| SELECTED PUBLICATIONS |
| Ren J., Dong F., Cai G.J., Zhao P., Nunn J.M., Wold L.E. and J. Pei. (2010) Interaction between age and obesity on cardiomyocyte contractile function: role of leptin and stress signaling. PLoS One. 5(4):e10085. PubMed ID: 20396382 |
| Sun Q., Hong X. and L.E. Wold. (2010) Cardiovascular effects of ambient particulate air pollution exposure. Circulation. In press. |
| Chatterjee S, Wang JW, Cismowski MJ, Bower JR, Rosenthal KS. HSV-2 ICP34.5 protein modulates herpes simplex virus glycoprotein processing. Arch Virol. 2009;154(4):661-3. Epub 2009 Mar 7. PubMed ID: 19267180 |
| Kaushal S., Bouchard C.P. and L.E. Wold. (2009) Myocardial oxygenation is critical for improving regeneration capacity. Am J Physiol Heart Circ Physiol. 296:H1215-H1216. PubMed ID: 19329768 |
| Kaushal S., Jacobs J.P., Gossett J.G., Steele A., Steele P., Davis C.R., Pahl E., Vijayan K., Asante-Korang A., Boucek R.J., Backer C.L. and L.E. Wold. (2009) Innovation in basic science: stem cells and their role in the treatment of paediatric cardiac failure – opportunities and challenges. Cardiol Young. 19(Suppl. 2):74-84. PubMed ID: 19857353 |
| Maitra, M., Schluterman, M.K., Nichols, H., Richardson, J.A., Lo, C., Srivastava, D. and Garg, V. “Interaction of Gata4 and Tbx5 is critical for normal cardiac development” Dev Biol, 326(2):368-77 (2009). PubMed ID: 19084512 |
| Mihai C, Chotani M, Elton TS, Agarwal G. Mapping of DDR1 distribution and oligomerization on the cell surface by FRET microscopy. J Mol Biol. 2009 Jan 16;385(2):432-45. Epub 2008 Nov 5. PubMed ID: 19007791 |
| Pan, H., Richards, A.A., Xhu, X., Joglar, J.A., Yin, H.L., and Garg, V. “A novel mutation in LAMIN A/C is associated with isolated early-onset atrial fibrillation and progressive atrioventricular block followed by cardiomyopathy and sudden cardiac death” Heart Rhythm, 6(5):707-710 (2009). PubMed ID: 19328042 |
| Xu X., Kherada N., Hong X., Quan C., Zheng L., Wang A., Wold L.E., Lippmann M., Chen L.C., Rajagopalan S. and Q. Sun. (2009) Diesel exhaust exposure induces angiogenesis. Toxicol Lett. 191(1):57-68. PubMed ID: 19683567 |
| Youtz D.J. and L.E. Wold. (2009) Role of aldehyde dehydrogenase-2 in alcoholic liver disease. Clin Exp Pharm Phys. 36:462. PubMed ID: 19215230 |
| Eid AH, Chotani MA, Mitra S, Miller TJ, Flavahan S, Flavahan NA. 2008. Cyclic AMP acts through Rap1 and JNK signaling to increase expression of cutaneous smooth muscle α2C-adrenoceptors. Am J Physiol. Heart Circ Physiol. 295: H266-H272. PubMed ID: 18487435 |
| Monreal G., Nicholson L.M., Han B., Joshi M.S., Phillips A.B., Wold L.E., Bauer J.A. and M.A. Gerhardt. (2008) Cytoskeletal remodelling of desmin is a more accurate measure of cardiac dysfunction than fibrosis or myocyte hypertrophy. Life Sci. 83:786-794. PubMed ID: 18955067 |
| Richards, A., Jaeckle, L., Nichols, H., Crider, B., Elder, F., Hauser, N., Zinn, A.R., and Garg, V. Cryptic chromosomal abnormalities identified in children with congenital heart disease and additional birth anomalies. Pediatr Res 64(4):358-363 (2008). PubMed ID: 18535492 |
| Shenouda SK, Lord KC, McIlwain E, Lucchesi PA, Varner KJ. Ecstasy produces left ventricular dysfunction and oxidative stress in rats. Cardiovasc Res. 2008 Jun 4. PubMed ID: 18495670 |
