| SELECTED PUBLICATIONS |
| Bakaletz, L.O. (2009). Chinchilla as a robust, reproducible and polymicrobial model of otitis media and its prevention. Expert Rev Vaccines, 8(8):1063-1082. PubMed ID: 19627188 |
| Bakaletz, L.O. (2009). Immunopathogenesis of polymicrobial otitis media. J of Leukocyte Biol, (Epub ahead of print, Oct 20). doi: 10.1189/jlb.0709518 PubMed ID: 19843575 |
| McGillivary, G., Mason, K.M., Jurcisek, J.A., Peeples, M.E., Bakaletz, L.O. (2009). RSV-induced dysregulation of expression of a mucosal β-defensin augments colonization of the upper airway by nontypeable Haemophilus influenzae. Cell Micro, 11(9):1399-1408. PubMed ID: 19500108 |
| Morton, D.J., Seale, T.W., Bakaletz, L.O., Jurcisek, J.A., Smith, A., VanWagoner, T.M., Whitby, P.W., Stull, T.L. (2009). The heme-binding protein (HbpA) of Haemophilus influenzae as a virulence determinant. Int J Med Microbiol, 299(7):479-488. PubMed ID: 19451029 |
| Murphy, T.F, Bakaletz, L.O., Smeesters, P. (2009). Microbial interactions in the respiratory tract. Pediatr Infect Dis J, 28(10):S121-S126. |
| Murphy, T.F., Faden, H., Bakaletz, L.O., Kyd, J.M., Forsgren, A., Campos, J., Virgi, M., Pelton, S.I. (2009). Nontypeable Haemophilus influenzae as a pathogen in children. Pediatr Infect Dis J, 28(1):43-48. PubMed ID: 19057458 |
| Novotny, L.A., Adams, L.D., Kang, D.R., Wiet, G.J., Cai, X., Sethi, S., Murphy, T.F., Bakaletz, L.O. (2009). Epitope mapping immunodominant regions of the PilA protein of nontypeable Haemophilus influenzae (NTHI) to facilitate the design of two novel chimeric vaccine candidates. Vaccine, 28(1):279-289. PubMed ID: 19699813 |
Bochkis IM, Rubins NE, White P, Furth EE, Friedman JR, Kaestner KH. (2008) Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress. Nature Medicine; 14(8):828-36. PubMed ID: 18660816 |
Tuteja G, Jensen ST, White P, Kaestner KH (2008). Cis-regulatory modules in the mammalian liver: composition depends on strength of Foxa2 consensus site. Nucleic Acids Research; 36(12):4149-57. PubMed ID: 18556755 |
| Bookwalter, J.E., Jurcisek, J.A., Gray-Owen, S.D., Fernandez, S., McGillivary, G., Bakaletz, L.O. (2008). A carcinoembryonic antigen-related cell adhesion molecule 1 homologue plays a pivotal role in nontypeable Haemophilus influenzae colonization of the chinchilla nasopharynx via the outer membrane protein P5-homologous adhesin. Infect Immun, 76(1):48-55. PubMed ID: 17938212 |
| McGillivary, G., Bakaletz, L.O. (2008). Innate immune defenses: Finding a new way to calm the storm. Immunol Cell Biol, 86(8):639-40. PubMed ID: 18794905 |
| Mullany LK, White P, Hanse EA, Nelsen CJ, Goggin MM, Mullany JE, Anttila CK, Greenbaum LE, Kaestner KH, Albrecht JH.(2008) Distinct proliferative and transcriptional effects of the D-type cyclins in vivo. Cell Cycle;7(14):2215-24. PubMed ID: 18635970 |
| Novotny LA, Partida-Sanchez S, Munson RS Jr., and Bakaletz LO. Differential uptake and processing of a Haemophilus influenzae P5-derived immunogen by chinchilla dendritic cell. Infect and Immun. 2008; 76:867-77. PubMed ID: 18160476 |
