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DAS LABORATORY
My lab uses theoretical and computational approaches based on statistical physics to uncover basic mechanistic principles underlying our innate and adaptive immune response. Obtaining such mechanistic principles from experimental observations alone is often difficult because the pertinent processes include co-operative dynamic events with many participating components. A further complication that confounds intuition is stochastic fluctuations in these systems with small numbers of molecules. However, by synergistically integrating observations from experiments with transgenic animals, single molecule techniques and imaging studies probing molecular events in live animals with these theoretical and computational approaches we can provide system-level understanding into such complex systems. The mechanistic insight gained from such studies not only will help develop future experiments to unravel basic principles of our immune system, but may also help envision therapeutic strategies for infectious diseases and autoimmune disorders. More details about the projects and the resources available can be found in the lab web page.
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| Education |
| 2000 |
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Ph.D. |
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Physics |
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Raman Research Institute, Bangalore, India |
| 1996 |
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M.Sc. |
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Physics |
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Institute of Mathematical Sciences, Chennai (Madras) India |
| Professional Experience |
| 2008- PRES |
Assistant Professor, Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children's Hospital |
| 2008- PRES |
Assistant Professor, Department of Pediatrics, The Ohio State University |
| 2005- 2008 |
Postdoctoral Fellow, Massachusetts Institute of Technology |
| 2002- 2005 |
Postdoctoral Fellow, University of California at Berkeley |
| 2000- 2002 |
Postdoctoral Fellow, Virginia Institute of Polytechnic and State University |
DAS LABORATORY STAFF
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Principal Investigator:
Jayajit Das, Ph.D.
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| Selected Publications |
| Das J, Frechet JM, Chakraborty AK. Self-Assembly of Dendronized Polymers(dagger). J Phys Chem B. 2009 July 2.(Epub ahead of print) PubMed ID: 19572661 |
| Das J, Kardar M, Chakraborty AK. J Chem Phys. 2009 June 28;130(24):245102. Positive feedback regulation results in spatial clustering and fast spreading of active signaling molecules on a cell membrane. PubMed ID: 19566183 |
Chakraborty, AK, Das, J, Zikherman J, Yang M, Govern cc, Ho M, Weiss A, and Roose J. Molecular origin and functional consequences of digital signaling and hysteresis during Ras activation in lymphocytes.Sci Signal 2009 Apr 14; 2(66) pt2. doi: 10. 1126/scisignal.266pt2 PubMed ID: 19366993 |
Das J, Ho M, Zikherman J, Govern C, Yang M, Weiss A, Chakraborty AK, and Roose JP. Digital signaling and hysteresis characterize ras activation in lymphoid cells. Cell 2009 Jan 23; 136(2) 337-51.doi: 10. 1016/j.cell.2008.11.051 PubMed ID: 19167334 |
| Prasad A. Zikherman J, Das J, Roose JP, Weiss A, and Chakraborty AK. Origin of the sharp boundary that discriminates positive and negative selection of thymocytes. Proc Natl Acad Sci U S A 2009 Jan 13; 106(2) 528-33. doi: 10. 1073/pnas.0805981105 PubMed ID: 19098101 |
S. Cemerski, Jayajit Das, Emanuele Giurisato, Mary A. Markiewicz, Paul M. Allen, Arup K. Chakraborty and Andrey S. Shaw, "Evidence for signaling from the center of the immune synapse" Immunity 29(3):414-22, 2008.
This paper is in the Editors Choice of Science Signaling (Issue 23rd September 2008.) Also see a preview of this paper by S. Valitutti in the same issue of Immunity. PubMed ID: 18760640 |
| Maxim Artyomov, Jayajit Das, Mehran Kardar and Arup K. Chakraborty. "Purely stochastic binary decision in cell signaling models without underlying deterministic bistabilities"Proc Natl Acad Sci U S A. 104(48):18958-18963, 2007. Special mention in Physics Today 61, 28(2008) PubMed ID: 18025473 |
| Dennis Wylie, Jayajit Das and Arup K. Chakraborty. "Sensitivity of T cells to antigen and antagonism emerges from differential regulation of the same molecular signaling module"Proc Natl Acad Sci U S A. 27;104(13):5533-5538, 2007. This paper is selected in the faculty of 1000 Biology papers PubMed ID: 17360359 |
| S. Cemerski, Jayajit Das, Jason Locasale, Pheobe Arnold, Emanuele Giurisato, Mary A. Markiewicz, Daved Fremont, Paul M. Allen, Arup K. Chakraborty and Andrey S. Shaw, "The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse" Immunity 26(3):345-55, 2007. These authors have equal contribution PubMed ID: 17346997 |
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