| SELECTED PUBLICATIONS |
Hasman H., Pachucki C.T., Unal A., Nguyen D., Devlin T., Peeples M.E., and Kwilas S.A. Aetiology if ubfkuenza-like illness in adults includes parainfluenzavirus type 4. J. Med. Micro. 58: 408-413. PubMed ID: 19273634 |
| Ardura MI, Banchereau R, Mejias A, Di Pucchio T, Glaser C, Allantaz F, Pascual V, Banchereau J, Chaussabel D, Ramilo O. Enhaced monocyte response and decreased central memoryt T cells in Children with invasive Staphylococcus aureus infections. PLoS One 2009;4(5):e5446. PubMed ID: 19424507 |
| Kwilas S., Liesman R.M., Zhang L., Pickles R.J., Walsh E., and Peeples M.E. Respiratory syncytial virus grown in Vero cells contains a truncated attachment protein that alters its tropism. J. Virol., 83: 10710-10718. PubMed ID: 19656891 |
| Lo MK, Harcourt BH, Mungall BA, Tamin A, Peeples ME, Bellini WJ, and Rota PA. 2009. Determination of the henipavirus phosphoprotein gene mRNA editing frequencies and detection of the C, V, and W proteins of Nipah virus in virus-infected cells. J. Gen. Virol. 90:398-404. PubMed ID: 19141449 |
| McGillivary D., Mason K.M., Jurcisek J.A., Peeples M.E., and Bajaletz L.O. Rsv-induces dysregulation of expression of a mucosal β-defensin augments coloization of the upper airway by nontypeable Haemophilus influenza. Cell Microbiol. 11: 1399-1408. PubMed ID: 19500108 |
| Mejías A, Bustos R, Ardura M, Ramírez C, Sánchez PJ. Persistence of Herpes Simplex Virus DNA in Cerebrospinal Fluid of Neonates with Herpes Simplex Virus Encephalitis. J Perinatol 2009 (4): 290-6. PubMed ID: 19194454 |
| Ramilo O, Mejias A. Shifting the Paradigm: Host Gene Signatures for Diagnosis of Infectious Diseases. Cell and Host Microbe 2009: 9 (in press) |
| Somers C, Naveed A, Mejías A, Buckingham S. C, Carubelli C, Katz-Gaynor K, Leos N, Gomez A, DeVincenzo J.P, Ramilo O, Jafri H.S. Effect of dexamethasone on RSV-induced lung inflammation in children: results of a randomized, placebo controlled clinical trial. Ped Allergy and Immunol 2009: 20 (5):477-85 PubMed ID: 19397752 |
Wolk KE, Lazarowski ER, Traylor ZP, Yu EN, Jewell NA, Durbin JE, Davis IC. 2008 Influenza A Virus Inhibits Alvelar FLuid Clearence in BALB/c mice. AM J Respir Crit Care Med. Nov 1; 178(9) 969-76. Epub 2008 Aug 8. PubMed ID: 18689466 |
| Bhoj VG, Sun Q, Bhoj E, Somers C, Chen X, Torres JP, Mejias A, Gomez A, Jafri HS, Ramilo O, and Chen ZJ. MAVS and MyD88 Are Essential for Innate Immunity But Not Cytotoxic T Lymphocyte Response Against Respiratory Syncytial Virus. Proc. Natl. Acad. Sci. USA 2008 105:14046-51. PubMed ID: 18780793 |
| Bowen D, Shoukry NH, Grakoui A, Fuller MJ, Cawthon AG, Dong C, Hasselschwert DL, Brasky KM, Freeman GJ, Seth NP, Wucherpfennig KW, Houghton M, and Walker CM. Variable patterns of programmed death-1 expression on fully functional memory T cells after spontaneous resolution of hepatitis C virus infection. J Virol 82(10):5109-14, 2008. |
| Burns JC, Best BM, Mejias A, Mahony L, Fixler DE, Jafri HS, Melish ME, Jackson MA, Asmar BI, Lang DJ, Connor JD, Capparelli EV, Keen ML, Mamun K, Keenan GF, Ramilo O. Infliximab treatment of intravenous immunoglobulin-resistant Kawasaki disease. J Pediatr 2008; 153:833-8. PubMed ID: 18672254 |
| Estripeaut D, Torrres JP, Somers C, Tagliabue C, Khokhar S, Bohj V.G, Grube S, Wozniakowski A, Gomez A, Ramilo O, Jafri H and Mejías A. Respiratory Syncytial Virus persistence in the lungs correlates with airway hyperreactivity in the mouse model. J Infect Dis 2008; 198: 1435-43. PubMed ID: 18828742 |
