The Research Institute at Nationwide Children's Hospital - Jayajit Das, Ph.D. Profile
Jayajit Das, Ph.D.
photo of Jayajit Das, Ph.D.

LAB DESCRIPTION

BIOGRAPHY

STAFF INFO

PUBLICATIONS
Battelle Center for Mathematical Medicine

PRINCIPAL INVESTIGATOR

Jayajit.Das@
nationwidechildrens.org

700 Children's Drive

Columbus, OH 43205
p: 614.355.4526 | f: 614.355.2728

DAS LABORATORY
My lab uses theoretical and computational approaches based on statistical physics to uncover basic mechanistic principles underlying our innate and adaptive immune response. Obtaining such mechanistic principles from experimental observations alone is often difficult because the pertinent processes include co-operative dynamic events with many participating components. A further complication that confounds intuition is stochastic fluctuations in these systems with small numbers of molecules. However, by synergistically integrating observations from experiments with transgenic animals, single molecule techniques and imaging studies probing molecular events in live animals with these theoretical and computational approaches we can provide system-level understanding into such complex systems. The mechanistic insight gained from such studies not only will help develop future experiments to unravel basic principles of our immune system, but may also help envision therapeutic strategies for infectious diseases and autoimmune disorders. More details about the projects and the resources available can be found in the lab web page.