The Research Institute at Nationwide Children's Hospital - Christopher J. Phiel, Ph.D. Profile
Christopher J. Phiel, Ph.D.
photo of Christopher J. Phiel, Ph.D.
Center for Molecular and Human Genetics

PRINCIPAL INVESTIGATOR

Christopher.Phiel@
nationwidechildrens.org


The Research Institute at Nationwide Children's Hospital
700 Childrens Drive, WA2525
Columbus, OH 43205
p: 614.722.2700

PHIEL LABORATORY
My laboratory is interested in the posttranslational modification of proteins, with a focus on how these modifications affect neurodegeneration.  Currently, our main project involves understanding how glycogen synthase kinase-3 (GSK-3) isoforms contribute to the amyloid plaques and neurofibrillary tangles which are pathological hallmarks of Alzheimer’s disease.  This effort is being approached through the development of novel transgenic mice and cell lines.  Our long-term goal is to define the molecular mechanism underlying the role for GSK-3 in plaque and tangle formation, with the eventual hope of developing alternative therapeutic strategies for the prevention of Alzheimer’s disease.