| Flaño, E. and Durbin J. 2008. Methods Used to Study Respiratory Viruses. Current Protocols in Cell Biology (in press). |
| Flaño, E. 2008 Viral Immunity: It Takes Two to Tango. Viral Immunol 21(3):(in press). |
| Gill MA, Long K, Kwon T, Muniz L, Mejias A, Connolly J, Roy L, Banchereau J, and Ramilo O. Differential Recruitment of Dendritic cells and Monocytes to Respiratory Mucosal Sites in Children with Influenza and Respiratory Syncytial Virus Infections. J Infect Dis 2008; 198(11):1667-76. PubMed ID: 18847373 |
| Moore ML, Chi MH, Goleniewska K, Durbin JE, Peebles RS Jr. 2008. Differential regulation of GM1 expression by T cells and natural killer (NK) cells in respiratory syncytial virus infection. Viral Immunol. 21: (3): 327-339. PubMed ID: 18788941 |
| Saavedra-Lozano J*, Mejías A*, Ahmad N, Peromingo E, Ardura MI, Guillen S, Syed S, Cavuoti D, and Ramilo O. Changing Trends in Acute Osteomyelitis in Children. Impact of Methicillin-Resistant Staphylococcus aureus Infections. J. Pediatr Orthop 2008; 28:569-575. PubMed ID: 18580375 |
| Velazquez VM, Bowen DG, and Walker CM. Silencing of T lymphocytes by antigen-driven programmed death in recombinant adeno-associated virus vector (rAAV)-mediated gene therapy. Blood 2008 (in press). |
| Wang S, Raven JF, Durbin JE, Koromilas AE. Stat 1 phosphorylation determines Ras oncogenicity by regulating p27 kip1. PLoS ONE. 2008;3 (10):e3476. Epub 2008 Oct 22. PubMed ID: 18941537 |
Tompkins SM, Lin Y, Leser GP, Kramer KA, Haas DL, Howerth EW, Xu J, Kennett MJ, Durbin RK, Durbin JE, Tripp R, Lamb RA, He B. 2007. Recombinant parainfluenza virus 5(PIV5) expressing the influenza A virus hemagglutinin provides immunity in mice to influenza A virus challenge. Virology 22. PubMed ID: 17254623 |
| Cush, S.S., Anderson, K.M., Ravneberg, D.H., Weslow-Schmidt,, J.L., Flaño, E. 2007 Memory generation and maintenance of CD8+ T cell function during viral persistence. Journal of Immunology. 179:141-153. |
| G. Pérez-Yarza E, Moreno A, Lazaro P, Mejías A and Ramilo O. The Association between Respiratory Syncytial Virus Infection and the Development of Childhood Asthma: A Systematic Review of the Literature. Pediatric Infectious Diseases Journal 2007; 26: 733-39. PubMed ID: 17848887 |
| Hattori H, Rosas LE, Okano M, Durbin JE, Nishizaki K, Satoskar AR. STAT1 is involved in the pathogenesis of murine allergic rhinitis. Am J Rhinol. 2007; 21:241-247. PubMed ID: 17424888 |
| Jewell N, Vaghefi N, Mertz SE, Akter P, Peebles RS, Bakaletz LO, Durbin RK, Flaon E, and Durbin JE. 2007 Differential type I interferon induction by respiratory syncytial virus and influenza A virus in vivo. J. Virol. 81:9790 PubMed ID: 17626092 |
| Jewell, N.A., Gitiban, N., Mertz, S.E., Akter, P., Stokes Peebles Jr., R., Bakaletz, L.O., Durbin, R.K., Flaño, E., Durbin, J.E. 2007 Differential type I IFN induction by respiratory viruses in vivo. Journal of Virology 81(18):9790-9800. |
| Mejías A, Chavez-Bueno S, Raynor M.B, Connolly J, Kiener P.A, Jafri HS, Ramilo O. Motavizumab, an enhanced anti-respiratory syncytial virus (RSV) neutralizing monoclonal antibody significantly modifies the local and systemic cytokine responses induced by RSV in the mouse model. Virol J 2007; Oct 25; 4(1):109. PubMed ID: 17961258 |
