, Lucchesi PA. NAD(P)H oxidases and TGF-beta-induced cardiac fibroblast differentiation: Nox-4 gets Smad. Circ Res. 2005 97:850-852, 2005. |
| Chotani MA, Mitra S, Su B Y, Flavahan S, Eid AH, Clark KR, Montague C, Paris H, Handy D E, Flavahan NA. 2004. Regulation of α2C-adrenoceptors in human vascular smooth muscle cells. Am. J. Physiol. Heart Circ. Physiol, special “Translational Physiology” series article; 286: H59-H67. PubMed ID: 12946937 |
| Baliga RS, Liu C, Hoyt DG, Chaves AA and Bauer JA. Vascular endothelial toxicity induced by HIV protease inhibitor: evidence of oxidant-related dysfunction and apoptosis. Cardiovas Toxicol 4(2): 199-206, 2004. |
| Cao, X., Cismowski, M.J., Sato, M., Blumer, J.B. and Lanier, S.M. (2004) Identification and characterization of AGS4: A GPR protein that regulates the activation state of Gia. J. Biol. Chem. 279:27567-27574. PubMed ID: 15096500 |
| Cepoi, D., Phillips, T., Cismowski, M., Goodfellow, V.S., Ling, N., Cone, R.D. and Fan, W. (2004) Assessment of a small molecule melanocortin-4 receptor-specific agonist on energy homeostasis. Brain Res. 1000:64-71. PubMed ID: 15053953 |
| Chaves AA, Mihm MJ, Basuray A, Baliga R, Ayers LW and Bauer JA. HIV/AIDS-related cardiovascular disease. Cardiovasc Toxicol 4(3): 229-242, 2004. |
| Cordero L, Giannone PJ, Ramirez N and Joy SD. Mean arterial pressure in concordant and discordant triplets during the first week of life. J Perinatol (accepted). |
| Giannone PJ, Abu Dayyeh BK, Bienieki TC, Wands JR and Gruppuso PA. Targeted hepatic overexpression of human IRS-1: postnatal effects in the developing mouse. Biochim Biophys Acta 3;1672(2):112-9, 2004. |
| Janicki, J.S., Brower, G.L., Gardner, J.D., Chancey, A.L., and Stewart, Jr., J.A.. The dynamic interaction between matrix metalloproteinase activity and adverse myocardial remodeling. Heart Failure Reviews. 9, 33-42, 2004. PubMed ID: 14739766 |
| Knudson DV, Noffal GJ, Bahamonde RE, Bauer JA and Blackwell JR. Stretching has no effect on tennis serve performance. Cond Res 18(3): 654-656, 2004. |
| Monreal G, Gerhardt MA, Kambara A, Abrishamchian AR, Bauer JA and Goldstein AH. Selective microembolization of the circumblex coronary artery in an ovine model: Dilated, ischemic cardiomyopathy and left ventricular dysfunction. J Card Fail 10(2): 174-183, 2004. |
| Poladia DP and Bauer JA. Nitric oxide in the urinary bladder:involvement of auto-relaxation. Nitric Oxide 10 (1): 51-52, 2004. |
| Poladia DP and Bauer JA. Oxidant driven signaling pathways during diabetes:role of Rac1 andmodulation of protein kinase activity in mouse urinary bladder. Biochimie 86(8): 543-551, 2004. |
| Vaidyanathan, G., Cismowski, M.J., Wang, G., Vincent, T.S., Brown, K.D. and Lanier, S.M. (2004) The Ras-related protein AGS1/RASD1 suppresses cell growth. Oncogene 23:5858-5863. PubMed ID: 15184869 |
| Garg, V., Kathiriya, I.S., Barnes, R., Schluterman, M.K., King, I.N., Butler, C. A., Rothrock, C.R., Eapen, R.S., Hirayama-Yamada, K., Joo, K., Matsuoka, R., Cohen, J.C., and Srivastava, D. “GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5”. Nature 424(6947):443-447 (2003). PubMed ID: 12845333 |
| Cordero L, Giannone PJ and Rich JT. Mean arterial pressure in very low birth weight (801 to 1500 g) concordant and discordant twins during the first day of life. J Perinatol 23(7): 545-51, 2003. |
| Dyck, B., Parker, J., Phillips, T., Carter, L., Murphy, B., Summers, R., Hermann, J., Baker, T., Cismowski, M., Saunders, J. and Goodfellow, V. (2003) Aryl piperazine melanocortin MC4 receptor agonists. Bioorg. Med. Chem. Lett. 13:3793-3796. PubMed ID: 14552781 |
| Foster, A.C., Joppa, M., Markison, S., Gogas, K.R., Fleck, B.A., Murphy, B.J., Wolff, M., Cismowski, M.J., Ling, N., Goodfellow, V.S., Chen, C., Saunders, J. and Conlon, P.J. (2003) Body weight regulation by selective MC4 receptor agonists and antagonists. Ann. NY Acad. Sci. 994:103-110. PubMed ID: 12851304 |
| Nickolls, S.A., Cismowski, M., Wang, X., Wolff, M., Conlon, P. and Maki, R.A. (2003) Molecular determinants of melanocortin 4 receptor ligand binding and MC4/MC3 receptor selectivity. J. Pharmacol. Exp. Ther., 304:1217-1227. PubMed ID: 12604699 |
| Stewart, Jr., J.A., Wei, C.C., Brower, G.L., Hankes, G.H., Dillon, A.R., Rynders, P.E., Lucchesi, P.A., Janicki, J.S., and Dell'Italia, L.J. Cardiac mast cell- and chymase-mediated matrix metalloproteinase activity and left ventricular remodeling in mitral regurgitation in the dog. J. Mol Cell Cardiol. 35, 311-319, 2003. PubMed ID: 12676546 |
| Chotani MA, Flavahan S, Mitra S, Daunt D, Flavahan NA. 2000. Silent α2C-adrenergic receptors enable cold-induced vasoconstriction in cutaneous arteries. Am. J. Physiol. Heart Circ. Physiol. 278:H1075-H1083. PubMed ID: 10749700 |
| Karlowicz MG, Giannone PJ, Pestian J, Morrow AL and Shults J. Does candidemia predict threshold retinopathy of prematurity in extremely low birth weight (</= 10000g) neonates? Pediatrics 105(5): 1036-40, 2000. |
| Stewart, Jr., J.A., Brower, G.L., and Janicki, J.S. Correlation of matrix metalloproteinase (MMP) activity and mast cell density in mitral regurgitation (MR). J. Mol. Cell. Cardiol. 32, A-69, 2000. |
| Stewart, Jr., J.A., Wei, C.C., Lucchesi, P.A., Janicki, J.S., Brower, G.L., and Dell'Italia, L.J. Differential activation of ACE and chymase during early and late phases of left ventricular remodeling in response to the volume overload of mitral regurgitation. Circulation 102 (18, Suppl. 2), II-131, 2000. |
| Yamagishi, H., Garg, V., Matsuoka, R., Thomas, T., and Srivastava, D. “A molecular pathway revealing a genetic basis for human cardiac and craniofacial defects.” Science 283:1158-1161 (1999). PubMed ID: 10024240 |
| Brower, G.L., Stewart, Jr., J.A., and Janicki, J.S. Beta-receptor downregulation in heart failure is protective against angiotensin II mediated myocardial necrosis. Circulation 98 (17, Suppl. 1), I-70, 1998. |
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