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| Education |
| 1990 |
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Postdoctor |
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Molecular Biology |
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Princeton University, Princeton, NJ |
| 1984 |
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Ph.D. |
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Microbiology |
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New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ |
| 1979 |
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Certificate in Computer Programming |
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Computer Programming |
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National Taiwan University, Graduate Institute of Electric Engineering, Taipei, Taiwan, ROC |
| 1978 |
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B.S. |
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Medical Technology |
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National Taiwan University, Taipei, Taiwan, R.O.C. |
| Professional Experience |
| 2007- PRES |
Adjunct Professor, Departments of Molecular Cellular Biochemistry, Pathology, Otolaryngology, and Vet. Biosci., The Ohio State University, Columbus, OH |
| 2007- PRES |
Professor, Department of Pediatrics, The Ohio State University College of Medicine, and Center for Childhood Cancer, Children’s Research Institute, Children’s Hospital, Columbus, OH |
| 2006- PRES |
Senate Member, University Senate’s Committee on Academic Misconduct, The Ohio State University, Columbus, OH |
| 2001- PRES |
Judge, Otolaryngology Resident and Fellow Presentations at the Annual Otolaryngology Alumni Symposium, Department of Otolaryngology, The Ohio State University College of Medicine, Columbus, OH
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| 2001- PRES |
Otolaryngology Fellow Training Program Committee, Department of Otolaryngology, The Ohio State University College of Medicine, Columbus, OH |
| 1996- PRES |
Institutional Animal Care and Use Committee, Children’s Hospital Research Foundation, Children's Hospital, Columbus, OH |
| 1995- PRES |
Institutional Biosafety Recombinant DNA Committee, The Ohio State University Research Foundation, The Ohio State University, Columbus, OH |
| 1995- PRES |
Medical Staff Committee on Comprehensive Cancer Care, Children's Hospital, Columbus, OH |
| 1994- PRES |
Appointment to Category III Service on the Graduate Faculty in Molecular Cellular Development Biology Program and Ohio State Biochemistry Program, The Ohio State University, Columbus, OH |
| 1993- PRES |
Oncology Training Grant Committee, Division of Hematology-Oncology, Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, OH |
| 1990- PRES |
Member, Molecular, Cellular, and Developmental Biology (MCDB) Program and Ohio State Biochemistry Program (OSBP), The Ohio State University, Columbus, OH |
| 2007- 2007 |
Peer-Review Scientific Reviewer, The Department of Defense Post-Traumatic Stress Disorder/Traumatic Brain Injury (PTSD/TBI) Research Program Panel 4 |
| 2007- 2007 |
Peer-Review Online Reviewer, The Department of Defense Post-Traumatic Stress Disorder/Traumatic Brain Injury (PTSD/TBI) Research Program Panel 2 |
| 2003- 2007 |
Adjunct Associate Professor, Department of Veterinary Biosciences, The Ohio State University, Columbus, OH |
| 2001- 2007 |
Adjunct Associate Professor, Department of Otolaryngology, The Ohio State University College of Medicine, Columbus, OH |
| 1998- 2007 |
Adjunct Associate Professor, Department of Pathology, The Ohio State University College of Medicine, Columbus, OH |
| 1996- 2007 |
Adjunct Associate Professor, Department of Molecular Cellular Biochemistry (former Medical Biochemistry), The Ohio State University College of Medicine, Columbus, OH |
| 1996- 2007 |
Associate Professor, Department of Pediatrics, Children's Hospital and The Ohio State University, Columbus, OH |
| 2006- 2006 |
Referee, Grants Committee, Medical Research Council, UK |
| 1993- 2006 |
Graduate Studies Committee, Molecular Cellular Development Biology Program, The Ohio State University, Columbus, OH |
| 2005- 2005 |
Referee, Project Grants Committee, Cancer Research UK |
| 2005- 2005 |