| Su J, Lucchesi PA, Gonzalez-Villalobos RA, Palen DI, Rezk BM, Suzuki Y, Boulares HA, Matrougui K. Role of Advanced Glycation End Products With Oxidative Stress in Resistance Artery Dysfunction in Type 2 Diabetic Mice. Arterioscler Thromb Vasc Biol. 2008 May 15. PubMed ID: 18483403 |
| Bayoumi MM, Alkheraije KA, El-Sayed O, Wisel S, Sarker K, Chotani MA, Zweier JL, Nuovo G, Goldschmidt-Clermont PJ, Hassanain H. 2007. Vascular hypertrophy caused by transgenic overexpression of profilin 1. J Biol Chem. 282:37632-37639. PubMed ID: 17942408 |
| Eid A H, Maiti K, Mitra S, Chotani MA, Flavahan S, Bailey SR, Thompson-Torgerson CS, Flavahan NA. 2007. Estrogen increases smooth muscle expression of α2C-adrenoceptors and cold-induced constriction of cutaneous arteries. Am J Physiol. Heart Circ Physiol. 293: H1955-H1961. PubMed ID: 17644575 |
| Guggilam A, Haque M, Kerut EK, McIiwain E, Lucchesi PA, Sehgal I, Francis J. TNF? blockade decreases oxidative stress in the paraventricular nucleus and attenuates sympathoexcitation in heart failure rats. Am J Physiol Heart Circ Physiol. 293:H599-609, 2007. |
| Martin MM, Buckenberger JA, Jiang J, Malana GE, Nuovo GJ, Chotani M, Feldman DS, Schmittgen TD, Elton TS. 2007. The human angiotensin II type 1 receptor +1166 A/C polymorphism attenuates microRNA-155 binding. J Biol Chem. 282: 24262-24269. PubMed ID: 17588946 |
| Ryan TD, Rothstein EC, Aban I, Tallaj JA, Husain A, Lucchesi PA, Dell'Italia LJ. Left ventricular eccentric remodeling and matrix loss are mediated by bradykinin and precede cardiomyocyte elongation in rats with volume overload. J Am Coll Cardiol. 497:811-821, 2007. |
| Schluterman, M.K., Krysiak, A.E., Kathiriya, I.S., Abate, N., Chandalia, M., Srivastava, D., and Garg, V. “Screening and Biochemical Analysis of GATA4 Sequence Variations in Patients with Congenital Heart Disease”. Am J Med Genet A 143(8):817-823 (2007). PubMed ID: 17352393 |
| Zhang, X., Stewart, Jr., J.A., Kane, I.D., Massey, E.P., Cashatt, D.O., and Carver, W.E. Effects of elevated glucose on the interactions of cardiac fibroblasts with the extracellular matrix. In Vitro Cell Dev Biol , 2007. (Co-First Author). PubMed ID: 17849168 |
| Wold L.E., Ceylan-Isik A.F., Fang C.X., Yang X., Li SY, Sreejayan N., Privratsky J.R. and J. Ren. (2006) Metallothionein alleviates cardiac dysfunction in streptozotocin-induced diabetes: Role of Ca(2+) cycling proteins, NADPH oxidase, Poly(ADP-Ribose) polymerase and myosin heavy chain isozyme. Free Radic Biol Med. 40(8):1419-1429. PubMed ID: 16631532 |
| Wold L.E., Simkhovich B.Z., Kleinman M.T., Nordlie M.A., Dow J.S., Sioutas C., Kloner R.A. (2006) In vivo and in vitro models to test the hypothesis of particle-induced effects on cardiac function and arrhythmias. Cardiovasc Toxicol. 6(1):69-78. PubMed ID: 16845184 |
| Garg, V. “Insights into the Genetic Basis of Congenital Heart Disease”. Cellular Molecular Life Sciences. 63(10):1141-1148 (2006). PubMed ID: 16568242 |
| Garg, V. “Molecular Genetics of Aortic Valve Disease”. Curr Opin in Cardiology 21(3): 180-184 (2006). PubMed ID: 16601454 |
| McNicholas-Bevensee. CM, DeAndrade, KB, Bradley, WE, Dell’Italia LJ, Lucchesi PA and Bevensee MO. Activation of gadolinium-sensitive ion channels in cardiomyocytes in early adaptive stages of volume-overload induced heart failure. Cardiovasc Res. 72:262-270, 2006 |