| Pérez-Yarza EG, Moreno A, Lázaro P, Mejías A, Ramilo O. The association between respiratory syncytial virus infection and the development of childhood asthma: A systematic review of the literature. Pediatr Infec Dis J 2007; 26:733-739. PubMed ID: 17848887 |
| Ramilo O., Allman W., Chung W., Mejías A., Ardura M., Glaser C., Wittkowski K. M., Piqueras B., Banchereau J., Palucka K. and Chaussabel D. Gene Expression Patterns in Blood Leukocytes Discriminate patients with Acute Infections. Blood. 2007 Mar 1;109(5):2066-77. PubMed ID: 17105821 |
| Weslow-Schmidt J, Jewell NA, Mertz SA, Simas JP, Durbin JE, and Flano E. 2007. Type I IFN inhibition and dendritic cell activation during respiratory gamma-herpesvirus infection. J Virol. 81:9778. PubMed ID: 17626106 |
| Weslow-Schmidt, J., Jewell, N.A., Mertz, S.E., Durbin, J.E., Flaño, E. 2007 Type I IFN inhibition and plasmacytoid dendritic cell activation during respiratory virus infection. Journal of Virology 81(18):9778-89. |
Martinez-Sobrido L, Gitiban N, Fernandez-Sesma A, Cros J, Mertz SE, Jewell NA, Hammond S, Flano E, Durbin RK, Garcia-Sastre A, Durbin JE. 2006. Protection against respiratory syncytial virus by a recombinant Newcastle disease virus vector. J Viro. 80(3):1130-9. PubMed ID: 16414990 |
| Guerrero-Plata A, Casola A, Suarez G, Yu X, Spetch L, Peeples ME, Garofalo RP. 2006. Differential response of dendritic cells to human metapneumovirus and respiratory syncytial virus. Am J Respir Cell Mol Bio 34:(3):320-9. PubMed ID: 16284360 |
| Laliberte JP, McGinnes LW, Peeples ME, Morrison TG. 2006. Integrity of membrane lipid rafts is necessary for the ordered assembly and release of infectious Newcastle disease virus particles. J Virol 80(21):10652-62. PubMed ID: 17041223 |
| Moore PE, Cunningham G, Calder MM, DeMatteo AD Jr, Peeples ME, Summar ML, Peebles RS Jr. 2006. Respiratory syncytial virus infection reduces beta2-adrenergic responses in human airway smooth muscle. Am J Respir Cell Mol Biol 35(5):559-64. PubMed ID: 16763224 |
| Pantua HD, McGinnes LW, Peeples ME, Morrison TG. 2006. Requirements for the assembly and release of Newcastle disease virus-like particles. J Virol 80(22):11062-73. PubMed ID: 16971425 |
| Rosas LE, Snider HM, Barbi J, Satoskar AA, Lugo-Villarino G, Keiser T, Papenfuss T, Durbin JE, Radzioch D, Glimcher LH, Satoskar AR. 2006. Cutting edge: STAT-1 and T-bet play distinct roles in determining outcome of visceral leishmaniasis caused by Leishmania donovani. J Immunol 1;177(1):22-5. PubMed ID: 16785492 |
| VanDeusen JB, Shah MH, Becknell B, Blaser BW, Ferketich AK, Nuovo GJ, Ahmer BM, Durbin J, Caligiuri MA. 2006. STAT-1-mediated repression of monocyte interleukin-10 gene expression in vivio. Eur J Immunol 36(3):623-30. PubMed ID: 16482512 |
| Zhou W, Hashimoto K, Moore ML, Elias JA, Zhu Z, Durbin J, Colasurdo G, Rutigliano JA, Chiappetta CL, Goleniewska K, O'Neal JF, Graham BS, Peebles RS Jr. 2006. IL-13 is associated with reduced illness and replication in primary respiratory syncytial virus infection in the mouse. Microbes Infect 8(14-15):2880-9. PubMed ID: 17110149 |
Flano, E.Jia, Q., Moore, J., Woodland, DL., Sun, R., Blackman, MA. Early Establishment of {gamma}-Herpesvirus Latency: Implications for Immune Control. J Immunol. Apr 15;174(8):4972-8. |
| Bowen D and Walker CM. Adaptive immune responses in acute and chronic hepatitis C virus infection. Nature 436:946-952, 2005. |