| Novotny, L.A., Partida-Sanchez, S., Munson Jr., R.S., Bakaletz, L.O. (2008). Differential uptake and processing of an OMP P5-derived immunogen by chinchilla dendritic cells. Infect Immun, 76(3):967-77. PubMed ID: 18160476 |
| Randolph GJ, Ochando J and Partida-Sánchez S. Migration of dendritic cell subsets and their precursors. Annu Rev Immunol. 2008; 26:293-316. PubMed ID: 18045026 |
| White P & Kaestner KH (2008). Gene expression analysis in diabetes research. In: ‘Methods of Molecular Medicine: Type 2 Diabetes’; In Press. The Humana Press Inc (ed Stocker, C). |
| White P, Lee May C, Lamounier RN, Brestelli JE, Kaestner KH (2008). Defining pancreatic endocrine precursors and their descendants. Diabetes; 57(3): 654 -668. PubMed ID: 18071024 |
Roche, A M., King, S.J., and Weiser, J.N (2007) Live attenuated Streptococcus pneumoniae strains induce serotype-independent mucosal and systemic protection in mice.Infect Immun. May;75(5):2469-75. PubMed ID: 17339359 |
Burnaugh AM, Frantz LJ, King SJ. Growth of Streptococcus pneumonniae on human glycoconjugates is dependent upon the sequential activity of bacterial exoglycosidases. J Bateriol. Jan;190(1):221-30
PubMed ID: 17981977 |
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Justice SS, Hunstad DA, Cegelski L, Hultgren SJ. (2007) Morphological plasticity as a bacterial survival strategy.Nat Rev Microbiol. Dec 24 PubMed ID: 18157153 |
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Seib KL, Wu H-J, Srikhanta Y, Edwards JL, Falsetta ML, Hamilton AJ, Maguire TL, Grimmond SM, Apicella MA, McEwan AG, and Jennings MP. (2007). Characterization of the OxyR regulon of N. gonorrhoeae. Mol Micro, 63(1):54-68.
PubMed ID: 17140413 |
Gao N, White P, Doliba N, Golson ML, Matschinsky FM, Kaestner KH. (2007). Foxa2 controls vesicle docking and insulin secretion in mature Beta cells. Cell Metabolism; 6(4):267-79. PubMed ID: 17908556 |
Gupta RK, Gao N, Gorski RK, White P, Hardy OT, Rafiq K, Brestelli JE, Chen G, Stoeckert CJ Jr, Kaestner KH. (2007). Expansion of adult beta-cell mass in response to increased metabolic demand is dependent on HNF-4alpha. Genes and Development; 21(7):756-69. PubMed ID: 17403778 |
Hardy OT, Hohmeier HE, Becker TC, Manduchi E, Doliba NM, Gupta RK, White P, Stoeckert CJ Jr, Matschinsky FM, Newgard CB, Kaestner KH (2007). Functional genomics of the ß-cell: SCHAD regulates insulin secretion independent of K+ currents. Molecular Endocrinology; 21(3):765-73. PubMed ID: 17185391 |
Keller DM, McWeeney S, Arsenlis A, Drouin J, Wright CV, Wang H, Wollheim CB, White P, Kaestner KH, Goodman RH (2007). Characterization of pancreatic transcription factor Pdx-1 binding sites using promoter microarray and serial analysis of chromatin occupancy. Journal of Biological Chemistry; 282(44):32084-92. PubMed ID: 17761679 |
Ku HT, Chai J, Kim YJ, White P, Purohit-Ghelani S, Kaestner KH, Bromberg JS (2007). Insulin-expressing colonies developed from murine embryonic stem cell-derived progenitors. Diabetes; 56(4):921-9. PubMed ID: 17395739 |