2005 Peer-Review Panel Member, Cancer Research Program, The US Army Medical Research and Material Command (USAMRMC) Congressionally Directed Medical Research Program (CDMRP) |
| 2002- 2003 |
Organizer, the Center for Childhood Cancer Bi-monthly Research Meeting, Children’s Research Institute, Columbus, OH |
| 1998- 2003 |
Graduate Admission Committee, Ohio State Biochemistry Program, The Ohio State University, Columbus, OH |
| 1999- 1999 |
Organizer, 11th Annual Stone Lab Meeting, The Ohio State University Comprehensive Cancer Center Molecular Biology & Human Cancer Genetics Program, F.T. Stone Laboratory, The Ohio State University Put-in-Bay Campus, OH
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| 1997- 1998 |
Rotation Research Advisory Committee, Molecular, Cellular, & Developmental Biology Program, The Ohio State University, Columbus, OH |
| 1995- 1996 |
Laboratory Director, The Ohio State University Comprehensive Cancer Center Transgenic Mouse Facility at Children's Hospital, The Ohio State University, Columbus, OH |
| 1995- 1996 |
Design Task Force for Wexner Institute for Pediatric Research, Children’s Hospital, Columbus, OH |
| 1993- 1996 |
Transgenic Advisory Committee, Biotechnology Center, The Ohio State University, Columbus, OH
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| 1991- 1996 |
Program Committee, Children's Hospital Research Foundation, Children's Hospital, Columbus, OH |
| 1991- 1996 |
Adjunct Assistant Professor, Department of Medical Biochemistry, The Ohio State University College of Medicine, Columbus, OH |
| 1990- 1996 |
Assistant Professor, Department of Pediatrics, Children's Hospital and The Ohio State University College of Medicine, Columbus, OH |
| 1994- 1995 |
Gene Therapy Task Force, College of Medicine, The Ohio State University, Columbus, OH |
| 1992- 1995 |
Strategic Planning Task Force Committee, Children's Hospital Research Foundation, Children's Hospital, Columbus, OH |
| 1992- 1995 |
Operation Committee, Children's Hospital Research Foundation, Children's Hospital, Columbus, OH |
| 1991- 1995 |
Laboratory Director, The Ohio State University/Children's Hospital Transgenic Mouse Facility, Columbus, OH |
| 1988- 1990 |
Research Staff Member, Department of Molecular Biology, Princeton University, Princeton, NJ. Mentor: Dr. Thomas E. Shenk |
| 1985- 1987 |
Leukemia Society Research Fellow, Leukemia Society of America, Advisor: Dr. Thomas E. Shenk, Professor, Howard Hughes Professor, and Member of National Academy of Sciences |
| 1985- 1985 |
Research Associate, Department of Molecular Biology, Princeton University, Princeton, NJ. Advisor: Dr. Thomas E. Shenk, Professor and Member of National Academy of Sciences, Department of Molecular Biology, Princeton University |
| 1985- 1985 |
Research Associate, Department of Molecular Biology, Princeton University, Princeton, NJ. Advisor: Dr. Thomas E. Shenk, Professor and Member of National Academy of Sciences, Department of Molecular Biology, Princeton University |
| 1984- 1984 |
Research Associate, Department of Microbiology, New Jersey Medical School, UMDNJ, Newark, NJ. Advisor: Dr. Giampiero di Mayorca, Professor and Chairman |
| 1979- 1984 |
Ph.D. Research, Department of Microbiology, New Jersey Medical School, UMDNJ, Newark, NJ. Advisor: Dr. Giampiero di Mayorca, Professor and Chairman |
| 1978- 1979 |
Medical Technologist, Department of Medical Technology, National Taiwan University Hospital, Taipei, Taiwan, R.O.C. |
| 1977- 1978 |
Undergraduate Thesis Research. Advisor: Dr. C.-S. Yang, M.D., Professor and Director, Graduate Institute of Bacteriology, College of Medicine, National Taiwan University, Taipei, Taiwan, R.O.C. |
Research Interests
The main focus of Dr. Chang’s laboratory is to better understand how tumor suppressor genes are regulated and function during development and tumorigenesis. His laboratory is interested in the function and regulation of the neurofibromatosis type 2 (NF2) tumor suppressor gene. Recent studies show that mutations in the NF2 gene are associated with vestibular schwannoma formation. Together with D. Bradley Welling, MD, PhD, Department of Otolaryngology, Dr. Chang is studying the molecular mechanism by which the NF2 gene acts to prevent tumor formation. In addition, the laboratory is examining the regulation of the NF2 gene during nervous system development and the role of the NF2 protein during neural tube closure and neural crest cell migration.