| Bowen D and Walker CM. Mutational escape from CD8+ cell immunity: HCV evolution, from chimpanzees to man. J Exp Med 201:1709-1714, 2005. (Commentary Review) |
| Flaño, E., Basak, K., Woodland, D.L. and Blackman, M.A. 2005. Infection of dendritic cells by a γ-herpesvirus induces functional modulation. Journal of Immunology. 175:3225-3234. |
| Gill MA, Palucka K, Barton T, Ghaffar F, Jafri H, Banchereau J, Ramilo O.Sustained Mobilization of Plasmacytoid and Myeloid Dendritic Cells to Mucosal Sites in Children with Respiratory Syncytial Virus Infection and other Respiratory Viral Infections. Journal of Infectious Diseases 2005; 191:1105-1115. |
| Gitiban N, Harris R, Jurcisek JA, Durbin RK, Mertz SE, Bakaletz LO and Durbin JE. Chinchilla and murine models of upper respiratory tract infection by respiratory syncytial virus. 2005. J Virol 79(10):6035-6042. |
| Gower TL, Pastey MK, Peeples ME, Collins PL, McCurdy LH, Hart TK, Guth A, Johnson TR, Graham BS. 2005. RhoA signaling is required for respiratory syncytial virus-induced syncytium formation and filamentous virion morphology. J Virol 9(9)5326-5336. PubMed ID: 15827147 |
| Johnson TR, Mertz SE, Durbin RK, Gitiban N, Hammond S, LeGallo R and Durbin JE. Role for innate IFNs in determining respiratory syncytial virus immunopathology. 2005. J Immunol 174:7234-7241. |
| Kimura Y, Gushima T, Rawale S, Kaumaya P, and Walker CM. 2005. Escape mutations alter proteasome processing of major histocompatibility complex class I-restricted epitopes in persistent hepatitis C virus infection. J Virol 79(8):4870-4876. |
| Mejías A, Chávez-Bueno S. Ríos A.M, Fonseca Aten M., Raynor B., Peromingo E., Soni P., Olsen K.D, Kiener, PA, Gómez A.M, Jafri H.S. and Ramilo O. Comparative Effect of Two Neutralizing anti-RSV Monoclonal Antibodies in the Respiratory Syncytial Virus Murine Model. Time versus Potency. Antimicrobial Agents and Chemotherapy 2005: 49 (11): 4700-7. PubMed ID: 16251314 |
| Mejías A., Chávez-Bueno S and Ramilo O. Respiratory syncytial virus pneumonia: mechanisms of inflammation and prolonged airway hyperresponsiveness. Current Opinion in Infectious Diseases 2005: 18(3): 199-204. PubMed ID: 15864095 |
| Mejías A.M. Chávez-Bueno, S., Ríos, AM. Fonseca Aten M, Raynor B, Peromingo E, Soni P, Olsen KD, Kiener PA, Gómez AM, Jafri HS and Ramilo O. Comparative Effect of Two Neutralizing anti-RSV Monoclonal Antibodies in the Respiratory Syncytial Virus Murine Model. Time versus Potency. Antimicrobial Agents and Chemotherapy November 2005; 49:4700-7. PubMed ID: 16251314 |
| Zhang L, Bukreyev A, Thompson CI, Watson B, Peeples ME, Collins PL, Pickles RJ. 2005. Infection of ciliated cells by human parainfluenza virus type 3 in an in vitro model of human airway epithelium. J Virol 70(2)1113-1124. PubMed ID: 15613339 |
| Flaño E, Hardy CL, Kim IJ, Frankling C, Coppola MA, Nguyen P, Woodland DL and Blackman MA. T cell reactivity during infectious mononucleosis and latent stages of g-herpesvirus infection in mice. Journal of Immunology 172: 3078-3085, 2004. |
| Jafri HS, Chávez-Bueno S, Mejías A, Ríos AM, Nassi SS, Yusuf M, Kapur P, Gómez AM, Hardy RD, Hatfield J, Rogers BB, Krisher K, Ramilo O. Respiratory syncytial virus lower respiratory tract infection induces acute pneumonia, cytokine response, airway obstruction and chronic inflammatory infiltrates associated with long-term airway hyperresponsiveness in a murine model. Journal of Infectious Diseases 2004;189:1856-65. PubMed ID: 15122522 |
