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RAFFEL LABORATORY
The focus of the Raffel Lab is to use recombinant measles virus to treat medulloblastoma. Traditionally, medulloblastomas have been treated with radical surgical resection and radiation therapy, resulting in 5-year survival rates of about 50%. As the devastating effects of radiation therapy to the pediatric brain have been recognized, emphasis has been placed on decreasing the dose of radiation used and adding chemotherapy. Thus, there is a critical need to develop alternative therapies for children with medulloblastoma.
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| Education |
| 1987 |
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Fellowship |
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Pediatric Neurosurgery |
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University of California, San Francisco, California |
| 1986 |
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Residency |
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Neurological Surgery |
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University of California, San Francisco , California |
| 1986 |
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Fellowship |
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Pediatric Neurosurgery |
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Hospital for Sick Children, Toronto, Canada |
| 1980 |
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MD |
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Medicine |
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Univeristy of California School of Medicine, San Diego, California |
| Professional Experience |
| 2007- PRES |
Professor and Vice Chair in the Department of Neurological Surgery at The Ohio State University College of Medicine, Columbus, OH
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| 2007- PRES |
Chief of Neurosurgery, Nationwide Children’s Hospital, Columbus, OH
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| 1999- 2006 |
Full Faculty Privileges in Tumor Biology - Mayo Graduate School
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| 1996- 1999 |
Associate Professor of Neurosurgery - Mayo Clinic College of Medicine
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| 1995- 1999 |
Associate Faculty Privileges in Molecular Neuroscience - Mayo Graduate School
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| 1995- 1999 |
Associate Faculty Privileges in Tumor Biology - Mayo Graduate School |
| 1995- 1996 |
Senior Associate Consultant - Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota
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| 1992- 1995 |
Associate Professor of Neurological Surgery - University of Southern California School of Medicine, Los Angeles, California
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| 1987- 1992 |
Assistant Professor of Neurological Surgery - University of Southern California School of Medicine, Los Angeles, California
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| 1987- 1987 |
Clinical Instructor - Department of Neurological Surgery, University of California, San Francisco, San Francisco, California
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Research Interests
Tumor Suppressor Genes and Oncogenes in Medulloblastoma, Growth Factor and Growth Factor Receptor, Expression in Medulloblastoma, Gene Therapy for Brain Tumors.
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| Selected Publications |
| White JB, Raffel C, Balckwell RE. A case of infertility in a patient with a ventriculoperitoneal shunt. Pediatric Neurosurgery 43 (2): 146-8, 2007. PubMed ID: 17337930 |
| Amador N, Scheithauer BW, Giannini C, Raffel C. Acute cerebellitis presenting as tumor. Report of two cases. Journal of Neurosurgery 107(1 Suppl): 57-61, July 2007. PubMed ID: 17644922 |
| Clarke MJ, Foy AB, Wetjen N, Raffel C. Imaging characteristics and growth of subependymal giant cell astrocytomas. Neurosurgical Focus 2006; 20(1):E5. PubMed ID: 16459995 |
| Raffel C. Control of B-catenin/Tcf-directed transcription in medulloblastoma. Acta Paediatr 2004(Suppl 445):12-17 |
| Jarrar RG, Buchhalter JR, Raffel C. Long-term outcome of epilepsy surgery in patients with tuberous sclerosis. Neurology 2004 Feb 10; 62(3):479-81. PubMed ID: 14872037 |
| Maher CO, Raffel C. Neurosurgical treatment of brain tumors in children. Pediatr Clin North Am 2004 Apr; 51(2):327-57. PubMed ID: 15062674 |
| Raffel C. Medulloblastoma: Molecular genetics and animal models. Neoplasia 2004 Jul-Aug; 6(4):310-22. PubMed ID: 15256053 |
| Cascino GD, Buchhalter JR, Sirven JI, So EL, Drazkowski JF, Zimmerman RS, Raffel C. Peri-ictal SPECT and surgical treatment for intractable epilepsy related to schizencephaly. Neurology 2004 Dec 28; 63(12):2426-8. PubMed ID: 15623720 |
| Cohen-Gadol AA, Britton JW, Wetjen NM, Marsh WR, Meyer FB, Raffel C. Neurostimulation therapy for epilepsy: Current modalities and future directions. Mayo Clin Proc 2003 Feb; 78(2):238-48. PubMed ID: 12583536 |
| Warnick RE, Raffel C, Glick RP. Neuro-oncology research opportunities in North America: results of a survey by the AANS/CNS Section on Tumors. J Neurooncol 2003 Feb; 61(3):197-201. PubMed ID: 12675311 |
| Maher CO, Cohen-Gadol AA, Raffel C. Cortical resection for epilepsy in children with linear sebaceous nevus syndrome. Pediatr Neurosurg 2003 Sep; 39(3):129-35. PubMed ID: 12876391 |
| Cohen-Gadol AA, Koch CA, Raffel C, Spinner RJ, Patterson RH, Giannotta SL, Hoff JT, Stern WE, Kline DG. Confirmation of research publications reported by neurological surgery residency applicants. Surg Neurol 2003 Oct; 60(4):280-4. PubMed ID: 14505831 |
| Woodruff JM, Scheithauer BW, Kurtkaya-Yapicier O, Raffel C, Amr SS, LaQuaglia MP, Antonescu CR. Congenital and childhood plexiform (Multinodular) cellular Schwannoma - A troublesome mimic of malignant peripheral nerve sheath tumor. Am J Surg Pathol 2003 Oct; 27(10):1321-9. PubMed ID: 14508393 |
| Taylor MD, Raffel C, Bayani J, Marrano P, Mainprize TG, Squire J. Advanced cancer genetics in neurosurgical research. Neurosurgery 2003 Nov; 53(5):1168-78. PubMed ID: 14580285 |
| Maher CO, Friedman JA, Meyer FB, Lynch JJ, Unni K, Raffel C. Surgical treatment of fibrous dysplasia of the skull in children. Pediatr Neurosurg 2002 Aug; 37(2):87-92. PubMed ID: 12145517 |
| Phuong LK, Schoeberl KA, Raffel C. Natural history of tethered cord in patients with meningomyelocele. Neurosurgery 2002 May; 50(5):989-93. PubMed ID: 11950401 |
| Taylor MD, Liu L, Raffel C, Hui CC, Mainprize TG, Zhang XY, Agatep R, Chiappa S, Gao LZ, Lowrance A, Hao AH, Goldstein AM, Stavrou T, Scherer SW, Dura WT, Wainwright B, Squire JA, Rutka JT, Hogg D. Mutations in SUFU predispose to medulloblastoma. Nat Genet 2002 Jul; 31(3):306-10. PubMed ID: 12068298 |
| Ramin KD, Raffel C, Breckle RJ, Ogburn PL Jr, Friedman JD, Ramsey PS. Chronology of neurological manifestations of prenatally diagnosed open neural tube defects. Journal of Maternal-Fetal & Neonatal Medicine 2002 Feb; 11(2):89-92. PubMed ID: 12375549 |
| Park K, Buchhalter J, McClelland R, Raffel C. Frequency and significance of acute postoperative seizures following epilepsy surgery in children and adolescents. Epilepsia 2002 Aug; 43(8):874-81. PubMed ID: 12181006 |
| Perry A, Scheithauer BW, Macaulay RJB, Raffel C, Roth KA, Kros JM. Oligodendrogliomas with neurocytic differentiation. A report of 4 cases with diagnostic and histogenetic implications. Journal of Neuropathology & Experimental Neurology 2002 Nov; 61(11):947-55. PubMed ID: 12430711 |
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