Mazzarelli JM, Brestelli J, Gorski RK, Liu J, Manduchi E, Pinney DF, Schug J, White P, Kaestner KH, Stoeckert CJ Jr (2007). EPConDB: a web resource for gene expression related to pancreatic development, beta-cell function and diabetes. Nucleic Acids Research; 35(Database issue):D751-5. PubMed ID: 17071715 |
Post DM, Munson RS Jr., Baker BD, Zhong H, Bozue JA, and Gibson BW. "Identification of genes involved in the expression of atypical lipooligosaccharide structures from a second class Haemophilus ducreyi, Infect. Immun 2007; 75(1):113-21. |
| Partida-Sanchez S, Gasser A, Fliegert R, Siebrands CC, Dammermann W, Shi G, Mousseau BJ, Sumoza-Toledo A, Bhagat H, Walseth TH, Guse AH, and Lund FE. Chemotaxis of mouse bone marrow neutrophils and dendritic cells is controlled by ADP-Ribose, the major product generated by the CD38 enzyme reaction. J Immunol. 2007; 179:7827-39. PubMed ID: 18025229 |
| Partida-Sanchez S, Rivero-Nava L, Shi G, and Lund FE. CD38: an ecto-enzyme at the crossroads of innate and adaptive immune responses. Adv Exp Med Biol. 2007;590:171-83. PubMed ID: 17191385 |
| Harrison A, Dyer DW, Gillaspy A, Ray WC, Mungur R, Carson MB, Zhong H, Gipson J, Gipson M, Johnson LS, Lewis L, Bakaletz LO and Munson RS Jr. "Genomic sequence of an otitis media isolate of nontypeable Haemophilus influenzae: Comparative study with H. influenzae serotype d, strain KW20", J Bacteriol 2005; 187(13):4627-36. |
| Harrison A, Ray WC, Baker BD, Armbruster DW, Bakaletz LO and Munson RS Jr. "The OxyR regulon in nontypeable Haemophilus influenze", J Bacteriol 2007; 189(3):1004-12. |
| Hong, W, Mason KM, Jurcisek JA, Novotny LA, Bakaletz LO, Swords WE. (2007) Phosphorylcholine decreases early inflammation and promotes establishment of stable biofilm communities of NTHi strain 86-028NP in the chinchilla models of otitis media. Infect Immun. 75(2):958-965. PubMed ID: 17130253 |
| Johnston JW, Zaleski A, Allen S, Mootz JM, Armbruster D, Gibson BW, Apicella MA, and Munson RS Jr. "Regulation of sialic acid transport and catabolism in Haemophilus influenzae", Molecular Microbiology 2007; 66(1):26-39. |
| Randolph GJ, Ochando J and Partida-Sanchez S. Migration of dendritic cell subsets and their precursors. Annual Review of Immunology 2007 Nov 15 [Epub ahead of print]. PubMed ID: 18045026 |
| Shi G*, Partida-Sanchez S*, Misra RS, Tighe M, Borchers MT, Lee JJ, Simon MI, and Lund FE. Identification of an alternative G{alpha}q-dependent chemokine receptor signal transduction pathway in dendritic cells and granulocytes. J Exp Med. 2007; 204:2705-18. (*Equal contribution first author). PubMed ID: 17938235 |
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Justice SS, Hunstad DA, Seed PC, and Hultgren SJ. (2006) Filamentation by E. coli subverts innate defenses during urinary tract infections. Proceedings of the National Academy of Sciences USA, Dec 26;103(52):19884-9.
PubMed ID: 17172451 |
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Justice SS, Lauer SR, Hultgren SJ, Hunstad DA. (2006) Maturation of intracellular Escherichia coli communities requires SurA Infection and Immunity Aug;74(8):4793-800.
