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KITAGAWA LABORATORY
A fundamental requirement of the cell division cycle is the maintenance, replication, and segregation of chromosomal DNA, the specific order of which is ensured by checkpoints. Dr. Kitagawa is interested in the role that the spindle checkpoint plays in tumor development. Mutations in genes required for kinetochore function and mitotic checkpoint surveillance possibly contribute development of cancer.
The Kitagawa Lab is employing a series of genetic and biochemical strategies to identify additional interacting gene products, regulators, and potential substrates of Sgt1/Skp1/Hsp90 action in yeast and vertebrates. In studies with human cells, Dr. Kitagawa has found a novel mechanism by which 17-AAG (an Hsp90 inhibitor and a novel anti-cancer drug) inhibits cell proliferation and provide the first evidence of HSP90 being required for assembly of kinetochore protein complexes in humans. Other projects include studying the relationship between mitotic cell death and the spindle checkpoint, and the role of the mitotic cell death in tumorigenesis using mouse models.
Web Site:: http://www.nationwidechildrens.org/k-kitagawa-lab
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| Education |
| 1995 |
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PhD |
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Molecular Biology |
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Nagoya University, Chikusa-ku, Nagoya (Japan) |
| 1991 |
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Pharm D (in Japan) |
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Pharmacy |
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Nagoya City University, Mizuho-ku, Nagoya City (Japan) |
| 1990 |
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Bachelor of Pharmacy |
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Pharmacy |
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Nagoya City University, Mizuho-ku, Nagoya City (Japan) |
| Professional Experience |
| 2010- PRES |
Principal Investigator, Center for Childhood Cancer, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio |
| 2002- 2010 |
Afftliate Assistant Professor, University of Tennessee, Department of Pathology, CoUege of Medicine |
| 2001- 2010 |
Assistant Member, Department of Molecular Pharmacology St. Jude Children's Research Hospital |
| 2000- 2001 |
Research Associate, University of British Columbia, Centre for Molecular Medicine and Therapeutics, Faculty of Medicine |
| 1997- 2000 |
Postdoctoral fellow, University of British Columbia, Centre for Molecular Medicine and Therapeutics, Faculty of Medicine |
| 1995- 1997 |
Postdoctoral fellow, Department of Molecular Biology and Genetics, School of Medicine, The Johns Hopkins University |
| 1995- 1996 |
Research Fellow, Graduate School, School of Science, Department of Molecular Biology, Nagoya University |
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