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BARTLETT LABORATORY
My laboratory seeks to identify genetic factors for language impairments. As animal models of language development are of limited utility, we examine DNA from families segregating specific language impairment or autism as part of two separate but interacting projects. These projects are heavily interdisciplinary, utilizing a wide range of molecular and computational methods developed in-house and though close collaborations with experts in statistics and computer science. We hope that use of genetics will allow for identification of at-risk children to promote early intervention.
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| Education |
| 2004 |
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Ph.D. |
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Behavioral and Neural Sciences |
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Rutgers, Newark, New Jersey |
| Professional Experience |
| 2007- PRES |
Assistant Professor, Battelle Center for Mathematical Medicine (formerly known at the Center for Quantitative and Computational Biology, The Research Institute at Nationwide Children's Hospital |
| 2006- PRES |
Assistant Professor, Center for Molecular and Human Genetics, The Research Institute at Nationwide Children's Hospital |
| 2006- PRES |
Assistant Professor of Pediatrics, The Ohio State University
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| 2006- 2007 |
Assistant Professor, Center for Quantitative and Computational Biology, The Research Institute at Nationwide Children's Hospital |
Research Interests
My laboratory seeks to identify genetic factors for language impairments. As animal models of language development are of limited utility, we examine DNA from families segregating specific language impairment or autism as part of two separate but interacting projects. These projects are heavily interdisciplinary, utilizing a wide range of molecular and computational methods developed in-house and through close collaborations with experts in statistics and computer science. We hope that use of genetics will allow for identification of at-risk children to promote early intervention.
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BARTLETT LABORATORY STAFF
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Principal Investigator:
Christopher Bartlett, Ph.D.
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 Tabatha Simmons, BS
Graduate Student -- The main focus of my work is centered around studying families that segregate Specific Language Impairment (SLI) to hone in on chromosomal regions that are likely to harbor susceptibility alleles. email: tabatha.simmons@nationwidechildrens.org |
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| Selected Publications |
| Autism Genome Project (in press). Mapping autism risk loci using genetic linkage and chromosomal rearrangements. Nature Genet. |
| Bartlett CW, Vieland VJ (in press). Accumulating quantitative trait linkage evidence across multiple datasets using the posterior probability of linkage. Genetic Epidemiology |
Wassink TH, Vieland VJ, Sheffield VC, Bartlett CW, Goedken R, Childress D, Piven J (in press). Posterior probability of linkage analysis of autism dataset identifies linkage to chromosome 16. Psychiatric Genet |
| Bartlett CW, Vieland VJ. Two novel quantitative trait linkage analysis statistics based on the posterior probability of linkage: application to the COGA families. BMC Genetics 6 (Suppl 1):S44, 2005 |
| Bartlett CW, Goedken R, Vieland VJ. Effects of updating linkage evidence across subsets of data: reanalysis of autism genetic resource exchange dataset. American Journal of Human Genetics 76:688-695, 2005 |
| Bartlett CW, Gharani N, Millonig JH, Brzustowicz LM. Three autism candidate genes: a synthesis of human genetic analysis with other disciplines. International Journal of Developmental Neuroscience 23:221-234, 2005 |
| Bartlett CW, Flax JF, Logue MW, Smith BJ, Vieland VJ, Tallai P, Brzustowicz LM. Examination of potential overlap in autism and language loci on chromosomes 2, 7 and 13 in two independent samples ascertained for specific language impairment. Human Heredity 57:10-20, 2004 |
| Flax J, Realpe-Bonilla T, Hirsch LS, Brzustowicz LB, Bartlett CW, Tallal P. Specific language impairment in families: evidence for co-occurrence with reading impairments. Journal of Speech, Language and Hearing Research. 46:530-543, 2003 |
| Bartlett CW, Flax JF, Logue MW, Vieland VJ, Bassett AS, Tallal P, Brzustowicz LM. A major susceptibility locus for specific language impairment is located on 13q21. American Journal of Human Genetics. 71:45-55, 2002 |
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