PubMed ID: 16861667 |
Mazzarelli JM, White P, Gorski R, Brestelli J, Pinney DF, Arsenlis A, Katokhin A, Belova O, Bogdanova V, Elisafenko E, Gubina M, Nizolenko L, Perelman P, Puzakov M, Shilov A, Trifonoff V, Vorobjeva N, Kolchanov N, Kaestner KH, Stoeckert CJ Jr (2006). Novel genes identified by manual annotation and microarray expression analysis in the pancreas. Genomics 88(6):752-61. PubMed ID: 16725306 |
Lund FE, Muller-Steffner H, Romero-Ramirez H, Moreno-Garcia M, Partida-Sanchez S, Makris M, Oppenheimer N, Santos-Argumedo L, and Shuber F. (2006). CD38 induces apoptosis of a murine pre-B cell leukemic cell line by an ADP-ribosyl cyclase and NAD glycohydrolase independent mechanism. Int. Immunol. 2006; 18:1029-42. PubMed ID: 16720618 |
Burkhardt BR, Greene SR, White P, Wong RK, Brestelli JE, Yang J, Robert CE, Brusko TM, Wasserfall CH, Wu J, Atkinson MA, Gao Z, Kaestner KH, Wolf BA (2006). PANDER-induced cell-death genetic networks in islets reveal central role for caspase-3 and cyclin-dependent kinase inhibitor 1A (p21). Gene 2006 369:134-141. PubMed ID: 16412588 |
Khader SA, Partida-Sanchez S, Bell G, Jelley-Gibbs DM, Swain S, Pearl JE, Ghilardi N, Desauvage FJ, Lund FE, Cooper AM. Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infection. J Exp Med 2006 Jul 10; 203:1805-15. PubMed ID: 16818672 |
Mason KM, Bruggeman ME, Munson Jr. RS, Bakaletz LO. (2006) The nontypeable Haemophilus influenzae Sap transporter provides a mechanism of antimicrobial peptide resistance and SapD-dependent potassium acquisition. Mol Micro. 62(5):1357-1372. PubMed ID: 17064364 |
| Edwards JL and Apicella MA. (2006). Neisseria gonorrhoeae PLD directly interacts with Akt kinase upon infection of primary human cervical epithelial cells. Cell Microbiol, 8(8):1253-1271. PubMed ID: 16882030 |
| King S. J., Hippe K.R., Weiser J.N. (2006). Deglycosylation of human glycoconjugates by the sequential activities of exoglycosidases expressed by Streptococcus pneumoniae. Molecular Microbiology, 59:691-74. PubMed ID: 16420364 |
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Hunstad DA, Justice SS, Hung CS, Lauer SR, and Hultgren SJ (2005) Suppression of bladder epithelial cytokine responses by uropathogenic Escherichia coli. Infection and Immunity 73(7); 3999-4006.
PubMed ID: 15972487 |
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Justice SS, Hunstad DA, Reiss Harper J, Duguay A, Pinkner JS, Bann J, Frieden C, Silhavy TJ, and Hultgren SJ (2005) Periplasmic peptidyl prolyl cis-trans isomerases are not essential for viability but are required for pilus biogenesis in Escherichia coli. Journal of Bacteriology Nov;187(22):7680-6.
PubMed ID: 16267292 |
Bakaletz LO, Baker BD, Jurcisek JA, Harrison A, Novotny LA, Bookwalter JE, Mungur R and Munson RS Jr,. “Demonstration of type IV pilus expression and a twitching phenotype by Haemophilus influenzae”, Infect Immun 2005; 73(3):1635-43. |
Post DM, Mungur R, Gibson BW and Munson RS Jr., "Identification of a novel sialic acid transporter in Haemophilus ducreyi", Infect Immun. 2005; 73(10):6727-35.
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White P, Brestelli JE, Kaestner KH, Greenbaum LE (2005). Identification of transcriptional networks during liver regeneration. Journal of Biological Chemistry; 280(5): 3715-3722. PubMed ID: 15546871 |
| Edwards JL and Apicella MA. (2005). I-domain-containing integrins serve as pilus receptors for Neisseria gonorrhoeae adherence to human epithelial cells. Cell Microbiol, 7:1197-1211. PubMed ID: 16008586 |
| Greiner LL, Edwards JL, Rabinak CA, Shao JQ, and Apicella MA. (2005). Biofilm formation by Neisseria gonorrhoeae. Infect Immun, 73:1964-1970. PubMed ID: 15784536 |
| King S.J., Whatmore A.M., Dowson C.G. (2005). NanA, a neuraminidase from Streptococcus pneumoniae, shows high levels of sequence diversity, at least in part through recombination with Streptococcus oralis. Journal of Bacteriology, 187:5376-86. PubMed ID: 16030232 |
| Mason KM, Munson Jr. RS, Bakaletz LO. (2005) A mutation in the sap operon attenuates survival of NTHi in a chinchilla model of otitis media. Infect Immun. 73(1):599. PubMed ID: 15618200 |
| Novotny LA, Mason KM, Bakaletz LO. (2005) Development of a chinchilla model to allow direct continuous biophotonic imaging of bioluminescent NTHi during experimental otitis media. Infect Immun. 73(1):609. PubMed ID: 15618201 |
| Dauncey MJ and White P (2004). Nutrition and cell communication: Insulin signalling in development, health and disease. Recent Research Developments in Nutrition; 6: 49-81. Research Signpost (ed. Pandalai, SG). |