Dr. Chang’s laboratory is also elucidating the regulatory mechanisms governing the expression of the retinoblastoma gene product (Rb) and related p107 genes. Dr. Chang’s group is examining how the Rb-family suppressor proteins and E2F-family transcription factors interplay to modulate gene expression during cell cycle and development. Additionally, his laboratory is studying the neural-specific serotonin 5-HT2C receptor, which plays important roles in epilepsy and obesity.
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| Selected Publications |
| Dorogova, N.V., E.M. Akhmameteva, S.A. Kopyl, N.V. Gubanova, O.S. Yudina, L.V. Omelyanchuk, and L.-S. Chang. 2008. The Role of Drosophila Merlin in Spermatogenesis. BMC Cell Biol. 9: 1-15. |
| Chang, L.-S. and D.B. Welling. 2008. Molecular Biology of Vestibular Schwannomas. In Auditory/Vestibular Research, Sokolowski, B. (Ed.), The Humana Press, Totowa, NJ. |
| Welling, D.B., M.D. Packer, and L.-S. Chang. 2007. Molecular Studies of Vestibular Schwannomas: A Review. Curr. Opin. Otolaryngol. Head Neck Surg. 15:341-346. |
| Welling, D.B., M.D. Packer, E.M. Akhmametyeva, and L.-S. Chang. 2007. The Biology and Genetics of Vestibular Schwannomas. In Tumors of the Cerebellopontine Angle, Bambakidis, N.C., Megerian, Porter, and R.F. Spetzler (Eds), B.C. Decker, Inc., Hamilton, Ontario, CA. |
| Jacob, A., T.X. Lee, B.A. Neff, S. Miller, D.B. Welling, and L.-S. Chang. 2007. Activation of the AKT Pathway in Human Vestibular Schwannomas. Otol. Neurotol. 29:58-68. |
| Neff, B.A., D.B. Welling, E.M. Akhmametyeva, and L.-S. Chang. 2006. The Molecular Biology of Vestibular Schwannomas: Dissecting the Pathogenic Process at the Molecular Level. Otol. Neurotol. 27:197-208. |
| Neff, B.A., E. Oberstein, M. Lorenz,, A. Chadhury, D.B. Welling, and L.-S. Chang. 2006. Cyclin D1 and D3 Expression in Vestibular Schwannomas. Laryngoscope 116:423-426. |
| Akhmametyeva, E.M., M.M. Mihaylova, H. Luo, S. Kharzai, D.B. Welling, and L.-S. Chang. 2006. Regulation of the NF2 Gene Promoter Expression During Embryonic Development. Dev. Dyn. 235:2771-2785. |
| Jiang, Y., W.D. Lo, E.M. Akhmametyeva, and L.-S. Chang. 2006. Over-expression of p73? Results in Apoptotic Death of Postmitotic hNT Neurons. J. Neurol. Sci. 240:1-6. |
| Chang, L.-S., A. Jacob, M. Lorenz, J. Rock, E.M. Akhmametyeva, G. Mihai, P. Schmalbrock, A.R. Chaudhury, R. Lopez, J. Yamate, M.R. John, H. Wickert, B.A. Neff, E. Dodson, and D.B. Welling. 2006. Magnetic Resonance Imaging Noninvasively Quantifies Schwannoma Xenografts in SCID Mice. Laryngoscope 116:2018-2026. |
| Chang, L.-S., E.M. Akhmametyeva, M. Mihaylova, H. Luo, S. Tae, B. Neff, and D.B. Welling. 2005. Dissecting the Molecular Pathways in Vestibular Schwannoma Tumorigenesis. Recent Research Development in Genes & Genomes 1: 1-33. |