| Palen DI, Ouhtit A, Belmadani S, Lucchesi PA, Matrougui K. Hydrogen peroxide acts as relaxing factor in human vascular smooth muscle cells independent of MAP-kinase and nitric oxide. Front Biosci. 11:2526-34, 2006. |
| Rocic P, Rezk B, Lucchesi PA. PPAR-? agonists decrease hyperhomcysteinemia and cardiac dysfunction: new hope for ailing diabetic hearts? Am J Physiol Heart Circ Physiol. 291:H26-H28, 2006. |
| Sato M, Cismowski MJ, Toyota E, Smrcka AV, Lucchesi PA, Chilian WM, Lanier SM. Identification of a receptor-independent activator of G-Protein signaling (AGS8) in ischemic heart and its interaction with G??. Proc Natl Acad Sci USA. 103:797-802, 2006. |
| Sato, M., Cismowski, M.J., Toyota, E., Smrcka, A.V., Lucchesi, P.A., Chilian, W.M. and Lanier, S.M. (2006) Identification of a receptor-independent activator of G-protein signaling (AGS8) in ischemic heart and its interaction with Gbg. Proc. Natl. Acad. Sci. USA 103:797-802. PubMed ID: 16407149 |
| Su, J DI Palen, PA Lucchesi, K Matrougui. MMP-9 deletion regulates flow-induced dilation but not myogenic tone in mesenteric resistance arteries. Biochem Biophys Res Commun, 349:1177-1181, 2006. |
| Chotani MA, Mitra S, Eid AH, Han SA, Flavahan NA. 2005. Distinct cyclic AMP signaling pathways differentially regulate α2C-adrenoceptor expression: role in serum induction in human arteriolar smooth muscle cells. Am. J. Physiol. Heart Circ. Physiol, special “Translational Physiology” series article; 288: H69-H76. PubMed ID: 15345481 |
| Cismowski, M.J. and Lanier, S.M. (2005) Activation of heterotrimeric G-proteins independent of a G-protein coupled receptor and the implications for signal processing. Rev. Physiol. Biochem. Pharmacol. 155:57-80. PubMed ID: 16041530 |
| Garg, V., Muth, A.N., Ransom, J.F., Schluterman, M.K., Barnes, R., King, I.N., Grossfeld, P.D., and Srivastava, D. “Mutations in NOTCH1 Cause Aortic Valve Disease”. Nature 437(7056):270-274 (2005). PubMed ID: 16025100 |
| Blumer, J.B., Cismowski, M.J., Sato, M. and Lanier, S.M. (2005) AGS proteins diversify G-protein signaling. Trends Pharmacol. Sci. 26:470-476. PubMed ID: 16084602 |
| Borg T.K., Stewart, Jr., J.A., and Sutton, M.A. Imaging the cardiovascular system: Seeing is believing. Microsc Microanal. 11, 189-99, 2005. PubMed ID: 16060971 |
| Palen DI, S Belmadani, PA Lucchesi, K Matrougui. Role of SHP-1, Kv.1.2, and cGMP in nitric oxide-induced ERK1/2 MAP kinase dephosphorylation in rat vascular smooth muscle cells. Cardiovasc Res. 2005, Nov 1;68(2):268-77. |
| Rocic P, Lucchesi PA. NAD(P)H oxidases and TGF-beta-induced cardiac fibroblast differentiation: Nox-4 gets Smad. Circ Res. 2005 97:850-852, 2005. |
| Chotani MA, Mitra S, Su B Y, Flavahan S, Eid AH, Clark KR, Montague C, Paris H, Handy D E, Flavahan NA. 2004. Regulation of α2C-adrenoceptors in human vascular smooth muscle cells. Am. J. Physiol. Heart Circ. Physiol, special “Translational Physiology” series article; 286: H59-H67. PubMed ID: 12946937 |
| Cao, X., Cismowski, M.J., Sato, M., Blumer, J.B. and Lanier, S.M. (2004) Identification and characterization of AGS4: A GPR protein that regulates the activation state of Gia. J. Biol. Chem. 279:27567-27574. PubMed ID: 15096500 |