| Kong X, San Juan H, Behera A, Peeples ME, Wu J, Lockey RF, Mohapatra SS. 2004. ERK-1/2 activity is required for efficient RSV infection. FEBS Letters 559:33-38. PubMed ID: 14960303 |
| Mejías A. Chávez-Bueno S., Ríos A.M., Saavedra-Lozano J., Fonseca-Aten M., Hatfield J., Kapur P., Gómez A.M, Jafri H.S. and Ramilo O. Anti-RSV Neutralizing Antibody decreases lung inflammation, airway obstruction and airway hyperresponsiveness in the Respiratory Syncytial Virus model. Antimicrobial Agents and Chemotherapy 2004: 48 (5); 1811-1822. PubMed ID: 15105140 |
| Mejías A., Chavez-Bueno S. and Ramilo O. Human Metapneumovirus: A Not so new Virus. CME review. Pediatric Infectious Disease Journal, 2004: 23 (1): 1-10. |
| Meyer-Olson D, Shoukry NH, Brady KW, Kim H, Olson DP, Hartman K, Shintani AK, Walker CM, Kalams SA. 2004. Limited T cell receptor diversity of HCV-specific T cell responses is associated with CTL escape. J. Exp. Med. 200:307-319. |
| Shoukry NH, Cawthon AG and Walker CM. 2004. Cell-mediated immunity and the outcome of hepatitis C virus infection. Ann. Rev. Microbiol. 50:391-424. |
| Shoukry NH, Sidney J, Sette A, and Walker CM. 2004. Conserved hierarchy of helper T cell responses in a chimpanzee during primary and secondary hepatitis C virus infections. J Immunol 172:483-492. |
| Barretto N, Hallak L, and Peeples ME. 2003. Neuraminidase treatment of respiratory syncytial virus-infected cells or virions, but not target cells, enhances cell-cell fusion and infection. Virology, 313:33-43. PubMed ID: 12951019 |
| Borrego-Diaz E, Peeples ME, Markosyan RM, Melikyan GB, and Cohen FS. 2003. Completion of trimeric hairpin formation of influenza virus hemagglutinin is critical for the transition from hemifusion to fusion. Virology 316:234-244. |
| Flaño E, Kim I-J, Woodland DL and Blackman MA.Differential g-herpesvirus distribution in distinct anatomical locations and cell subsets during persistent infection in mice. Journal of Immunology 170: 3828-3834, 2003. |
| Grakoui A, Shoukry NH, Woollard D, Han J-H, Hanson HL, Ghrayeb J, Murthy KK, Rice CM, and Walker CM. 2003. HCV persistence and immune evasion in the absence of memory T cell help. Science 302:659-662. |
| Kim I-J, Flaño E, Woodland DL, Lund FE, Randall TD and Blackman MA. Maintenance of long-term g-herpesvirus B cell latency is dependent on CD40-mediated development of memory B cells. Journal of Immunology 171: 886-892, 2003. |
| Shoukry NH, Grakoui A, Houghton M, Chien DY, Ghrayeb J, Reimann KA, and Walker CM. 2003. Memory CD8+ T cells are required for protection from persistent hepatitis C virus infection. J Exp Med 197:1645-1655. |
| Erickson, A.L., Kimura, Y., Igarashi, S., Eichelberger, J., Houghton, M., Sidney, J., McKinney, D., Sette, A., Hughes, A.L., and Walker, C.M. 2001. The outcome of hepatitis C virus infection is predicted by escape mutations in epitopes targeted by cytotoxic T lymphocytes. Immunity 15:883-895. |
| Flaño E, Kim IJ, Woodland DL and Blackman MA. g-Herpesvirus latency is preferentially maintained in splenic germinal center and memory B cells. Journal of Experimental Medicine 196: 1363-1372, 2002. |
| Techaarpornkul S, Collins PL, and Peeples ME. 2002 Respiratory syncytial virus containing the fusion protein as its only glycoprotein attaches to cells via either glycosaminoglycans or another molecule. Virology 259, 294:296-304. PubMed ID: 12009871 |
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