Zarife Sahenk, MD, PhD

Medical School:

Hacettepe University   MD   07/31/1972

Internship:

Hacettepe University   06/30/1972

Residency:

Hacettepe University   09/30/1972
Ohio State University Medical Center   06/30/1975

Fellowship:

Ohio State University Medical Center   06/30/1978
Ohio State University Medical Center   06/30/1978

Section:

Neurology   Click to learn about this department

Specialty:

Neurology, Certified  

Gender:

Female

Languages Spoken:

English

Date of Appointment at
Children's Hospital:

06/30/2005

Office Practice Information:

• Accepts patients 0-18
• Accepts patients 18 years or older
• Accepts Medicaid
• Requires a written physician referral
• This office is wheelchair accessible

Academic Title:

Professor of Pathology
Professor of Pediatrics

Clinical, Teaching & Research Interests*:

Zarife Sahenk, MD, PhD, is the Director of Clinical and Experimental Neuromuscular Pathology at The Research Institute at Nationwide Children's Hospital and a Professor of Pathology and Pediatrics at The Ohio State University College of Medicine. Her research aims to define the anatomical and molecular basis of hereditary peripheral neuropathies, emphasizing the role of trophic factors secreted by Schwann cells in regeneration-associated myelination. The role of neurotrophin-3 in nerve regeneration in patients and animal models of Charcot-Marie-Tooth (CMT) is currently under investigation. These studies are relevant to understanding the mechanism of axonal loss and impaired regeneration in CMT disorders and developing rational therapies to promote nerve repair.

Publications*:

Acharyya S, Villalta SA, Bakkar N, Janssen PM, Carathers M, Li ZW, Beg AA, Ghosh S, Sahenk Z, et al. Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy. Journal of Clinical Investigation 117: 889-901, 2007.

Research Funding*:

Evaluating the Potential Efficacy of trkB, trkC Receptor Agonists and Their Combination in a Mouse Model of Charcot-Marie-Tooth Disease, Anonymous

*Physician publications, awards and honors, and presentations and teaching activities represent work completed in 2007 only.