| Cepoi, D., Phillips, T., Cismowski, M., Goodfellow, V.S., Ling, N., Cone, R.D. and Fan, W. (2004) Assessment of a small molecule melanocortin-4 receptor-specific agonist on energy homeostasis. Brain Res. 1000:64-71. PubMed ID: 15053953 |
| Janicki, J.S., Brower, G.L., Gardner, J.D., Chancey, A.L., and Stewart, Jr., J.A.. The dynamic interaction between matrix metalloproteinase activity and adverse myocardial remodeling. Heart Failure Reviews. 9, 33-42, 2004. PubMed ID: 14739766 |
| Vaidyanathan, G., Cismowski, M.J., Wang, G., Vincent, T.S., Brown, K.D. and Lanier, S.M. (2004) The Ras-related protein AGS1/RASD1 suppresses cell growth. Oncogene 23:5858-5863. PubMed ID: 15184869 |
| Garg, V., Kathiriya, I.S., Barnes, R., Schluterman, M.K., King, I.N., Butler, C. A., Rothrock, C.R., Eapen, R.S., Hirayama-Yamada, K., Joo, K., Matsuoka, R., Cohen, J.C., and Srivastava, D. “GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5”. Nature 424(6947):443-447 (2003). PubMed ID: 12845333 |
| Dyck, B., Parker, J., Phillips, T., Carter, L., Murphy, B., Summers, R., Hermann, J., Baker, T., Cismowski, M., Saunders, J. and Goodfellow, V. (2003) Aryl piperazine melanocortin MC4 receptor agonists. Bioorg. Med. Chem. Lett. 13:3793-3796. PubMed ID: 14552781 |
| Foster, A.C., Joppa, M., Markison, S., Gogas, K.R., Fleck, B.A., Murphy, B.J., Wolff, M., Cismowski, M.J., Ling, N., Goodfellow, V.S., Chen, C., Saunders, J. and Conlon, P.J. (2003) Body weight regulation by selective MC4 receptor agonists and antagonists. Ann. NY Acad. Sci. 994:103-110. PubMed ID: 12851304 |
| Nickolls, S.A., Cismowski, M., Wang, X., Wolff, M., Conlon, P. and Maki, R.A. (2003) Molecular determinants of melanocortin 4 receptor ligand binding and MC4/MC3 receptor selectivity. J. Pharmacol. Exp. Ther., 304:1217-1227. PubMed ID: 12604699 |
| Stewart, Jr., J.A., Wei, C.C., Brower, G.L., Hankes, G.H., Dillon, A.R., Rynders, P.E., Lucchesi, P.A., Janicki, J.S., and Dell'Italia, L.J. Cardiac mast cell- and chymase-mediated matrix metalloproteinase activity and left ventricular remodeling in mitral regurgitation in the dog. J. Mol Cell Cardiol. 35, 311-319, 2003. PubMed ID: 12676546 |
| Chotani MA, Flavahan S, Mitra S, Daunt D, Flavahan NA. 2000. Silent α2C-adrenergic receptors enable cold-induced vasoconstriction in cutaneous arteries. Am. J. Physiol. Heart Circ. Physiol. 278:H1075-H1083. PubMed ID: 10749700 |
| Stewart, Jr., J.A., Brower, G.L., and Janicki, J.S. Correlation of matrix metalloproteinase (MMP) activity and mast cell density in mitral regurgitation (MR). J. Mol. Cell. Cardiol. 32, A-69, 2000. |
| Stewart, Jr., J.A., Wei, C.C., Lucchesi, P.A., Janicki, J.S., Brower, G.L., and Dell'Italia, L.J. Differential activation of ACE and chymase during early and late phases of left ventricular remodeling in response to the volume overload of mitral regurgitation. Circulation 102 (18, Suppl. 2), II-131, 2000. |
| Yamagishi, H., Garg, V., Matsuoka, R., Thomas, T., and Srivastava, D. “A molecular pathway revealing a genetic basis for human cardiac and craniofacial defects.” Science 283:1158-1161 (1999). PubMed ID: 10024240 |
| Brower, G.L., Stewart, Jr., J.A., and Janicki, J.S. Beta-receptor downregulation in heart failure is protective against angiotensin II mediated myocardial necrosis. Circulation 98 (17, Suppl. 1), I-70, 1998. |
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