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PHIEL LABORATORY
My laboratory is interested in the posttranslational modification of proteins, with a focus on how these modifications affect neurodegeneration. Currently, our main project involves understanding how glycogen synthase kinase-3 (GSK-3) isoforms contribute to the amyloid plaques and neurofibrillary tangles which are pathological hallmarks of Alzheimer’s disease. This effort is being approached through the development of novel transgenic mice and cell lines. Our long-term goal is to define the molecular mechanism underlying the role for GSK-3 in plaque and tangle formation, with the eventual hope of developing alternative therapeutic strategies for the prevention of Alzheimer’s disease.
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| Education |
| 2003 |
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Postdoctoral Fellowship |
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Molecular Biology |
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University of Pennysylvania, Howard Hughes Medical Institute, Philadelphia, PA |
| 1998 |
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Ph.D. |
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Developmental Biology |
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Thomas Jefferson University, Philadelphia, PA |
| 1992 |
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B.S. |
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Biology |
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Ursinus College, Collegeville, PA |
| Professional Experience |
| 2003- PRES |
Assistant Professor, Department of Pediatrics, The Ohio State University |
| 1998- 2003 |
Postdoctoral Fellow, Department of Medicine, Division of Hematology/Oncology, Howard Hughes Medical Institute, University of Pennsylvania School of Medicine |
| 1993- 1998 |
Graduate Student, Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University |
PHIEL LABORATORY STAFF
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Principal Investigator:
Christopher J. Phiel, Ph.D.
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| Selected Publications |
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Rorick AM, et al. PP2A:B56 epsilon is required for eye induction and eye field separation. Dev Biol, 2006.
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| Phiel CJ, Wilson CA, Lee VM-Y and Klein PS. GSK-3a Regulates Production of Alzheimer's Disease Amyloid-b Peptides, Nature 423:435-439, 2003. PubMed ID: 12761548 |
| Zhang F, Phiel CJ, Spece L, Gurvich N and Klein PS. Inhibitory phosphorylation of glycogen synthase kinase-3 (GSK-3) in response to lithium: Evidence for autoregulation of GSK-3, Journal of Biological Chemistry, 278:33067-33077, 2003. PubMed ID: 12796505 |
| Gabetta V, Trzyna WT, Phiel CJ and McHugh KM. Vesicle-Associated Protein-A is Differentially Expressed During Intestinal Smooth Muscle Cell Differentiation, Developmental Dynamics 228:11-20, 2003 PubMed ID: 12950075 |
| Phiel CJ, Zhang F, Huang EY, Guenther MG, Lazar MA and Klein PS. Histone Deacetylase is a Direct Target of Valproic Acid, a Poetnt Anticonvulsant, Mood Stabilizer, and Teratogen, Journal of Biological Chemistry 276:36734-36741, 2001. PubMed ID: 11473107 |
| Phiel CJ and Klein, PS. Molecular Targets of Lithium Action, Annual Reviews in Pharmacology and Toxicology 41:789-813, 2001. PubMed ID: 11264477 |
| Phiel CJ, Gabbeta V, Parsons LM, Rothblat D, Harvey RP and McHugh KM. Differential binding of an SRF/NK-2 transcription factor complex in normal versus neoplatic smooth muscle tissues, Journal of Biological Chemistry 276:34637-34650, 2001. PubMed ID: 11457859 |
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