| Dauncey MJ, Katsumata M and White P (2004). Nutrition, hormone receptor expression, and gene interactions: implications for development and disease. In: ‘Muscle Development of Livestock Animals: Physiology, Genetics and Meat Quality’; pp. 105-124. CAB International Publishing (eds. te Pas MFW, Everts ME & Haagsman HP). |
| Edwards JL and Apicella MA. (2004). Neisseria gonorrhoeae: The molecular mechanisms that initiate infection differ between men and women. Clin Microbiol Rev, 17:965-981. PubMed ID: 15489357 |
| Kesty NC, Mason KM, Reedy M, Miller SE, Kuehn MJ. (2004) enterotoxigenic Escherichia coli vesicles target toxin delivery into mammalian cells. EMBO J. 23(23):4538. PubMed ID: 15549136 |
| King S.J., Allen A.G., Maskell D. J., Dowson C.G., Whatmore A.M. (2004). Distribution, genetic diversity, and variable expression of the gene encoding hyaluronate lyase within the Streptococcus suis population. Journal of Bacteriology, 186:4740-4747. PubMed ID: 15231806 |
| King, S.J., Hippe, K.R., Gould, J.M., Bae, D., Peterson, S., Cline, R.T., Fasching, C., Janoff, E.N., Weiser, J.N. (2004). Phase variable desialylation of host proteins that bind Streptococcus pneumoniae in vivo and protect the airway. Molecular Microbiology, 54:159-171. PubMed ID: 15458413 |
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Justice SS, Hung CS, Theriot JA, Fletcher DA, Anderson GG, Footer MJ, and Hultgren SJ (2003) From the cover: Differentiation and Developmental Pathways of Uropathogenic E. coli in Urinary Tract Pathogenesis. Proceedings of the National Academy of Sciences USA 101(5): 1333-8.
PubMed ID: 14739341 |
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Schilling JD, Martin SM, Hunstad DA, Patel KP, Mulvey MA, Justice SS, Lorenz RG, and Hultgren SJ. (2003) CD14- and Toll-like receptor- Dependent Activation of Bladder Epithelial Cells by Lipopolysaccharide and Type 1-piliated E. coli. Infection and Immunity Mar;71(3):1470-80.
PubMed ID: 12595465 |
| Edwards JL, Entz DD and Apicella MA. (2003). Gonococcal phospholipase D modulates the expression and function of complement receptor 3 in primary cervical epithelial cells. Infect Immun, 71:6381-6391. PubMed ID: 14573659 |
| Mason KM, Munson Jr. RS, Bakaletz LO. (2003) Nontypeable Haemophilus influenzae gene expression induced in vivo in a chinchilla model of otitis media. Infect Immun. 71(6):3454. PubMed ID: 12761130 |
| Edwards JL and Apicella MA. (2002). The role of lipooligosaccharide in Neisseria gonorrhoeae pathogenesis of cervical epithelia: lipid A serves as a C3 acceptor molecule. Cell Microbiol, 4:585-598. PubMed ID: 12390351 |
| Edwards JL, Brown EJ, Uk-Nham S, Cannon JG, Blake MS and Apicella MA. (2002). A co-operative interaction between Neisseria gonorrhoeae and complement receptor 3 mediates infection of primary cervical epithelial cells. Cell Microbiol, 4:571-584. PubMed ID: 12390350 |
| King S.J., Leigh J.A., Heath P.J., Luque I., Tarradas C., Dowson C.G., Whatmore A.M. (2002). Development of a multilocus sequence typing scheme for the pig pathogen Steptococcus suis: identification of virulent clones and potential capsular serotype exchange. Journal of Clinical Microbiology, 40:3671-3680. PubMed ID: 12354864 |
| Shakhnovich E.A., King S.J., Weiser J.N. (2002). Neuraminidase expressed by Streptococcus pneumoniae desialylates the lipopolysaccharide of Neisseria meningitidis and Haemophilus influenzae: A paradigm for interbacterial competition among pathogens of the human respiratory tract. Infection and Immunity, 70: 7161-7164. PubMed ID: 12438402 |
| Edwards JL, Brown EJ, Ault KA and Apicella MA (2001). The role of complement receptor 3 (CR3) in Neisseria gonorrhoeae infection of human cervical epithelia. Cell Microbiol, 3:611-622. PubMed ID: 11553013 |
| King S.J., Heath P., Luque I., Tarradas C., Dowson C.G., Whatmore A.M. (2001). Distribution and genetic diversity of suilysin in Streptococcus suis isolated from different diseases of pigs: characterisation of the genetic basis of suilysin absence in isolates frequently associated with pneumonia. Infection and Immunity, 69:7572-7582. PubMed ID: 11705935 |
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Justice SS, Garcia-Lara J, Rothfield LI. (2000) Cell division inhibitors SulA and MinC/MinD block septum formation at different steps in the assembly of the Escherichia coli division machinery. Moleclular Microbiology. July;37(2):410-23.
