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MCHUGH LABORATORY
The current research efforts in my lab focus on the development and pathogenesis of the urogenital system. Urinary tract malformations, obstructive nephropathy, and renal hypoplasia/dysplasia comprise over 50% of the children with end-stage renal disease worldwide. These defects are extremely important in the terms of pediatric health care costs with end-stage renal disease estimated to cost 1.5 billion dollars annually in the United States alone. Studies in our lab focus on congenital defects in bladder smooth muscle development as well as the resulting pathologies associated with the development of obstructive nephropathy including chronic renal failure and kidney disease. We have identified a highly unique mouse model, designated mgb for megabladder, which permits the study of the development of obstructive nephropathy in utero, and our currently using a wide range of genetic and molecular approaches to identify the genes responsible for the developmental defects and subsequent pathologies observed in mgb mice. The identification and characterization of the factors responsible for the pathogenic changes in renal function following the development of congenital bilateral obstructive nephropathy in mgb mice will provide a platform for the evaluation of pharmacological, surgical, and gene therapy strategies designed to prevent and treat the pathogenic processes associated with the development of progressive renal failure in utero.
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| Education |
| 1986 |
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Ph.D. |
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Anatomy and Cell Biology |
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University of Cincinnati College of Medicine, Cincinnati, OH |
| 1982 |
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B.S. |
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Biology and Chemistry |
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Mount Union College, Alliance, OH |
| Professional Experience |
| 2002- PRES |
Associate Professor, Department of Pediatrics, The Ohio State University |
| 1994- 2002 |
Associate Professor, Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson Unversity, Philadelphia, PA |
| 1989- 1994 |
Assistant Professor, Department of Anatomy and Developmental Biology, Thomas Jefferson University, Philadelphia |
| 1986- 1989 |
Research Fellow, Basic Sciences Division, Children's Hospital Research Foundation, Cincinnati, OH |
MCHUGH LABORATORY STAFF
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Principal Investigator:
Kirk M. McHugh, Ph.D.
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| Selected Publications |
| Schwaderer AL, Bates CM, McHugh KM and McBride KL. Renal anomalies in family members of infants with bilateral renal agenesis/adysplasia. Pediatr Nephrol, 22(1):52-56, 2006. PubMed ID: 16977473 |
| Gabbeta V, Trzyna W, Phiel C, McHugh KM. Vesical Associated Protein A is Differentially Expressed During Intestinal Smooth Muscle Cell Differentiation. Developmental Dynamics, 228:11-20, 2003. PubMed ID: 12950075 |
| Phiel C, Gabbeta V, Parsons L, Rothblat D, Harvey R, and McHugh KM. Differential Binding of an SRF/NK-2/MEF2 Transcription Factor Complex in Normal Versus Neoplastic Smooth Muscle Tissues, Journal Biological Chemistry, 276, 34637-34650, 2001. PubMed ID: 11457859 |
| Brittingham J, Phiel C, Trzyna W, Gabbeta V, and McHugh KM. Identification of Distinct Molecular Phenotypes in Cultured Gastrointestinal Smooth Muscle Cells, Gastroenterology, 115: 605-617, 1998. PubMed ID: 9721158 |
| McCue P, McHugh M, and McHugh KM. Diagnosing Uterine Smooth Muscle Tumors: A Review. Invited Review, LabMedica International, 15: 12-16, 1998. |
| Trzyna W, McHugh M, McCue P, and McHugh KM. Finally - A Clear Diagnostic Test that Shows if Uterine Smooth Muscle Tumors Are Benign or Malignant. Editors, Wilson K, Chisholm R, Albertinin D, Dasso M and Payne G. 1997 ASCB Annual Meeting Selected Biomedical Abstracts, American Society for Cell Biology 19, 1997. |
| Brittingham J, Liaw D, Liddell R, McHugh M, McCue P, and McHugh KM. Comparative Analysis of Smooth Muscle Isoactin Gene Expression in a Variety of Normal and Neoplastic Tissues. Pathobiology, 65: 113-122, 1997. |
| Trzyna W, McHugh M, McCue P, and McHugh KM. Molecular Determination of the Malignant Potential of Smooth Muscle Neoplasms. Cancer, 80: 211-217, 1997. PubMed ID: 9217032 |
| Trzyna WC, Gabbeta V, McHugh KM. Isolation and characterization of a novel short chain alcohol dehydrogenase-like isozyme by differential display of distinct smooth muscle cell phenotypes. J Steroid Biochem Mol Biol, 63 (1-3):115-121, 1997. PubMed ID: 9449212 |
| McHugh KM. Molecular Analysis of Gastrointestinal Smooth Muscle Development: Invites Review. Journal Pediatric Gastroenterology and Nutrition, 23: 379-394, 1996. PubMed ID: 8956171 |
| McHugh KM. Molecular Analysis of Smooth Muscle Development in the Mouse. Developmental Dynamics. 204: 278-290, 1995. PubMed ID: 8573719 |
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