The Research Institute at Nationwide Children's Hospital - David R. Brigstock, Ph.D. Profile
David R. Brigstock, Ph.D.
photo of David R. Brigstock, Ph.D.
Center for Clinical and Translational Research

PRINCIPAL INVESTIGATOR

David.Brigstock@
nationwidechildrens.org


The Research Institute at Nationwide Children's Hospital
700 Childrens Drive
Columbus, OH 43205
p: 614.722.2700

BRIGSTOCK LABORATORY
We are studying the role of connective tissue growth factor (CTGF) in fibrotic diseases, which are characterized by excessive production and deposition of insoluble collagen matrix, resulting in loss of tissue structure and organ dysfunction. Our main research efforts are currently focussed on liver and pancreatic fibrosis but we have collaborative efforts that focus on other organ systems such as the lung, intestine, heart and skin. Using molecular, cellular and biochemical approches, both in vitro and in vivo, our goals are to understand the mechanisms by which CTGF stimulates collagen production by fibrogenic cells types. In this manner, we will determine the therapeutic value of targetting pathways of CTGF biosynthesis or action to treat a variety of fibrotic disorders.