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PARTIDA-SANCHEZ LABORATORY
My laboratory is interested in the study of immune cell recruitment induced by infection and/or inflammation. Our research projects are focused on molecular analyses of chemokine receptor-mediated G-protein-linked signaling and calcium influx in neutrophils and DCs. We are conducting experiments to study regulation of calcium influx mediated by CD38-catalyzed metabolites and the ADPR-activated calcium channel TRPM2 in inflammatory cells. We would like to assess whether CD38 inhibiting drugs, CD38-derived antagonists, and/or TRPM2 channel inhibitors, have potential therapeutic use to block undesired chronic inflammatory responses, or harmful T cell responses leading to autoimmunity. This knowledge could allow us to design new strategies for clinical intervention in several immunological disorders, as well as inflammatory and infectious diseases.
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| Education |
| 2003 |
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Post-doctoral Fellow |
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The Trudeau Institute, Saranac Lake, NY |
| 1998 |
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Ph.D. |
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Immunology |
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National Polytechnic Institute, Mexico City, Mexico |
| Professional Experience |
| 2004- PRES |
Graduate Faculty Member, Integrated Biomedical Science Graduate Program and Molecular, Cellular and Development Biology Program, The Ohio State University, College of Medicine and Public Health, Columbus, OH. |
| 2004- PRES |
Assistant Professor of Pediatrics, The Research Institute at Nationwide Children's Hospital, The Ohio State University, College of Medicine and Public Health, Columbus, OH. |
| 2003- 2004 |
Research Scientist, The Trudeau Institute, Saranac Lake, NY. PI. Dr. Frances E. Lund. |
| 1998- 2003 |
Post-Doctoral Fellow, The Trudeau Institute, Saranac Lake, NY. PI. Dr. Frances E. Lund. |
PARTIDA-SANCHEZ LABORATORY STAFF
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Principal Investigator:
Santiago Partida-Sanchez, Ph.D.
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| Selected Publications |
| Novotny LA, Partida-Sanchez S, Munson RS Jr., and Bakaletz LO. Differential uptake and processing of a Haemophilus influenzae P5-derived immunogen by chinchilla dendritic cell. Infect and Immun. 2008; 76:867-77. PubMed ID: 18160476 |
| Randolph GJ, Ochando J and Partida-Sánchez S. Migration of dendritic cell subsets and their precursors. Annu Rev Immunol. 2008; 26:293-316. PubMed ID: 18045026 |
| Randolph GJ, Ochando J and Partida-Sanchez S. Migration of dendritic cell subsets and their precursors. Annual Review of Immunology 2007 Nov 15 [Epub ahead of print]. PubMed ID: 18045026 |
| Partida-Sanchez S, Gasser A, Fliegert R, Siebrands CC, Dammermann W, Shi G, Mousseau BJ, Sumoza-Toledo A, Bhagat H, Walseth TH, Guse AH, and Lund FE. Chemotaxis of mouse bone marrow neutrophils and dendritic cells is controlled by ADP-Ribose, the major product generated by the CD38 enzyme reaction. J Immunol. 2007; 179:7827-39. PubMed ID: 18025229 |
| Shi G*, Partida-Sanchez S*, Misra RS, Tighe M, Borchers MT, Lee JJ, Simon MI, and Lund FE. Identification of an alternative G{alpha}q-dependent chemokine receptor signal transduction pathway in dendritic cells and granulocytes. J Exp Med. 2007; 204:2705-18. (*Equal contribution first author). PubMed ID: 17938235 |
| Partida-Sanchez S, Rivero-Nava L, Shi G, and Lund FE. CD38: an ecto-enzyme at the crossroads of innate and adaptive immune responses. Adv Exp Med Biol. 2007;590:171-83. PubMed ID: 17191385 |
Khader SA, Partida-Sanchez S, Bell G, Jelley-Gibbs DM, Swain S, Pearl JE, Ghilardi N, Desauvage FJ, Lund FE, Cooper AM. Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infection. J Exp Med 2006 Jul 10; 203:1805-15. PubMed ID: 16818672 |
Lund FE, Muller-Steffner H, Romero-Ramirez H, Moreno-Garcia M, Partida-Sanchez S, Makris M, Oppenheimer N, Santos-Argumedo L, and Shuber F. (2006). CD38 induces apoptosis of a murine pre-B cell leukemic cell line by an ADP-ribosyl cyclase and NAD glycohydrolase independent mechanism. Int. Immunol. 2006; 18:1029-42. PubMed ID: 16720618 |
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