| Popov, B., L.-S. Chang, and V. Serikov. 2005. Cell Cycle-Related Transformation of the E2F4-p130 Repressor Complex. Biochem. Biophys. Res. Commun. 336:762-769. |
| Golovnina, K., A. Blinov, E.M. Akhmametyeva, L.V. Omelyanchuk, and L.-S. Chang. 2005. Evolution and Origin of Merlin, the Product of the Neurofibromatosis Type 2 (NF2) Tumor-Suppressor Gene. BMC Evol. Biol. 5:69-86. |
| Lo, W., L. Zhu, E. Akhmametyeva, and L.-S. Chang. 2003. Induction of Apoptosis by the p53-Related p73 and Partial Inhibition by the Baculovirus-Encoded p35 in Neuronal Cells. Brain Res. Mol. Brain Res. 113:1-12. |
| Xu, Z., S. Huang, L.-S. Chang, A.D. Agulnick, and S.J. Brandt. 2003. Identification of a TAL1 Target Gene Reveals a Positive Role for the LIM Domain-Binding Protein Ldb1 in Erythroid Gene Expression and Differentiation. Mol. Cell. Biol. 23: 7585-7599. |
| Chang, L.-S., E.M. Akhmametyeva, Y. Wu, L. Zhu, and D.B. Welling. 2002. Multiple Transcription Initiation Sites, Alternative Splicing, and Differential Polyadenylation Contribute to the Complexity of Human Neurofibromatosis 2 Transcripts. Genomics 79:63-76. |
| Podust, V.N., L.-S. Chang, R. Ott, G.L. Dianov, and E. Fanning. 2002. Reconstitution of human DNA Polymerase ? Using Recombinant Baculoviruses: The p12 Subunit Potentiates DNA Polymerizing Activity of the Four-Subunit Enzyme. J. Biol. Chem. 277:3894-3901. |
| Welling, D.B., J.M. Lasak, E. Akhmametyeva, B. Ghehari, and L.-S. Chang. 2002. cDNA Microarray Analysis of Vestibular Schwannomas. Otology Neurology 23:736-748. |
| Lasak, J.M., D.B. Welling, E. Akhmametyeva, M. Salloum, and L.-S. Chang. 2002. Retinoblastoma-CDK Pathway Deregulation in Vestibular Schwannomas. Laryngoscope 112:1555-1561. |
| Zhu, L., S.B. Kahwash, and L.-S. Chang. 1998. Developmental Expression of Mouse Erythrocyte Protein 4.2 mRNA: Evidence for Specific Expression in Erythroid Cells. Blood 91: 695-705. |
| Zhao, L. and L.-S. Chang. 1997. The Human POLD1 Gene: Identification of An Upstream Activator Sequence, Activation by Sp1 and Sp3, and Cell Cycle Regulation. J. Biol. Chem. 272: 4869-4882. |
| Zhu, L., L. Zhu, E. Xie, and L.-S. Chang. 1995. Differential Role of Two Tandem E2F Sites in Repression of Human p107 Promoter by Retinoblastoma and p107 proteins. Mol. Cell. Biol. 15:3552-3562. |
| Shi, Y., E. Seto, L.-S. Chang, and T. Shenk. 1991. Transcription Repression by a Human Kruppel-Related Protein and Relief of Repression by Adenovirus E1A. Cell 67:377-388. |
| Samulski, R.J., L.-S. Chang, and T. Shenk. 1987. A Recombinant Plasmid from Which an Infectious Adeno-Associated Virus Genome Can Be Exised In Vitro and Its Use to Study Viral Replication. J. Virol. 61:3096-3101. |
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