PubMed ID: 10931335 |
Edwards, J. L., J. Q. Shao, K. A. Ault, and M. A. Apicella (2000) Neisseria gonorrhoeae elicits membrane ruffling and cytoskeletal rearrangements upon infection of primary human endocervical and ectocervical cells. Infect Immun, 68:5354-5363. PubMed ID: 10948165 |
| Katsumata M, Cattaneo D, White P, Burton KA and Dauncey MJ (2000). Growth hormone receptor gene expression in porcine skeletal and cardiac muscles is selectively regulated by postnatal undernutrition. Journal of Nutrition (USA); 130: 2482-2488. PubMed ID: 11015477 |
| Murphy ML and White P (2000). Immunology 2000: The American Association of Immunologists and Clinical Immunology Society joint annual meeting. Investigational Drugs Weekly Highlights (Current Drugs); 23:46-49. |
| Muller-Graf, C., Whatmore A.M., King S.J., Pickerill A.P., Doherty N., Paul J., Griffiths D., Crook D., Dowson C.G. (1999) Population biology of Streptococcus pneumoniae isolated from oropharyngeal carriage and invasive disease. Mircobiology, 145: 3283-3293, PubMed ID: 10589738 |
| Whatmore, A.M., King, S.J., Doherty, N.C., Sturgeon, D., Chanter, N., Dowson, C.G. (1999). Molecular characterisation of equine isolates of Streptococcus pneumoniae: a natural disruption of genes encoding the virulence factors pneumolysin and autolysin. Infection and Immunity, 67:2776-2782. PubMed ID: 10338480 |
Mason KM, Dryden TD, Bigley NJ, Fink PS. (1998) Staphylococcal enterotoxin B (SEB) primes CD8+ Interferon-y (INF-y) secretion and cytotoxic effects in response to native bacterial antigens. Infect Immun. 66(11):5082. PubMed ID: 9784507 |
| Curiel RE, Mason KM, Dryden TD, Bigley NJ. (1998). Cytokines produced early in picornavirus infection reflect resistance or susceptibility to disease. J Interferon Cyt Res. 18(8):587. PubMed ID: 9726440 |
| Mason KM, Bigley NJ, Fink PS. (1998) Development of a novel in vitro co-culture system for studying host response to native bacterial antigens. J Immunol Meth. 211(1-2):147. PubMed ID: 9617839 |
| White P and Dauncey MJ (1998). An enhanced method for RNase protection assays using SeeDNA Co-precipitant. Life Science News; 1:23. |
| Dowson C.G., Barcus V., King S., Pickerill P., Whatmore A.M., Yeo M. Horizontal gene transfer and the evolution of resistance and virulence determinants of Streptococcus. Journal of Applied Microbiology, 83: 42S-51S, 1997. PubMed ID: 9436316 |
| White P, Burton KA, Cattaneo D, Harrison AP and Dauncey MJ (1995). Biotechnological approach to the study of the interactions between nutritional status and animal growth. In: ‘State of the Art of Italian Research in the Field of Biotechnologies Applied to Veterinary Medicine’; pp. 271-279. Breshia, Italy. |
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